keyword
https://read.qxmd.com/read/36615720/nutritional-management-of-intestinal-failure-due-to-short-bowel-syndrome-in-children
#21
REVIEW
Maria Giovanna Puoti, Jutta Köglmeier
BACKGROUND: The most common cause of intestinal failure (IF) in childhood remains short bowel syndrome (SBS), where bowel mass is significantly reduced due to a congenital atresia or resection and parenteral nutrition (PN) needed. Home PN has improved outcome and quality of life, but the long-term therapeutic goal is to achieve enteral autonomy whilst avoiding long term complications. This paper is aimed at discussing nutritional strategies available to clinicians caring for these patients...
December 23, 2022: Nutrients
https://read.qxmd.com/read/36445066/introduction-of-soy-free-plant-based-pediatric-formula-in-infants-with-fpies-a-case-report
#22
JOURNAL ARTICLE
Emily Bair
Background: Standard practice for management of food protein-induced enterocolitis syndrome (FPIES) frequently requires the use of hypoallergenic semi-elemental or elemental formulas. For some patients, there is poor tolerance of these formulas and no improvement of gastrointestinal symptoms. For others, especially those over 4 months of age, the introduction of these formulas is difficult due to their scientifically demonstrated poor palatability. Case presentation: This case report features an 18-month-old child diagnosed with FPIES at 4 months who failed to tolerate standard hypoallergenic semi-elemental and elemental formulas to supplement maternal breast milk feedings resulting in suboptimal growth...
November 29, 2022: Nutrition and Health
https://read.qxmd.com/read/36359934/a-method-for-screening-proteases-that-can-specifically-hydrolyze-the-epitope-aa83-105-of-%C3%AE-s1-casein-allergen
#23
JOURNAL ARTICLE
Di Liu, Xiaozhe Lv, Yanjun Cong, Linfeng Li
Milk protein hydrolysates are common in infant formula, but some of them retain allergenicity due to incomplete hydrolysis of the epitopes for milk allergens. This study explored a method for screening proteases that could specifically hydrolyze the epitope of αs1 -casein allergen. Firstly, the αs1 -casein epitope AA83-105 was synthesized by the solid-phase synthesis method. Then, after purification and identification, the complete antigen was prepared through coupling with bovine serum albumin (BSA) and was used to raise monoclonal antibodies (mAb) in BALB/c mice...
October 23, 2022: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36282131/diagnosis-and-management-of-food-allergy-associated-gastroesophageal-reflux-disease-in-young-children-eaaci-position-paper
#24
JOURNAL ARTICLE
Rosan Meyer, Yvan Vandenplas, Adriana Chebar Lozinsky, Mario C Vieira, Roberto Berni Canani, Christophe Dupont, Pinar Uysal, Ozlem Cavkaytar, Rebecca Knibb, David M Fleischer, Anna Nowak-Wegrzyn, Carina Venter
Gastro-oesophageal reflux (GOR) and food allergy (FA) are common conditions, especially during the first 12 months of life. When GOR leads to troublesome symptoms, that affect the daily functioning of the infant and family, it is referred to as GOR disease (GORD). The role of food allergens as a cause of GORD remains controversial. This European Academy of Allergy and Clinical Immunology (EAACI) position paper aims to review the evidence for FA-associated GORD in young children and translate this into clinical practice that guides healthcare professionals through the diagnosis of suspected FA-associated GORD and medical and dietary management...
October 2022: Pediatric Allergy and Immunology
https://read.qxmd.com/read/36235669/the-role-of-infant-formulas-in-the-primary-prevention-of-allergies-in-non-breastfed-infants-at-risk-of-developing-allergies-recommendations-from-a-multidisciplinary-group-of-experts
#25
JOURNAL ARTICLE
Jorge Amil Dias, Edmundo Santos, Inês Asseiceira, Sylvia Jacob, Carmen Ribes Koninckx
The worldwide incidence of allergic diseases has been continuously increasing, and up to one in every five people are currently affected by these medical conditions. Although seldom fatal, allergies have a profound impact on children's growth, development, and quality of life, besides being associated with heavy healthcare costs and resource utilisation. In this context, a group of experts in nutrition, paediatric gastroenterology, allergology, and neonatology joined forces to discuss the role of infant formulas in the primary prevention of allergies in infants for whom breastfeeding is not an option and who are at risk of developing allergies...
