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https://www.readbyqxmd.com/read/29445145/canagliflozin-mediated-dual-inhibition-of-mitochondrial-glutamate-dehydrogenase-and-complex-i-an-off-target-adverse-effect
#1
Philipp F Secker, Sascha Beneke, Nadja Schlichenmaier, Johannes Delp, Simon Gutbier, Marcel Leist, Daniel R Dietrich
Recent FDA Drug Safety Communications report an increased risk for acute kidney injury in patients treated with the gliflozin class of sodium/glucose co-transport inhibitors indicated for treatment of type 2 diabetes mellitus. To identify a potential rationale for the latter, we used an in vitro human renal proximal tubule epithelial cell model system (RPTEC/TERT1), physiologically representing human renal proximal tubule function. A targeted metabolomics approach, contrasting gliflozins to inhibitors of central carbon metabolism and mitochondrial function, revealed a double mode of action for canagliflozin, but not for its analogs dapagliflozin and empagliflozin...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29441029/the-bi-directional-relationship-between-source-characteristics-and-message-content
#2
Peter J Collins, Ulrike Hahn, Ylva von Gerber, Erik J Olsson
Much of what we believe we know, we know through the testimony of others (Coady, 1992). While there has been long-standing evidence that people are sensitive to the characteristics of the sources of testimony, for example in the context of persuasion, researchers have only recently begun to explore the wider implications of source reliability considerations for the nature of our beliefs. Likewise, much remains to be established concerning what factors influence source reliability. In this paper, we examine, both theoretically and empirically, the implications of using message content as a cue to source reliability...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29439796/-understanding-the-other-s-body-testimonies-of-student-nurses
#3
Valentin Fauconnier, Sophie Roucher, Florence Michon
From their very first practical placement, student nurses are confronted with suffering and bodies which are wounded, fatigued and worn down by pain, disease or age. They learn, through their experience and the support provided by health professionals, that showing consideration for others means taking care of their body with the utmost respect, in order to preserve the patient's dignity.
January 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29428464/why-do-people-search-wikipedia-for-information-on-multiple-sclerosis
#4
F Brigo, S Lattanzi, N Bragazzi, R Nardone, M Moccia, L Lavorgna
BACKGROUND: Wikipedia is a frequently-accessed online source of health-related information. In this study we evaluated the number of views of the Italian Wikipedia articles related to multiple sclerosis (MS) and its treatment. METHODS: Using Pageviews Analysis we assessed the total views, and mean monthly and daily views of the Italian Wikipedia articles on MS and its treatments from 1 January 2015 to 31 October 2017. We compared the views of the article on MS with those for Alzheimer´s disease, epilepsy, migraine and stroke, and adjusted results for crude disease prevalence...
February 5, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29428333/the-fit-beauty-ideal-a-healthy-alternative-to-thinness-or-a-wolf-in-sheep-s-clothing
#5
Laura R Uhlmann, Caroline L Donovan, Melanie J Zimmer-Gembeck, Hayley S Bell, Robin A Ramme
Anecdotal testimony suggests the 'fit' female body ideal is 'healthier' than the thin ideal, because it simultaneously focuses on muscularity. However, statistical investigation into the outcomes associated with fit ideal internalisation is absent. This study used moderation analyses to investigate whether concurrent muscular internalisation mitigated the relationship between thin internalisation and; negative affect, body dissatisfaction, bulimic symptoms, and dieting. Additional analyses investigated whether concurrent thin internalisation amplified the relationship between muscular internalisation, compulsive exercise, and supplement use...
February 8, 2018: Body Image
https://www.readbyqxmd.com/read/29421474/improving-recruitment-to-clinical-trials-during-pregnancy-a-mixed-methods-investigation
#6
Sofia Strömmer, Wendy Lawrence, Taylor Rose, Christina Vogel, Daniella Watson, Joanne N Botell, Nicholas C Harvey, Cyrus Cooper, Hazel Inskip, Janis Baird, Mary Barker
OBJECTIVE: To identify reasons underlying women's refusal to participate in a pregnancy trial and to identify ways of increasing recruitment. DESIGN: Mixed methods study using a questionnaire and qualitative interviews. SAMPLE: A questionnaire asking them to indicate reasons for their decision was completed by 296 pregnant women who declined to participate in one of two trials of nutritional supplementation in a large teaching hospital in southern England...
