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Mohammad Riazi

Elham Sadat Mostafavi, Mohammad Ali Nasiri Khalili, Sirus Khodadadi, Gholam Hossein Riazi
No abstract text is available yet for this article.
October 18, 2016: Journal of Biomolecular Structure & Dynamics
Abolfazl Jangholi, Mohammad Reza Ashrafi-Kooshk, Seyed Shahriar Arab, Gholamhossein Riazi, Farzad Mokhtari, Mansour Poorebrahim, Hamid Mahdiuni, Boris I Kurganov, Ali Akbar Moosavi-Movahedi, Reza Khodarahmi
In many neurodegenerative diseases, formation of protein fibrillar aggregates has been observed as a major pathological change. Neurofibrillary tangles, mainly composed of fibrils formed by the microtubule-associated protein; Tau, are a hallmark of a group of neurodegenerative diseases such as Alzheimer's disease. Tau belongs to the class of natively unfolded proteins and partially folds into an ordered β-structure during aggregation. Polyanionic cofactors such as heparin are commonly used as inducer of Tau aggregation in vitro...
November 1, 2016: Archives of Biochemistry and Biophysics
Azam Azimi, Seyed Mahmood Ghaffari, Gholam Hossein Riazi, Seyed Shahriar Arab, Mohammad Mehdi Tavakol, Shahriar Pooyan
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus rotundus L. (Cyperaceae), commonly known as purple nutsedge or nut grass is one of the most invasive and endemic weeds in tropical, subtropical and temperate regions. This plant has been extensively used in traditional medicine for anti-arthritic, antidiarrheal and antiplatelet properties as well as treatment for several CNS disorders such as epilepsy, depression and inflammatory disorders. Inflammation is evidently occurring in pathologically susceptible regions of the Alzheimer's disease (AD) brain as well as other disorders...
June 25, 2016: Journal of Ethnopharmacology
Nazanin Ebrahimiadib, Ramak Roohipour, Reza Karkhaneh, Afsar Farahani, Mohammad Riazi Esfahani, Alireza Khodabande, Mohammad Zarei, Arash Taheri, Marjan Imani Fouladi, Mehdi Yaseri, Bobeck S Modjtahedi
PURPOSE: To compare the efficacy of an internet-based versus traditional referral system for retinopathy of prematurity (ROP) screening in Iran. METHODS: Two referral screening systems were compared in this prospective observational study. Group A (internet-based) comprised premature babies who were registered into an online system for screening. Their appointments were scheduled automatically based on standardized criteria. Group B (conventional) comprised premature babies whose referrals were based on oral or written recommendations...
October 2016: Ophthalmic Epidemiology
Reza Karkhane, Aliasghar Ahmadraji, Mohammad Riazi Esfahani, Ramak Roohipour, Zahra Alami Harandi, Alireza Lashay, Mehdi Sharifzadeh Kermani, Reza Roozafzoon, Ahad Khoshzaban
PURPOSE: To evaluate the frequency of 12 single nucleotide polymorphisms (SNPs) of complement factor H (CFH) and LOC387715/ARMS2/HRTA1 and their association with some of the presenting clinical features of neovascular age-related macular degeneration (AMD). METHODS: In this prospective non-comparative case series forty four naïve patients with neovascular AMD were genotyped using sequencing or Sequenom iPLEX technology. Descriptive tests were used for displaying the magnitude of each allele, gender distribution, and age at diagnosis...
March 2016: Journal of Current Ophthalmology
Ramak Roohipoor, Reza Karkhaneh, Afsar Farahani, Nazanin Ebrahimiadib, Bobeck Modjtahedi, Akbar Fotouhi, Mehdi Yaseri, Alireza Khodabande, Mohammad Zarei, Marjan Imani Fuladi, Arash Taheri, Mohammad Riazi Esfahani, John Loewenstein
OBJECTIVE: To test the applicability of existing retinopathy of prematurity (ROP) guidelines on Iranian patients and to develop novel ROP screening criteria in Iran. METHODS: Both eyes of 1932 infants born ≤37 weeks of gestation and/or weighting ≤3000 g were included in this prospective cohort study that was conducted across nine neonatal intensive care units and a tertiary eye hospital ROP clinic. The patients were examined for ROP and the need for treatment (type 1 ROP or worse)...
July 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
Ramak Roohipoor, Mohammad Riazi-Esfahani, Nazanin Ebrahimiadib, Reza Karkhaneh, Mohammad Zarei, Sara Besharat, Fariba Ghassemi, Mohammad Reza Ostovaneh
PURPOSE: To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. METHODS: This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 grams and gestational age less than 33 weeks. A composite eye drop composed of phenylephrine 1%, tetracaine and tropicamide 0.5% was applied 3 times within 5-minute intervals and pupil diameters were measured. The eyes were examined by experienced ROP specialists using an indirect ophthalmoscope...
