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Saeed Heidari

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https://www.readbyqxmd.com/read/29767280/carnosine-and-histidine-supplementation-blunt-lead-induced-reproductive-toxicity-through-antioxidative-and-mitochondria-dependent-mechanisms
#1
Mohammad Mehdi Ommati, Akram Jamshidzadeh, Reza Heidari, Zilong Sun, Mohammad Javad Zamiri, Forouzan Khodaei, Saeed Mousapour, Fatemeh Ahmadi, Nafiseh Javanmard, Babak Shirazi Yeganeh
Lead (Pb)-induced reproductive toxicity is a well-characterized adverse effect associated with this heavy metal. It has been found that Pb exposure is associated with altered spermatogenesis, increased testicular degeneration, and pathological sperm alterations. On the other hand, it has been reported that Pb-induced reproductive toxicity is associated with increased reactive oxygen species (ROS) formation and diminished antioxidant capacity in the reproductive system. Hence, administration of antioxidants as protective agents might be of value against Pb-induced reproductive toxicity...
May 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29707025/cytotoxicity-of-two-experimental-epoxy-resin-based-sealers
#2
Hengameh Ashraf, Farhood Najafi, Soolmaz Heidari, Zahra Yadegary, Saeede Zadsirjan
Introduction: Many endodontic sealers are available, but search for the ideal sealer continues. This study aimed to assess the cytotoxicity of two experimental endodontic sealers in comparison with AH-26 resin sealer. Methods and Materials: This in vitro study was conducted on conventional and experimental root canal sealers: AH-26, an epoxy resin experimental sealer A (ES-A) composed of calcium tungstate, zirconium oxide, aerosil, bismuth oxide, titanium oxide, hexamine and an epoxy resin and experimental sealer B (ES-B) with compositions similar to ES-A except for the presence of imidazoline as a catalyst...
2018: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29671367/3d-bio-printing-technology-for-body-tissues-and-organs-regeneration
#3
Esmaeil Biazar, Masoumeh Najafi S, Saeed Heidari K, Meysam Yazdankhah, Ataollah Rafiei, Dariush Biazar
In the last decade, the use of new technologies in the reconstruction of body tissues has greatly developed. Utilising stem cell technology, nanotechnology and scaffolding design has created new opportunities in tissue regeneration. The use of accurate engineering design in the creation of scaffolds, including 3D printers, has been widely considered. Three-dimensional printers, especially high precision bio-printers, have opened up a new way in the design of 3D tissue engineering scaffolds. In this article, a review of the latest applications of this technology in this promising area has been addressed...
April 19, 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29375986/safety-threshold-of-intravitreal-clonidine-in-rabbit-s-eyes
#4
Homayoun Nikkhah, Kiumars Heidari Garfami, Mozhgan Rezaei Kanavi, Ebrahim Mohammad Nashtaei, Saeed Karimi, Masoud Soheilian
AIM: To determine the safe dose of intravitreal clonidine (IVC), a potential drug for neuroprotection and angiogenesis inhibition in rabbits. METHODS: A total of 28 rabbits were divided into four groups. Three groups received IVC with concentrations of 15 (Group A), 25 (Group B), and 50 (Group C) µg/0.1 mL and the control group (Group D) received 0.1 mL balanced salt solution (BSS). To investigate IVC safety, electroretinography (ERG) was performed at baseline, then at 1, 4 and 8wk after injection...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29336177/in-vivo-assessment-of-a-nanofibrous-silk-tube-as-nerve-guide-for-sciatic-nerve-regeneration
#5
Maryam Ebrahimi, Jafar Ai, Esmaeil Biazar, Somayeh Ebrahimi-Barough, Arash Khojasteh, Meysam Yazdankhah, Siavash Sharifi, Arman Ai, Saeed Heidari-Keshel
A nanofibrous silk nerve conduit has been evaluated for its efficiency based on the promotion of peripheral nerve regeneration in rats. The designed tubes with or without Schwann cells were implanted into a 10 mm gap in the sciatic nerves of the rats. Four months after the surgery, the regenerated nerves were monitored and evaluated by macroscopic assessments and histology. The results demonstrated that the nanofibrous grafts, especially in the presence of Schwann cells, enabled reconstruction of the rat sciatic nerve trunk with a restoration of nerve continuity and formation of nerve fibres with myelination...
January 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29331014/biochemical-characterization-of-recombinant-thermostable-cohnella-sp-a01-%C3%AE-glucanase
#6
Meysam Rezaie, Saeed Aminzadeh, Farid Heidari, Masoud Mashhadi Akbar Boojar, Ali Asghar Karkhane
Background: Typically, non-cellulytic glucanase, including fungi and yeast cell wall hydrolyzing enzymes, are release by some symbiotic fungi and plants during the mycoparasitic fungi attack on plants. These enzymes are known as the defense mechanisms of plants. This study intends to investigate the biochemical properties of β-1,6-glucanase (bg16M) from native thermophilic bacteria, Cohnella A01. Methods: bg16M gene was cloned and expressed in E. coli BL21 (DE3)...
