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hydrolysed infant formula

Pernille Henriksen, Malene Landbo Børresen, Kathrin Dahl
Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE mediated condition. Symptoms of acute FPIES include vomiting, diarrhoea and dehydration. Symptoms are often misread as acute abdomen or sepsis. The condition can be fatal. There are no biomarkers for FPIES, and skin prick test for cow milk is often negative. Treatment is hydrolysed formula milk. This case story describes a one-month-old boy with diarrhoea and an output of up till 2.3 l per day. With this case story we wish to increase the knowledge of FPIES and emphasize the importance of having the diagnosis in mind when confronted with the very ill, dehydrated infant...
October 10, 2016: Ugeskrift for Laeger
Yvan Vandenplas, Muath Abdurrahman Alturaiki, Wafaa Al-Qabandi, Fawaz AlRefaee, Ziad Bassil, Bassam Eid, Ahmed El Beleidy, Ali Ibrahim Almehaidib, Pierre Mouawad, Maroun Sokhn
This paper covers algorithms for the management of regurgitation, constipation and infantile colic in infants. Anti-regurgitation formula may be considered in infants with troublesome regurgitation, while diagnostic investigations or drug therapy are not indicated in the absence of warning signs. Although probiotics have shown some positive evidence for the management of functional gastrointestinal disorders (FGIDs), the evidence is not strong enough to make a recommendation. A partially hydrolyzed infant formula with prebiotics and β-palmitate may be considered as a dietary intervention for functional constipation in formula fed infants...
September 2016: Pediatric Gastroenterology, Hepatology & Nutrition
T Banti, A Carsin, B Chabrol, R Reynaud, A Fabre
: Infant food diversification has undergone a rapid succession of good practice recommendations in France, but there has been no assessment of pediatrician practices on food diversification. OBJECTIVE: To assess the practices of pediatricians in relation to current recommendations of the French Society of Pediatrics on infant food diversification. METHODS: This was an observational study conducted from 1 November 2014 to 31 March 2015. The study population consisted of 97 pediatricians in the Var department and 84 pediatric residents assigned to the University of Aix-Marseille in France...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Germán Errázuriz, Yalda Lucero, Sergio Ceresa, Mónica Gonzalez, Maureen Rossel, Andrés Vives
INTRODUCTION: Cow's milk protein allergy (CMPA) is highly prevalent in infants (2-5%). It has a wide clinical spectrum, and confirmation through an oral food challenge (OFC) is relevant for its differential diagnosis. Information on this topic is scarce in Chile. OBJECTIVE: To describe the demographic and clinical features of infants with suspected CMPA. PATIENTS AND METHOD: A retrospective study of patients<1 year-old, treated for suspected CMPA between 2009 and 2011...
September 12, 2016: Revista Chilena de Pediatría
(no author information available yet)
No abstract text is available yet for this article.
August 2016: Journal of Pediatric Gastroenterology and Nutrition
R Rosas, M P Sanz, P Fernández-Calle, M J Alcaide, M T Montes, N Pastrana, C Segovia, F Omeñaca, M Sáenz de Pipaón
AIM: Measuring milk osmolality after adjustable fortification is clinically relevant, as values exceeding recommended safety thresholds might result in gastrointestinal consequences. The aim of this study was to evaluate the effect of four fortification levels and storage time on the osmolality of human milk. METHODS: This was an experimental study using 71 spare samples of fresh breast milk collected from 31 mothers of preterm infants. Osmolality was measured before and after adding commercial human milk fortifier containing dextrinomaltose and hydrolysed proteins at four different concentrations...
July 8, 2016: Acta Paediatrica
Alexandre Lapillonne, Maroun Matar, Ariane Adleff, Marwa Chbihi, Elsa Kermorvant-Duchemin, Florence Campeotto
OBJECTIVE: To evaluate the prevalence of and reasons for using extensively hydrolysed formulas (EHFs) of cow's milk proteins in the French neonatal units as well as the modality of their prescription for refeeding infants recovering from necrotising enterocolitis (NEC). METHODS: A multicentre nationwide cross-sectional study using a questionnaire to address the prevalence of use and the reasons for prescribing EHF in hospitalised neonates and to examine the protocols and the actual reasons for their use for refeeding infants in recovery from NEC...
