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Staphylococcus, pseudomonas, soft tissue,

Aurelien Forget, Neha Arya, Rotsiniaina Randriantsilefisoa, Florian Miessmer, Marion Buck, Vincent Ahmadi, Daniel Jonas, Anton Blencowe, V Prasad Shastri
Hydrogel forming polysaccharides, such as the seaweed derived agarose, are well suited for wound dressing applications as they have excellent cell and soft tissue compatibility. For wound dressings, fibrous structure is desirable as the high surface area can favor adsorption of wound exudate and promote drug delivery. Although electrospinning offers a straightforward means to produce nonwoven fibrous polymeric structures, processing agarose and its derivatives into fibers through electrospinning is challenging as it has limited solubility in solvents other than water...
December 12, 2016: Biomacromolecules
Andrés F Duque, Zachary D Post, Rex W Lutz, Fabio R Orozco, Sergio H Pulido, Alvin C Ong
BACKGROUND: Periprosthetic joint infection (PJI) is an important cause of failure in total knee arthroplasty. Irrigation and debridement including liner exchange (I&D/L) success rates have varied for acute PJI. The purpose of this study is to present results of a specific protocol for I&D/L with retention of total knee arthroplasty components. METHODS: Sixty-seven consecutive I&D/L patients were retrospectively evaluated. Inclusion criteria for I&D/L were as follows: fewer than 3 weeks of symptoms, no immunologic compromise, intact soft tissue sleeve, and well-fixed components...
November 1, 2016: Journal of Arthroplasty
Bianca L Price, Andrew M Lovering, Frank L Bowling, Curtis B Dobson
Diabetes has major implications for public health, with diabetic foot ulcers (DFUs) being responsible for significant morbidity and mortality. A key factor in the development of nonhealing ulcers is infection, which often leads to the development of biofilm, gangrene, and amputation. A novel approach to treating DFUs is the local release of antibiotics from calcium sulfate beads. We have developed a novel model system to study and compare the release and efficacy of antibiotics released locally, using collagen as a substrate for biofilm growth and incorporating serum to mimic the biochemical complexity of the wound environment...
November 2016: Antimicrobial Agents and Chemotherapy
C Ludwig, A de Jong, H Moyaert, F El Garch, R Janes, U Klein, I Morrissey, J Thiry, M Youala
AIMS: The ComPath project is a pan-European programme dedicated to the monitoring of antimicrobial susceptibility of pathogens from diseased dogs and cats using standardized methods and centralized minimum inhibitory concentration (MIC) determination. Here, the susceptibility of major pathogens is reported from antimicrobial nontreated animals with acute clinical signs of skin, wound or ear infections in 2008-2010. METHODS AND RESULTS: MICs were determined by agar dilution for commonly used antibiotics and interpreted using CLSI breakpoints, if available...
November 2016: Journal of Applied Microbiology
Hanaa A Yamani, Edwin C Pang, Nitin Mantri, Margaret A Deighton
In recent years scientists worldwide have realized that the effective life span of any antimicrobial agent is limited, due to increasing development of resistance by microorganisms. Consequently, numerous studies have been conducted to find new alternative sources of antimicrobial agents, especially from plants. The aims of this project were to examine the antimicrobial properties of essential oils distilled from Australian-grown Ocimum tenuiflorum (Tulsi), to quantify the volatile components present in flower spikes, leaves and the essential oil, and to investigate the compounds responsible for any activity...
2016: Frontiers in Microbiology
Vivek Bhat, Sudeep Gupta, Rohini Kelkar, Sanjay Biswas, Navin Khattry, Aliasgar Moiyadi, Prashant Bhat, Reshma Ambulkar, Preeti Chavan, Shubadha Chiplunkar, Amol Kotekar, Tejpal Gupta
INTRODUCTION: This increased risk of bacterial infections in the cancer patient is further compounded by the rising trends of antibiotic resistance in commonly implicated organisms. In the Indian setting this is particularly true in case of Gram negative bacilli such as Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Increasing resistance among Gram positive organisms is also a matter of concern. The aim of this study was to document the common organisms isolated from bacterial infections in cancer patients and describe their antibiotic susceptibilities...
January 2016: Indian Journal of Medical and Paediatric Oncology
Jin Lei, Chunsheng Hou, Peng Duan, Zhengming Hao, Yanbin Zhai, Yanbin Meng
OBJECTIVE: To observe the clinical effect of modified skin soft tissue expansion in repair of devastating wound on the head due to electrical burn in the early stage. METHODS: Twenty-one patients with partial scalp soft tissue defect accompanying skull exposure and necrosis in different degree due to high-voltage electrical burn were hospitalized from April 2009 to October 2014, with wound area ranging from 7 cm × 5 cm to 15 cm × 13 cm. The wounds were debrided as early as possible, and necrotic skulls were kept in situ and covered with porcine ADM and silver-containing dressing...
