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Mohammad Riazi

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https://www.readbyqxmd.com/read/28691584/fibrin-gel-as-a-scaffold-for-photoreceptor-cells-differentiation-from-conjunctiva-mesenchymal-stem-cells-in-retina-tissue-engineering
#1
Mostafa Soleimannejad, Somayeh Ebrahimi-Barough, Masoud Soleimani, Samad Nadri, Seyed Mohammad Tavangar, Ramak Roohipoor, Meysam Yazdankhah, Neda Bayat, Mohammad Riazi-Esfahani, Jafar Ai
Stem cell-based therapies are attraction approaches for regenerative medicine for treating retinal diseases. One of the limitations in cell therapy is cell death following post-injection whit preventing functional integration with retinal tissue. Fibrin gel, a bio-polymeric material with excellent biocompatibility, provides numerous advantages as a tissue engineering scaffold and a stem cell carrier. Therefore, current research is focusing on developing fibrin hydrogel scaffolds to protect stem cells during delivery and to stimulate endogenous regeneration through interactions of transplanted stem cells and retinal tissue...
July 10, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28626822/a-prospective-randomized-trial-of-azithromycin-versus-trimethoprim-sulfamethoxazole-in-treatment-of-toxoplasmic-retinochoroiditis
#2
Alireza Lashay, Ahmad Mirshahi, Najaf Parandin, Hamid Riazi Esfahani, Mehdi Mazloumi, Mohammad Reza Lashay, Mohammad Karim Johari, Elham Ashrafi
PURPOSE: To assess the efficacy of oral azithromycin in the treatment of toxoplasmic retinochoroiditis. METHODS: A randomized interventional comparative study was conducted on 14 patients with ocular toxoplasmosis who were treated with oral azithromycin and 13 patients who were treated with oral trimethoprim/sulfamethoxazole for 6-12 weeks. The achievement of treatment criteria in the two groups and lesion size reduction were considered as primary outcome measures...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28351499/retina-tissue-engineering-by-conjunctiva-mesenchymal-stem-cells-encapsulated-in-fibrin-gel-hypotheses-on-novel-approach-to-retinal-diseases-treatment
#3
Mostafa Soleimannejad, Somayeh Ebrahimi-Barough, Samad Nadri, Mohammad Riazi-Esfahani, Masoud Soleimani, Seyed Mohammad Tavangar, Jafar Ai
BACKGROUND: Retinitis pigmentosa (RP) and age related macular degeneration (AMD) are two retinal diseases that progress by photoreceptor cells death. In retinal transplantation studies, stem and progenitor cells inject into the sub retinal space or vitreous and then these cells can be migrate to the site of retinal degeneration and locate in the host retina and restitute vision. PRESENTATION OF THE HYPOTHESIS: Our hypothesis suggests that using human conjunctiva stem cells (as the source for increasing the number of human stem cells progenitor cells in retina dysfunction diseases) with fibrin gel and also assessing its relating in vitro (cellular and molecular processes) and in vivo (vision tests and pathology) could be a promising strategy for treatment of AMD and RP disorders...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28349504/intravitreal-bevacizumab-alone-or-combined-with-1%C3%A2-mg-triamcinolone-in-diabetic-macular-edema-a-randomized-clinical-trial
#4
Mohammad Riazi-Esfahani, Hamid Riazi-Esfahani, Aliasghar Ahmadraji, Reza Karkhaneh, Alireza Mahmoudi, Ramak Roohipoor, Fariba Ghasemi, Mehdi Yaseri
PURPOSE: To compare the results of intravitreal bevacizumab (IVB) injection alone or in combination with intravitreal 1 mg triamcinolone acetonide (IVT) in center-involved diabetic macular edema. METHODS: In this randomized clinical trial study, ninety-two eyes of 46 patients with bilateral center-involved diabetic macular edema and no previous treatment were included in the study. One eye of each patient was randomly assigned to 1.25 mg of IVB injection or combination of 1...
