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https://www.readbyqxmd.com/read/29301359/identification-of-conserved-and-diverse-metabolic-shift-of-the-stylar-intermediate-and-peduncular-segments-of-cucumber-fruit-during-development
#1
Chaoyang Hu, Huiyu Zhao, Wen Wang, Mingfei Xu, Jianxin Shi, Xiangbo Nie, Guiling Yang
Cucumber (Cucumis sativus L.) is one of the most important vegetables and contains a high content of nutritionally beneficial metabolites. However, little is known about the metabolic variations among different parts of cucumber fruit and their kinetics during growth. In this study, the dynamic metabolic profiles in the stylar end, the intermediate segment and the peduncular end of cucumber fruit during the development were investigated by employing a non-targeted metabolomics approach, where 238 metabolites were identified...
January 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29301208/effects-of-plant-oil-interesterified-triacylglycerols-on-lipemia-and-human-health
#2
REVIEW
Andreina Alfieri, Esther Imperlini, Ersilia Nigro, Daniela Vitucci, Stefania Orrù, Aurora Daniele, Pasqualina Buono, Annamaria Mancini
The position of the fatty acids (sn-1, sn-2 and sn-3) (stereospecific numbering (sn)) in triacylglycerol (TAG) molecules produces a characteristic stereospecificity that defines the physical properties of the fats and influences their absorption, metabolism and uptake into tissues. Fat interesterification is a process that implies a positional distribution of fatty acids (FAs) within the TAG molecules, generating new TAG species, without affecting the FA cis-trans natural balance. The interesterified (IE) fats, frequently used in the food industry comprise fats that are rich in long-chain saturated FAs, such as palmitic acid (16:0) and stearic acid (18:0)...
December 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29282829/electrochemical-oxidation-of-phosphatidylethanolamines-studied-by-mass-spectrometry
#3
Simone Colombo, Giulia Coliva, Agnieszka Kraj, Jean-Pierre Chervet, Maria Fedorova, Pedro Domingues, M Rosário Domingues
Phosphatidylethanolamines (PEs) are widely present in cellular membranes and lipoproteins. Oxidation of PEs fatty acyl chains generates several oxidized products, exerting a vast number of biological functions, not totally unveiled yet. In vitro biomimetic models have been used to identify oxidized PEs and to develop analytical strategies for their targeted detection in vivo. Most of the models are based on oxidation by reactive oxygen species (ROS), but the oxidative metabolism of PE also relies on controlled reactions catalyzed by enzymes as lipoxygenase (LOX), which can be mimicked by electrochemical (EC) oxidation...
December 28, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29223060/recent-advances-in-lipid-separations-and-structural-elucidation-using-mass-spectrometry-combined-with-ion-mobility-spectrometry-ion-molecule-reactions-and-fragmentation-approaches
#4
REVIEW
Xueyun Zheng, Richard D Smith, Erin S Baker
Lipids are a vital class of molecules that play important and varied roles in biological processes, however, fully understanding these roles is extremely difficult due to the immense number and diversity of possible lipid species. While recent advances in chromatography and high resolution mass spectrometry have greatly progressed knowledge about distinct lipid species and functions, effectively separating many lipids still remains problematic. Isomeric lipids have made lipid characterization especially difficult and occur due to subclasses having the same chemical composition, or species having multiple acyl chain connectivities (sn-1, sn-2, or sn-3), double bond positions and orientations (cis or trans), and functional group stereochemistries (R versus S)...
December 6, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29219561/long-range-order-in-the-dipolar-xy-antiferromagnet-er_-2-sn_-2-o_-7
#5
S Petit, E Lhotel, F Damay, P Boutrouille, A Forget, D Colson
Er_{2}Sn_{2}O_{7} remains a puzzling case among the extensively studied frustrated compounds of the rare-earth pyrochlore family. Indeed, while a first-order transition towards a long-range antiferromagnetic state with the so-called Palmer-Chalker structure is theoretically predicted, it has not yet been observed, leaving the issue as to whether it is a spin-liquid candidate open. We report on neutron scattering and magnetization measurements which evidence a second-order transition towards this Palmer-Chalker ordered state around 108 mK...
