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Esmaeil Biazar

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https://www.readbyqxmd.com/read/27458512/synthesis-and-evaluation-of-multi-wall-carbon-nanotube-paclitaxel-complex-as-an-anti-cancer-agent
#1
Fariba Ghasemvand, Esmaeil Biazar, Sara Tavakolifard, Mohammad Khaledian, Saeid Rahmanzadeh, Daruosh Momenzadeh, Roshanak Afroosheh, Faezeh Zarkalami, Marjan Shabannezhad, Saeed Hesami Tackallou, Nilofar Massoudi, Saeed Heidari Keshel
AIM: The aim of this study was to design multi-walled carbon nanotubes (MWCNTs) loaded with paclitaxel (PTX) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer. BACKGROUND: Carbon nanotubes (CNTs) represent a novel nano-materials applied in various fields such as drug delivery due to their unique chemical properties and high drug loading. PATIENTS AND METHODS: In this study, multi-walled carbon nanotubes (MWCNTs) pre-functionalized covalently with a paclitaxel (PTX) as an anti-cancer drug and evaluated by different analyses including, scanning electron microscope (SEM), particle size analyzer and cellular analyses...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27095384/fabrication-of-polyhydroxybutyrate-phb-%C3%AE-fe2o3-nanocomposite-film-and-its-properties-study
#2
Shokooh Moghaddam, Mohammad Taghi Khorasani, Hesam Hosseinkazemi, Esmaeil Biazar, Mahyar Fazeli
Magnetic separation has numerous advantages in isolating cancerous and normal cells used in the diagnosis and treatment sectors. Here, we produced magnetic nanocomposite films made of polyhydroxybutyrate (PHB)/magnetite nanoparticles (γ-Fe2O3), and the properties of the films by SEM, TEM, FTIR, DMTA, contact angle, and cellular analyses were investigated. The microscopic images showed uniform distribution of γ-Fe2O3 magnetic nanoparticles in polymeric matrix. The chemical bounds between magnetic nanoparticles and polymeric matrix demonstrated using the FTIR spectrophotometer...
June 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/26837778/electrospun-mat-with-eyelid-fat-derived-stem-cells-as-a-scaffold-for-ocular-epithelial-regeneration
#3
Daruosh Momenzadeh, Alireza Baradaran-Rafii, Saeed Heidari Keshel, Maryam Ebrahimi, Esmaeil Biazar
The aim of this study was to develop nanofibrous gelatin substrates for eyelid fat stem cell (EFSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane. Biocompatibility results indicated that all substrates were highly biocompatible, as EFSCs could favorably attach and proliferate on the nanofibrous surfaces. Microscopic figures showed that the EFSC were firmly anchored to the substrates and were able to retain a normal stem cell phenotype. Immunocytochemistry (ICC) and real time-PCR results revealed change in the expression profile of EFSCs grown on nanofibrous substrates when compared to those grown on control in epithelial induction condition...
February 2, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/26836973/chitosan-and-polypropylene-oriented-surface-modification-using-excimer-laser-and-their-biocompatibility-study
#4
Mohammad Khaledian, Faeze Jiroudhashemi, Esmaeil Biazar
Surface modification of medical polymers is carried out to improve biocompatibility. In this study, conventional polymers (chitosan and polypropylene) were modified to laser at different features (oriented and non-oriented) to create a vast range of physicochemical characteristics on the surface of polymers and investigate their effects on biocompatibility of treated surfaces. Atomic force microscope (AFM) was applied to study the morphology of treated samples in comparison with those of the untreated PS. Contact angle analyses were used to evaluate the wettability and surface energy of the treated films...
February 2, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/26324020/oriented-nanofibrous-silk-as-a-natural-scaffold-for-ocular-epithelial-regeneration
#5
COMPARATIVE STUDY
Esmaeil Biazar, Alireza Baradaran-Rafii, Saeed Heidari-keshel, Sara Tavakolifard
The aim of this study was to develop nanofibrous silk substrates for limbal stem cell expansion that can serve as a potential alternative substrate to replace human amniotic membrane. The human limbal stem cell was used to evaluate the biocompatibility of substrates (random and oriented nanofibrous mats, and human amniotic membrane) based on their phenotypic profile, viability, proliferation, and attachment ability. Biocompatibility results indicated that all substrates were highly biocompatible, as limbal stem cells could favorably attach and proliferate on the nanofibrous surfaces...
