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Lobat Tayebi

Hossein E Jazayeri, Mohammadreza Tahriri, Mehdi Razavi, Kimia Khoshroo, Farahnaz Fahimipour, Erfan Dashtimoghadam, Luis Almeida, Lobat Tayebi
Tissue regeneration is rapidly evolving to treat anomalies in the entire human body. The production of biodegradable, customizable scaffolds to achieve this clinical aim is dependent on the interdisciplinary collaboration among clinicians, bioengineers and materials scientists. While bone grafts and varying reconstructive procedures have been traditionally used for maxillofacial defects, the goal of this review is to provide insight on all materials involved in the progressing utilization of the tissue engineering approach to yield successful treatment outcomes for both hard and soft tissues...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Kimia Khoshroo, Tahereh S Jafarzadeh Kashi, Fathollah Moztarzadeh, Mohammadreza Tahriri, Hossein E Jazayeri, Lobat Tayebi
In this research, the three dimensional porous scaffolds made of a polycaprolactone (PCL) microsphere/TiO2 nanotube (TNT) composite was fabricated and evaluated for potential bone substitute applications. We used a microsphere sintering method to produce three dimensional PCL microsphere/TNT composite scaffolds. The mechanical properties of composite scaffolds were regulated by varying parameters, such as sintering time, microsphere diameter range size and PCL/TNT ratio. The obtained results ascertained that the PCL/TNT (0...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Pouya Amrollahi, Brinda Shah, Amir Seifi, Lobat Tayebi
Although human mouth benefits from remarkable mechanical properties, it is very susceptible to traumatic damages, exposure to microbial attacks, and congenital maladies. Since the human dentition plays a crucial role in mastication, phonation and esthetics, finding promising and more efficient strategies to reestablish its functionality in the event of disruption has been important. Dating back to antiquity, conventional dentistry has been offering evacuation, restoration, and replacement of the diseased dental tissue...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Arash Khojasteh, Farahnaz Fahimipour, Mohamadreza Baghaban Eslaminejad, Mohammad Jafarian, Shahrbanoo Jahangir, Farshid Bastami, Mohammadreza Tahriri, Akbar Karkhaneh, Lobat Tayebi
Bone tissue engineering is sought to apply strategies for bone defects healing without limitations and short-comings of using either bone autografts or allografts and xenografts. The aim of this study was to fabricate a thin layer poly(lactic-co-glycolic) acid (PLGA) coated beta-tricalcium phosphate (β-TCP) scaffold with sustained release of vascular endothelial growth factor (VEGF). PLGA coating increased compressive strength of the β-TCP scaffolds significantly. For in vitro evaluations, canine mesenchymal stem cells (cMSCs) and canine endothelial progenitor cells (cEPCs) were isolated and characterized...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Reza Masaeli, Tahereh Sadat Jafarzadeh Kashi, Rassoul Dinarvand, Vahid Rakhshan, Hossein Shahoon, Behzad Hooshmand, Fatemeh Mashhadi Abbas, Majid Raz, Alireza Rajabnejad, Hossein Eslami, Kimia Khoshroo, Mohammadreza Tahriri, Lobat Tayebi
AIMS: The purpose of this multi-phase explorative in vivo animal/surgical and in vitro multi-test experimental study was to (1) create a 3wt%-nanostrontium hydroxyapatite-enhanced calcium phosphate cement (Sr-HA/CPC) for increasing bone formation and (2) creating a simvastatin-loaded poly(lactic-co-glycolic acid) (SIM-loaded PLGA) microspheres plus CPC composite (SIM-loaded PLGA+nanostrontium-CPC). The third goal was the extensive assessment of multiple in vitro and in vivo characteristics of the above experimental explorative products in vitro and in vivo (animal and surgical studies)...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Mahnoush Tayebi, Mohammad Tavakkoli Yaraki, Azadeh Mogharei, Mahnaz Ahmadieh, Mohammadreza Tahriri, Daryoosh Vashaee, Lobat Tayebi
In the present research, water soluble thioglycolic acid-capped CdS quantum dots (QDs) were synthesized by chemical precipitation method. The characteristics of prepared quantum dots were determined using X-Ray Diffraction (XRD) and Transmission Electron Microscopy (TEM). The obtained results revealed that CdS QDs have 5.60 nm crystallite size, hexagonal wurtzite structure and spherical morphology with less than 10 nm diameter. The photoluminescence (PL) spectroscopy was performed in order to study the effect of the presence of starch solutions...