December 2015: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Cristina Vazquez Guillamet, Marin H Kollef
PURPOSE OF REVIEW: This article describes the strategies for stratifying patients with skin and soft tissue infections (SSTIs) according to their risk for infection with multidrug-resistant (MDR) pathogens. RECENT FINDINGS: Methicillin-resistant Staphylococcus aureus (MRSA) now represents the main cause in a variety of serious SSTIs. Risk factors for MRSA are constantly evolving and the distinction between community-acquired MRSA and hospital-acquired MRSA is becoming less clear from a therapeutic standpoint because of overlapping susceptibility patterns...
April 2016: Current Opinion in Infectious Diseases
Mbiye A Mpenge, Alasdair P MacGowan
Ceftaroline is a new parenteral cephalosporin approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) for the treatment of complicated skin and soft tissue infections (cSSTIs) including those due to methicillin-resistant Staphylococcus aureus (MRSA), and community-acquired pneumonia (CAP). Ceftaroline has broad-spectrum activity against gram-positive and gram-negative bacteria and exerts its bactericidal effects by binding to penicillin-binding proteins (PBPs), resulting in inhibition of bacterial cell wall synthesis...
2015: Therapeutics and Clinical Risk Management
N Saltoglu, M Yemisen, O Ergonul, A Kadanali, G Karagoz, A Batirel, O Ak, H Eraksoy, A Cagatay, A Vatan, G Sengoz, F Pehlivanoglu, T Aslan, Y Akkoyunlu, D Engin, N Ceran, B Erturk, L Mulazimoglu, O Oncul, H Ay, F Sargin, N Ozgunes, F Simsek, T Yildirmak, N Tuna, O Karabay, K Yasar, N Uzun, Y Kucukardali, M Sonmezoglu, F Yilmaz, U Tozalgan, S Ozer, M Ozyazar
We aimed to investigate the predictors for limb loss among patients with diabetes who have complicated skin/soft-tissue infections. In this observational study, consecutive patients with diabetic foot infection (DFI) from 17 centres in Turkey, between May 2011 and May 2013 were included. The Turkish DFI Working Group performed the study. Predictors of limb loss were investigated by multivariate analysis. In total, 455 patients with DFI were included. Median age was 61 years, 68% were male, 65% of the patients were hospitalized, 52% of the patients had used antibiotics within the last month, and 121 (27%) had osteomyelitis...
July 2015: Clinical Microbiology and Infection
Lu Wnag, Chen Yang, Qian Zhang, Bing Han, Jun-jing Zhuang, Miao Chen, Nong Zou, Jian Li, Ming-hui Duan, Wei Zhang, Tie-nan Zhu, Ying Xu, Shu-jie Wang, Dao-bin Zhou, Yong-qiang Zhao, Hui Zhang, Peng Wang, Ying-chun Xu
OBJECTIVE: To investigate the incidence, pathogens, and clinical features of infection in consecutive cases from 2010 to 2012 in Peking Union Medical College Hospital. METHOD: The incidence, pathogen, treatment, and outcomes of patients with hematological diseases who had positive findings of bacterium in their samples from 2010 to 2012 were retrospectively analyzed. RESULTS: There were 449 positive samples (5.8%) from 4 890 patients during this period, among which 388 were proved to be with pathogenic bacteria...
August 2014: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
E C Bursle, E G Playford, D F M Looke
BACKGROUND: Infectious diseases (ID) clinicians provide an important service within tertiary hospitals. However, as a largely consultation-based service, their value can be difficult to evaluate. AIMS: A review of 13.5 years of consultations was undertaken to define the scope of the service and any changes over time. METHODS: ID consultations at the Princess Alexandra Hospital are tracked on a database, recording information including the requesting team, indication for and outcome of the consult...
October 2014: Internal Medicine Journal
Alpesh N Amin, Elizabeth A Cerceo, Steven B Deitelzweig, James C Pile, David J Rosenberg, Bradley M Sherman
The prevalence of skin and soft tissue infections (SSTIs) has been increasing in the United States. These infections are associated with an increase in hospital admissions. Hospitalists play an increasingly important role in the management of these infections and need to use hospital resources efficiently and effectively. When available, observation units are useful for treating low-risk patients who do not require hospital admission. Imaging tools may help to exclude abscesses and necrotizing soft tissue infections; however, surgical exploration remains the principal means of diagnosing necrotizing soft tissue infections...