October 2015: Journal of Ophthalmic & Vision Research
Ramak Roohipoor, Elaheh Sharifian, Fariba Ghassemi, Mohammad Riazi-Esfahani, Reza Karkhaneh, Masoud Aghsaei Fard, Mohammad Zarei, Bobeck S Modjtahedi, Sasan Moghimi
PURPOSE: To compare choroidal thickness (CT) and retinal thickness (RT) between eyes with proliferative diabetic retinopathy treated with panretinal photocoagulation (PRP) or PRP with intravitreal bevacizumab (PRP + IVB). METHODS: Thirty-three patients with proliferative diabetic retinopathy were randomized to have one eye treated with PRP and the other with PRP + IVB. Change in CT was compared with baseline using enhanced depth imaging-optical coherence tomography at baseline and Months 1, 3, 6, and 10 after treatment...
October 2016: Retina
Reza Karkhaneh, Alireza Khodabande, Mohammad Riazi-Eafahani, Ramak Roohipoor, Fariba Ghassemi, Marjan Imani, Afsar Dastjani Farahani, Nazanin Ebrahimi Adib, Hamidreza Torabi
PURPOSE: To assess the effect of intravitreal bevacizumab for Type 1 retinopathy of prematurity (ROP) in zone II ROP. METHODS: We conducted a randomized clinical trial. Preterm infants with a gestational age less than 34 weeks or birthweight less than 2000 g were examined at 4 weeks chronological age or 31 weeks postmenstrual age (whichever was later). Preterm infants with Zone-II/Stage 2 or 3 and plus disease were included. Eligible infants were randomized to receive either conventional indirect laser therapy or intravitreal bevacizumab injections (0...
September 2016: Acta Ophthalmologica
Ramak Roohipoor, Reza Karkhaneh, Mohammad Riazi Esfahani, Fateme Alipour, Mahtab Haghighat, Nazanin Ebrahimiadib, Mohammad Zarei, Ramin Mehrdad
AIM: To compare refractive error changes in retinopathy of prematurity (ROP) patients treated with diode and red lasers. METHODS: A randomized double-masked clinical trial was performed, and infants with threshold or prethreshold type 1 ROP were assigned to red or diode laser groups. Gestational age, birth weight, pretreatment cycloplegic refraction, time of treatment, disease stage, zone and disease severity were recorded. Patients received either red or diode laser treatment and were regularly followed up for retina assessment and refraction...
2016: Ophthalmologica. Journal International D'ophtalmologie
Mohammad M Akbarzadeh, Neda Kazemin Jasemi, Fatemeh Hedayati Ktuli, Fahimeh Yazdani, Kazem Asadollahi, Nasrin Sartipnia, Ali Akbar Saboury, Mohammad Amin Moosavi, Gholam Hossein Riazi, Mojtaba Falahati
Herein, we report the catalase-like activity for Zn(II) ions in the presence of monomeric tau protein at low pH values. Monomeric tau protein contains two -SH groups that are a target for disulfide bound formation and are able to interact with Zn ion which create a thiol bond as a mimetic model of chloroperoxidase active site. Zn(II)/tau complex decomposes H2O2 with a high rate (Vm) as well as efficient turn oven number (kcat). Isothermal Titration Calorimetry (ITC) indicates the stoichiometry of 1:1 interaction between Zn(II) ion and tau protein at low pH values...
February 18, 2016: International Journal of Biological Macromolecules
Zare-Abdollahi Davood, Safari Shamsi, Hamid Ghaedi, Riazi-Isfahani Sahand, Ghadyani Mojtaba, Tabarraee Mahdi, Mirfakhraie Reza, Mohammad Javad Ebrahimi, Reyhaneh Sadat Miri-Moosavi, Sara Boosaliki, Omrani Mir Davood
In acute myeloid leukemia (AML), despite the acceptance of standard intensive chemotherapy as an optimal induction regimen for all age groups, in the elderly patients, the best treatment should meet the challenge of multiple factors like age, comorbidities, and cytogenetics, making them ineligible for standard induction chemotherapy. Using the current low-intensity therapies like decitabine, azacitidine, and low-dose cytarabine as a single arm, outcomes for these patients remain poor. As a histone deacetylase inhibitor valproic acid (VPA) exhibit anticancer activity by triggering apoptosis, the mechanism of which is not yet completely clarified...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Mohammad Riazi Esfahani, Hamid Riazi Esfahani, Alireza Mahmoudi, Mohammad Karim Johari, Karim Hemati
Focal choroidal excavation (FCE) was first reported as a choroidal posteriorly excavated zone without any scleral change. Choroidal excavation also divided into conforming and nonconforming type. Numerous reports demonstrated association between FCE and other disease such as choroidal neovascularization and central serous choroidoretinopathy. Here, we report a rare case of FCE in a patient with Best disease. The patient was diagnosed by spectoral domain optical coherence tomography (SD-OCT). To the best of our knowledge, our patient is the second report of choroidal excavation in Best vitelliform macular dystrophy...