March 27, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28238867/aqueous-extract-of-launaea-acanthodes-induces-glutamate-uptake-and-gaba-release-in-astrocyte-cell-culture-via-a-ros-scavenging-mediated-process
#5
Hamid Kasnavi Yazdi, Mohammad Fazilati, Raheleh Rahbarian, Gholamhossein Riazi, Habibollah Nazem
Launaea acanthodes is extensively used in the semiarid region of Iran for treatment of seizure. However, the underlying mechanism has not been studied well. In our previous study we showed that Launaea acanthodes extract could effectively stimulate GABA release from PC12 cell culture. The critical role of astrocytes in epileptic brain in regulation of neurotransmitter balance in central nervous system encouraged us to investigate the effect of Launaea acanthodes extract on GABA and glutamate release from astrocytes...
February 24, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28090795/isolation-and-characterization-of-anti-c-met-single-chain-fragment-variable-scfv-antibodies
#6
Elmira Safaie Qamsari, Zahra Sharifzadeh, Salman Bagheri, Farhad Riazi-Rad, Vahid Younesi, Mohsen Abolhassani, Sepideh Safaei Ghaderi, Behzad Baradaran, Mohammad Hossein Somi, Mehdi Yousefi
The receptor tyrosine kinase (RTK) Met is the cell surface receptor for hepatocyte growth factor (HGF) involved in invasive growth programs during embryogenesis and tumorgenesis. There is compelling evidence suggesting important roles for c-Met in colorectal cancer proliferation, migration, invasion, angiogenesis, and survival. Hence, a molecular inhibitor of an extracellular domain of c-Met receptor that blocks c-Met-cell surface interactions could be of great thera-peutic importance. In an attempt to develop molecular inhibitors of c-Met, single chain variable fragment (scFv) phage display libraries Tomlinson I + J against a specific synthetic oligopeptide from the extracellular domain of c-Met receptor were screened; selected scFv were then characterized using various immune techniques...
January 16, 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/27994809/diabetic-retinopathy-clinical-practice-guidelines-customized-for-iranian-population
#7
Zhale Rajavi, Sare Safi, Mohammad Ali Javadi, Mohsen Azarmina, Siamak Moradian, Morteza Entezari, Ramin Nourinia, Hamid Ahmadieh, Armin Shirvani, Saeid Shahraz, Alireza Ramezani, Mohammad Hossein Dehghan, Mohsen Shahsavari, Masoud Soheilian, Homayoun Nikkhah, Hossein Ziaei, Hasan Behboudi, Fereydoun Farrahi, Khalil Ghasemi Falavarjani, Mohammad Mehdi Parvaresh, Hamid Fesharaki, Majid Abrishami, Nasser Shoeibi, Mansour Rahimi, Alireza Javadzadeh, Reza Karkhaneh, Mohammad Riazi-Esfahani, Masoud Reza Manaviat, Alireza Maleki, Bahareh Kheiri, Faegheh Golbafian
PURPOSE: To customize clinical practice guidelines (CPGs) for management of diabetic retinopathy (DR) in the Iranian population. METHODS: Three DR CPGs (The Royal College of Ophthalmologists 2013, American Academy of Ophthalmology [Preferred Practice Pattern 2012], and Australian Diabetes Society 2008) were selected from the literature using the AGREE tool. Clinical questions were designed and summarized into four tables by the customization team. The components of the clinical questions along with pertinent recommendations extracted from the above-mentioned CPGs; details of the supporting articles and their levels of evidence; clinical recommendations considering clinical benefits, cost and side effects; and revised recommendations based on customization capability (applicability, acceptability, external validity) were recorded in 4 tables, respectively...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27994808/effects-of-benzo-e-pyrene-on-reactive-oxygen-nitrogen-species-and-inflammatory-cytokines-induction-in-human-rpe-cells-and-attenuation-by-mitochondrial-involved-mechanism
#8