2015: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/26140614/human-unrestricted-somatic-stem-cells-loaded-in-nanofibrous-pcl-scaffold-and-their-healing-effect-on-skin-defects
#6
Hoda Bahrami, Saeed Heidari Keshel, Aliakbar Jafari Chari, Esmaeil Biazar
Unrestricted somatic stem cells (USSCs) loaded in nanofibrous polycaprolactone (PCL) scaffolds can be used for skin regeneration when grafted onto full-thickness skin defects of rats. Nanofibrous PCL scaffolds were designed by the electrospinning method and crosslinked with laminin protein. Afterwards, the scaffolds were evaluated by scanning electron microscopy, and physical and mechanical assays. In this study, nanofibrous PCL scaffolds loaded with USSCs were grafted onto the skin defects. The wounds were subsequently investigated 21 days after grafting...
September 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/25897888/cellular-response-of-limbal-stem-cells-on-polycaprolactone-nanofibrous-scaffolds-for-ocular-epithelial-regeneration
#7
Alireza Baradaran-Rafii, Esmaeil Biazar, Saeed Heidari-keshel
PURPOSE: The aim of this study was to develop nanofibrous polycaprolactone (PCL) substrate for limbal stem cell (LSC) expansion that can serve as a potential alternative substrate to replace human amniotic membrane (AM). MATERIALS AND METHODS: The human limbus stem cell was used to evaluate the biocompatibility of substrates (nanofibrous scaffold and, human AM) based on their phenotypic profile, viability, proliferation and attachment ability. RESULTS: Biocompatibility results indicated that the all substrates were highly biocompatible, as LSCs could favorably attach and proliferate on the nanofibrous surface...
2016: Current Eye Research
https://www.readbyqxmd.com/read/25783856/synthesis-and-evaluation-of-single-wall-carbon-nanotube-paclitaxel-folic-acid-conjugate-as-an-anti-cancer-targeting-agent
#8
Sara Tavakolifard, Esmaeil Biazar, Khalil Pourshamsian, Mohammad H Moslemin
Single-wall carbon nanotubes (SWCNT) represent a novel nanomaterial applied in various nanotechnology fields because of their surface chemistry properties and high drug cargo capacity. In this study, SWCNT are pre-functionalized covalently with paclitaxel (PTX) - an anticancer drug, and folic acid (FA), as a targeting agent for many tumors. The samples are investigated and evaluated by different analyses such as Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), absorption spectroscopic measurements (UV-Visible), elemental analysis, and cell analyses with cancer cell line cultures...
August 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/25710767/electrospun-poly-3-hydroxybutyrate-co-3-hydroxyvalerate-hydroxyapatite-scaffold-with-unrestricted-somatic-stem-cells-for-bone-regeneration
#9
Esmaeil Biazar, Saeed Heidari Keshel
The combination of scaffolds and cells can be useful in tissue reconstruction. In this study, nanofibrous poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/nanohydroxyapatite (nano-HAp) scaffolds, filled with unrestricted somatic stem cells (USSCs), were used for healing calvarial bone in rat model. The healing effects of these scaffolds, with and without stem cells, in bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting. The results of CT analysis showed that bone regeneration on the scaffolds, and the amounts of regenerated new bone for polymer/nano-HAp scaffold with USSC, was significantly greater than the scaffold without cell and untreated control samples...
May 2015: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/25206560/efficacy-of-nanofibrous-conduits-in-repair-of-long-segment-sciatic-nerve-defects
#10
Esmaeil Biazar, Saeed Heidari Keshel, Majid Pouya
Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous sciatic nerve to bridge 30-mm-long rat sciatic nerve gaps. Within 4 months after surgery, rat sciatic nerve functional recovery was evaluated per month by behavioral analyses, including toe out angle, toe spread analysis, walking track analysis, extensor postural thrust, swimming test, open-field analysis and nociceptive function...