2016: BMJ Open
Silvia Salvatore, Yvan Vandenplas
Hydrolyzed proteins are used worldwide in the therapeutic management of infants with allergic manifestations and have long been proposed as a dietetic measure to prevent allergy in at risk infants. The degree and method of hydrolysis, protein source and non-nitrogen components characterize different hydrolyzed formulas (HFs) and may determine clinical efficacy, tolerance and nutritional effects. Cow's milk (CM)-based HFs are classified as extensively (eHF) or partially HF (pHF) based on the percentage of small peptides...
2016: Nestlé Nutrition Institute Workshop Series
Kate Maslin, Erin M Oliver, Karen S Scally, Josh Atkinson, Keith Foote, Carina Venter, Graham Roberts, Kate E C Grimshaw
BACKGROUND: Infants with suspected cows' milk allergy are required to follow a strict milk exclusion diet which may lead to nutritional deficiencies, especially if not supervised by a healthcare professional. The aim of this study was to assess the nutritional adequacy of a cows' milk exclusion diet in a group of UK infants over a period of 6 months. METHODS: Participants in this study are a subgroup of the Prevalence of Infant Food Allergy study, a prospective food allergy birth cohort study from the South of England...
2016: Clinical and Translational Allergy
S F Tan, H J Tong, X Y Lin, B Mok, C H Hong
AIM: To systematically evaluate the cariogenic potential of various commercially available infant formulas. MATERIALS AND METHODS: A literature search was conducted using Pubmed and Scopus databases for articles published between 1966 and November 2014. Reference lists of all eligible studies were searched. Only human studies were included. Data extraction and risk of bias assessments were performed. RESULTS: Seven of the 83 articles identified were included in this review, of which six studies employed plaque harvesting methods, while one study utilised an intra-oral cariogenicity/in situ model...
June 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
Alice J Goldsmith, Jennifer J Koplin, Adrian J Lowe, Mimi Lk Tang, Melanie C Matheson, Marnie Robinson, Rachel Peters, Shyamali C Dharmage, Katrina J Allen
AIM: To determine whether infant-feeding practices, including duration of exclusive breastfeeding and use of partially hydrolysed formula, modify the risk of developing infant food allergy. METHODS: In an observational population-based study, 1 year olds were recruited from community immunisation clinics in Melbourne, Australia. Parent-reported data on infant-feeding practices and potential confounders were collected prior to infant skin prick testing for four food allergens...
April 2016: Journal of Paediatrics and Child Health
R J Boyle, M L-K Tang, W C Chiang, M C Chua, I Ismail, A Nauta, J O'B Hourihane, P Smith, M Gold, J Ziegler, J Peake, P Quinn, R Rao, N Brown, A Rijnierse, J Garssen, J O Warner
BACKGROUND: Prevention guidelines for infants at high risk of allergic disease recommend hydrolysed formula if formula is introduced before 6 months, but evidence is mixed. Adding specific oligosaccharides may improve outcomes. OBJECTIVE: To evaluate whether partially hydrolysed whey formula containing oligosaccharides (0.8 g/100 ml) (pHF-OS) can prevent eczema in high-risk infants [ISRCTN65195597]. METHODS: We conducted a parallel-group, multicentre, randomized double-blind controlled trial of pHF-OS vs standard cow's milk formula...
May 2016: Allergy
David Luyt, M Thirumala Krishnan, Pia Huber, Andrew Clark
BACKGROUND: The management of cow's milk allergy (CMA) includes initial dairy exclusion with suitable dietary substitution, diagnostic challenges where indicated, and supervised re-introduction as the condition resolves. Information on clinician practice is limited. We audited the current practice of clinicians in the UK to evaluate adherence to international guidelines. METHODS: An online questionnaire was sent to all clinicians whose practice included children identified on the national allergy society website...
2016: International Archives of Allergy and Immunology
Robert J Boyle, Despo Ierodiakonou, Tasnia Khan, Jennifer Chivinge, Zoe Robinson, Natalie Geoghegan, Katharine Jarrold, Thalia Afxentiou, Tim Reeves, Sergio Cunha, Marialena Trivella, Vanessa Garcia-Larsen, Jo Leonardi-Bee
OBJECTIVE: To determine whether feeding infants with hydrolysed formula reduces their risk of allergic or autoimmune disease. DESIGN: Systematic review and meta-analysis, as part of a series of systematic reviews commissioned by the UK Food Standards Agency to inform guidelines on infant feeding. Two authors selected studies by consensus, independently extracted data, and assessed the quality of included studies using the Cochrane risk of bias tool. DATA SOURCES: Medline, Embase, Web of Science, CENTRAL, and LILACS searched between January 1946 and April 2015...