M Fernanda Estrago-Franco, M Tarek Moustafa, Mohammad Riazi-Esfahani, Ashish U Sapkal, Rhina Piche-Lopez, A Jayaprakash Patil, Ashish Sharma, Payam Falatoonzadeh, Marilyn Chwa, Georgia Luczy-Bachman, Baruch D Kuppermann, M Cristina Kenney
PURPOSE: To identify inhibitors that could effectively lower reactive oxygen/nitrogen species (ROS/RNS), complement and inflammatory cytokine levels induced by Benzo(e)pyrene [B(e)p], an element of cigarette smoke, in human retinal pigment epithelial cells (ARPE-19) in vitro. METHODS: ARPE-19 cells were treated for 24 hours with 200 μM, 100 μM, and 50 μM B(e)p or DMSO (dimethyl sulfoxide)-equivalent concentrations. Some cultures were pre-treated with ROS/RNS inhibitors (NG nitro-L-arginine, inhibits nitric oxide synthase; Apocynin, inhibits NADPH oxidase; Rotenone, inhibits mitochondrial complex I; Antimycin A, inhibits mitochondria complex III) and ROS/RNS levels were measured with a fluorescent H2 DCFDA assay...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27753295/an-in-vitro-study-of-the-role-of-docosahexaenoic-acid-in-human-tau-protein-aggregation
#9
Elham Sadat Mostafavi, Mohammad Ali Nasiri Khalili, Sirus Khodadadi, Gholam Hossein Riazi
No abstract text is available yet for this article.
November 7, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27638048/appraisal-of-role-of-the-polyanionic-inducer-length-on-amyloid-formation-by-412-residue-1n4r-tau-protein-a-comparative-study
#10
COMPARATIVE STUDY
Abolfazl Jangholi, Mohammad Reza Ashrafi-Kooshk, Seyed Shahriar Arab, Gholamhossein Riazi, Farzad Mokhtari, Mansour Poorebrahim, Hamid Mahdiuni, Boris I Kurganov, Ali Akbar Moosavi-Movahedi, Reza Khodarahmi
In many neurodegenerative diseases, formation of protein fibrillar aggregates has been observed as a major pathological change. Neurofibrillary tangles, mainly composed of fibrils formed by the microtubule-associated protein; Tau, are a hallmark of a group of neurodegenerative diseases such as Alzheimer's disease. Tau belongs to the class of natively unfolded proteins and partially folds into an ordered β-structure during aggregation. Polyanionic cofactors such as heparin are commonly used as inducer of Tau aggregation in vitro...
November 1, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27353867/%C3%AE-cyperone-of-cyperus-rotundus-is-an-effective-candidate-for-reduction-of-inflammation-by-destabilization-of-microtubule-fibers-in-brain
#11
Azam Azimi, Seyed Mahmood Ghaffari, Gholam Hossein Riazi, Seyed Shahriar Arab, Mohammad Mehdi Tavakol, Shahriar Pooyan
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus rotundus L. (Cyperaceae), commonly known as purple nutsedge or nut grass is one of the most invasive and endemic weeds in tropical, subtropical and temperate regions. This plant has been extensively used in traditional medicine for anti-arthritic, antidiarrheal and antiplatelet properties as well as treatment for several CNS disorders such as epilepsy, depression and inflammatory disorders. Inflammation is evidently occurring in pathologically susceptible regions of the Alzheimer's disease (AD) brain as well as other disorders...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27267654/internet-based-versus-conventional-referral-system-for-retinopathy-of-prematurity-screening-in-iran
#12
Nazanin Ebrahimiadib, Ramak Roohipour, Reza Karkhaneh, Afsar Farahani, Mohammad Riazi Esfahani, Alireza Khodabande, Mohammad Zarei, Arash Taheri, Marjan Imani Fouladi, Mehdi Yaseri, Bobeck S Modjtahedi
PURPOSE: To compare the efficacy of an internet-based versus traditional referral system for retinopathy of prematurity (ROP) screening in Iran. METHODS: Two referral screening systems were compared in this prospective observational study. Group A (internet-based) comprised premature babies who were registered into an online system for screening. Their appointments were scheduled automatically based on standardized criteria. Group B (conventional) comprised premature babies whose referrals were based on oral or written recommendations...