November 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29167338/inhibition-of-cytosolic-phospholipase-a2%C3%AE-impairs-an-early-step-of-coronavirus-replication-in-cell-culture
#6
Christin Müller, Martin Hardt, Dominik Schwudke, Benjamin W Neuman, Stephan Pleschka, John Ziebuhr
Coronavirus replication is associated with intracellular membrane rearrangements in infected cells, resulting in the formation of double membrane vesicles (DMV) and other membranous structures that are referred to as replicative organelles (RO). The latter provide a structural scaffold for viral replication/transcription complexes (RTC) and help to sequester RTC components from recognition by cellular factors involved in antiviral host responses. There is increasing evidence that plus-strand (+) RNA virus replication, including RO formation and virion morphogenesis, affects cellular lipid metabolism and critically depends on enzymes involved in lipid synthesis and processing...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29166379/bcfa-enriched-vernix-monoacylglycerol-reduces-lps-induced-inflammatory-markers-in-human-enterocytes-in-vitro
#7
Yuanyuan Yan, Zhen Wang, Donghao Wang, Peter Lawrence, Xingguo Wang, Kumar S D Kothapalli, Jacelyn Greenwald, Ruijie Liu, Hui Gyu Park, J Thomas Brenna
BACKGROUND: Excess vernix caseosa produced by the fetal skin appears as particles suspended in the amniotic fluid in late gestation, is swallowed by the fetus and is found throughout the newborn GI tract as the first organisms are arriving to colonize the gut. Lipid rich vernix contains an unusually high 29% branched chain fatty acid (BCFA). BCFA reduce the incidence of necrotizing enterocolitis in an animal model, recently found predominantly in the sn-2 position of human milk triacylglycerols...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29156157/continuous-gradient-temperature-raman-spectroscopy-from-100-to-40%C3%A2-c-yields-new-molecular-models-of-arachidonic-acid-and-2-arachidonoyl-1-stearoyl-sn-glycero-3-phosphocholine
#8
C Leigh Broadhurst, Walter F Schmidt, Julie K Nguyen, Jianwei Qin, Kuanglin Chao, Moon S Kim
Despite its biochemical importance, a complete Raman analysis of arachidonic acid (AA, 20:4n-6) has never been reported. Gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry (DSC) to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions. Herein we utilize the GTRS technique for AA and 1-18:0, 2-20:4n-6 phosphatidyl choline (AAPC) from cryogenic to mammalian body temperatures...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29145606/-prokaryotic-pathway-is-not-prokaryotic-non-cyanobacterial-origin-of-the-chloroplast-lipid-biosynthetic-pathway-revealed-by-comprehensive-phylogenomic-analysis
#9
Naoki Sato, Koichiro Awai
Lipid biosynthesis within the chloroplast, or more generally plastids, was conventionally called "prokaryotic pathway", which produces glycerolipids bearing C18 acids at the sn-1 position and C16 acids at the sn-2 position, as in cyanobacteria such as Anabaena and Synechocystis. This positional specificity is determined during the synthesis of phosphatidate, which is a precursor to diacylglycerol, the acceptor of galactose for the synthesis of galactolipids. The first acylation at sn-1 is catalyzed by glycerol-3-phosphate acyltransferase (GPAT or GPT), whereas the second acylation at sn-2 is performed by lysophosphatidate acyltransferase (LPAAT, AGPAT or PlsC)...
November 14, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29136584/unprecedented-chemosensing-behavior-of-novel-tetra-substituted-benzimidazole-zinc-ii-phthalocynine-for-selective-detection-of-bi-3-ion-synthesis-characterization-and-ros-generation
#10
Azeem Ullah, Faheem Shah, Imran Khan, Muhammad Anwar, Kiramat Shah, Munira Taj Muhammad, Farid Ahmad
In this work, synthesis of novel symmetrical 4-(2-bromo-4-(5-bromo-1H-benzo[d] imidazol-2-yl) phenoxy) tetra substituted zinc phthalocyanine has been reported. The novel benzimidazole zinc phthlocynine compound (3) has been characterized by MALDI-TOF MS, FT-IR, UV-vis, and (1)H NMR spectroscopy. This new compound 3 displayed excellent selectivity towards Bi(3+) ion in the presence of other competitive ions including Ca(2+), Cd(2+), Co(2+) Cu(2+), Fe(3+), Hg(2+), Sn(2+), Mg(2+), Na(+), Ni(2+) and Pb(2+) respectively...
