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Saeed Heidari Keshel

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https://www.readbyqxmd.com/read/27458512/synthesis-and-evaluation-of-multi-wall-carbon-nanotube-paclitaxel-complex-as-an-anti-cancer-agent
#1
Fariba Ghasemvand, Esmaeil Biazar, Sara Tavakolifard, Mohammad Khaledian, Saeid Rahmanzadeh, Daruosh Momenzadeh, Roshanak Afroosheh, Faezeh Zarkalami, Marjan Shabannezhad, Saeed Hesami Tackallou, Nilofar Massoudi, Saeed Heidari Keshel
AIM: The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer. BACKGROUND: Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading. PATIENTS AND METHODS: In this study, multi-walled carbon nanotubes (MWCNTs) pre-functionalized covalently with a paclitaxel (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope (SEM), particle size analyzer and cellular analyses...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27433816/the-evaluation-of-alteration-of-elam-1-expression-in-the-endometriosis-patients
#2
Hoda Bahrami, Reza Roozafzoon, Zinat Ghanbari, Neda Jegargooshe, Parvaneh Jafari, Mohammad Nazari, Saeed Heidari-Keshel
BACKGROUND: As a definition, Endometriosis is a commonly encountered gynecological disease; as endometrial glandular and stromal cells existing in the outside of the uterus. In spite of several studies on endometriosis, its molecular mechanism and pathogenesis nevertheless have been not completely illuminated. Role of ELAM-1 gene in mediating the adhesion of tumor cells to endothelial cells by binding to ELAM-1 ligands expressed by eosinophils, neutrophils, monocytes, natural killer cell effectors T-lymphocyte cell, and cancer (progenitor/stem) cells is well studied...
July 19, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/26837778/electrospun-mat-with-eyelid-fat-derived-stem-cells-as-a-scaffold-for-ocular-epithelial-regeneration
#3
Daruosh Momenzadeh, Alireza Baradaran-Rafii, Saeed Heidari Keshel, Maryam Ebrahimi, Esmaeil Biazar
The aim of this study was to develop nanofibrous gelatin substrates for eyelid fat stem cell (EFSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane. Biocompatibility results indicated that all substrates were highly biocompatible, as EFSCs could favorably attach and proliferate on the nanofibrous surfaces. Microscopic figures showed that the EFSC were firmly anchored to the substrates and were able to retain a normal stem cell phenotype. Immunocytochemistry (ICC) and real time-PCR results revealed change in the expression profile of EFSCs grown on nanofibrous substrates when compared to those grown on control in epithelial induction condition...
February 2, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/26324020/oriented-nanofibrous-silk-as-a-natural-scaffold-for-ocular-epithelial-regeneration
#4
COMPARATIVE STUDY
Esmaeil Biazar, Alireza Baradaran-Rafii, Saeed Heidari-keshel, Sara Tavakolifard
The aim of this study was to develop nanofibrous silk substrates for limbal stem cell expansion that can serve as a potential alternative substrate to replace human amniotic membrane. The human limbal stem cell was used to evaluate the biocompatibility of substrates (random and oriented nanofibrous mats, and human amniotic membrane) based on their phenotypic profile, viability, proliferation, and attachment ability. Biocompatibility results indicated that all substrates were highly biocompatible, as limbal stem cells could favorably attach and proliferate on the nanofibrous surfaces...
2015: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/26140614/human-unrestricted-somatic-stem-cells-loaded-in-nanofibrous-pcl-scaffold-and-their-healing-effect-on-skin-defects
#5
Hoda Bahrami, Saeed Heidari Keshel, Aliakbar Jafari Chari, Esmaeil Biazar
Unrestricted somatic stem cells (USSCs) loaded in nanofibrous polycaprolactone (PCL) scaffolds can be used for skin regeneration when grafted onto full-thickness skin defects of rats. Nanofibrous PCL scaffolds were designed by the electrospinning method and crosslinked with laminin protein. Afterwards, the scaffolds were evaluated by scanning electron microscopy, and physical and mechanical assays. In this study, nanofibrous PCL scaffolds loaded with USSCs were grafted onto the skin defects. The wounds were subsequently investigated 21 days after grafting...