October 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27239600/complement-factor-h-and-loc387715-arms2-htra1-variant-s-frequencies-and-phenotypic-associations-in-neovascular-age-related-macular-degeneration-a-pilot-study
#13
Reza Karkhane, Aliasghar Ahmadraji, Mohammad Riazi Esfahani, Ramak Roohipour, Zahra Alami Harandi, Alireza Lashay, Mehdi Sharifzadeh Kermani, Reza Roozafzoon, Ahad Khoshzaban
PURPOSE: To evaluate the frequency of 12 single nucleotide polymorphisms (SNPs) of complement factor H (CFH) and LOC387715/ARMS2/HRTA1 and their association with some of the presenting clinical features of neovascular age-related macular degeneration (AMD). METHODS: In this prospective non-comparative case series forty four naïve patients with neovascular AMD were genotyped using sequencing or Sequenom iPLEX technology. Descriptive tests were used for displaying the magnitude of each allele, gender distribution, and age at diagnosis...
March 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27073259/retinopathy-of-prematurity-screening-criteria-in-iran-new-screening-guidelines
#14
Ramak Roohipoor, Reza Karkhaneh, Afsar Farahani, Nazanin Ebrahimiadib, Bobeck Modjtahedi, Akbar Fotouhi, Mehdi Yaseri, Alireza Khodabande, Mohammad Zarei, Marjan Imani Fuladi, Arash Taheri, Mohammad Riazi Esfahani, John Loewenstein
OBJECTIVE: To test the applicability of existing retinopathy of prematurity (ROP) guidelines on Iranian patients and to develop novel ROP screening criteria in Iran. METHODS: Both eyes of 1932 infants born ≤37 weeks of gestation and/or weighting ≤3000 g were included in this prospective cohort study that was conducted across nine neonatal intensive care units and a tertiary eye hospital ROP clinic. The patients were examined for ROP and the need for treatment (type 1 ROP or worse)...
July 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/27051486/predictive-value-of-pupillary-response-to-mydriatic-agents-for-diagnosis-of-retinopathy-of-prematurity
#15
Ramak Roohipoor, Mohammad Riazi-Esfahani, Nazanin Ebrahimiadib, Reza Karkhaneh, Mohammad Zarei, Sara Besharat, Fariba Ghassemi, Mohammad Reza Ostovaneh
PURPOSE: To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. METHODS: This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 grams and gestational age less than 33 weeks. A composite eye drop composed of phenylephrine 1%, tetracaine and tropicamide 0.5% was applied 3 times within 5-minute intervals and pupil diameters were measured. The eyes were examined by experienced ROP specialists using an indirect ophthalmoscope...
October 2015: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27046456/choroidal-thickness-changes-in-proliferative-diabetic-retinopathy-treated-with-panretinal-photocoagulation-versus-panretinal-photocoagulation-with-intravitreal-bevacizumab
#16
RANDOMIZED CONTROLLED TRIAL
Ramak Roohipoor, Elaheh Sharifian, Fariba Ghassemi, Mohammad Riazi-Esfahani, Reza Karkhaneh, Masoud Aghsaei Fard, Mohammad Zarei, Bobeck S Modjtahedi, Sasan Moghimi
PURPOSE: To compare choroidal thickness (CT) and retinal thickness (RT) between eyes with proliferative diabetic retinopathy treated with panretinal photocoagulation (PRP) or PRP with intravitreal bevacizumab (PRP + IVB). METHODS: Thirty-three patients with proliferative diabetic retinopathy were randomized to have one eye treated with PRP and the other with PRP + IVB. Change in CT was compared with baseline using enhanced depth imaging-optical coherence tomography at baseline and Months 1, 3, 6, and 10 after treatment...
