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JOURNAL ARTICLE
Kristyn Galbraith, Varshini Vasudevaraja, Jonathan Serrano, Guomiao Shen, Ivy Tran, Nancy Abdallat, Mandisa Wen, Seema Patel, Misha Movahed-Ezazi, Arline Faustin, Marissa Spino-Keeton, Leah Geiser Roberts, Ekrem Maloku, Steven A Drexler, Benjamin L Liechty, David Pisapia, Olga Krasnozhen-Ratush, Marc Rosenblum, Seema Shroff, Daniel R Boué, Christian Davidson, Qinwen Mao, Mariko Suchi, Paula North, Amanda Hopp, Annette Segura, Jason A Jarzembowski, Lauren Parsons, Mahlon D Johnson, Bret Mobley, Wesley Samore, Declan McGuone, Pallavi P Gopal, Peter D Canoll, Craig Horbinski, Joseph M Fullmer, Midhat S Farooqui, Murat Gokden, Nitin R Wadhwani, Timothy E Richardson, Melissa Umphlett, Nadejda M Tsankova, John C DeWitt, Chandra Sen, Dimitris G Placantonakis, Donato Pacione, Jeffrey H Wisoff, Eveline Teresa Hidalgo, David Harter, Christopher M William, Christine Cordova, Sylvia C Kurz, Marissa Barbaro, Daniel A Orringer, Matthias A Karajannis, Erik P Sulman, Sharon L Gardner, David Zagzag, Aristotelis Tsirigos, Jeffrey C Allen, John G Golfinos, Matija Snuderl
BACKGROUND: Central nervous system (CNS) cancer is the 10th leading cause of cancer-associated deaths for adults, but the leading cause in pediatric patients and young adults. The variety and complexity of histologic subtypes can lead to diagnostic errors. DNA methylation is an epigenetic modification that provides a tumor type-specific signature that can be used for diagnosis. METHODS: We performed a prospective study using DNA methylation analysis as a primary diagnostic method for 1921 brain tumors...
2023: Neuro-oncology advances
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JOURNAL ARTICLE
Thida Ong, Aricca D Van Citters, Christopher Dowd, Jason Fullmer, Rhonda List, Shine-Ann Pai, Clement L Ren, Peter Scalia, George M Solomon, Gregory S Sawicki
BACKGROUND: Cystic fibrosis (CF) programs and people with CF (PwCF) employed various monitoring methods for virtual care during the COVID-19 pandemic. This paper characterizes experiences with remote monitoring across the U.S. CF community. METHODS: The CF Foundation (CFF) sponsored distribution of home spirometers (April 2020 to May 2021), surveys to PwCF and CF programs (July to September 2020), and a second program survey (April to May 2021). We used mixed methods to explore access, use, and perspectives regarding the use of remote monitoring in future care...
December 2021: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
#3
JOURNAL ARTICLE
Jasmim Leal, Xiujuan Peng, Xinquan Liu, Dhivya Arasappan, Dennis C Wylie, Sarah H Schwartz, Jason J Fullmer, Bennie C McWilliams, Hugh D C Smyth, Debadyuti Ghosh
Therapeutic delivery of drug and gene delivery systems have to traverse multiple biological barriers to achieve efficacy. Mucosal administration, such as pulmonary delivery in cystic fibrosis (CF) disease, remains a significant challenge due to concentrated viscoelastic mucus, which prevents drugs and particles from penetrating the mucus barrier. To address this problem, we used combinatorial peptide-presenting phage libraries and next-generation sequencing (NGS) to identify hydrophilic, net-neutral charged peptide coatings that enable penetration of human CF mucus ex vivo with ~600-fold better penetration than control, improve uptake into lung epithelial cells compared to uncoated or PEGylated-nanoparticles, and exhibit enhanced uniform distribution and retention in the mouse lung airways...
March 31, 2020: Journal of Controlled Release
#4
JOURNAL ARTICLE
Giuseppe N Colasurdo, Jason J Fullmer, Okan Elidemir, Constance Atkins, Amir M Khan, James M Stark
Viral respiratory infections play an important role in the development and progression of pulmonary disease in cystic fibrosis (CF). The CF mouse model provides a tool to examine the relationship between the cystic fibrosis transmembrane conductance regulator (CFTR) defect and lung disease. This work investigates the cellular response to a common viral pathogen, respiratory syncytial virus (RSV) in the lung of CF mice. RSV was administered by intranasal inoculation of CFTR(tm1Unc)-Tg(FABPCFTR)1Jaw/J (CFTR-/-) and control mice...
May 2006: Journal of Medical Virology
#5
JOURNAL ARTICLE
Jason J Fullmer, Amir M Khan, Okan Elidemir, Connie Chiappetta, James M Stark, Giuseppe N Colasurdo
Cysteinyl leukotrienes (CysLTs) contribute to the development of airway obstruction and inflammation in asthma; however little information is available on the role of these molecules in the pathophysiology of respiratory syncytial virus (RSV) bronchiolitis. This study was designed to evaluate the effects of RSV infection on CysLTs production in a well-established mouse infection model. Furthermore, we assessed the effect of anti-inflammatory agents (a leukotriene receptor antagonist, MK-571, and dexamethasone) on the functional and immune changes induced by RSV infection...
November 2005: Pediatric Allergy and Immunology
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JOURNAL ARTICLE
Jason J Fullmer, Leland L Fan, Megan K Dishop, Cheryl Rodgers, Robert Krance
Bronchiolitis obliterans (BO) in children is a rare, inflammatory/fibrosing process involving the small airways that often results in progressive, irreversible obstructive pulmonary disease. Because treatment has focused mainly on supportive care and generally unsuccessful immunosuppression, children with BO experience significant morbidity and mortality. We report a case of biopsy-proven BO after bone marrow transplantation in a child who, after failed corticosteroid therapy, was treated with infliximab, a monoclonal antibody with binding specificity for human tumor necrosis factor-alpha...
September 2005: Pediatrics
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COMPARATIVE STUDY
Jason J Fullmer, Claire Langston, Megan K Dishop, Leland L Fan
OBJECTIVE: To review clinical, laboratory, and outcome characteristics of children diagnosed with pulmonary capillaritis (PC), a small-vessel vasculitis, presenting as diffuse alveolar hemorrhage (DAH), and to compare these findings with those for children with other alveolar hemorrhage syndromes. STUDY DESIGN: A retrospective chart review of patients who underwent a lung biopsy because of a clinical suggestion of pulmonary hemorrhage. RESULTS: PC was identified in 8 of 23 patients...
March 2005: Journal of Pediatrics
#8
JOURNAL ARTICLE
John R Cochran, Amir M Khan, Okan Elidemir, Hasen Xue, Beatrize Cua, Jason Fullmer, Gary L Larsen, Giuseppe N Colasurdo
Exposure to endotoxin has been associated with an exacerbation of asthmatic responses in humans and animal models. However, recent evidence suggests that microbial exposure in early life may protect from the development of asthma and atopy. In this study, we sought to evaluate the effects of lipopolysaccaride (LPS) on airway function in developing mice. In addition, we evaluated the influence of LPS on subsequent allergen sensitization and challenge. Under light anesthesia, 2-3-week-old Balb/c mice received a single intranasal instillation of LPS or sterile physiologic saline...
October 2002: Pediatric Pulmonology
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