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https://www.readbyqxmd.com/read/28225268/structure-and-characterization-of-a-zero-dimensional-alkali-tin-dihalides-compound-cs3sn3f2cl7-with-the-sn2f2cl4-2-clusters
#1
Pifu Gong, Siyang Luo, Ke Xiao, Qian Huang, Yi Yang, Hongwei Huang, Yicheng Wu, Chuangtian Chen, Zheshuai Lin
A new perovskite stoichiometric alkali tin dihalides compound, Cs3Sn3F2Cl7, is synthesized by a hydrothermal method. This compound belongs to the monoclinic space group of P21/c with cell parameters of a = 9.5645(4) Å, b = 14.2057(7) Å, c = 13.5828(6) Å, and β = 93.2450(10)°. Unlike the common perovskites in which octahedra are interconnected to be a three-dimensional network, Cs3Sn3F2Cl7 possesses a zero-dimensional structure consisting of Cs(+) cations, isolated [SnCl3](-) trigonal pyramids, and dimer structural units [Sn2F2Cl4](2-); the latter microscopic unit is found for the first time...
February 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28212406/accumulation-of-medium-chain-saturated-fatty-acyl-moieties-in-seed-oils-of-transgenic-camelina-sativa
#2
Zhaohui Hu, Qian Wu, Jyoti Dalal, Naresh Vasani, Harry O Lopez, Heike W Sederoff, Rongda Qu
With its high seed oil content, the mustard family plant Camelina sativa has gained attention as a potential biofuel source. As a bioenergy crop, camelina has many advantages. It grows on marginal land with low demand for water and fertilizer, has a relatively short life cycle, and is stress tolerant. As most other crop seed oils, camelina seed triacylglycerols (TAGs) consist of mostly long, unsaturated fatty acyl moieties, which is not desirable for biofuel processing. In our efforts to produce shorter, saturated chain fatty acyl moieties in camelina seed oil for conversion to jet fuel, a 12:0-acyl-carrier thioesterase gene, UcFATB1, from California bay (Umbellularia californica Nutt...
2017: PloS One
https://www.readbyqxmd.com/read/28196124/isoprenoid-phospholipid-conjugates-as-potential-therapeutic-agents-synthesis-characterization-and-antiproliferative-studies
#3
Anna Gliszczyńska, Natalia Niezgoda, Witold Gładkowski, Marta Świtalska, Joanna Wietrzyk
The aim of this research was to extend application field of isoprenoid compounds by their introduction into phospholipid structure as the transport vehicle. The series of novel isoprenoid phospholipids were synthesized in high yields (24-97%), their structures were fully characterized and its anticancer activity was investigated in vitro towards several cell lines of different origin. Most of synthesized compounds showed a significantly higher antiproliferative effect on tested cell lines than free terpene acids...
2017: PloS One
https://www.readbyqxmd.com/read/28191598/diacylglycerol-kinase-%C3%AE%C2%B5-localizes-to-subsurface-cisterns-of-cerebellar-purkinje-cells
#4
Yasukazu Hozumi, Hiroki Fujiwara, Kenya Kaneko, Satoshi Fujii, Matthew K Topham, Masahiko Watanabe, Kaoru Goto
Following activation of Gq protein-coupled receptors, phospholipase C yields a pair of second messengers: diacylglycerol (DG) and inositol 1,4,5-trisphosphate. Diacylglycerol kinase (DGK) phosphorylates DG to produce phosphatidic acid, another second messenger. Of the DGK family, DGKε is the only DGK isoform that exhibits substrate specificity for DG with an arachidonoyl acyl chain at the sn-2 position. Recently, we demonstrated that hydrophobic residues in the N-terminus of DGKε play an important role in targeting the endoplasmic reticulum in transfected cells...
February 13, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28185537/a-concise-update-on-the-relevance-of-secretory-phospholipase-a2-group-iia-and-its-inhibitors-to-cancer
#5
Juan Chen, Long Ye, Yu Sun, Yoshikazhu Takada
Secretory phospholipase A2 group IIA (sPLA2-IIA) is an enzyme that hydrolyzes the sn-2 ester bond in glyceroacyl phospholipids present in lipoproteins and cell membranes. As many immunohistochemical studies reveal that the high expression of sPLA2-IIA in the tumorous tissue or plasma of cancer patients, though low expression in other cases, the enzyme is considered highly relevant with cancer development. Effort has been made to establish the mechanism of how sPLA2-IIA is involved in various cancers in order to understand its pathogenic role and to utilize it as a target for cancer diagnosis and therapy...