September 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/25972860/dissection-of-the-cis-2-decenoic-acid-signaling-network-in-pseudomonas-aeruginosa-using-microarray-technique
#6
Azadeh Rahmani-Badi, Shayesteh Sepehr, Hossein Fallahi, Saeed Heidari-Keshel
Many bacterial pathogens use quorum-sensing (QS) signaling to regulate the expression of factors contributing to virulence and persistence. Bacteria produce signals of different chemical classes. The signal molecule, known as diffusible signal factor (DSF), is a cis-unsaturated fatty acid that was first described in the plant pathogen Xanthomonas campestris. Previous works have shown that human pathogen, Pseudomonas aeruginosa, also synthesizes a structurally related molecule, characterized as cis-2-decenoic acid (C10: Δ(2), CDA) that induces biofilm dispersal by multiple types of bacteria...
2015: Frontiers in Microbiology
https://www.readbyqxmd.com/read/25897888/cellular-response-of-limbal-stem-cells-on-polycaprolactone-nanofibrous-scaffolds-for-ocular-epithelial-regeneration
#7
Alireza Baradaran-Rafii, Esmaeil Biazar, Saeed Heidari-keshel
PURPOSE: The aim of this study was to develop nanofibrous polycaprolactone (PCL) substrate for limbal stem cell (LSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane (AM). MATERIALS AND METHODS: The human limbus stem cell was used to evaluate the biocompatibility of substrates (nanofibrous scaffold and, human AM) based on their phenotypic profile, viability, proliferation and attachment ability. RESULTS: Biocompatibility results indicated that the all substrates were highly biocompatible, as LSCs could favorably attach and proliferate on the nanofibrous surface...
2016: Current Eye Research
https://www.readbyqxmd.com/read/25730017/retraction-of-absolute-quantification-of-free-tumor-cells-in-the-peripheral-blood-of-gastric-cancer-patients-by-n-bayat-m-m-mokhtari-m-rezaei-tavirani-a-baradaran-rafii-s-rahman-zadeh-s-heidari-keshel-and-f-ghasemvand-genet-mol-res-13-2-4425-4432-2014
#8
(no author information available yet)
The article "Absolute quantification of free tumor cells in the peripheral blood of gastric cancer patients" by N. Bayat, M.M. Mokhtari, M. Rezaei-Tavirani, A. Baradaran-Rafii, S. Rahman Zadeh, S. Heidari-Keshel and F. Ghasemvand published in Genetics and Molecular Research vol. 13 (2), pp. 4425-4432 in 2014, DOI: http://dx.doi.org/10.4238/2014.June.16.1, has been found to be substantially equal to the article "Quantitative analysis of TEM-8 and CEA tumor markers indicating free tumor cells in the peripheral blood of colorectal cancer patients"...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25730016/retraction-retraction-of-znf797-plays-an-oncogenic-role-in-gastric-cancer-by-d-momenzadeh-s-rahman-zadeh-m-rezaei-tavirani-a-baradaran-rafii-f-ghasemvand-and-s-heidari-keshel-genet-mol-res-13-4-8421-8427-2014
#9
(no author information available yet)
The article "ZNF797 plays an oncogenic role in gastric cancer" by D. Momenzadeh, S. Rahman Zadeh, M. Rezaei-Tavirani, A. Baradaran-Rafii, F. Ghasemvand and S. Heidari-Keshel published in Genetics and Molecular Research vol. 13 (4), pp. 8421-8427 in 2014, DOI: http://dx.doi.org/10.4238/2014.October.20.18, has been found to be substantially equal to the article "Role of SALL4 in the progression and metastasis of colorectal cancer" published in the Journal of Biomedical Science, vol. 20, p. 6 in 2013, DOI: 10...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25710767/electrospun-poly-3-hydroxybutyrate-co-3-hydroxyvalerate-hydroxyapatite-scaffold-with-unrestricted-somatic-stem-cells-for-bone-regeneration
#10
Esmaeil Biazar, Saeed Heidari Keshel
The combination of scaffolds and cells can be useful in tissue reconstruction. In this study, nanofibrous poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/nanohydroxyapatite (nano-HAp) scaffolds, filled with unrestricted somatic stem cells (USSCs), were used for healing calvarial bone in rat model. The healing effects of these scaffolds, with and without stem cells, in bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting. The results of CT analysis showed that bone regeneration on the scaffolds, and the amounts of regenerated new bone for polymer/nano-HAp scaffold with USSC, was significantly greater than the scaffold without cell and untreated control samples...