January 17, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29414543/epilepsy-in-hildegard-of-bingen-s-writings-a-comprehensive-overview
#7
REVIEW
Francesco Brigo, Eugen Trinka, Bruno Brigo, Nicola Luigi Bragazzi, Giammario Ragnedda, Raffaele Nardone, Mariano Martini
Hildegard of Bingen (1098-1179AD) is one of the most relevant figures of the Middle Ages. She wrote two medical books, Physica (Natural history) and Causae et curae (Causes and remedies). Our aim was to provide a comprehensive account of Hildegard of Bingen's conception of epilepsy, of the remedies proposed to treat it, and of the medical and physiological theories behind their use. We searched Hildegard of Bingen's entire body of writings to identify any possible reference to epilepsy or epileptic seizures...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29412398/-impacts-of-long-term-illness-experience-of-young-adults-with-acute-myeloid-leukemia
#8
Reni Aparecida Barsaglini, Beluci Bianca Nunes de Siqueira Soares
This article analyzes the tangible and intangible impacts involved in the experience of young adults diagnosed with a long-term illness, namely Acute Myeloid Leukemia. It follows on from broader research, inspired by the Phenomenology of Alfred Schutz. The data were obtained through in-depth interviews with four young adults, aged between 20 and 28, who were in the maintenance phase of cancer treatment between November 2013 and January 2014 in the State of Mato Grosso. The results focus on striking aspects of the impacts of the experience during the process of becoming aware of the illness in which the diagnosis provoked feelings mobilized by ideas regarding a serious illness...
February 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29402111/mygrief-ca
#9
Shelly Cory
Bereavement represents a significant public health concern as grievers often suffer from co-morbid health problems, increased use of health care resources, periodic hospitalizations, and even mortality in the first 2 years after the death. Furthermore, grievers frequently encounter major obstacles when seeking formal support, including lack of access to specialized grief support due to temporal, financial or geographic constraints. To address these gaps in service, the Canadian Virtual Hospice, in collaboration with pan-Canadian partners developed MyGrief...
January 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29398863/comprehensive-rehabilitation-using-dental-implants-in-generalized-aggressive-periodontitis
#10
Asha Ramesh, Sheethalan Ravi, Gurumoorthy Kaarthikeyan
Generalized aggressive periodontitis (GAP) is a debilitating form of the disease and it results in deteriorating effects on the esthetic and functional aspects of the oral cavity. This case report describes the comprehensive rehabilitation of GAP patient using dental implants. The treatment planning involved thorough scaling and root planning (SRP) with oral hygiene instructions. The patient was motivated to adhere to a strict oral hygiene regimen following which periodontal flap surgery employing guided tissue regeneration and bone grafts was performed...
March 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29383056/acgme-clinical-and-educational-work-hour-standards-perspectives-and-recommendations-from-emergency-medicine-educators
#11
Stephen J Wolf, Saadia Akhtar, Eric Gross, David Barnes, Michael Epter, Jonathan Fisher, Maria Moreira, Michael Smith, Hans House
Introduction: The American College of Emergency Physicians (ACEP) and the Council of Emergency Medicine Residency Directors (CORD) were invited to contribute to the 2016 Accreditation Council for Graduate Medical Education's (ACGME) Second Resident Duty Hours in the Learning and Working Environment Congress. We describe the joint process used by ACEP and CORD to capture the opinions of emergency medicine (EM) educators on the ACGME clinical and educational work hour standards, formulate recommendations, and inform subsequent congressional testimony...
January 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29373418/litigation-in-perinatal-care-the-deposition-process
#12
Lisa A Miller
Litigation in perinatal nursing represents a disproportionate share of indemnity payouts and results in excessive psychological stress. Testimony at deposition or trial can be challenging for clinicians; little is taught in training or postgraduate education regarding litigation. Nurses, midwives, and physicians can effectively navigate the deposition process and prepare for trial testimony by understanding the plaintiff's goals, recognizing the role of documentation, and becoming familiar with various plaintiff's strategies including reptile theory...
January 2018: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/29369655/early-parental-loss-and-intimate-relationships-in-adulthood-a-nationwide-study
#13
Beverley Lim Høeg, Christoffer Johansen, Jane Christensen, Kirsten Frederiksen, Susanne Oksbjerg Dalton, Atle Dyregrov, Per Bøge, Annemarie Dencker, Pernille Envold Bidstrup
Being able to form and maintain intimate relationships is an essential part of development and the early loss of a parent may negatively affect this ability. This study investigates the association between parental loss before the age of 18 years and the formation and dissolution of marriage and cohabitation relationships in adulthood, in relation to factors that may help identify potentially vulnerable subgroups of bereaved children, that is, sex of the deceased parent, cause of death and child's age at the time of death...