January 13, 2018: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29296038/melatonin-ameliorates-radiation-induced-oxidative-stress-at-targeted-and-nontargeted-lung-tissue
#7
Alireza Ghobadi, Alireza Shirazi, Masoud Najafi, Masoud Heidari Kahkesh, Saeed Rezapoor
Purpose: Radiation causes damage to irradiated tissues and also tissues that do not receive direct irradiation through a phenomenon called out-of-field effects. This damage through signals such as inflammatory responses can be transmitted to unirradiated cells/tissues and causes many effects such as oxidative damage. The radioprotective and anti-inflammatory effects of melatonin have been demonstrated in various studies. The aim of this study was to evaluate the effect of pretreatment with melatonin on oxidative damage caused by direct irradiation and out-of-field effects on the lung tissue after pelvic irradiation in rats...
October 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/29201078/anticancer-activity-of-curcumin-loaded-plga-nanoparticles-on-pc3-prostate-cancer-cells
#8
Seyed Saeed Azandeh, Mohammadreza Abbaspour, Ali Khodadadi, Layasadat Khorsandi, Mahmoud Orazizadeh, Abbas Heidari-Moghadam
Curcumin (Cur) has been found to be very efficacious against many different types of cancer cells. However, the major disadvantage associated with the use of Cur is its low systemic bioavailability. Our present work investigated the toxic effect of encapsulation of Cur in PLGA (poly lactic-coglycolic acid) nanospheres (NCur) on PC3 human cancer prostate cell. In the present study, we have investigated the effects of NCur on growth, autophagia, and apoptosis in PC3 cells, respectively, by MTT assay, fluorescence microscopy, and Flow cytometry...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29197623/dual-effects-of-sulfasalazine-on-rat-sperm-characteristics-spermatogenesis-and-steroidogenesis-in-two-experimental-models
#9
Mohammad Mehdi Ommati, Reza Heidari, Akram Jamshidzadeh, Mohammad Javad Zamiri, Zilong Sun, Samira Sabouri, Jundong Wang, Fatemeh Ahmadi, Nafiseh Javanmard, Kazem Seifi, Saeed Mousapour, Babak Shirazi Yeganeh
There are reports of sulfasalazine (Salazosulfapyridine; SASP)-induced reproductive toxicity, but there it is not known whether the SASP molecule or its intestinal metabolites are responsible for this effect. Rats received SASP (150, 300, and 600mg/kg) for 60 consecutive days (in vivo). Additionally, epididymal sperm was isolated and incubated with SASP (10μM-1600μM) (in vitro). Markers of oxidative stress, mitochondrial function, and sperm functionality, along with testis histopathology as well as several steroidogenic genes and proteins, including steroidogenic acute regulatory (StAR) protein, cytochrome P450 side chain cleavage enzyme (P450scc; Cyp11a), 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β-hydroxysteroid dehydrogenase (17β-HSD) were measured...
March 1, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29112894/study-the-effects-of-mesenchymal-stem-cell-conditioned-medium-injection-in-mouse-model-of-acute-colitis
#10
Sedigheh Pouya, Maryam Heidari, Kaveh Baghaei, Hamid Asadzadeh Aghdaei, Afshin Moradi, Saeed Namaki, Mohammad Reza Zali, Seyed Mahmoud Hashemi
BACKGROUND AND AIM: Inflammatory bowel disease (IBD) is an autoimmune-inflammatory disorder that results in inflammatory responses in individuals who are genetically susceptible. Uncontrolled inflammation in Crohn's disease (CD) or Ulcerative colitis (UC) affects the patient quality of life. Current therapies are not completely effective while cell therapy, especially the treatment with mesenchymal stem cells (MSCs) absorb lots of attention due to its immunomodulatory properties. So, we examined the effects of mesenchymal stem cells-conditioned medium (MSC-CM) in the experimental model of acute colitis...
January 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29071029/safety-and-effectiveness-of-low-level-laser-therapy-in-patients-with-knee-osteoarthritis-a-systematic-review-and-meta-analysis
#11
REVIEW
Seyed Mansour Rayegani, Seyed Ahmad Raeissadat, Saeed Heidari, Mohammad Moradi-Joo
Introduction: Low-level laser therapy (LLLT) was introduced as an alternative non-invasive treatment for osteoarthritis, but its effectiveness is still controversial. The main objective of this article was to determine the safety and efficacy of LLLT in patients with knee osteoarthritis (KOA). Methods: In order to gather evidence, main medical databases as well as relevant websites were browsed without time limit. We searched with appropriate keywords and strategies. After quality assessment of studies, study data were extracted by two reviewers...
