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hydrolysed infant formula

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https://www.readbyqxmd.com/read/29693777/milk-feeding-and-first-complementary-foods-during-the-first-year-of-life-in-the-teddy-study
#1
Anne Riikonen, David Hadley, Ulla Uusitalo, Nicole Miller, Sibylle Koletzko, Jimin Yang, Carin Andrén Aronsson, Sandra Hummel, Jill M Norris, Suvi M Virtanen
The aim was to describe milk feeding patterns and first weaning foods during the first year of life in a large prospective birth cohort of infants with increased genetic risk for Type 1 diabetes (T1D) recruited in 4 different countries: the United States, Finland, Germany, and Sweden. All enrolled children with dietary information (n = 8,673) were included in the analyses; 1,307 (15%) children who dropped out before the first birthday were excluded from some analyses. Supplementary milk feeding in the first 3 days of life was common in all the four countries, although the type of the supplementary milk differed by country and by maternal T1D...
April 25, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29579976/in-vitro-lipolysis-of-dairy-and-soy-based-infant-formula
#2
Thao T P Nguyen, Bhesh Bhandari, Julie Cichero, Sangeeta Prakash
Hydrolysed and non-hydrolysed dairy and soy proteins with vegetable oils are commonly used in infant formulations. Lipid digestion of these infant formula emulsions was studied under an in vitro gastrointestinal condition for 60 min in the stomach and 120 min in the small intestine (with and without the presence of enzyme proteases). The distribution of oil droplets, the released free fatty acids, and micro-structure changes of the digesta were monitored over the digestion period. Oil droplet coalescence was observed during gastric phase but not in the intestinal phase for most of formulations...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29494498/comparison-of-growth-of-healthy-term-infants-fed-extensively-hydrolyzed-protein-and-amino-acid-based-infant-formulas
#3
REVIEW
Marlene W Borschel, Geraldine E Baggs, Jeffery S Oliver
The aim of this narrative review was to assess published growth data for healthy, term, infants consuming extensively hydrolyzed protein-based (EHF), or amino acid-based formulas (AAF). These data may be of use to clinicians managing infants with medical conditions consuming these products. A search was conducted using key terms: amino acid-based, hydrolysate, hydrolyzed, hydrolysed, infant formula, infant formulae or formulas, baby formula, or formulae or formulas, infant, infants, infantile, and growth. Seven controlled, randomized, prospective growth trials of healthy term infants fed EHFs or AAFs at similar time points during the first four months of age met these and other criteria, including that the trial was published in a peer-reviewed journal, subjects were enrolled by ≤14 days of age and were exclusively formula-fed at entry and throughout the duration of the trial, and infants were assessed at regular intervals with weight measures available ideally at 14 days, one, two, three, and four months of age...
March 1, 2018: Nutrients
https://www.readbyqxmd.com/read/29383302/a-synbiotic-infant-formula-with-high-magnesium-content-improves-constipation-and-quality-of-life
#4
Ioannis Xinias, Antonis Analitis, Antigoni Mavroudi, Ioannis Roilides, Maria Lykogeorgou, Varvara Delivoria, Vasilis Milingos, Mayra Mylonopoulou, Yvan Vandenplas
Purpose: To evaluate the efficacy of synbiotic formula with partial whey hydrolysate and high magnesium content in infants presenting with functional constipation. Methods: Sixty-five infants with functional constipation were included. Forty infants were treated during one month with parental reassurance and the intervention formula and were compared to a control group of 25 infants treated with parental reassurance only. Parents completed a quality of life (QoL) questionnaire at baseline and during the last week of the study...
January 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29297078/effect-of-hydrolyzed-infant-formula-vs-conventional-formula-on-risk-of-type-1-diabetes-the-trigr-randomized-clinical-trial
#5
RANDOMIZED CONTROLLED TRIAL
Mikael Knip, Hans K Åkerblom, Eva Al Taji, Dorothy Becker, Jan Bruining, Luis Castano, Thomas Danne, Carine de Beaufort, Hans-Michael Dosch, John Dupre, William D Fraser, Neville Howard, Jorma Ilonen, Daniel Konrad, Olga Kordonouri, Jeffrey P Krischer, Margaret L Lawson, Johnny Ludvigsson, Laszlo Madacsy, Jeffrey L Mahon, Anne Ormisson, Jerry P Palmer, Paolo Pozzilli, Erkki Savilahti, Manuel Serrano-Rios, Marco Songini, Shayne Taback, Outi Vaarala, Neil H White, Suvi M Virtanen, Renata Wasikowa
Importance: Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact proteins in extensively hydrolyzed formulas. Objective: To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children. Design, Setting, and Participants: An international double-blind randomized clinical trial of 2159 infants with human leukocyte antigen-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited from May 2002 to January 2007 in 78 study centers in 15 countries; 1081 were randomized to be weaned to the extensively hydrolyzed casein formula and 1078 to a conventional formula...