September 27, 2022: Nutrients
https://read.qxmd.com/read/36192967/model-infant-formulas-influence-of-types-of-whey-proteins-and-lipid-composition-on-the-in-vitro-static-digestion-behavior
#26
JOURNAL ARTICLE
Guilherme de Figueiredo Furtado, Flávia Souza Almeida, Ana Carla Kawazoe Sato, Miriam Dupas Hubinger
This work aimed at evaluating the influence of types of whey proteins (lactoferrin, whey protein isolate and/or whey protein hydrolysates) and lipid composition (high oleic sunflower oil, coconut oil and/or medium chain triacylglycerols) on the behavior of model infant formulas (IFs) under simulated conditions of the infant gastrointestinal tract using an in vitro static digestion model. The physicochemical conditions of the gastric medium resulted in the aggregation of oil the droplets and partial hydrolysis of the proteins, considering whey proteins were resistant to the gastric conditions...
November 2022: Food Research International
https://read.qxmd.com/read/36179081/validation-of-the-test-method-determination-of-available-carbohydrates-in-cereal-and-cereal-products-dairy-products-vegetables-fruit-and-related-food-products-and-animal-feeds-collaborative-study-final-action-2020-07
#27
JOURNAL ARTICLE
Ciara McLoughlin, Vincent A McKie, Barry V McCleary
BACKGROUND: A simple, accurate, and reliable method to measure available carbohydrate components of food products, including cereal and dairy products, fruits, vegetables, processed food, food ingredients and animal foods, was developed by Megazyme (product K-AVCHO, Bray, Ireland). A single-laboratory validation of the enzymatic method resulted in First Action status as Official Method of Analysis (OMA) 2020.07. OBJECTIVE: A collaborative study was conducted to evaluate the repeatability and reproducibility of OMA 2020...
September 30, 2022: Journal of AOAC International
https://read.qxmd.com/read/36109763/non-syndromic-bile-duct-paucity-and-non-ige-cow-s-milk-allergy-a-case-report-of-challenging-nutritional-management-and-maltodextrin-intolerance
#28
JOURNAL ARTICLE
Irene Degrassi, Martina Chiara Pascuzzi, Enza D'Auria, Laura Fiori, Dario Dilillo, Gianluca Lista, Francesca Maria Castoldi, Francesco Cavigioli, Alessandra Bosetti, Alessandro Pellegrinelli, Gian Vincenzo Zuccotti, Elvira Verduci
BACKGROUND: Cholestasis in extremely premature infants (EPI) constitutes a nutritional challenge and maltodextrins have been reported as a possible strategy for hypoglycaemia. We aim to describe the nutritional management of an EPI with non-syndromic bile duct paucity (NSBDP) and feeding intolerance. CASE PRESENTATION: A patient, born at 27 weeks of gestational age, presented cholestatic jaundice at 20 days of life with a clinical picture of NSBDP. Patient's growth was insufficient with formula rich in medium-chain triglyceride (MCT) and branched-chain amino acids (BCAA)...
September 15, 2022: Italian Journal of Pediatrics
https://read.qxmd.com/read/36037686/insight-into-the-molecular-level-details-of-%C3%AE-s1-casein-interactions-with-igg-combining-with-lc-ms-ms-and-molecular-modelling-techniques
#29
JOURNAL ARTICLE
Jianhua Zeng, Kai Lin, Xiaoqian Zhang, Junzhe Zou, Lanwei Zhang, Pimin Gong, Jinlong Zhao, Chunhua Han, Yuhai Liu, Huaxi Yi, Tongjie Liu
αs1-Casein (αs1-CN) is a major cow milk allergen, while the tertiary structure of αs1-CN and conformational epitopes of αs1-CN have not been clarified. Here, a reasonable three-dimensional structure of αs1-CN was established using ab initio methods, and hot-spot residues and epitopes were investigated by combining molecular dynamics simulation, peptides synthesis, and ELISA. Obtained results demonstrated that the binding mechanism between αs1-CN and IgG was located on three main regions: a helical structure zone (E77-Q97), the flexible loop zone (Y154-T174), and a flexible C-terminal (N190-L198), mainly connecting via hydrogen bond and ionic bonds...
August 22, 2022: Food Chemistry
https://read.qxmd.com/read/35885248/an-in-vitro-and-in-vivo-translational-research-approach-for-the-assessment-of-sensitization-capacity-and-residual-allergenicity-of-an-extensive-whey-hydrolysate-for-cow-s-milk-allergic-infants
#30
JOURNAL ARTICLE
Karen Knipping, Laura Buelens, Peter J Simons, Johan Garssen
INTRODUCTION: Hypoallergenic formulas prepared from hydrolyzed cow's milk proteins are often used for the management of cow's milk allergy (CMA) in infants. In this study, both in vitro assays and an in vivo mouse model for CMA were used to assess the sensitizing and allergenic potential of a newly developed, extensive whey hydrolysate (eWH). METHODS: Gel permeation chromatography was used to characterize the molecular weight distribution of the peptides. Residual antigenicity was measured using a beta-lactoglobulin ELISA as well as with immunoblotting using anti-beta-lactoglobulin (BLG) and anti-alpha-lactalbumin antibodies...
