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Staphylococcus, pseudomonas, soft tissue,

Innus K Shaikh, Prashant P Dixit, Balasaheb S Pawade, Mugdha Potnis-Lele, Babasaheb P Kurhe
Snakebite is a common, frequently devastating, occupational, socio-economic hazard, and it has a great impact on the rural population of India. Snakebite is a major cause of the human morbidity and mortality since ancient times, as it not only affects the victim by systemic envenomation but also by wound infections originating from deadly pathogenic microorganisms from the oral cavity of the offending snake. The pathogens from the oral cavity of the snake tend to initiate an infection, resulting in gas gangrene, soft tissue necrosis, and permanent physical disabilities...
July 21, 2017: Current Microbiology
Mark A Sellmyer, Iljung Lee, Catherine Hou, Chi-Chang Weng, Shihong Li, Brian P Lieberman, Chenbo Zeng, David A Mankoff, Robert H Mach
There is often overlap in the diagnostic features of common pathologic processes such as infection, sterile inflammation, and cancer both clinically and using conventional imaging techniques. Here, we report the development of a positron emission tomography probe for live bacterial infection based on the small-molecule antibiotic trimethoprim (TMP). [(18)F]fluoropropyl-trimethoprim, or [(18)F]FPTMP, shows a greater than 100-fold increased uptake in vitro in live bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) relative to controls...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
D M T Adler, P Damborg, D R Verwilghen
Lameness is the most commonly reported health problem in horses, and lameness investigations which include local anaesthetic injections are routinely performed by equine practitioners. Through this process, bacteria can enter the tissues perforated by the needle and may cause local infections at the injection site. The objective of this in vitro study was to investigate if local anaesthetics at concentrations available in commercially available solutions could inhibit growth and/or kill bacteria that could be inoculated into the synovial space or soft tissues during injection...
May 2017: Veterinary Journal
Ovidio Catanzano, Rachael Docking, Patricia Schofield, Joshua Boateng
This study aimed to develop advanced biomaterial polysaccharide based dressings to manage pain associated with infected chronic leg ulcers in older adults. Composite carrageenan (CARR) and hyaluronic acid (HA) dressings loaded with lidocaine (LID) and AgNPs were formulated as freeze-dried wafers and functionally characterized for porous microstructure (morphology), mechanical strength, moisture handling properties, swelling, adhesion and LID release. Antimicrobial activity of AgNPs was evaluated (turbidity assay) against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus whilst cell viability studies (MTT) was performed on normal adult human primary epidermal keratinocyte cells...
September 15, 2017: Carbohydrate Polymers
Michal Benkler, Ori Shulman, Yoav Avrahamy, David Mendes, Yoav Arus, Ron Fishel, Amos Leviav, Dana Egozi
AIMS: This study concentrates on microbiological data collection of deep sternal wounds to delineate early and correct antibiotic therapy. BACKGROUND: Deep sternal wound infection, mediastinitis and sternal osteomyelitis are devastating and life-threatening complications of median-sternotomy incisions after cardiac surgical procedures. The incidence of surgical wound infection in sternotomies should be similar to that in any clean surgical procedure (i.e. approximately 2%)...
February 2017: Harefuah
Kerrie McAllister, Hannah Linkhorn, Mayaan Gruber, Ellen Giles, Michel Neeff
OBJECTIVE: The aim of this study was to examine the effect of cochlear implant (CI) site infection and its subsequent management on CI mapping and CI performance. Risk factors for CI infections and pathogens causing infections were reviewed. Treatment options for CI infections were examined. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Adult patients with a significant CI soft tissue infection from the Northern Cochlear Implant Programme, New Zealand over a 10-year period (August 2004 until August 2014)...
June 2017: Otology & Neurotology
Aurelien Forget, Neha Arya, Rotsiniaina Randriantsilefisoa, Florian Miessmer, Marion Buck, Vincent Ahmadi, Daniel Jonas, Anton Blencowe, V Prasad Shastri
Hydrogel forming polysaccharides, such as the seaweed derived agarose, are well suited for wound dressing applications as they have excellent cell and soft tissue compatibility. For wound dressings, fibrous structure is desirable as the high surface area can favor adsorption of wound exudate and promote drug delivery. Although electrospinning offers a straightforward means to produce nonwoven fibrous polymeric structures, processing agarose and its derivatives into fibers through electrospinning is challenging as it has limited solubility in solvents other than water...