February 9, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28131878/phospholipase-a2-potential-roles-in-native-membrane-fusion
#6
Deepti Dabral, Jens R Coorssen
Membrane fusion is a fundamental molecular mechanism by which two apposed membrane bilayers coalesce in rapid, transient steps that enable the successive merging of the outer and inner leaflets allowing lipid intermixing and subsequent mixing of the two previously separate compartments. The actual membrane merger mechanism - fusion, by definition - is conceptualized to be protein- or lipid-centric. According to the widely vetted stalk-pore hypothesis, membrane fusion proceeds via high curvature lipid intermediates...
January 25, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28112859/the-catalytic-mechanism-of-the-class-c-radical-s-adenosylmethionine-methyltransferase-nosn
#7
Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Tao Tu, Zixin Deng, Yi Yu, Fener Chen, Qi Zhang
S-Adenosylmethionine (SAM) is one of the most common co-substrates in enzyme-catalyzed methylation reactions. Most SAM-dependent reactions proceed through an SN 2 mechanism, whereas a subset of them involves radical intermediates for methylating non-nucleophilic substrates. Herein, we report the characterization and mechanistic investigation of NosN, a class C radical SAM methyltransferase involved in the biosynthesis of the thiopeptide antibiotic nosiheptide. We show that, in contrast to all known SAM-dependent methyltransferases, NosN does not produce S-adenosylhomocysteine (SAH) as a co-product...
January 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28108360/archaeal-lipids-in-oral-delivery-of-therapeutic-peptides
#8
Ann-Christin Jacobsen, Sara M Jensen, Gert Fricker, Martin Brandl, Alexander H Treusch
Archaea contain membrane lipids that differ from those found in the other domains of life (Eukarya and Bacteria). These lipids consist of isoprenoid chains attached via ether bonds to the glycerol carbons at the sn-2,3 positions. Two types of ether lipids are known, polar diether lipids and bipolar tetraether lipids. The inherent chemical stability and unique membrane-spanning characteristics of tetraether lipids render them interesting for oral drug delivery purposes. Archaeal lipids form liposomes spontaneously (archaeosomes) and may be incorporated in conventional liposomes (mixed vesicles)...
January 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28102312/correlations-of-charge-neutrality-level-with-electronic-structure-and-p-d-hybridization
#9
Arkaprava Das, Subodh K Gautam, D K Shukla, Fouran Singh
The formation of charge neutrality level (CNL) in highly conducting Cadmium oxide (CdO) thin films is demonstarted by the observed variation in the band gap upon annealing and doping. It may be explained by the observation that Tin (Sn) doping breaks the perfect periodicity of CdO cubic crystal structure and creates virtual gap states (ViGS). The level of local CNL resides at the branch point of ViGS, making the energy at which native defect's character changes from predominantly donor-like below CNL to predominantly acceptor-like above the CNL and a schematic band diagram is developed to substantiate the same...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076953/effects-of-lithium-and-other-monovalent-ions-on-palmitoyl-oleoyl-phosphatidylcholine-bilayer
#10
James Kruczek, See-Wing Chiu, Eric Jakobsson, Sagar A Pandit
Interactions of monovalent salts with lipid membranes are explored with molecular dynamics (MD) simulations. The simulations included the monovalent ions Na(+) and K(+), for their importance in physiology, Li(+) for its small size and importance in several medical conditions including bipolar disorder, and Rb(+) for its large size. All simulations included Cl(-) as counterions. One bilayer was simulated without salt as a control. Palmitoyl oleoyl phosphatidylcholine (POPC) bilayers experienced reductions in area per lipid with the addition of salt; the smaller the ion the smaller the area, with the exception of Li(+)...
January 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28063792/syntheses-and-antiproliferative-activities-of-novel-phosphatidylcholines-containing-dehydroepiandrosterone-moieties
#11
Marek Kłobucki, Aleksandra Grudniewska, Damian A Smuga, Małgorzata Smuga, Joanna Jarosz, Joanna Wietrzyk, Gabriela Maciejewska, Czesław Wawrzeńczyk
Dehydroepiandrosterone (DHEA) is a natural hormone with many beneficial properties including an anticancer activity. Unfortunately, DHEA is unstable in the body and exhibits cytotoxicity against healthy cells. In this study, a series of new phosphocholines containing DHEA at sn-1 and/or sn-2 positions were prepared. Succinic acid was used as a linker between the active drug and sn-glycero-3-phosphocholine. All the compounds were evaluated in vitro for their antiproliferative activities against four cell lines: Balb/3T3, HL-60, B16, and LNCaP...