January 25, 2018: Developmental Psychology
https://www.readbyqxmd.com/read/29364402/-barriers-and-facilitators-of-micronutrient-powder-supplementation-maternal-perceptions-and-dynamics-of-health-services
#14
Juan Pablo Aparco, Lucio Huamán-Espino
OBJECTIVES: To explore the barriers and facilitators of micronutrient powder (MNP) supplementation to mothers of children aged 6 to 35 months living in the Peruvian cities of Tacna, Loreto, Puno, and Lima. MATERIALS AND METHODS: This qualitative exploratory study with a grounded theory approach was conducted in the Peruvian cities of Lima, Tacna, Loreto, and Puno in 2014. In-depth interviews were conducted with mothers of children younger than 3 years, and observations in health care facilities (HCFs) were made to determine the barriers and facilitators of MNP supplementation...
October 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29362205/testimonials-and-informational-videos-on-branded-prescription-drug-websites-experimental-study-to-assess-influence-on-consumer-knowledge-and-perceptions
#15
Helen W Sullivan, Amie C O'Donoghue, Jennifer Gard Read, Jacqueline B Amoozegar, Kathryn J Aikin, Douglas J Rupert
BACKGROUND: Direct-to-consumer (DTC) promotion of prescription drugs can affect consumer behaviors and health outcomes, and Internet drug promotion is growing rapidly. Branded drug websites often capitalize on the multimedia capabilities of the Internet by using videos to emphasize drug benefits and characteristics. However, it is unknown how such videos affect consumer processing of drug information. OBJECTIVE: This study aimed to examine how videos on prescription drug websites, and the inclusion of risk information in those videos, influence consumer knowledge and perceptions...
January 23, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29354889/-my-invisalign-experience-content-metrics-and-comment-sentiment-analysis-of-the-most-popular-patient-testimonials-on-youtube
#16
Christos Livas, Konstantina Delli, Nikolaos Pandis
BACKGROUND: The aim of the study was to investigate the popularity, content of Invisalign patient testimonials on YouTube, as well as the sentiment of the related comments. METHODS: Using the term "Invisalign experience," the top 100 results on YouTube by view count were screened for English spoken patient videos that attracted comments. Video information (time since video upload, sponsorship), engagement metrics (comments, likes, dislikes, subscriptions), and views were collected...
January 22, 2018: Progress in Orthodontics
https://www.readbyqxmd.com/read/29342483/-fitness-to-drive-after-stroke
#17
Peter Marx
In Germany, patient information and expert testimony on driving ability requires knowledge of the corresponding legislation and the Guideline for expertises on driver aptitude. The testimony should clearly identify handicaps with regard to driving, give estimates on the future risks of a sudden loss of control, and also consider personal attitudes such as inadequate behavior, lack of insight etc. Physical handicaps often can be compensated for by restrains or restrictions such as vehicle modifications, daylight driving only etc...
January 2018: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29340446/-tensions-and-contradictions-in-government-interventions-for-the-promotion-of-breastfeeding
#18
Rosa María Ramos Rodríguez, María Gabriela Hernández González
With the purpose of shedding light on the decrease in the practice of breastfeeding in rural areas of Mexico, this article looks at the current biomedical model and the policies and actions to promote breastfeeding derived from the model's theoretical approach. The article also discusses operational strategies of the governmental social welfare program Oportunidades. For this purpose, the study utilizes the testimonies of 39 young breastfeeding mothers, 11 mothers and grandmothers and 12 members of the health staff in the Nahuatl population of Cuentepec, Morelos, Mexico, which were collected during a previous study in 2008 and 2009...
October 2017: Salud Colectiva
https://www.readbyqxmd.com/read/29339938/understanding-cancer-survivors-information-needs-and-information-seeking-behaviors-for-complementary-and-alternative-medicine-from-short-to-long-term-survival-a-mixed-methods-study
#19
Lou Ann Scarton, Guilherme Del Fiol, Ingrid Oakley-Girvan, Bryan Gibson, Robert Logan, T Elizabeth Workman
Objective: The research examined complementary and alternative medicine (CAM) information-seeking behaviors and preferences from short- to long-term cancer survival, including goals, motivations, and information sources. Methods: A mixed-methods approach was used with cancer survivors from the "Assessment of Patients' Experience with Cancer Care" 2004 cohort. Data collection included a mail survey and phone interviews using the critical incident technique (CIT)...
January 2018: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/29335149/-learning-to-separate-together-the-separation-individuation-group
#20
Gwénäelle Andro
The 'separation-individuation' group is offered to children aged between three and five, in outpatient consultations with a paediatric psychiatrist. It was created following the testimonies of early childhood professionals describing the feeling on the part of parents of being torn from their child, during the first year of school. Open and held on a weekly basis, it is combined with a parents' meeting organised simultaneously. The individualised group tool supports the separation-individuation process when this is particularly painful, for the child and the parents...
January 2018: Soins. Pédiatrie, Puériculture
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