2017: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29059358/daptomycin
#12
Mohsen Heidary, Azar Dohkt Khosravi, Saeed Khoshnood, Mohammad Javad Nasiri, Saleh Soleimani, Mehdi Goudarzi
Daptomycin is a cyclic lipopeptide antibiotic used for the treatment of Gram-positive infections including complicated skin and skin structure infections, right-sided infective endocarditis, bacteraemia, meningitis, sepsis and urinary tract infections. Daptomycin has distinct mechanisms of action, disrupting multiple aspects of cell membrane function and inhibiting protein, DNA and RNA synthesis. Although daptomycin resistance in Gram-positive bacteria is uncommon, there are increasing reports of daptomycin resistance in Staphylococcus aureus, Enterococcus faecium and Enterococcus faecalis...
January 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28846013/feasibility-and-data-quality-of-the-national-spinal-cord-injury-registry-of-iran-nscir-ir-a-pilot-study
#13
Khatereh Naghdi, Zahra Azadmanjir, Soheil Saadat, Aidin Abedi, Sahar Koohi Habibi, Pegah Derakhshan, Mahdi Safdarian, Shayan Abdollah Zadegan, Abbas Amirjamshidi, Mahdi Sharif-Alhoseini, Jalil Arab Kheradmand, Mahdi Mohammadzadeh, Kazem Zendehdel, Zahra Khazaeipour, Seyed Mahmood Ramak Hashemi, Hooshang Saberi, Kourosh Karimi Yarandi, Seyed Ebrahim Ketabchi, Shahrokh Yousefzadeh-Chabok, Hamid Heidari, Arezo Sotodeh, Khalil Pestei, Zahra Ghodsi, Farideh Sadeghian, Vanessa Noonan, Edward C Benzel, Gerard Oreilly, Jens Chapman, Ellen Merete Hagen, Michael G Fehlings, Alexander R Vaccaro, Morteza Faghih Jooybari, Mohammad Reza Zarei, Mohammad Reza Zafarghandi, Payman Salamati, Saeed Nezareh, Moein Khormali, Mohsen Sadeghi-Naini, Seyed Behzad Jazayeri, Bizhan Aarabi, Vafa Rahimi-Movaghar
BACKGROUND: Spinal cord injury (SCI) is one of the most disabling consequences of trauma with unparalleled economic, social, and personal burden. Any attempt aimed at improving quality of care should be based on comprehensive and reliable data. This pilot investigation studied the feasibility of implementing the National Spinal Cord and Column Injury Registry of Iran (NSCIR-IR) and scrutinized the quality of the registered data. METHODS: From October 2015 to May 2016, over an 8-month period, 65 eligible trauma patients who were admitted to hospitals in three academic centers in mainland Iran were included in this pilot study...
August 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28810536/drug-resistant-gram-negative-uropathogens-a-review
#14
REVIEW
Saeed Khoshnood, Mohsen Heidary, Reza Mirnejad, Aghil Bahramian, Mansour Sedighi, Habibollah Mirzaei
Urinary tract infection(UTI) caused by Gram-negative bacteria is the second most common infectious presentation in community medical practice. Approximately 150 million people are diagnosed with UTI each year worldwide. Drug resistance in Gram-negative uropathogens is a major global concern which can lead to poor clinical outcomes including treatment failure, development of bacteremia, requirement for intravenous therapy, hospitalization, and extended length of hospital stay. The mechanisms of drug resistance in these bacteria are important due to they are often not identified by routine susceptibility tests and have an exceptional potential for outbreaks...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28706612/polymorphisms-in-the-estrogen-receptor-beta-gene-and-the-risk-of-unexplained-recurrent-spontaneous-abortion
#15
Marzieh Mahdavipour, Saeed Zarei, Ramina Fatemi, Haleh Edalatkhah, Hamed Heidari-Vala, Mahmood Jeddi-Tehrani, Farah Idali
BACKGROUND: Recurrent Spontaneous Abortion (RSA) is caused by multiple genetic and non-genetic factors. Around 50% of the RSA cases have no known etiology and are considered as Unexplained RSA (URSA). Estrogens, via binding to their receptors, play an important role in female reproduction. This study aimed to investigate whether single nucleotide polymorphisms (SNPs; +1082G/A, +1730G/A and rs1256030 C/T) in the estrogen receptor beta (ESR2) gene are associated with susceptibility to URSA in a population of Iranian women...