July 7, 2022: Foods (Basel, Switzerland)
https://read.qxmd.com/read/35789408/comparison-of-tastes-of-available-nutritional-integrated-or-non-integrated-formulas-for-infants-older-than-1-year-of-age-with-cow-s-milk-allergy-a-multicenter-prospective-single-blind-cross-sectional-observational-clinical-study-contest-study
#31
RANDOMIZED CONTROLLED TRIAL
Derya Ufuk Altıntas, Ipek Turktas, Mustafa Arga, Haluk Cezmi Cokugras, Ersoy Civelek, Ozlem Keskin, Betul Buyuktiryaki, Deniz Ertem, Metin Aydogan, Cıgdem Omur Ecevit, Yesim Ozturk, Zeynep Tamay, Esra Yucel, Gonul Caltepe, Omer Faruk Beser, Nermin Guler
Palatability of the infant formulas lacking cow milk protein formulas is reported by parents to be an important drawback. The purpose of this study is to examine decisions made by mothers of infants having cow milk protein allergy, and physicians concerning the palatability of unflavored extensively hydrolyzed formulas and amino acid-based formulas. We conducted a multi-center, randomized, single-blinded, observational taste study involving 149 pediatricians from gastroenterology and allergy subspecialties at 14 tertiary healthcare units from different regions of Turkey and involving 94 mothers of infants with cow milk protein allergy...
2022: Allergologia et Immunopathologia
https://read.qxmd.com/read/35769218/clinical-observation-of-extensively-hydrolysis-protein-formula-with-feeding-intolerance-in-preterm-infants
#32
JOURNAL ARTICLE
Liping Yin, Jingjing Ma, Heng Liu, Qianying Gu, Li Huang, Qi Mu, Ning An, LiJuan Qian, Lixing Qiao
OBJECTIVE: To investigate whether feeding extensively hydrolysis protein formula during the NICU hospitalization was more beneficial for preterm infants with a gestational age (GA) ≤34 weeks when breastfeeding was not possible. METHODS: In total, 587 preterm infants were randomly divided into two groups: observation groups fed with extensively hydrolyzed formula (EHF) milk and control groups fed with standard preterm formula (SPF) milk until discharge from the neonatal intensive care unit (NICU)...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/35689606/lactose-concentration-in-low-lactose-and-lactose-free-milk-milk-products-and-products-containing-dairy-ingredients-by-high-sensitivity-enzymatic-method-k-lolac-collaborative-study-final-action-2020-08
#33
JOURNAL ARTICLE
Ruth Ivory, David Mangan, Barry V McCleary
BACKGROUND: The AOAC Stakeholder Panel on Strategic Food Analytical Methods issued a call for methods in 2018 for the measurement of lactose in low-lactose and lactose-free products under Standard Method Performance Requirements (SMPR®) 2018.009. Megazyme's Lactose Assay Kit (K-LOLAC) was reviewed and accepted as a First Action Official Method in 2020 (2020.08). OBJECTIVE: A collaborative study was conducted to evaluate the to evaluate the reproducibility of AOAC Method 2020...
June 11, 2022: Journal of AOAC International
https://read.qxmd.com/read/35663446/a-partially-hydrolyzed-whey-formula-provides-adequate-nutrition-in-high-risk-infants-for-allergy
#34
JOURNAL ARTICLE
Jiyeon Yang, Song I Yang, Kyunguk Jeong, Kyung Won Kim, Yoon Hee Kim, Taek Ki Min, Bok Yang Pyun, Jeongmin Lee, Ji A Jung, Jeong Hee Kim, Sooyoung Lee
BACKGROUND/OBJECTIVES: Hydrolyzed formula is often fed to infants with gastrointestinal or immune issues, such as malabsorption or cow's milk allergy, because enzymatic treatment has rendered it more digestible and less allergenic than standard cow's milk formula (SF). Partially hydrolyzed formula (PHF) should be considered for those infants who are intolerant to extensively hydrolyzed formula. However, there are concerns about the nutritional insufficiencies of PHF. We aimed to evaluate the effects of PHF on the growth and health indicators in infants who were at high-risk of allergic disease and potential candidates for consuming PHF...
June 2022: Nutrition Research and Practice
https://read.qxmd.com/read/35407012/alternatives-to-cow-s-milk-based-infant-formulas-in-the-prevention-and-management-of-cow-s-milk-allergy
#35
REVIEW
Natalia Zofia Maryniak, Ana Isabel Sancho, Egon Bech Hansen, Katrine Lindholm Bøgh
Cow's milk-based infant formulas are the most common substitute to mother's milk in infancy when breastfeeding is impossible or insufficient, as cow's milk is a globally available source of mammalian proteins with high nutritional value. However, cow's milk allergy (CMA) is the most prevalent type of food allergy among infants, affecting up to 3.8% of small children. Hypoallergenic infant formulas based on hydrolysed cow's milk proteins are commercially available for the management of CMA. Yet, there is a growing demand for more options for infant feeding, both in general but especially for the prevention and management of CMA...