January 2, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29214323/economic-value-of-using-partially-hydrolysed-infant-formula-for-risk-reduction-of-atopic-dermatitis-in-high-risk-infants-not-exclusively-breastfed-in-singapore
#6
Marc F Botteman, Abhijeet J Bhanegaonkar, Erica G Horodniceanu, Xiang Ji, Bee Wah Lee, Lynette P Shek, Hugo Ps Van Bever, Patrick Detzel
INTRODUCTION: Previous trials have demonstrated reductions in atopic dermatitis (AD) incidence when healthy, high-risk, non-exclusively breastfed infants were fed until four months of age with 100% whey-based partially hydrolysed formula (PHF-W) versus standard cow's milk formula (CMF). We assessed this intervention's cost-effectiveness in Singapore. METHODS: Modelling techniques were used to simulate, from birth to Month 30, the incidence, and clinical and economic burden of AD in high-risk, non-exclusively breastfed infants fed with PHF-W or CMF for up to four months...
December 7, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29143799/effect-of-a-partially-hydrolysed-whey-infant-formula-supplemented-with-starch-and-lactobacillus-reuteri-dsm-17938-on-regurgitation-and-gastric-motility
#7
Flavia Indrio, Giuseppe Riezzo, Paola Giordano, Maria Ficarella, Maria Paola Miolla, Silvia Martini, Luigi Corvaglia, Ruggiero Francavilla
Functional regurgitation (FR) is common in early infancy and represents a major drain on healthcare resources. This double-blind, randomized controlled trial investigated the effects of a formula containing partially hydrolysed, 100% whey protein, starch and Lactobacillus reuteri (DSM 17938) on gastric emptying rate (GErate) and regurgitation frequency in infants with FR. Enrolled infants were randomly allocated to receive either the test formula or a standard starter formula for four weeks. Ultrasound GErate assessment was performed at baseline (week 0) and at week 4; the number of regurgitations, feed volumes and potential adverse events were recorded in a daily diary...
October 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29098889/cost-effectiveness-of-using-an-extensively-hydrolyzed-casein-formula-containing-lactobacillus-rhamnosus-gg-in-managing-infants-with-cow-s-milk-allergy-in-the-us
#8
Julian F Guest, Roger H Kobayashi, Vinay Mehta, Gary Neidich
OBJECTIVE: To estimate the cost-effectiveness of using an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (eHCF + LGG; Nutramigen LGG) compared with an eHCF alone and an amino acid formula (AAF) in treating cow's milk allergy (CMA) in the US, from the perspective of third-party insurers and from parents. METHODS: A decision model was used to estimate the probability of cow's milk allergic infants developing tolerance to cow's milk by 18 months...
November 3, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28968486/protein-hydrolysate-versus-standard-formula-for-preterm-infants
#9
REVIEW
Derek Hang Cheong Ng, Joel Klassen, Nicholas D Embleton, William McGuire
BACKGROUND: When human milk is not available for feeding preterm infants, protein hydrolysate rather than standard cow's milk formulas (with intact proteins) are often used because they are perceived as being tolerated better and less likely to lead to complications. However, protein hydrolysate formulas are more expensive than standard formulas, and concern exists that their use in practice is not supported by high-quality evidence. OBJECTIVES: To assess the effect of feeding preterm infants with hydrolysed formula (versus standard cow's milk formulas) on the risk of feed intolerance, necrotising enterocolitis, and other morbidity and mortality in preterm infants...