September 2016: Journal of Fluorescence
Fatemeh Heidari, Mehdi Razavi, Mohammad E Bahrololoom, Reza Bazargan-Lari, Daryoosh Vashaee, Hari Kotturi, Lobat Tayebi
Chitosan (CS), hydroxyapatite (HA), and magnetite (Fe3O4) have been broadly employed for bone treatment applications. Having a hybrid biomaterial composed of the aforementioned constituents not only accumulates the useful characteristics of each component, but also provides outstanding composite properties. In the present research, mechanical properties of pure CS, CS/HA, CS/HA/magnetite, and CS/magnetite were evaluated by the measurements of bending strength, elastic modulus, compressive strength and hardness values...
August 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Venkata Raveendra Pothineni, Dhananjay Wagh, Mustafeez Mujtaba Babar, Mohammed Inayathullah, David Solow-Cordero, Kwang-Min Kim, Aneesh V Samineni, Mansi B Parekh, Lobat Tayebi, Jayakumar Rajadas
Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that >300,000 cases per annum are reported in USA alone. A total of 10%-20% of patients who have been treated with antibiotic therapy report the recrudescence of symptoms, such as muscle and joint pain, psychosocial and cognitive difficulties, and generalized fatigue. This condition is referred to as posttreatment Lyme disease syndrome. While there is no evidence for the presence of viable infectious organisms in individuals with posttreatment Lyme disease syndrome, some researchers found surviving Borrelia burgdorferi population in rodents and primates even after antibiotic treatment...
2016: Drug Design, Development and Therapy
Hossein E Jazayeri, Mina D Fahmy, Mehdi Razavi, Brett E Stein, Aatif Nowman, Radi M Masri, Lobat Tayebi
Clinical advances in the treatment of dentoalveolar defects continue to evolve with the introduction of new innovations in regenerative medicine and tissue bioengineering. Recent developments in tissue engineering are aimed at safely and effectively regenerating a damaged or necrotic area by replenishing its cells and increasing surrounding gene expression. Various techniques have successfully given rise to porous scaffolds being used by clinicians to treat the defect and initiate the repair process. Tissue reconstruction using bioengineered scaffolds is advantageous over traditional autografting, since it prevents the instigation of pain and donor site morbidity while ultimately creating both the environment and machinery needed to induce cell proliferation, migration, and reattachment within the affected area...
August 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Mohammad Mahdi Hasani-Sadrabadi, Shahrouz Taranejoo, Erfan Dashtimoghadam, Ghasem Bahlakeh, Fatemeh Sadat Majedi, Jules John VanDersarl, Mohsen Janmaleki, Fatemeh Sharifi, Arnaud Bertsch, Kerry Hourigan, Lobat Tayebi, Philippe Renaud, Karl I Jacob
A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.
June 2016: Advanced Materials
M Hashemi, A Yadegari, G Yazdanpanah, Meisam Omidi, S Jabbehdari, F Haghiralsadat, F Yazdian, Lobat Tayebi
Graphene oxide (GO) has been recently introduced as a suitable anti-cancer drug carrier, which could be loaded with doxorubicin (DOX) as a general chemotherapy agent. Herein, the attempts were to optimize the effective parameters on both loading and release of DOX on GO. GO and GO-DOX were characterized using transition electron micrographs (TEM), zeta potential, Raman, UV-visible and FTIR spectroscopy. In addition, loading and releasing behaviour of DOX on GO were studied in terms of different temperature and pH values...
February 16, 2016: Biotechnology and Applied Biochemistry
Mina D Fahmy, Hossein E Jazayeri, Mehdi Razavi, Radi Masri, Lobat Tayebi
Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon's skills and the inherent potential in the patients' bodies for regenerating lost tissues. Employing custom-designed 3D printed scaffolds that securely and effectively reconstruct the defects by using tissue engineering and regenerative medicine techniques can revolutionize preprosthetic surgeries. Various polymers, ceramics, natural and synthetic bioplastics, proteins, biomolecules, living cells, and growth factors as well as their hybrid structures can be used in 3D printing of scaffolds, which are still under development by scientists...
June 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Mohammad Mahdi Hasani-Sadrabadi, Erfan Dashtimoghadam, Ghasem Bahlakeh, Fatemeh S Majedi, Hamid Keshvari, Jules J Van Dersarl, Arnaud Bertsch, Arash Panahifar, Philippe Renaud, Lobat Tayebi, Morteza Mahmoudi, Karl I Jacob
AIMS: Here we report a one-step approach for reproducible synthesis of finely tuned targeting multifunctional hybrid nanoparticles (HNPs). MATERIALS & METHODS: A microfluidic-assisted method was employed for controlled nanoprecipitation of bisphosphonate-conjugated poly(D,L-lactide-co-glycolide) chains, while coencapsulating superparamagnetic iron oxide nanoparticles and the anticancer drug Paclitaxel. RESULTS: Smaller and more compact HNPs with narrower size distribution and higher drug loading were obtained at microfluidic rapid mixing regimen compared with the conventional bulk method...