May 2015: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/25543058/dental-pulp-stem-cells-differentiation-into-retinal-ganglion-like-cells-in-a-three-dimensional-network
#11
Reza Roozafzoon, Alireza Lashay, Mohammad Vasei, Jafar Ai, Ahad Khoshzaban, Saeed Heidari Keshel, Zahra Barabadi, Hoda Bahrami
The loss of retinal ganglion cells (RGCs) in majority of retinal degenerative diseases is the first seen pathological event. A lot of studies aim to discover suitable cell sources to replace lost and damaged RGCs. Among them dental pulp stem cells (DPSCs) have a great potential of differentiating into neuronal lineages as well as RGCs. Moreover, three-dimensional (3D) networks and its distribution for growing and differentiation of stem cells as much as possible mimic to native tissue holds great potential in retinal tissue engineering...
February 6, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/25250135/aqueous-extract-of-lavender-angustifolia-inhibits-lymphocytes-proliferation-of-hodgkin-s-lymphoma-patients
#12
Sona Dalilan, Mostafa Rezaei-Tavirani, Mohammad Nabiuni, Saeed Heidari-Keshel, Mona Zamanian Azodi, Hakimeh Zali
BACKGROUND: There are several types of cancer, which cause millions of deaths worldwide every year. Many studies have confirmed that plants are adequate natural sources to be examined as anti-cancer drugs with fewer side effects than chemotherapy and radiotherapy. In this study the anti-cancer properties of Lavender aqueous extract on lymphocytes derived from patients with Hodgkin's lymphoma has been studied. METHODS: In order to determine the cytotoxic effects of the extract on lymphocytes of patients in stages III and IV of Hodgkin's lymphoma and two different cell lines in the presence of different concentrations of aqueous extract of Lavender, MTT colorimetric assay and flow cytometry analysis were used...
2013: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/25206560/efficacy-of-nanofibrous-conduits-in-repair-of-long-segment-sciatic-nerve-defects
#13
Esmaeil Biazar, Saeed Heidari Keshel, Majid Pouya
Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous sciatic nerve to bridge 30-mm-long rat sciatic nerve gaps. Within 4 months after surgery, rat sciatic nerve functional recovery was evaluated per month by behavioral analyses, including toe out angle, toe spread analysis, walking track analysis, extensor postural thrust, swimming test, open-field analysis and nociceptive function...
September 25, 2013: Neural Regeneration Research
https://www.readbyqxmd.com/read/25206536/nanofibrous-nerve-conduits-for-repair-of-30-mm-long-sciatic-nerve-defects
#14
Esmaeil Biazar, Saeed Heidari Keshel, Majid Pouya, Hadi Rad, Melody Omrani Nava, Mohammad Azarbakhsh, Shirin Hooshmand
It has been confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit can promote peripheral nerve regeneration in rats. However, its efficiency in repair of over 30-mm-long sciatic nerve defects needs to be assessed. In this study, we used a nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit to bridge a 30-mm-long gap in the rat sciatic nerve. At 4 months after nerve conduit implantation, regenerated nerves were cally observed and histologically assessed. In the nanofibrous graft, the rat sciatic nerve trunk had been reconstructed by restoration of nerve continuity and formation of myelinated nerve fiber...