March 23, 2022: Foods (Basel, Switzerland)
https://read.qxmd.com/read/35334900/the-macronutrient-composition-of-infant-formula-produces-differences-in-gut-microbiota-maturation-that-associate-with-weight-gain-velocity-and-weight-status
#36
JOURNAL ARTICLE
Julie A Mennella, Yun Li, Kyle Bittinger, Elliot S Friedman, Chunyu Zhao, Hongzhe Li, Gary D Wu, Jillian C Trabulsi
This proof-of-principle study analyzed fecal samples from 30 infants who participated in a randomized controlled trial on the effects of the macronutrient composition of infant formula on growth and energy balance. In that study, infants randomized to be fed cow milk formula (CMF) had faster weight-gain velocity during the first 4 months and higher weight-for-length Z scores up to 11.5 months than those randomized to an isocaloric extensive protein hydrolysate formula (EHF). Here we examined associations among infant formula composition, gut microbial composition and maturation, and children's weight status...
March 15, 2022: Nutrients
https://read.qxmd.com/read/35334859/managing-cow-s-milk-protein-allergy-with-an-extensively-hydrolyzed-formula-results-from-a-prospective-non-interventional-study-in-france-eva-study
#37
JOURNAL ARTICLE
Julie Lemale, Jean-Luc Decline, Catherine Dive-Pouletty, Chantal Touboul, Nadège Pichon, Christophe Dupont
Symptoms related cow's milk proteins allergy (CMPA) usually improve between two to four weeks following an elimination diet, firstly with extensively hydrolyzed formulas (eHF). The aim of the EVA study was to observe the evolution of CMPA-related symptoms in real life after initiation of a whey-based extensively hydrolyzed formula (w-eHF, Althéra® , Nestlé Health Science, Switzerland). This cross-sectional prospective non-interventional study was carried out alongside paediatricians in private practice in France between June 2019 and June 2020...
March 12, 2022: Nutrients
https://read.qxmd.com/read/35147359/-infant-feeding-how-to-choose-an-infant-milk
#38
JOURNAL ARTICLE
Olivier Mouterde
Infant feeding, how to choose an infant milk? The infant's nutrition is of particular concern, not only to assume a good nutritional status, an adequate growth and development, but also, to some extent, for his future health. Breast feeding remains the best choice but needs to be counseled in practice and in order to avoid deficiencies as well as chemical or in¬fectious contaminations. As a substitute to breast milk, none non modified mammalian milk fits the infant's nutritional needs. Similarly, no non-modified vegetal juice fits these needs, being able to provoke severe nutritional deficiencies...
December 2021: La Revue du Praticien
https://read.qxmd.com/read/35058993/safety-evaluation-of-the-food-enzyme-trypsin-from-porcine-pancreas
#39
JOURNAL ARTICLE
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Magdalena Andryszkiewicz, Yi Liu, Sandra Rainieri, Andrew Chesson
The food enzyme trypsin (EC 3.4.21.4) is extracted from porcine pancreas by Ningbo Linzyme Biosciences Co., Ltd. It is intended to be used for the hydrolysis of whey proteins for use in infant formulae and follow-on formulae. Based on maximum use levels and the maximum permitted protein content in infant formula, dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be 16.8 mg TOS/kg body weight (bw) per day for infants. In the toxicological evaluation, clinical studies with pancreatic enzymes were considered...
January 2022: EFSA journal
https://read.qxmd.com/read/34883428/digestibility-of-proteins-in-camel-milk-in-comparison-to-bovine-and-human-milk-using-an-in-vitro-infant-gastrointestinal-digestion-system
#40
JOURNAL ARTICLE
Zhengzheng Zou, John A Duley, David M Cowley, Sarah Reed, Buddhika J Arachchige, Pieter Koorts, Paul N Shaw, Nidhi Bansal
The absence of β-lactoglobulin, high β-/αs -casein ratio and protective proteins make camel milk a promising alternative protein base for making human infant formulae. In this study, protein digestibility of camel milk was compared with that of bovine and human milk using an in vitro infant gastrointestinal digestion system. A low degree of gastric proteolysis was observed in all three kinds of milk, and a single clot was formed in camel milk. The soluble milk proteins remaining in the gastric digesta were digested rapidly and extensively in the intestinal phase, while the proteins in the camel milk clot were hydrolysed gradually...
November 30, 2021: Food Chemistry
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