September 25, 2013: Neural Regeneration Research
https://www.readbyqxmd.com/read/25206536/nanofibrous-nerve-conduits-for-repair-of-30-mm-long-sciatic-nerve-defects
#11
Esmaeil Biazar, Saeed Heidari Keshel, Majid Pouya, Hadi Rad, Melody Omrani Nava, Mohammad Azarbakhsh, Shirin Hooshmand
It has been confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit can promote peripheral nerve regeneration in rats. However, its efficiency in repair of over 30-mm-long sciatic nerve defects needs to be assessed. In this study, we used a nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit to bridge a 30-mm-long gap in the rat sciatic nerve. At 4 months after nerve conduit implantation, regenerated nerves were cally observed and histologically assessed. In the nanofibrous graft, the rat sciatic nerve trunk had been reconstructed by restoration of nerve continuity and formation of myelinated nerve fiber...
August 25, 2013: Neural Regeneration Research
https://www.readbyqxmd.com/read/24456082/use-of-umbilical-cord-and-cord-blood-derived-stem-cells-for-tissue-repair-and-regeneration
#12
REVIEW
Esmaeil Biazar
INTRODUCTION: Potential use of umbilical cord (UC) is one of the most exciting frontiers in medicine for repairing damaged tissues. UC and cord blood-derived stem cells are the world's largest potential sources of stem cells. UC contains a mixture of stem and progenitor cells at different lineage commitment stages and UC has been verified as a candidate for cell-based therapies and tissue engineering applications due to the capability of these cells for extensive self-renewal and multi-lineage character in differentiation potential...
March 2014: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/24456006/bone-reconstruction-in-rat-calvarial-defects-by-chitosan-hydroxyapatite-nanoparticles-scaffold-loaded-with-unrestricted-somatic-stem-cells
#13
Esmaeil Biazar, Saeed Heidari Keshel, Mostafa Rezaei Tavirani, Rahim Jahandideh
Calcium phosphates are one of the biomaterials that are used for bone regeneration. In this study, Hydroxyapatite (HAp) nanoparticles with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model. The healing effects of these injectable scaffolds with and without stem cells for bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting. The results of CT analysis showing bone regeneration on the scaffolds, also the amounts of regenerated new bone for USSC scaffold was significantly greater than the scaffold without cell and untreated controls...
April 2015: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/24399063/rat-sciatic-nerve-reconstruction-across-a-30-mm-defect-bridged-by-an-oriented-porous-phbv-tube-with-schwann-cell-as-artificial-nerve-graft
#14
Mina Karimi, Esmaeil Biazar, Saeed Heidari Keshel, Abdolaziz Ronaghi, Jafar Doostmohamadpour, Alireza Janfada, Arash Montazeri
An oriented poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit has been used to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rats. The oriented porous micropatterned artificial nerve conduit was designed onto the micropatterned silicon wafers, and then their surfaces were modified with oxygen plasma to increase cell adhesion. The designed conduits were investigated by cell culture analyses with Schwann cells (SCs). The conduits were implanted into a 30 mm gap in sciatic nerves of rats...
March 2014: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/24346243/regeneration-of-full-thickness-skin-defects-using-umbilical-cord-blood-stem-cells-loaded-into-modified-porous-scaffolds
#15
Reza Zeinali, Esmaeil Biazar, Saeed Heidari Keshel, Mostafa Rezaei Tavirani, Kamal Asadipour
In this study, we have demonstrated the ability of cord blood (CB)-derived unrestricted somatic stem cells (USSCs) and chitosan-modified poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffold to promote skin regeneration. Afterward, the scaffolds were evaluated by structural, microscopic, physical, and mechanical assays and cell culture analyses. Results of structural, physical, and mechanical analyses also showed a good resilience and compliance with movement as a skin graft. Cellular experiments showed a better cell adhesion, growth, and proliferation inside the modified scaffolds compared with unmodified ones...