August 25, 2013: Neural Regeneration Research
https://www.readbyqxmd.com/read/24834286/functionalization-of-mwnt-cooh-by-one-step-reaction-with-3-oxoindolin-2-ylidene-urea-and-in-vitro-antitumor-study-on-gastric-cancer
#15
Saeed Heidari-Keshel, Mahdieh Entezari, Mostafa Rezaei-Tavirani, Maryam Ebrahimi, Majid Rezaei-Tavirani
AIM: In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate. BACKGROUND: Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study. PATIENTS AND METHODS: MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification...
2013: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/24456006/bone-reconstruction-in-rat-calvarial-defects-by-chitosan-hydroxyapatite-nanoparticles-scaffold-loaded-with-unrestricted-somatic-stem-cells
#16
Esmaeil Biazar, Saeed Heidari Keshel, Mostafa Rezaei Tavirani, Rahim Jahandideh
Calcium phosphates are one of the biomaterials that are used for bone regeneration. In this study, Hydroxyapatite (HAp) nanoparticles with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model. The healing effects of these injectable scaffolds with and without stem cells for bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting. The results of CT analysis showing bone regeneration on the scaffolds, also the amounts of regenerated new bone for USSC scaffold was significantly greater than the scaffold without cell and untreated controls...
April 2015: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/24399063/rat-sciatic-nerve-reconstruction-across-a-30-mm-defect-bridged-by-an-oriented-porous-phbv-tube-with-schwann-cell-as-artificial-nerve-graft
#17
Mina Karimi, Esmaeil Biazar, Saeed Heidari Keshel, Abdolaziz Ronaghi, Jafar Doostmohamadpour, Alireza Janfada, Arash Montazeri
An oriented poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit has been used to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rats. The oriented porous micropatterned artificial nerve conduit was designed onto the micropatterned silicon wafers, and then their surfaces were modified with oxygen plasma to increase cell adhesion. The designed conduits were investigated by cell culture analyses with Schwann cells (SCs). The conduits were implanted into a 30 mm gap in sciatic nerves of rats...
March 2014: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/24346243/regeneration-of-full-thickness-skin-defects-using-umbilical-cord-blood-stem-cells-loaded-into-modified-porous-scaffolds
#18
Reza Zeinali, Esmaeil Biazar, Saeed Heidari Keshel, Mostafa Rezaei Tavirani, Kamal Asadipour
In this study, we have demonstrated the ability of cord blood (CB)-derived unrestricted somatic stem cells (USSCs) and chitosan-modified poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffold to promote skin regeneration. Afterward, the scaffolds were evaluated by structural, microscopic, physical, and mechanical assays and cell culture analyses. Results of structural, physical, and mechanical analyses also showed a good resilience and compliance with movement as a skin graft. Cellular experiments showed a better cell adhesion, growth, and proliferation inside the modified scaffolds compared with unmodified ones...
January 2014: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/24172271/chitosan-cross-linked-nanofibrous-phbv-nerve-guide-for-rat-sciatic-nerve-regeneration-across-a-defect-bridge
#19
Esmaeil Biazar, Saeed Heidari Keshel
The aim of this study was to produce a chitosan-cross-linked nanofibrous biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit. The artificial nerve scaffold designed by electrospinning method and cross-linked with chitosan by chemical method. Afterwards, the scaffolds were evaluated by microscopic, physical, and mechanical analyses and cell culture assays with Schwann cells. The conduits were implanted into a 10 mm gap in the sciatic nerves of the rats. Four months after surgery, the regenerated nerves were evaluated by macroscopic assessments and histology...
November 2013: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/24088030/bone-formation-in-calvarial-defects-by-injectable-nanoparticular-scaffold-loaded-with-stem-cells
#20
Esmaeil Biazar, Saeed Heidari Keshel, Mostafa Rezaei Tavirani, Rahim Jahandideh
OBJECTIVE: Calcium phosphates are one of biomaterials that are used for bone regeneration. In this study, calcium phosphate nanoparticles such as hydroxyapatite (HA)/fluorapatite (FA),with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model. METHODS: The healing effects of these injectable scaffolds, with and without stem cells, in bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting...
December 2013: Expert Opinion on Biological Therapy
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