May 2015: Journal of Clinical and Diagnostic Research: JCDR
Sima Darabi, Vahid Khaze, Farhad Riazi-Rad, Haiedeh Darabi, Fariborz Bahrami, Soheila Ajdary, Mohammad Hossein Alimohammadian
Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this study was to identify an ideal strain of L. major, capable of inducing protective and long-lasting Th1 responses in an animal model that mimics the human response to L. major infection. The isolates were from patients residing in 4 endemic areas of L...
December 2015: Cytokine
Reyhaneh Varshochian, Mohammad Riazi-Esfahani, Mahmood Jeddi-Tehrani, Ahmad-Reza Mahmoudi, Sara Aghazadeh, Mirgholamreza Mahbod, Morteza Movassat, Fatemeh Atyabi, Araz Sabzevari, Rassoul Dinarvand
Bevacizumab, an anti-VEGF antibody, has demonstrated trustworthy effects in treatment of retinal and choroidal neovascularization that both are crucial sight threatening conditions. However, the weak point is the short half-life of the drug in vitreous which necessitates frequent intravitreal injections. Accordingly employing controlled-release drug delivery systems such as polymeric nanoparticles (NPs) has been suggested. In this study albuminated-PLGA-NPs containing bevacizumab were prepared and studied intended for reducing the number of injections...
October 2015: Journal of Biomedical Materials Research. Part A
Lana Tamaddon, S Abolfazl Mostafavi, Reza Karkhane, Mohammad Riazi-Esfahani, Farid Abedin Dorkoosh, Morteza Rafiee-Tehrani
BACKGROUND: The release of the anti-toxoplasmosis drug, clindamycin phosphate, from intraocular implants of the biodegradable polymers poly (D, L-lactic acid) (PLA) and poly (D, L-lactide-co-glycolide) (PLGA) has been studied in vitro. MATERIALS AND METHODS: The preparation of the implants was performed by a melt-extrusion method. The developed extrudates were characterized and compared in in-vitro release profiles for elucidating the drug release mechanism. The formulations containing up to 40% w/w of drug were prepared...
2015: Advanced Biomedical Research
Mohammad Hossein Maghami, Amir Masoud Sodagar, Alireza Lashay, Hamid Riazi-Esfahani, Mohammad Riazi-Esfahani
Millions of patients are either slowly losing their vision or are already blind due to retinal degenerative diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) or because of accidents or injuries. Employment of artificial means to treat extreme vision impairment has come closer to reality during the past few decades. Currently, many research groups work towards effective solutions to restore a rudimentary sense of vision to the blind. Aside from the efforts being put on replacing damaged parts of the retina by engineered living tissues or microfabricated photoreceptor arrays, implantable electronic microsystems, referred to as visual prostheses, are also sought as promising solutions to restore vision...
October 2014: Journal of Ophthalmic & Vision Research
Niloofar Piri, Hamid Ahmadieh, Ramin Taei, Masoud Soheilian, Reza Karkhaneh, Alireza Lashay, Faegheh Golbafian, Mehdi Yaseri, Mohammad Riazi-Esfahani
PURPOSE: To compare the outcomes of photodynamic therapy (PDT) combined with intravitreal bevacizumab (IVB) with versus without intravitreal triamcinolone (IVT) in neovascular age-related macular degeneration (AMD). METHODS: Eighty-four eyes with active CNV secondary to AMD with no prior treatment were enrolled and followed for 1-year. Eligible eyes were randomly assigned to either PDT/IVB or PDT/IVB/IVT. The main outcome measure was change in best-corrected visual acuity (BCVA)...
October 2014: Journal of Ophthalmic & Vision Research
Farhad Riazi Rad, Soheila Ajdary, Ramesh Omranipour, Mohammad Hossein Alimohammadian, Zahir M Hassan
BACKGROUND: CD4+ and CD8+ T cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. The frequencies of T cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dLN) can be considered as useful markers for evaluation of the immune system in cancers. METHODS: In this study, the frequencies of CD4+ and CD8+ T cells in blood, tumor tissues, and dLN samples of breast cancer patients were compared with each other and with similar tissues from normal individuals...
2015: Iranian Biomedical Journal
Davood Zare-Abdollahi, Shamsi Safari, Abolfazl Movafagh, Sahand Riazi-Isfahani, Mojtaba Ghadyani, Hashemi-Gorji Feyzollah, Mohammad Foad Nasrollahi, Mir Davood Omrani
OBJECTIVES: Despite numerous studies in order to determine the allele frequency and clinical impact of DNA methyltransferase 3 A (DNMT3A) gene mutations in acute myeloid leukemia (AML), reports about the expression analysis of this gene are rare and between the available, differences are evident. METHODS: In this study, we decided to investigate DNMT3A possible expression changes with regard to their mutation and cytogenetic status in a series of 96 AML patients...
August 2015: Hematology (Amsterdam, Netherlands)
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