2016: BMJ: British Medical Journal
Caroline Jane Lodge, Adrian John Lowe, Shyamali Chandrika Dharmage
No abstract text is available yet for this article.
2016: BMJ: British Medical Journal
Karen Knipping, Manon van Roest, Laura Kruijssen, Mieke Smits, Marc Teunis, Linda Cox, Niels de Jong, Peter J Simons, Louis Boon, Reiko Teshima, Marjan Gros, Diane Kegler, Johan Garssen, Léon M J Knippels, Raymond Pieters
Cow's milk-derived whey hydrolysates are milk substitutes for cow's milk allergic infants. Safety assessment of these hydrolysates is crucial. Currently, huFcεRIα-RBL-2H3 cells, sensitized with serum IgE from cow's milk allergic patients, are used to assess in vitro residual allergenicity. However, limited availability and high inter-lot variation of sera impede the standardization of safety testing. Recently, we generated an oligoclonal pool of chimeric human (chu)IgE antibodies against bovine β-lactoglobulin (BLG) as an alternative for human serum...
June 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Yasuhiro Sato, Kenji Wakabayashi, Eishin Ogawa, Hiroko Kodama, Masakazu Mimaki
BACKGROUND: Given that nutritional biotin deficiency in Japanese infants has been reported, a straightforward method for estimating biotin level is needed. The biotin content in infant formula, breast milk, and the sera of infants fed with various types of formula were measured using avidin-binding assay. METHODS: A commercially available ELISA kit was used for the measurement of biotin in 54 types of formula, including hydrolysate formulas for milk allergy, as well as in breast milk and in the sera of 27 infants fed with these formulas...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Lucas Wauters, Trevor Brown, Carina Venter, Robert Dziubak, Rosan Meyer, Breege Brogan, Joanne Walsh, Adam T Fox, Neil Shah
OBJECTIVES: Cow's milk allergy (CMA) is the most common food allergy in children with many clinical manifestations, leading to misdiagnoses such as gastro-oesophageal reflux, infantile colic, and lactose intolerance with inappropriate prescribing. We aimed to determine the impact of infant feeding guidelines on CMA prescribing in UK primary care using a simple and inexpensive training package. METHODS: Prospectively collected data of infant feeding prescriptions in Northern Ireland from June 2012 to March 2014 were analysed with the intervention period between November 2012 and March 2013...
May 2016: Journal of Pediatric Gastroenterology and Nutrition
Yvan Vandenplas, Pedro Alarcon, David Fleischer, Olle Hernell, Sanja Kolacek, Hugo Laignelet, Bo Lönnerdal, Rita Raman, Jacques Rigo, Silvia Salvatore, Raanan Shamir, Annamaria Staiano, Hania Szajewska, Hans J Van Goudoever, Andrea von Berg, Way S Lee
Partially hydrolyzed formulas (pHFs) are increasingly used worldwide, both in the prevention of atopic disease in at-risk infants and in the therapeutic management of infants with functional gastrointestinal manifestations. Because prevention is always preferable to treatment, we reviewed the literature aiming to find an answer for the question whether pHF may be recommended for feeding all infants if breast-feeding is not possible. PubMed and Cochrane databases were searched up to December 2014. In addition, to search for data that remained undetected by the searches, we approached authors of relevant articles and major producers of pHFs asking for unpublished data...
January 2016: Journal of Pediatric Gastroenterology and Nutrition
Rosan Meyer, Ru-Xin Melanie Foong, Nikhil Thapar, Stamatiki Kritas, Neil Shah
BACKGROUND: The choice of infant formula is thought to play an important role on gastric emptying (GE) in a variety of gastrointestinal disorders. It is known that many ingredients impact on GE, including the type of protein and level of hydrolysis. In clinical practice, feeds are often recommended due to putative improved GE related to the type of protein and level of hydrolysis, however whether this is scientifically justified still needs to be established. A systematic review comparing the impact of protein type and hydrolysis on GE in children was therefore performed...
2015: BMC Gastroenterology
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