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Synthetic Cannabinoid-Related Illnesses and Deaths

Jordan Trecki, Roy R Gerona, Michael D Schwartz
Synthetic cannabinoids (SCs) were first created in the 1980s as laboratory research tools (ligands) for studying human endocannabinoid receptor systems. SC-containing products supplied by illicit manufacturers were then marketed throughout Europe as herbal incense, before arriving in the United..
July 9, 2015: New England Journal of Medicine
Diana Aguirre-Rueda, Sol Guerra-Ojeda, Martin Aldasoro, Antonio Iradi, Elena Obrador, Maria D Mauricio, Jose M Vila, Patricia Marchio, Soraya L Valles
Alzheimer's disease (AD), a neurodegenerative illness involving synaptic dysfunction with extracellular accumulation of Aβ1-42 toxic peptide, glial activation, inflammatory response and oxidative stress, can lead to neuronal death. Endogenous cannabinoid system is implicated in physiological and physiopathological events in central nervous system (CNS), and changes in this system are related to many human diseases, including AD. However, studies on the effects of cannabinoids on astrocytes functions are scarce...
2015: PloS One
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