January 2014: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/24172271/chitosan-cross-linked-nanofibrous-phbv-nerve-guide-for-rat-sciatic-nerve-regeneration-across-a-defect-bridge
#16
Esmaeil Biazar, Saeed Heidari Keshel
The aim of this study was to produce a chitosan-cross-linked nanofibrous biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nerve conduit. The artificial nerve scaffold designed by electrospinning method and cross-linked with chitosan by chemical method. Afterwards, the scaffolds were evaluated by microscopic, physical, and mechanical analyses and cell culture assays with Schwann cells. The conduits were implanted into a 10 mm gap in the sciatic nerves of the rats. Four months after surgery, the regenerated nerves were evaluated by macroscopic assessments and histology...
November 2013: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/24088030/bone-formation-in-calvarial-defects-by-injectable-nanoparticular-scaffold-loaded-with-stem-cells
#17
Esmaeil Biazar, Saeed Heidari Keshel, Mostafa Rezaei Tavirani, Rahim Jahandideh
OBJECTIVE: Calcium phosphates are one of biomaterials that are used for bone regeneration. In this study, calcium phosphate nanoparticles such as hydroxyapatite (HA)/fluorapatite (FA),with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model. METHODS: The healing effects of these injectable scaffolds, with and without stem cells, in bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting...
December 2013: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/24041294/behavioral-evaluation-of-regenerated-rat-sciatic-nerve-by-a-nanofibrous-phbv-conduit-filled-with-schwann-cells-as-artificial-nerve-graft
#18
Esmaeil Biazar, Saeed Heidari Keshel, Majid Pouya
The aim of this study is to develop a nanofibrous polymeric nerve conduit with Schwann cells (SCs) and to evaluate its efficiency on the promotion of functional and locomotive activities in rats. The conduits were implanted into a 30-mm gap in the sciatic nerves of the rats. Four months after surgery, the rats were monitored and evaluated by behavioral analyses such as toe out angle, toe spreading analysis, walking track analysis, extensor postural thrust, open-field analysis, swimming test and nociceptive function, four months post surgery...
October 2013: Cell Communication & Adhesion
https://www.readbyqxmd.com/read/24040773/development-of-chitosan-crosslinked-nanofibrous-phbv-guide-for-repair-of-nerve-defects
#19
Esmaeil Biazar, Saeed Heidari Keshel
The aim of this study was to produce a chitosan-crosslinked nanofibrous biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nerve conduit. The artificial scaffold was designed by electrospinning method, and cross-linked with chitosan by chemical method. The scaffolds were evaluated by microscopic, physical, and mechanical analyses, and cell culture assays with Schwann cells. Results of analyses showed a good resilience and compliance with movement as a neural graft. Cellular experiments showed a better cell adhesion and growth inside the crosslinked nanofibrous scaffolds compared with un-crosslinked ones...
December 2014: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/23909504/the-healing-effect-of-unrestricted-somatic-stem-cells-loaded-in-collagen-modified-nanofibrous-phbv-scaffold-on-full-thickness-skin-defects
#20
Saeed Heidari Keshel, Esmaeil Biazar, Mostafa Rezaei Tavirani, Mohammad Rahmati Roodsari, Abdolaziz Ronaghi, Maryam Ebrahimi, Hadi Rad, Ali Sahebalzamani, Azadeh Rakhshan, Kobra Afsordeh
Unrestricted somatic stem cells (USSCs) loaded in nanofibrous PHBV scaffold can be used for skin regeneration when grafted into full-thickness skin defects of rats. Nanofibrous PHBV scaffolds were designed using electrospinning method and then, modified with the immobilized collagen via the plasma method. Afterward, the scaffolds were evaluated using scanning electron microscopy, physical and mechanical assays. In this study; nanofibrous PHBV scaffolds loaded with and without USSCs were grafted into the skin defects...
June 2014: Artificial Cells, Nanomedicine, and Biotechnology
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