July 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28638809/dual-peer-mentoring-program-for-undergraduate-medical-students-exploring-the-perceptions-of-mentors-and-mentees
#16
Parya Abdolalizadeh, Saeed Pourhassan, Roghayeh Gandomkar, Farrokh Heidari, Amir Ali Sohrabpour
Background: Despite the advantages of dual peer mentoring, there are a few reports of implementing and evaluating such programs for medical students. This study aimed at exploring the perceptions of mentors and mentees about the dual peer mentoring program for the first year undergraduate medical students of Tehran University of Medical Sciences. Methods: This qualitative study was conducted at the end of the first year of implementing the mentoring program. All mentees and mentors were invited to participate in focus group discussions...
2017: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/28540005/post-photorefractive-keratectomy-pain-and-corneal-sub-basal-nerve-density
#17
Masoumeh Mohebbi, Amin Rafat-Nejad, Seyed-Farzad Mohammadi, Kosar Asna-Ashari, Maryam Kasiri, Saeed Heidari-Keshel, Farshad Askarizadeh
PURPOSE: The perceived and reported pain of patients receiving photorefractive keratectomy (PRK) widely varies. We assessed the potential role of the subbasal nerve plexus density as a predictor of postoperative pain level. Consecutive patients scheduled to undergo PRK at the Refractive Surgery Clinic of Farabi Eye Hospital, Tehran, were approached. METHODS: Forty-nine myopic left eyes from 49 patients who consented to undergo scanning slit confocal microscopy assessments preoperatively were included...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28532015/effect-of-sintering-temperature-rise-from-870-to-920%C3%A2-c-on-physicomechanical-and-biological-quality-of-nano-hydroxyapatite-an-explorative-multi-phase-experimental-in-vitro-vivo-study
#18
Ahad Khoshzaban, Vahid Rakhshan, Farhood Najafi, Leila Aghajanpour, Seyed Jafar Hashemian, Saeed Heidari Keshel, Ikuya Watanabe, Alireza Valanezhad, Tahereh Sadat Jafarzadeh Kashi
Hydroxyapatite (HA) is a proper scaffold for bone repair, however, it is not of excellent mechanical properties. Most previous studies on the effect of temperature increases were in vitro and had assessed merely improvements of HA's physicomechanical quality. This in vitro/vivo study investigated the effect of temperature increases from 870 to 920°C on physicomechanical and biological quality of Nano-HA. Forty experimentally produced HA disks sintered at 870 to 920°C were prepared (n=20×2). Disks were subjected to Vickers microindentation test (1 disk from each group divided into 4 quarters), Fourier transform infrared spectroscopy (1 disk), X-ray diffraction (XRD) [1 disk together with non-sintered HA], field emission scanning electron microscopy (FSEM, 1 disk from each group together with non-sintered HA), cell seeding and SEM assessment (2 disks), MTT assay over 4 different time periods (16 quadrants of 4 disks from each group), 6 one-thirds of 2 disks from each group for immunocytochemical (ICC) assay, and 8 disks from each group [as well as non-sintered HA] for the animal study (implantation in 4 sockets in 8 rabbits [32 specimens], histomorphometry, and computerized tomography) over two time periods...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28512477/physical-properties-and-chemical-characterization-of-two-experimental-epoxy-resin-root-canal-sealers
#19
Hengameh Ashraf, Farhood Najafi, Soolmaz Heidari, Manijeh Mohammadian, Saeede Zadsirjan
INTRODUCTION: The aim of this in vitro study was to evaluate the setting time, flow, film thickness, solubility, radiopacity and characterization analysis of three epoxy resin based sealers including two experimental sealers and AH-26. METHODS AND MATERIALS: Five samples of each material were evaluated for setting time, flow, film thickness, solubility and radiopacity according to ISO 6876 Standard. Characterization of sealers was performed under the scanning electron microscopy (SEM), X-ray energy dispersive spectroscopy, X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28497089/impact-of-oral-capsule-of-peganum-harmala-on-alleviating-urinary-symptoms-in-men-with-benign-prostatic-hyperplasia-a-randomized-clinical-trial
#20
Majid Shirani-Boroujeni, Saeed Heidari-Soureshjani, Zahra Keivani Hafshejani
Introduction: Benign prostatic hyperplasia (BPH) is considered as a major cause of lower urinary tract symptoms (LUTS) in older men and its most common sign is nocturia. Objectives: This study aimed to determine the effect of the seeds of Peganum harmala compared with tamsulosin on alleviating urinary symptoms in patients with BPH. Patients and Methods: In this single blind clinical trial study, 90 patients diagnosed with BPH and LUTS, based on international prostate standard survey (IPSS) were divided into three groups...
2017: Journal of Renal Injury Prevention
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