November 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29130691/insertion-of-a-transient-tin-nitride-into-carbon-carbon-and-boron-carbon-bonds
#11
Shuai Wang, Lizhi Tao, Troy A Stich, Marilyn M Olmstead, R David Britt, Philip P Power
A simple exchange reaction between [Ar(iPr4)Sn(μ-Cl)]2 (1) and sodium azide afforded the doubly bridged Sn(II) azide, [Ar(iPr4)Sn(μ-N3)]2 (2) (Ar(iPr4) = C6H3-2,6(C6H3-2,6-(i)Pr2)2) in 85% yield. Photolysis of a diethyl ether solution of 2 for ca. 16 h yielded an azepinyl-substituted insertion product, [C6H3-2-(C6H3-2,6-(i)Pr2)-6-(C6H3N-3,7-(i)Pr2)Sn]2 (3). The reaction of the Lewis acid, B(C6F5)3 (BCF), or the Lewis base, pyridine, with 2 dissociates the dimer to afford the corresponding complexed monomeric Sn(II) azide, Ar(iPr4)SnN3BCF (4) in which BCF coordinates the α-nitrogen, or Ar(iPr4)Sn(pyridine)N3 (6) in which pyridine coordinates to the tin atom...
November 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29129896/extraction-and-the-fatty-acid-profile-ofrosa-acicularis-seed-oil
#12
Huanan Du, Xu Zhang, Ruchun Zhang, Lu Zhang, Dianyu Yu, Lianzhou Jiang
Rosa acicularis seed oil was extracted from Rosa acicularis seeds by the ultrasonic-assisted aqueous enzymatic method using cellulase and protease. Based on a single experiment, Plackett-Burman design was applied to ultrasonic-assisted aqueous enzymatic extraction of wild rose seed oil. The effects of enzyme amount, hydrolysis temperature and initial pH on total extraction rate of wild rose seed oil was studied by using Box-Behnken optimize methodology. Chemical characteristics of a sample of Rosa acicularis seeds and Rosa acicularis seed oil were characterized in this work...
November 13, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29129849/lipoquality-control-by-phospholipase-a2-enzymes
#13
Makoto Murakami
The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. The mammalian genome encodes more than 50 PLA2s or related enzymes, which are classified into several subfamilies on the basis of their structures and functions. From a general viewpoint, the PLA2 family has mainly been implicated in signal transduction, producing bioactive lipid mediators derived from fatty acids and lysophospholipids...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/29125196/an-interacting-quantum-atom-study-of-model-sn-2-reactions-x-%C3%A2-%C3%A2-%C3%A2-ch3-x-x%C3%A2-%C3%A2-f-cl-br-and-i
#14
Ibon Alkorta, Joseph C R Thacker, Paul L A Popelier
The quantum chemical topology method has been used to analyze the energetic profiles in the X(-)  + CH3 X → XCH3  + X(-) SN 2 reactions, with X = F, Cl, Br, and I. The evolution of the electron density properties at the BCPs along the reaction coordinate has been analysed. The interacting quantum atoms (IQA) method has been used to evaluate the intra-atomic and interatomic energy variations along the reaction path. The different energetic terms have been examined by the relative energy gradient method and the ANANKE program, which enables automatic and unbiased IQA analysis...
November 10, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29120186/constrained-vs-free-cholesterol-in-dppc-membranes-a-comparison-of-chain-ordering-ability-using-deuterium-nmr
#15
Mehran Shaghaghi, Amir Keyvanloo, Zhaohua Huang, Francis C Szoka, Jenifer L Thewalt
We report here the first exploration of the nature of the hydrophobic region of bilayer membranes formed from sterol modified phospholipids [Huang, Z.; Szoka, F. C., Sterol-Modified Phospholipids: Cholesterol and Phospholipid Chimeras with Improved Biomembrane Properties. J. Am. Chem. Soc. 2008, 130 (46), 15702-15712] & [Ding, J.; Starling, A. P.; East, J.M.; Lee, A. G., Binding Sites for Cholesterol on Ca(2+)-ATPase Studied by using a Cholesterol-containing Phospholipid. Biochemistry. 1994, 33(16), 4974-4979]...