October 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28934137/evidence-for-involvement-of-il-9-and-il-22-in-cows-milk-allergy-in-infants
#10
Karina V Barros, Vera L Flor Silveira, Marisa S Laranjeira, Neusa F Wandalsen, Susana Passeti, Roberta de Oliveira, Regina V Munekata, Paul S Noakes, Elizabeth A Miles, Philip C Calder
Although allergic inflammation is characterized by a T helper (Th) 2-dominant immune response, the discovery of a role for new T cell subsets in inflammatory diseases has added an additional layer of complexity to the understanding of the pathogeneses of allergic diseases. We evaluated plasma cytokine profiles in infants with cows' milk allergy (CMA), who were being treated with an elimination diet. In a prospective, randomized and controlled study, infants (aged 8.4 ± 3.9 months) with CMA were treated with an elimination diet for 120 days, which replaced cows' milk with a hydrolysed soy protein formula (n = 26) or a free amino acid formula (n = 20)...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28925339/improving-the-artificial-diet-for-adult-of-seven-spotted-ladybird-beetle-coccinella-septempunctata-l-coleoptera-coccinellidae-with-orthogonal-design
#11
Y Cheng, J R Zhi, F L Li, W H Li, Y H Zhou
In this study, an orthogonal array design with 16 factors at two levels (216) was performed to develop an artificial diet rearing the adults of seven spotted ladybird beetle Coccinella septempunctata. The parameters of weight gain and survival rate of adults, preoviposition period, fecundity and hatching rate of diet-fed adults were monitored. The 16 factors were included: pork liver, infant formula, sucrose, olive oil, yolk, corn oil, yeast powder, cholesterol, casein, casein hydrolysate, vitamin powder, 65% juvenile hormone III, protein powder, vitamin E, honey and pumpkin...
September 19, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28875884/residual-allergenicity-of-amino-acid-based-and-extensively-hydrolysed-cow-s-milk-formulas
#12
M E Levin, D M Blackhurst, F Kirstein, D Kok, G F Van der Watt, A D Marais
BACKGROUND: Criteria for labelling infant feeds as suitable for the dietary management of cow's milk protein allergy (CMPA) rely on proving the hypoallergenicity of such feeds or clinical studies showing that the feeds are tolerated by 90% of children with proven CMPA. South African (SA) labelling legislation does not indicate what testing is necessary to prove hypoallergenicity. OBJECTIVES: To evaluate all extensively hydrolysed cow's milk formulas and amino acid-based formulas available in SA for residual allergen content, protein size and amino-acid content...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28730134/innovative-dietary-intervention-answers-to-baby-colic
#13
Ioannis Xinias, A Analitis, Antigoni Mavroudi, Ioannis Roilides, Maria Lykogeorgou, Varvara Delivoria, Vasilis Milingos, Mayra Mylonopoulou, Yvan Vandenplas
PURPOSE: The purpose of this paper is to evaluate the efficacy of a lactose- reduced synbiotic partial whey hydrolysate in formula fed infants presenting with colic and the impact of this dietary intervention in mean crying time and quality of life. METHODS: Forty infants with infantile colic were treated during one month with parental reassurance and the intervention formula (partial whey hydrolysate, reduced lactose, Bifidobacterium lactis BB12 and galacto-oligosaccharides) and were compared to a control group of 20 infants with infantile colic treated with parental reassurance and a standard infant formula...
June 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28720947/reduction-of-whey-protein-concentrate-antigenicity-by-using-a-combined-enzymatic-digestion-and-ultrafiltration-approach
#14
Laura Quintieri, Linda Monaci, Federico Baruzzi, Maria Gabriella Giuffrida, Silvia de Candia, Leonardo Caputo
The global interest in saving food resources is leading to recycle wasted-food materials to extract useful nutrients. In dairy industry, the recycling of whey proteins determines their utilization in the healthy-addressed foods, which, however, can cause immunological responses in allergic subjects. In this work, a whey protein concentrate (WPC) was alternatively hydrolyzed with pepsin, papain, trypsin and rennin in order to attenuate or abolish the β-lactoglobulin (BLG) antigenicity. The electrophoretic profiles of both pepsin and papain WPC hydrolysates proved the disappearance of the BLG band, even though a slight antigenicity was still found by ELISA...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28704923/production-of-cow-s-milk-free-from-beta-casein-a1-and-its-application-in-the-manufacturing-of-specialized-foods-for-early-infant-nutrition
#15
Miguel Á Duarte-Vázquez, Carlos García-Ugalde, Laura M Villegas-Gutiérrez, Blanca E García-Almendárez, Jorge L Rosado
Beta-casein (BC) is frequently expressed as BC A2 and BC A1 in cow's milk. Gastrointestinal digestion of BC A1 results in the release of the opioid peptide beta-casomorphin 7 (BCM7) which is less likely to occur from BC A2. This work was aimed to produce milk containing BC A2 with no BC A1 (BC A2 milk) using genetically selected CSN2 A2A2 Jersey cows. Additionally, we aimed to develop an infant formula (IF) suitable for healthy full-term infants during the first six months of life based on BC A2 milk. The concentration of BCM7 released from BC A2 IF, from commercially available IFs as well as from human milk and raw cow's milk was evaluated after simulated gastrointestinal digestion (SGID)...