October 2016: Retina
https://www.readbyqxmd.com/read/27009449/efficacy-of-intravitreal-bevacizumab-for-zone-ii-retinopathy-of-prematurity
#17
RANDOMIZED CONTROLLED TRIAL
Reza Karkhaneh, Alireza Khodabande, Mohammad Riazi-Eafahani, Ramak Roohipoor, Fariba Ghassemi, Marjan Imani, Afsar Dastjani Farahani, Nazanin Ebrahimi Adib, Hamidreza Torabi
PURPOSE: To assess the effect of intravitreal bevacizumab for Type 1 retinopathy of prematurity (ROP) in zone II ROP. METHODS: We conducted a randomized clinical trial. Preterm infants with a gestational age less than 34 weeks or birthweight less than 2000 g were examined at 4 weeks chronological age or 31 weeks postmenstrual age (whichever was later). Preterm infants with Zone-II/Stage 2 or 3 and plus disease were included. Eligible infants were randomized to receive either conventional indirect laser therapy or intravitreal bevacizumab injections (0...
September 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/26915028/comparison-of-refractive-error-changes-in-retinopathy-of-prematurity-patients-treated-with-diode-and-red-lasers
#18
RANDOMIZED CONTROLLED TRIAL
Ramak Roohipoor, Reza Karkhaneh, Mohammad Riazi Esfahani, Fateme Alipour, Mahtab Haghighat, Nazanin Ebrahimiadib, Mohammad Zarei, Ramin Mehrdad
AIM: To compare refractive error changes in retinopathy of prematurity (ROP) patients treated with diode and red lasers. METHODS: A randomized double-masked clinical trial was performed, and infants with threshold or prethreshold type 1 ROP were assigned to red or diode laser groups. Gestational age, birth weight, pretreatment cycloplegic refraction, time of treatment, disease stage, zone and disease severity were recorded. Patients received either red or diode laser treatment and were regularly followed up for retina assessment and refraction...
2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/26905468/a-bio-mimetic-zinc-tau-protein-as-an-artificial-catalase
#19
Kazem Asadollahi, Neda Sadat Kazemein Jasemi, Gholam Hossein Riazi, Fatemeh Hedayati Katuli, Fahimeh Yazdani, Nasrin Sartipnia, Mohammad Amin Moosavi, Arash Rahimi, Mojtaba Falahati
In this study, the catalase-like activity of monomeric tau protein was reported in the presence of of zinc (Zn(II)) ions at low pH value. Monomeric tau protein contains two SH groups that are a target of disulfide bond formation. However these SH groups are able to interact with Zn(II) ion at pH 7.2 which creates a thiol bond as a mimetic model of chloroperoxidase active site which performs catalase like activity at low pH. Zn(II)/tau protein complex decomposed H2O2 with a high rate (Vm) as well as an efficient turn oven number (kcat) at pH 3...
November 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26894600/valproic-acid-may-exerts-its-cytotoxic-effect-through-rassf1a-expression-induction-in-acute-myeloid-leukemia
#20
Zare-Abdollahi Davood, Safari Shamsi, Hamid Ghaedi, Riazi-Isfahani Sahand, Ghadyani Mojtaba, Tabarraee Mahdi, Mirfakhraie Reza, Mohammad Javad Ebrahimi, Reyhaneh Sadat Miri-Moosavi, Sara Boosaliki, Omrani Mir Davood
In acute myeloid leukemia (AML), despite the acceptance of standard intensive chemotherapy as an optimal induction regimen for all age groups, in the elderly patients, the best treatment should meet the challenge of multiple factors like age, comorbidities, and cytogenetics, making them ineligible for standard induction chemotherapy. Using the current low-intensity therapies like decitabine, azacitidine, and low-dose cytarabine as a single arm, outcomes for these patients remain poor. As a histone deacetylase inhibitor valproic acid (VPA) exhibit anticancer activity by triggering apoptosis, the mechanism of which is not yet completely clarified...
August 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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