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https://www.readbyqxmd.com/read/27711449/a-perspective-on-structural-and-computational-work-on-collagen
#1
Carmen Domene, Christian Jorgensen, Sumra Wajid Abbasi
Collagen is the single most abundant protein in the extracellular matrix in the animal kingdom, with remarkable structural and functional diversity and regarded one of the most useful biomaterials. Etymologically, the term collagen comes from Greek kola 'glue' and gen 'giving birth to'. Thus, it is not surprising that the various collagens and the structures they form all serve the same purpose, to help tissues withstand stretching. Among the functions the various collagens are involved in are cell adhesion and migration, tissue repair, scaffolding and morphogenesis...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27689740/synthesis-characterization-anti-bacterial-anti-fungal-and-nematicidal-activities-of-2-amino-3-cyanochromenes
#2
Muhammad Nawaz, Muhammad Waseem Abbasi, Soleiman Hisaindee
Soil-borne plant pathogens such as nematodes, fungi and some bacteria not only affect the plant cultures but also economy and environmental implications. As a result of these pathogens attacks, the yield and quality of crops is affected. Therefore, synthesis of new compounds to control these pathogens is very important and need of time. Chromenes are considered important group of heterocyclic compounds and exhibited significant biological activities. 2-amino-3-cyano chromenes are considered important medicinal scaffolds among the chromenes...
September 27, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27485451/recurrent-ppp2r1a-mutations-in-uterine-cancer-act-through-a-dominant-negative-mechanism-to-promote-malignant-cell-growth
#3
Dorien Haesen, Layka Abbasi Asbagh, Rita Derua, Antoine Hubert, Stefanie Schrauwen, Yana Hoorne, Frédéric Amant, Etienne Waelkens, Anna Sablina, Veerle Janssens
Somatic missense mutations in the Ser/Thr protein phosphatase 2A (PP2A) Aα scaffold subunit gene PPP2R1A are among the few genomic alterations that occur frequently in serous endometrial carcinoma (EC) and carcinosarcoma, two clinically aggressive subtypes of uterine cancer with few therapeutic options. Previous studies reported that cancer-associated Aα mutants exhibit defects in binding to other PP2A subunits and contribute to cancer development by a mechanism of haploinsufficiency. Here we report on the functional significance of the most recurrent PPP2R1A mutations in human EC, which cluster in Aα HEAT repeats 5 and 7...
October 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26277488/prediction-of-dual-agents-as-an-activator-of-mutant-p53-and-inhibitor-of-hsp90-by-docking-molecular-dynamic-simulation-and-virtual-screening
#4
Maryam Abbasi, Hojjat Sadeghi-Aliabadi, Farshid Hassanzadeh, Massoud Amanlou
Heat shock protein90s (Hsp90s) play a crucial role in the development of cancer, and their inhibitors are a main target for tumor suppression. P53 also is a tumor suppressor, but in cancer cells, mutations in the p53 gene lead to the inactivation and accumulation of protein. For instance, the ninth p53 cancer mutation, Y220C, destabilizes the p53 core domain. Small molecules have been assumed to bind to Y220C DNA-binding domain and reactivate cellular mutant p53 functions. In this study, one of the mutant p53 activators is suggested as an Hsp90 inhibitor according to a pyrazole scaffold...
September 2015: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/26255987/influence-of-oriented-nanofibrous-pcl-scaffolds-on-quantitative-gene-expression-during-neural-differentiation-of-mouse-embryonic-stem-cells
#5
Naghmeh Abbasi, Seyed Mahmoud Hashemi, Mohammad Salehi, Hoda Jahani, Seyed Javad Mowla, Masoud Soleimani, Hossein Hosseinkhani
Neural differentiation of mouse embryonic stem cells in combination with three-dimensional electrospun nanofibers as an artificial extracellular matrix can be utilized to reconstruct a spinal cord defect. In this study, random and parallel-aligned nanofibrous poly ɛ-caprolactone was fabricated using electrospinning. Its hydrophobicity was modified by O2 plasma treatment to facilitate enhanced cell attachment. Embryoid bodies (EBs), which contain all three embryonic germ layers, were cultured on poly ɛ-caprolactone scaffolds to study the effect of fiber orientation on cell morphology and differentiation...
January 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/26133100/one-pot-synthesis-of-spiropyrroloquinoline-isoindolinone-and-their-aza-analogs-via-the-ugi-4cr-metal-free-intramolecular-bis-annulation-process
#6
Mehdi Ghandi, Nahid Zarezadeh, Alireza Abbasi
This presentation discloses a one-pot synthesis of a series of spiropyrroloquinoline isoindolinone and spiropyrroloquinoline aza-isoindolinone scaffolds. The reaction proceeds by the combination of a Ugi four-component reaction (4CR) and two intramolecular cyclizations under metal-free conditions. The proof of the structures relies on analytical investigation and X-ray crystallography.