July 12, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28698533/prevention-and-management-of-cow-s-milk-allergy-in-non-exclusively-breastfed-infants
#16
REVIEW
Yvan Vandenplas
Introduction: The prevention and management of cow milk allergy (CMA) is still debated. Since CMA is much less frequent in breastfed infants, breastfeeding should be stimulated. Method: Literature was searched using databases to find original papers and reviews on this topic. Results: Hydrolysates with a clinical proof of efficacy are recommended in the prevention and treatment of CMA. However, not all meta-analyses conclude that hydrolysates do prevent CMA or other atopic manifestations such as atopic dermatitis...
July 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28687275/avoidance-of-cow-s-milk-based-formula-for-at-risk-infants-does-not-reduce-development-of-celiac-disease-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Mila Hyytinen, Erkki Savilahti, Suvi M Virtanen, Taina Härkönen, Jorma Ilonen, Kristiina Luopajärvi, Raivo Uibo, Outi Vaarala, Hans K Åkerblom, Mikael Knip
BACKGROUND & AIMS: Feeding during the first months of life might affect risk for celiac disease. Individuals with celiac disease or type 1 diabetes have been reported to have high titers of antibodies against cow's milk proteins. Avoidance of cow's milk-based formula for infants with genetic susceptibility for type 1 diabetes reduced the cumulative incidence of diabetes-associated autoantibodies. We performed a randomized controlled trial in the same population to study whether weaning to an extensively hydrolyzed formula reduced the risk of celiac disease autoimmunity or celiac disease...
October 2017: Gastroenterology
https://www.readbyqxmd.com/read/28594834/toll-like-receptor-mediated-activation-is-possibly-involved-in-immunoregulating-properties-of-cow-s-milk-hydrolysates
#18
M B Gea Kiewiet, Renske Dekkers, Marjan Gros, R J Joost van Neerven, Andre Groeneveld, Paul de Vos, Marijke M Faas
Immunomodulating proteins and peptides are formed during the hydrolysis of cow's milk proteins. These proteins are potential ingredients in functional foods used for the management of a range of immune related problems, both in infants and adults. However, the mechanism behind these effects is unknown. We hypothesize that the interaction of peptides with Toll-like receptors (TLRs) can induce immune effects, since these receptors are known to sample many dietary molecules in the intestine in order to regulate immune effects...
2017: PloS One
https://www.readbyqxmd.com/read/28542713/withdrawn-infant-formulas-containing-hydrolysed-protein-for-prevention-of-allergic-disease-and-food-allergy
#19
REVIEW
David A Osborn, John Kh Sinn, Lisa J Jones
BACKGROUND: Allergy is common and may be associated with foods, including cow's milk formula (CMF). Formulas containing hydrolysed proteins have been used to treat infants with allergy. However, it is unclear whether hydrolysed formulas can be advocated for prevention of allergy in infants. OBJECTIVES: To compare effects on allergy and food allergy when infants are fed a hydrolysed formula versus CMF or human breast milk. If hydrolysed formulas are effective, to determine what type of hydrolysed formula is most effective, including extensively or partially hydrolysed formula (EHF/PHF)...
May 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28460966/the-influence-of-breast-milk-and-infant-formulae-hydrolysates-on-bacterial-adhesion-and-caco-2-cells-functioning
#20
Ewa Fiedorowicz, Lidia Hanna Markiewicz, Katarzyna Sidor, Dominika Świątecka, Anna Cieślińska, Michał Matysiewicz, Krystyna Piskorz-Ogórek, Edyta Sienkiewicz-Szłapka, Małgorzata Teodorowicz, Aleksander Świątecki, Elżbieta Kostyra
The aim of the study was to determine the concentration of BCM7 in human milk and infant formulae (IF) before and after eznymatic hydrolysis, and to evaluate the effect of obtained hydrolysates on interleukin-8 (IL-8) secretion and on proliferation of enterocytes in the in vitro model (Caco-2 cells). This study evaluates also the effect of hydrolysates on the adhesion of intestinal microbiota isolated from faeces of both healthy (H) and allergic (A) infants. In the study we investigated breast milk delivered by mothers of healthy ('healthy milk'; HM) and allergic ('allergic milk'; AM) infants...
November 2016: Food Research International
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