January 4, 2017: Steroids
https://www.readbyqxmd.com/read/28063498/preparation-of-the-full-set-of-recombinant-mouse-and-human-secreted-phospholipases-a2
#12
F Ghomashchi, V Brglez, C Payré, L Jeammet, S Bezzine, M H Gelb, G Lambeau
A family of 14-20kDa, disulfide-rich, calcium-dependent secreted phospholipases A2 (sPLA2s) that release fatty acids from the sn-2 position of glycerophospholipids can be found in mammals. They have a diverse array of tissue distribution and biological functions. In this chapter we provide detailed protocols for production of nearly all of the mouse and human sPLA2s mainly by expression in bacteria and in vitro refolding or by expression in insect cells. High-resolution mass spectrometry and enzymatic assays were, respectively, used to show that all disulfides are formed and that the enzymes are active, strongly suggesting that each sPLA2 was prepared in the structurally native form...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28063487/secreted-phospholipase-a2-specificity-on-natural-membrane-phospholipids
#13
K Yamamoto, Y Miki, H Sato, R Murase, Y Taketomi, M Murakami
The secreted phospholipase A2 (sPLA2) family contains 10 catalytically active isoforms. Current in vitro biochemical studies have shown that individual sPLA2s have distinct substrate selectivity in terms of the polar head groups or sn-2 fatty acids of their substrate phospholipids. Importantly, transgenic or knockout mice for distinct sPLA2s display nonoverlapping phenotypes, arguing that they do act on different phospholipid substrates and mobilize unique lipid metabolites in vivo. In an effort to comprehensively understand lipid metabolism driven by individual sPLA2s under pathophysiological conditions, we took advantages of mass spectrometric lipidomics technology to monitor the spatiotemporal changes in phospholipids (substrates) and products (fatty acids, lysophospholipids, and their metabolites) in tissues or cells of sPLA2-transgenic or knockout mice...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28058412/new-metal-chalcogenides-found-in-mnn-1-gd2-xinx-sn-2-n-3-4-5-syntheses-structures-and-magnetic-properties
#14
I C Liang, C Y Weng, C Huang, C K Chang, H S Sheu, J G Lin, K F Hsu
Three new metal chalcogenides have been identified in MnN-1(Gd2-xInx)SN+2 with N = 3, 4, and 5 via a flux-growth synthesis. All compounds crystallize in the same space group of orthorhombic Cmcm with cell constants: Mn2GdInS5 (1), a = 3.789(1) Å, b = 12.411(1) Å, and c = 15.489(1) Å; Mn3Gd2S6 (2), a = 3.778(1) Å, b = 12.505(2) Å, and c = 19.114(2) Å; Mn4Gd2S7 (3), a = 3.769(1) Å, b = 12.466(2) Å, and c = 22.289(3) Å. Compounds 1-3 form a homologous series through the modulation of the MnS unit, whose structures represent a complete system of the corresponding lillianites ((N1,N2)L) of (3,3)L, (4,4)L and (5,5)L...
January 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28049928/comparison-of-catabolic-rates-of-sn-1-sn-2-and-sn-3-fatty-acids-in-triacylglycerols-using-13-co2-breath-test-in-mice
#15
Fumiaki Beppu, Takashi Kawamatsu, Yoshio Yamatani, Toshiharu Nagai, Kazuaki Yoshinaga, Hoyo Mizobe, Akihiko Yoshida, Atsushi Kubo, Jota Kanda, Naohiro Gotoh
Fatty acids in triacylglycerols (TAGs) are catabolized after digestion. However, the catabolic rates of the fatty acids at the sn-1, sn-2, and sn-3 positions of TAGs have not been compared. To elucidate the differences, we studied the catabolic rates of (13)C-labeled palmitic acid, oleic acid, and capric acid at the sn-1, sn-2, or sn-3 position of TAGs using isotope-ratio mass spectrometry. Specifically, we measured the (13)C-to-(12)C ratio in CO2 (Δ(13)C (‰)) exhaled by mice. For all analyzed fatty acids, we observed significant differences between sn-2 and other binding positions...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28042881/a-facile-reduction-method-for-roll-to-roll-production-of-high-performance-graphene-based-transparent-conductive-films
#16
Jing Ning, Long Hao, Meihua Jin, Xiongying Qiu, Yudi Shen, Jiaxu Liang, Xinghao Zhang, Bin Wang, Xianglong Li, Linjie Zhi
A facile roll-to-roll method is developed for fabricating reduced graphene oxide (rGO)-based flexible transparent conductive films. A Sn(2+) /ethanol reduction system and a rationally designed fast coating-drying-washing technique are proven to be highly efficient for low-cost continuous production of large-area rGO films and patterned rGO films, extremely beneficial toward the manufacture of flexible photoelectronic devices.