August 14, 2015: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/25925871/a-study-on-quantitative-structure-activity-relationship-and-molecular-docking-of-metalloproteinase-inhibitors-based-on-l-tyrosine-scaffold
#7
Maryam Abbasi, Fatemeh Ramezani, Maryam Elyasi, Hojjat Sadeghi-Aliabadi, Massoud Amanlou
BACKGROUND: MMP-2 enzyme is a kind of matrix metalloproteinases that digests the denatured collagens and gelatins. It is highly involved in the process of tumor invasion and has been considered as a promising target for cancer therapy. The structural requirements of an MMP-2 inhibitor are: (1) a functional group that binds the zinc ion, and (2) a functional group which interacts with the enzyme backbone and the side chains which undergo effective interactions with the enzyme subsites...
2015: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/25687012/mimicking-the-quasi-random-assembly-of-protein-fibers-in-the-dermis-by-freeze-drying-method
#8
Hakimeh Ghaleh, Farhang Abbasi, Mina Alizadeh, Ali Baradar Khoshfetrat
Freeze-drying is extensively used for fabrication of porous materials in tissue engineering and biomedical applications, due to its versatility and use of no toxic solvent. However, it has some significant drawbacks. Conventional freeze-drying technique leads to the production of heterogeneous porous structures with side orientated columnar pores. As the top and bottom surfaces of the sample are not in contact with similar environments, different rates of heat transfer in the surfaces and the temperature gradient across the sample establish the preferential direction of heat transfer...
April 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/24611137/the-effects-of-plasma-treated-electrospun-nanofibrous-poly-%C3%AE%C2%B5-caprolactone-scaffolds-with-different-orientations-on-mouse-embryonic-stem-cell-proliferation
#9
Naghmeh Abbasi, Sara Soudi, Nasim Hayati-Roodbari, Masumeh Dodel, Masoud Soleimani
OBJECTIVE: Assessments of cell reactions such as motility, orientation and activation to the topography of the substratum will assist with the fabrication of a proper implantable scaffold for future tissue engineering applications.The current challenge is to analyze the orientation effect of elecrospun nanofibers of poly (ε-caprolactone) (PCL) on viability and proliferation of mouse embryonic stem cells (mESCs). MATERIALS AND METHODS: In this experimental study, we used the electrospinning method to fabricate nanofibrous PCL scaffolds...
2014: Cell Journal
https://www.readbyqxmd.com/read/23910302/microstructure-and-characteristic-properties-of-gelatin-chitosan-scaffold-prepared-by-a-combined-freeze-drying-leaching-method
#10
M Alizadeh, F Abbasi, A B Khoshfetrat, H Ghaleh
A combined freeze-drying and particulate leaching method for scaffold synthesis showed an improvement in the horizontal microstructure of the gelatin/chitosan scaffolds. Type and concentration of the cross-linking agent, freezing temperature, concentration of the polymeric solution and gelatin/chitosan weight ratio were the variables affecting the scaffold properties. Assessment of the tensile properties of the scaffolds revealed that for a scaffold with 50% chitosan, glutaraldehyde, as a cross-linking agent, created much tighter polymeric network compared to N,N-(3-dimethylaminopropyl)-N'-ethyl carbodiimide (EDC)...
October 2013: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/21433138/de-novo-design-of-supercharged-unfolded-protein-polymers-and-their-assembly-into-supramolecular-aggregates
#11
Anke Kolbe, Loretta L del Mercato, Azhar Z Abbasi, Pilar Rivera Gil, Sekineh J Gorzini, Wim H C Huibers, Bert Poolman, Wolfgang J Parak, Andreas Herrmann
Here we report for the first time the design and expression of highly charged, unfolded protein polymers based on elastin-like peptides (ELPs). Positively and negatively charged variants were achieved by introducing lysine and glutamic acid residues, respectively, within the repetitive pentapeptide units. Subsequently it was demonstrated that the monodisperse protein polyelectrolytes with precisely defined amino acid compositions, sequences, and stereochemistries can be transferred into superstructures exploiting their electrostatic interactions...
January 17, 2011: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/19437725/wrapping-nanocrystals-with-an-amphiphilic-polymer-preloaded-with-fixed-amounts-of-fluorophore-generates-fret-based-nanoprobes-with-a-controlled-donor-acceptor-ratio
#12
Aleksey V Yakovlev, Feng Zhang, Ali Zulqurnain, Abbasi Azhar-Zahoor, Camilla Luccardini, Stéphane Gaillard, Jean-Maurice Mallet, Patrick Tauc, Jean-Claude Brochon, Wolfgang J Parak, Anne Feltz, Martin Oheim
Colloidal nanocrystal (NC) donors wrapped with a polymer coating including multiple organic acceptor molecules are promising scaffolds for fluorescence resonance energy transfer (FRET)-based nanobiosensors. Over other self-assembling donor-acceptor configurations, our preloaded polymers have the virtue of producing compact assemblies with a fixed donor/acceptor distance. This property, together with the possibility of stoichiometric polymer loading, allowed us to directly address how the FRET efficiency depended on the donor/acceptor...
March 3, 2009: Langmuir: the ACS Journal of Surfaces and Colloids
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