Fatemeh Karimi, Esmaeil Biazar, Saeed Heidari-Keshel, Bahareh Pourjabbar, Mohammad Reza Khataminezhad, Shervin Shirinbakhsh, S Yasaman Zolfaghari-Moghaddam
Platelet-rich fibrin (PRF) as a rich source of effective growth factors has been used as a scaffold in tissue regeneration. It is known that PRF exhibits rapid degradability against enzymes, which should be decreased using crosslinking agents to reduce the release rate of growth factors and increase the effectiveness of tissue regeneration. In this study, a carbodiimide crosslinker with different concentrations (0.01%, 0.05%, 1%, and 2%) was used to modify and improve the properties of PRF gel. The crosslinked gels were evaluated with analyses such as SEM, swelling, degradability, mechanical strength, release test, cytotoxicity, and cell adhesion...
April 28, 2022: RSC Advances