2015: Nanomedicine
Mostafa Yazdimamaghani, Mehdi Razavi, Masoud Mozafari, Daryoosh Vashaee, Hari Kotturi, Lobat Tayebi
UNLABELLED: Considering the well-known phenomenon of enhancing bone healing by applying electromagnetic stimulation, manufacturing conductive bone scaffolds is on demand to facilitate the delivery of electromagnetic stimulation to the injured region, which in turn significantly expedites the healing procedure in tissue engineering methods. For this purpose, hybrid conductive scaffolds composed of poly(3,4-ethylenedioxythiophene), poly(4-styrene sulfonate) ( PEDOT: PSS), gelatin (Gel), and bioactive glass (BaG) were produced employing freeze drying technique...
December 2015: Journal of Materials Science. Materials in Medicine
Wenchao Sun, Mohammed Inayathullah, Martin A C Manoukian, Andrey V Malkovskiy, Sathish Manickam, M Peter Marinkovich, Alfred T Lane, Lobat Tayebi, Alexander M Seifalian, Jayakumar Rajadas
Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities. This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system. The microneedle patches were made with concentrations of 1, 2, 4, and 8% type I collagen (w/w). Microneedle structures and the distribution of collagen were characterized using scanning electron microscopy and confocal microscopy...
December 2015: Annals of Biomedical Engineering
Mojgan Abdolrahim, Mohammad Rabiee, Sanaz Naghavi Alhosseini, Mohammadreza Tahriri, Sara Yazdanpanah, Lobat Tayebi
Acute myocardial infarction (AMI) is the leading cause of death among cardiovascular diseases. Among the numerous attempts to develop coronary marker concepts into clinical strategies, cardiac troponin is known as a specific marker for coronary events. The cardiac troponin concentration level in blood has been shown to rise rapidly for 4-10 days after onset of AMI, making it an attractive approach for a long diagnosis window for detection. The extremely low clinical sensing range of cardiac troponin levels consequently makes the methods of detection highly sensitive...
September 15, 2015: Analytical Biochemistry
Mohammad Mahdi Hasani-Sadrabadi, Sana Pour Hajrezaei, Shahriar Hojjati Emami, Ghasem Bahlakeh, Leila Daneshmandi, Erfan Dashtimoghadam, Ehsan Seyedjafari, Karl I Jacob, Lobat Tayebi
UNLABELLED: Advancement of bone tissue engineering as an alternative for bone regeneration has attracted significant interest due to its potential in reducing the costs and surgical trauma affiliated with the effective treatment of bone defects. We have improved the conventional approach of producing polymeric nanoparticles, as one of the most promising choices for drug delivery systems, using a microfluidics platform, thus further improving our control over osteogenic differentiation of mesenchymal stem cells...
October 2015: Nanomedicine: Nanotechnology, Biology, and Medicine
Mehdi Razavi, Mohammadhossein Fathi, Omid Savabi, Daryoosh Vashaee, Lobat Tayebi
Magnesium (Mg) alloys have been suggested as biodegradable bone implant materials due to their good intrinsic biocompatibility and great mechanical properties. Although magnesium has attractive properties as an orthopedic implant material, its quick degradation and low bioactivity may lead to the loss of mechanical integrity of the implant during the bone healing process. In this paper, we endeavor to surmount the abovementioned defects using the surface coating technique. We have recently coated AZ91 magnesium implants with merwinite (Ca3MgSi2O8) through the coupling of plasma electrolytic oxidation (PEO) and electrophoretic deposition method...
May 2015: Journal of Materials Science. Materials in Medicine
Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Lobat Tayebi
A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dip-coating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold...
April 2015: Materials Science & Engineering. C, Materials for Biological Applications
Mehdi Razavi, Mohammadhossein Fathi, Omid Savabi, Daryoosh Vashaee, Lobat Tayebi
Although magnesium (Mg) is a unique biodegradable metal which possesses mechanical property similar to that of the natural bone and can be an attractive material to be used as orthopedic implants, its quick corrosion rate restricts its actual clinical applications. To control its rapid degradation, we have modified the surface of magnesium implant using fluoridated hydroxyapatite (FHA: Ca10(PO4)6OH2-xFx) through the combined micro-arc oxidation (MAO) and electrophoretic deposition (EPD) techniques, which was presented in our previous paper...
March 2015: Materials Science & Engineering. C, Materials for Biological Applications
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