December 12, 2016: Biomacromolecules
Andrés F Duque, Zachary D Post, Rex W Lutz, Fabio R Orozco, Sergio H Pulido, Alvin C Ong
BACKGROUND: Periprosthetic joint infection (PJI) is an important cause of failure in total knee arthroplasty. Irrigation and debridement including liner exchange (I&D/L) success rates have varied for acute PJI. The purpose of this study is to present results of a specific protocol for I&D/L with retention of total knee arthroplasty components. METHODS: Sixty-seven consecutive I&D/L patients were retrospectively evaluated. Inclusion criteria for I&D/L were as follows: fewer than 3 weeks of symptoms, no immunologic compromise, intact soft tissue sleeve, and well-fixed components...
April 2017: Journal of Arthroplasty
Bianca L Price, Andrew M Lovering, Frank L Bowling, Curtis B Dobson
Diabetes has major implications for public health, with diabetic foot ulcers (DFUs) being responsible for significant morbidity and mortality. A key factor in the development of nonhealing ulcers is infection, which often leads to the development of biofilm, gangrene, and amputation. A novel approach to treating DFUs is the local release of antibiotics from calcium sulfate beads. We have developed a novel model system to study and compare the release and efficacy of antibiotics released locally, using collagen as a substrate for biofilm growth and incorporating serum to mimic the biochemical complexity of the wound environment...
November 2016: Antimicrobial Agents and Chemotherapy
C Ludwig, A de Jong, H Moyaert, F El Garch, R Janes, U Klein, I Morrissey, J Thiry, M Youala
AIMS: The ComPath project is a pan-European programme dedicated to the monitoring of antimicrobial susceptibility of pathogens from diseased dogs and cats using standardized methods and centralized minimum inhibitory concentration (MIC) determination. Here, the susceptibility of major pathogens is reported from antimicrobial nontreated animals with acute clinical signs of skin, wound or ear infections in 2008-2010. METHODS AND RESULTS: MICs were determined by agar dilution for commonly used antibiotics and interpreted using CLSI breakpoints, if available...
November 2016: Journal of Applied Microbiology
Hanaa A Yamani, Edwin C Pang, Nitin Mantri, Margaret A Deighton
In recent years scientists worldwide have realized that the effective life span of any antimicrobial agent is limited, due to increasing development of resistance by microorganisms. Consequently, numerous studies have been conducted to find new alternative sources of antimicrobial agents, especially from plants. The aims of this project were to examine the antimicrobial properties of essential oils distilled from Australian-grown Ocimum tenuiflorum (Tulsi), to quantify the volatile components present in flower spikes, leaves and the essential oil, and to investigate the compounds responsible for any activity...
2016: Frontiers in Microbiology
Vivek Bhat, Sudeep Gupta, Rohini Kelkar, Sanjay Biswas, Navin Khattry, Aliasgar Moiyadi, Prashant Bhat, Reshma Ambulkar, Preeti Chavan, Shubadha Chiplunkar, Amol Kotekar, Tejpal Gupta
INTRODUCTION: This increased risk of bacterial infections in the cancer patient is further compounded by the rising trends of antibiotic resistance in commonly implicated organisms. In the Indian setting this is particularly true in case of Gram negative bacilli such as Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Increasing resistance among Gram positive organisms is also a matter of concern. The aim of this study was to document the common organisms isolated from bacterial infections in cancer patients and describe their antibiotic susceptibilities...
January 2016: Indian Journal of Medical and Paediatric Oncology
Jin Lei, Chunsheng Hou, Peng Duan, Zhengming Hao, Yanbin Zhai, Yanbin Meng
OBJECTIVE: To observe the clinical effect of modified skin soft tissue expansion in repair of devastating wound on the head due to electrical burn in the early stage. METHODS: Twenty-one patients with partial scalp soft tissue defect accompanying skull exposure and necrosis in different degree due to high-voltage electrical burn were hospitalized from April 2009 to October 2014, with wound area ranging from 7 cm × 5 cm to 15 cm × 13 cm. The wounds were debrided as early as possible, and necrotic skulls were kept in situ and covered with porcine ADM and silver-containing dressing...
December 2015: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Cristina Vazquez Guillamet, Marin H Kollef
PURPOSE OF REVIEW: This article describes the strategies for stratifying patients with skin and soft tissue infections (SSTIs) according to their risk for infection with multidrug-resistant (MDR) pathogens. RECENT FINDINGS: Methicillin-resistant Staphylococcus aureus (MRSA) now represents the main cause in a variety of serious SSTIs. Risk factors for MRSA are constantly evolving and the distinction between community-acquired MRSA and hospital-acquired MRSA is becoming less clear from a therapeutic standpoint because of overlapping susceptibility patterns...