October 2014: Mayo Clinic Proceedings
Rick Tosti, Abtin Foroohar, Peter D Pizzutillo, Martin J Herman
BACKGROUND: Few studies have described the presentation, bacteriology, risk factors, and complications of Kirschner wire infections in pediatrics. The purpose of this study is to describe these factors to better understand, prevent, and treat infectious complications of smooth wires. METHODS: A retrospective review was performed to identify all patients (birth to 16 y) who were hospitalized for Kirschner wire infection from 1995 to 2012. Presentation, hospital course, bacteriology, outcomes, and complications were recorded...
January 2015: Journal of Pediatric Orthopedics
Teresa Bailey, Marina Mileva, Ibrahim Zardawi
BACKGROUND: Necrotising fasciitis is a severe, rapidly destructive soft tissue infection characterised by widespread fascial necrosis. Its estimated incidence is 3.5 cases per 100,000 persons, with a case-fatality rate of 24%. Traditional microbiological classification includes polymicrobial infections involving anaerobic bacteria and non-serogroup A streptococci (Type I), and Streptococcus pyogenes with or without Staphylococcus species (Type II). AIMS: To determine the morphological and microbiological characteristics of necrotising fasciitis in the Northern Territory...
February 2014: Pathology
Raquel de Oliveira Marreiro, Maria Fulgência Costa Lima Bandeira, Tatiane Pereira de Souza, Mailza Costa de Almeida, Katiana Bendaham, Gisely Naura Venâncio, Isis Costa Rodrigues, Cristiane Nagai Coelho, Patrícia Sâmea Lêdo Lima Milério, Glauber Palma de Oliveira, Nikeila Chacon de Oliveira Conde
Biofilm is a dense, whitish, noncalcified aggregate of bacteria, with desquamated epithelial cells and food debris creating conditions for an imbalance of resident oral microflora and favoring the destruction of hard and soft tissues by development of caries and gingivitis. The aim of this study was to obtain and characterize an extract of Libidibia ferrea, ex Caesalpinia ferrea L. and to evaluate its feasibility for formulation as a mouthwash, according to current legislation. For this purpose, pH, sedimentation, density, and stability were evaluated, along with microbiological testing of the extract...
2014: Clinical, Cosmetic and Investigational Dentistry
Morten Alhede, Özge Er, Steffen Eickhardt, Kasper Kragh, Maria Alhede, Louise Dahl Christensen, Steen Seier Poulsen, Michael Givskov, Lise H Christensen, Niels Høiby, Michael Tvede, Thomas Bjarnsholt
Injection of soft tissue fillers plays an important role in facial reconstruction and esthetic treatments such as cosmetic surgery for lip augmentation and wrinkle smoothening. Adverse events are an increasing problem, and recently, it has been suggested that bacteria are the cause of a vast fraction these. We developed a novel mouse model and evaluated hyaluronic acid gel, calcium hydroxyl apatite microspheres, and polyacrylamide hydrogel for their potential for sustaining bacterial infections and their possible treatments...
April 2014: Pathogens and Disease
Teresa Bailey, Marina Mileva, Ibrahim Zardawi
BACKGROUND: Necrotising fasciitis is a severe, rapidly destructive soft tissue infection characterised by widespread fascial necrosis. Its estimated incidence is 3.5 cases per 100,000 persons, with a case-fatality rate of 24%. Traditional microbiological classification includes polymicrobial infections involving anaerobic bacteria and non-serogroup A streptococci (Type I), and Streptococcus pyogenes with or without Staphylococcus species (Type II). AIMS: To determine the morphological and microbiological characteristics of necrotising fasciitis in the Northern Territory...
February 2014: Pathology
Marcos Serrano, Fernando Barcenilla, Enrique Limón
The long-term care facilities (LTCF) are the health care level that integrates medical assistance and social services according to the requirements of its beneficiaries. There is a great variability depending on the users profile, the professional staff and accessibility to technical resources for diagnosis, treatment or rehabilitation. In LTCF different factors are shaping a challenge in the infection control. These factors are high prevalence of infection and colonization by multiresistant microorganisms (MROs), a high rate of, often inadequate, antibiotic prescriptions, the high transfer of hospital patients, and the lack of diagnostic resources...
March 2014: Enfermedades Infecciosas y Microbiología Clínica
Ramin Mohammadzadeh, Nejla Ahmadiyan
Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) cause difficulties in the management of skin and soft tissue infections and have led to morbidity and mortality in hospital-acquired infections especially in susceptible individuals, those who are generally sick or immunosuppressed. Currently approaches in antibacterial agents offer opportunities to manage the trouble using novel anti-infection systems. Therefore, nanotechnology, a most promising field for generating new applications in medicine, has introduced a most prominent nanoproduct named as nanosilver that revealed excellent antimicrobial activity against some of the hazardous infections...
2013: Advanced Pharmaceutical Bulletin
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