January 2, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28042097/parkin-deficiency-accelerates-consequences-of-mitochondrial-dna-deletions-and-parkinsonism
#17
Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopassi
Parkinson's disease (PD) is a neurodegenerative condition caused by age-related death of dopaminergic (DA) neurons in the substantia nigra (SN). Mitochondrial DNA (mtDNA) deletions rise exponentially with age in humans and reach their highest levels approaching 60% in dopaminergic neurons of the substantia nigra and overlap with dying neurons. Parkin deletion causes Parkinsonism in humans, presumably through a decrease in mitochondrial quality control, but Parkin knockout mice do not have DA neurodegeneration...
December 29, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/28039812/fast-non-aqueous-reversed-phase-liquid-chromatography-separation-of-triacylglycerol-regioisomers-with-isocratic-mobile-phase-application-to-different-oils-and-fats
#18
Arnaud W G Tamba Sompila, Sylvie Héron, Dorra Hmida, Alain Tchapla
The distribution of fatty acid species at the sn-1/3 position or the sn-2 position of triacylglycerols (TAGs) in natural fats and oils affects their physical and nutritional properties. In fats and oils, determining the presence of one or two regioisomers and the identification of structure, where they do have one, as well as their separation, became a problem of fundamental importance to solve. A variety of instrumental technics has been proposed, such as MS, chromatography-MS or pure chromatography. A number of studies deal with the optimization of the separation, but very often, they are expensive in time...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28004908/triumphing-over-charge-transfer-limitations-of-pedot-nanofiber-reduction-catalyst-by-1-2-ethanedithiol-doping-for-quantum-dot-solar-cells
#19
Tea-Yon Kim, Tae Kyung Lee, Byung Su Kim, Seul Chan Park, Sungjin Lee, Seung Soon Im, Juan Bisquert, Yong Soo Kang
Charge transfer between a conducting polymer-based counter electrode (CE) and a polysulfide (S(2-)/Sn(2-)) electrolyte mediator is a key limitation to improvements of solar energy conversion efficiency (ECE) in quantum-dot-sensitized solar cells (QDSCs). In this paper, 1,2-ethanedithiol (EDT) was doped into nanofibrous poly(3,4-ethylenedioxythiophene) (PEDOT NF) to overcome the charge transfer limitation between PEDOT NF and S(2-)/Sn(2-). EDT not only helps to reduce the aggregation and thus enhance the linearization of the PEDOT chains but also changes the molecular conformation of the PEDOT chains from a benzoid to a quinoid structure...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27996213/versatile-homoallylic-boronates-by-chemo-sn-2-diastereo-and-enantioselective-catalytic-sequence-of-cu-h-addition-to-vinyl-b-pin-allylic-substitution
#20
Jaehee Lee, Sebastian Torker, Amir H Hoveyda
A highly chemo-, diastereo- and enantioselective catalytic method that efficiently combines a silyl hydride, vinyl-B(pin) (pin=pinacolato) and (E)-1,2-disubstituted allylic phosphates is introduced. Reactions, best promoted by a Cu-based complex with a chiral sulfonate-containing N-heterocyclic carbene, are broadly applicable. Aryl-, heteroaryl-, alkenyl-, alkynyl- and alkyl-substituted allylic phosphates may thus be converted to the corresponding homoallylic boronates and then alcohols (after C-B bond oxidation) in 46-91 % yield and in up to >98 % SN 2':SN 2 ratio, 96:4 diastereomeric ratio and 98:2 enantiomeric ratio...
January 16, 2017: Angewandte Chemie
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