April 2016: Current Opinion in Infectious Diseases
Mbiye A Mpenge, Alasdair P MacGowan
Ceftaroline is a new parenteral cephalosporin approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) for the treatment of complicated skin and soft tissue infections (cSSTIs) including those due to methicillin-resistant Staphylococcus aureus (MRSA), and community-acquired pneumonia (CAP). Ceftaroline has broad-spectrum activity against gram-positive and gram-negative bacteria and exerts its bactericidal effects by binding to penicillin-binding proteins (PBPs), resulting in inhibition of bacterial cell wall synthesis...
2015: Therapeutics and Clinical Risk Management
N Saltoglu, M Yemisen, O Ergonul, A Kadanali, G Karagoz, A Batirel, O Ak, H Eraksoy, A Cagatay, A Vatan, G Sengoz, F Pehlivanoglu, T Aslan, Y Akkoyunlu, D Engin, N Ceran, B Erturk, L Mulazimoglu, O Oncul, H Ay, F Sargin, N Ozgunes, F Simsek, T Yildirmak, N Tuna, O Karabay, K Yasar, N Uzun, Y Kucukardali, M Sonmezoglu, F Yilmaz, U Tozalgan, S Ozer, M Ozyazar
We aimed to investigate the predictors for limb loss among patients with diabetes who have complicated skin/soft-tissue infections. In this observational study, consecutive patients with diabetic foot infection (DFI) from 17 centres in Turkey, between May 2011 and May 2013 were included. The Turkish DFI Working Group performed the study. Predictors of limb loss were investigated by multivariate analysis. In total, 455 patients with DFI were included. Median age was 61 years, 68% were male, 65% of the patients were hospitalized, 52% of the patients had used antibiotics within the last month, and 121 (27%) had osteomyelitis...
July 2015: Clinical Microbiology and Infection
Lu Wnag, Chen Yang, Qian Zhang, Bing Han, Jun-jing Zhuang, Miao Chen, Nong Zou, Jian Li, Ming-hui Duan, Wei Zhang, Tie-nan Zhu, Ying Xu, Shu-jie Wang, Dao-bin Zhou, Yong-qiang Zhao, Hui Zhang, Peng Wang, Ying-chun Xu
OBJECTIVE: To investigate the incidence, pathogens, and clinical features of infection in consecutive cases from 2010 to 2012 in Peking Union Medical College Hospital. METHOD: The incidence, pathogen, treatment, and outcomes of patients with hematological diseases who had positive findings of bacterium in their samples from 2010 to 2012 were retrospectively analyzed. RESULTS: There were 449 positive samples (5.8%) from 4 890 patients during this period, among which 388 were proved to be with pathogenic bacteria...
August 2014: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
E C Bursle, E G Playford, D F M Looke
BACKGROUND: Infectious diseases (ID) clinicians provide an important service within tertiary hospitals. However, as a largely consultation-based service, their value can be difficult to evaluate. AIMS: A review of 13.5 years of consultations was undertaken to define the scope of the service and any changes over time. METHODS: ID consultations at the Princess Alexandra Hospital are tracked on a database, recording information including the requesting team, indication for and outcome of the consult...
October 2014: Internal Medicine Journal
Alpesh N Amin, Elizabeth A Cerceo, Steven B Deitelzweig, James C Pile, David J Rosenberg, Bradley M Sherman
The prevalence of skin and soft tissue infections (SSTIs) has been increasing in the United States. These infections are associated with an increase in hospital admissions. Hospitalists play an increasingly important role in the management of these infections and need to use hospital resources efficiently and effectively. When available, observation units are useful for treating low-risk patients who do not require hospital admission. Imaging tools may help to exclude abscesses and necrotizing soft tissue infections; however, surgical exploration remains the principal means of diagnosing necrotizing soft tissue infections...
October 2014: Mayo Clinic Proceedings
Rick Tosti, Abtin Foroohar, Peter D Pizzutillo, Martin J Herman
BACKGROUND: Few studies have described the presentation, bacteriology, risk factors, and complications of Kirschner wire infections in pediatrics. The purpose of this study is to describe these factors to better understand, prevent, and treat infectious complications of smooth wires. METHODS: A retrospective review was performed to identify all patients (birth to 16 y) who were hospitalized for Kirschner wire infection from 1995 to 2012. Presentation, hospital course, bacteriology, outcomes, and complications were recorded...
January 2015: Journal of Pediatric Orthopedics
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