November 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29117232/rate-of-acyl-migration-in-lysophosphatidylcholine-lpc-is-dependent-upon-the-nature-of-the-acyl-group-greater-stability-of-sn-2-docosahexaenoyl-lpc-compared-to-the-more-saturated-lpc-species
#16
Dhavamani Sugasini, Papasani V Subbaiah
Several previous studies reported that sn-2 acyl lysophosphatidylcholines (LPCs) undergo rapid isomerization due to acyl migration, especially at physiological pH and temperature. However, these studies have been carried out using mostly sn-2 palmitoyl LPC, whereas the naturally occurring sn-2 LPCs are predominantly unsaturated. In this study, we investigated the acyl migration in four naturally occurring sn-2 acyl LPCs (sn-2 16:0, sn-2 18:1, sn-2 20:4, and sn-2 22:6) stored at various temperatures in aqueous or organic solvents, employing LC/MS to analyze the isomer composition...
2017: PloS One
https://www.readbyqxmd.com/read/29101519/computational-modeling-and-in-vitro-in-silico-correlation-of-phospholipid-based-prodrugs-for-targeted-drug-delivery-in-inflammatory-bowel-disease
#17
Arik Dahan, Milica Markovic, Shahar Keinan, Igor Kurnikov, Aaron Aponick, Ellen M Zimmermann, Shimon Ben-Shabat
Targeting drugs to the inflamed intestinal tissue(s) represents a major advancement in the treatment of inflammatory bowel disease (IBD). In this work we present a powerful in-silico modeling approach to guide the molecular design of novel prodrugs targeting the enzyme PLA2, which is overexpressed in the inflamed tissues of IBD patients. The prodrug consists of the drug moiety bound to the sn-2 position of phospholipid (PL) through a carbonic linker, aiming to allow PLA2 to release the free drug. The linker length dictates the affinity of the PL-drug conjugate to PLA2, and the optimal linker will enable maximal PLA2-mediated activation...
November 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29093377/recovery-and-utilization-of-palm-oil-mill-effluent-source-as-value-added-food-products
#18
Soek Sin Teh, Augustine Soon Hock Ong, Siau Hui Mah
The environmental impacts of palm oil mill effluent (POME) have been a concern due to the water pollution and greenhouse gases emissions. Thus, this study was conducted to recover the value-added products from POME source before being discharged. The samples, before (X) and after (Y) the pre-recovery system in the clarification tank were sampled and analysed and proximate analysis indicated that both samples are energy rich source of food due to high contents of fats and carbohydrates. GCMS analysis showed that the oil extracts contain predominantly palmitic, oleic, linoleic and stearic acids...
2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29091407/role-of-acyl-chain-composition-of-phosphatidylcholine-in-tafazzin-mediated-remodeling-of-cardiolipin-in-liposomes
#19
Masato Abe, Yoshiki Sawada, Shinpei Uno, Shuhei Chigasaki, Masahide Oku, Yasuyoshi Sakai, Hideto Miyoshi
Remodeling of the acyl chain compositions of cardiolipin (CL) species by the transacylase tafazzin is an important process for maintaining optimal mitochondrial functions. The results of mechanistic studies on the tafazzin-mediated transacylation from phosphatidylcholine (PC) to monolyso-CL (MLCL) in artificial lipid membranes are controversial. The present study investigated the role of the acyl chain composition of PC in the Saccharomyces cerevisiae tafazzin-mediated remodeling of CL by examining the structural factors responsible for the superior acyl donor ability of dipalmitoleoyl (16:1) PC over dipalmitoyl (16:0) PC...
November 9, 2017: Biochemistry
https://www.readbyqxmd.com/read/29064240/structural-evolution-in-basn2f5x-x-cl-br-i-a-family-of-alkaline-earth-metal-tin-mixed-halides
#20
Zheshuai Lin, Pifu Gong, Yi Yang, Siyang Luo, Fei Liang, Xingxing Jiang
As the first family of Sn-based alkaline earth metal mixed halides, three new compounds, BaSn2F5X (X = Cl, Br, and I), are synthesized by hydrothermal method. These compounds are crystallized in the centrosymmetric space groups of P21/c, P4/nmm, and Pmma for BaSn2F5Cl, BaSn2F5Br, and BaSn2F5I, respectively, and their microscopic frameworks are all composed of the fundamental structural unit [SnF4](2-) and its derivatives ([SnF4Cl](3-) and [SnF5](3-) groups). Interestingly, the structures in BaSn2F5X are significantly changed from one-dimensional (1D) to two-dimensional (2D) and then to 1D motifs as X varies from Cl, Br, to I...
November 6, 2017: Inorganic Chemistry
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