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symblepharon ocular surgery

Pinnita Prabhasawat, Pattama Ekpo, Mongkol Uiprasertkul, Suksri Chotikavanich, Nattaporn Tesavibul, Kanograt Pornpanich, Panitee Luemsamran
The present study aimed to investigate the clinical outcomes of autologous cultivated oral mucosal epithelial transplantation (COMET) on human amniotic membrane (AM) for corneal limbal stem cell deficiency (LSCD). In this prospective, noncomparative case series, 20 eyes (18 patients) with bilateral severe ocular surface disease were chosen to undergo COMET on human AM. The primary outcome was clinical success, and the secondary outcomes were the best-corrected visual acuity difference, corneal opacification, symblepharon formation, and complications...
September 2016: Cell and Tissue Banking
Wendy W Lee, Dimitra Portaliou, Mohamed S Sayed, Shrutika Kankariya
To report the occurrence of diplopia and symblepharon following conjunctival Muellerectomy for ptosis repair in 3 patients under chronic antiglaucoma treatment. In this retrospective observational case series, 3 patients were identified who were being treated chronically with multiple antiglaucoma agents and concurrently underwent Mueller's muscle conjunctival resection (MMCR) for the management of ptosis. These patients developed conjunctival scarring and symblepharon extending from the operative site to the bulbar conjunctiva postoperatively...
July 21, 2016: Ophthalmic Plastic and Reconstructive Surgery
Shreya Thatte, Jagriti Jain
PURPOSE: Fornix contracture is an obstacle for fitting a prosthesis in blind or enucleated patients, and may lead to disfigurement and psychological issues. This study evaluates the efficacy of amniotic membrane transplantation (AMT) for fornix reconstruction with the aim of better retention of the ocular prosthesis. METHODS: This non-comparative interventional case series includes eighteen blind eyes with fornix deformity in which a cosmetic prosthesis could not be retained...
April 2016: Journal of Ophthalmic & Vision Research
Haijun Gong, Shiyou Zhou, Yuxin Hu, Yuqin Lan, Hong Zeng, Liangchun Wang, Qingyu Liu, Mei Wang
BACKGROUND: The ocular presentation of Castleman's disease (CD)-associated paraneoplastic pemphigus (PNP) has rarely been reported. In this report, we describe a young patient with CD-associated PNP who had recurrent corneal ulceration in addition to cicatrizing conjunctivitis. CASE PRESENTATION: We describe a case of 23-year-old male with mucocutaneous erosion and conjunctival injection and erosion who was found to have PNP. Pelvic hyaline-vascular CD was detected and completely excised...
2016: BMC Ophthalmology
Namrata Sharma, Divya Singh, Prafulla K Maharana, Alka Kriplani, Thirumurthy Velpandian, Ravindra Mohan Pandey, Rasik B Vajpayee
PURPOSE: To compare the efficacy of topical umbilical cord serum drops (UCS) and amniotic membrane transplantation (AMT) in acute ocular chemical burns. DESIGN: Randomized controlled trial. METHODS: setting: Tertiary care hospital. STUDY POPULATION: Forty-five eyes with acute chemical burns of grade III, IV, and V (Dua's classification) presenting within the first week of injury were randomized into 3 groups (15 each)...
August 2016: American Journal of Ophthalmology
Dandan Zhao, Han Y Yin, Anny Cheng, Rendian Chen, Hosam Sheha, Scheffer C G Tseng
PURPOSE: To report the surgical outcome of "sealing the gap" in treating symblepharon caused by various etiologies other than recurrent pterygium. DESIGN: Retrospective, interventional case series. METHODS: Sixteen eyes of 14 patients with pathogenic symblepharon were consecutively operated by conjunctival recession, sealing the gap between recessed conjunctiva and Tenon capsule with a running 9-0 nylon suture, and covering of the bare sclera with amniotic membrane...
September 2015: American Journal of Ophthalmology
Osman Ondas, Sadullah Keles
BACKGROUND: The aim of this study was to evaluate central corneal thickness in patients with atopic keratoconjunctivitis. MATERIAL AND METHODS: The study was conducted in the Atatürk University School of Medicine between April 2011 and June 2013. The study group included 60 eyes of 30 patients with atopic keratoconjunctivitis. Sixty eyes of 30 healthy individuals without any ophthalmic or systemic pathology were used as a control group. The central corneal thickness was measured with ultrasonic pachymetry...
2014: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Ladan Espandar, Delmar Caldwell, Richard Watson, Tomas Blanco-Mezquita, Shijia Zhang, Bruce Bunnell
PURPOSE: To evaluate the therapeutic effect of human adipose-derived stem cells (hASCs) overlaid on a scleral contact lens (SCL) carrier in a rabbit model of ocular alkaline burn. MATERIALS AND METHODS: After inducing alkaline burn in 11 New Zealand white rabbits, hASCs cultured on SCLs were placed on the right eye of 5 rabbits, SCLs without cells were used in 5, and no treatment was applied in 1 eye. Each eye was examined and photographed for corneal vascularization, opacities, and epithelial defect in week 1, 2, and 4 after surgery...
July 2014: Eye & Contact Lens
M Emesz, E M Krall, M Rasp, F M Bauer, G Grabner, E M Arlt
BACKGROUND: Mucosal grafts from the hard palate for reconstruction of the posterior lamella of the upper eyelid were compared for three different indications. The plastic reconstruction of the upper eyelid was carried out in patients with symblepharon and upper eyelid entropion following an autoimmune disease, in patients with subtotal or total upper eyelid resection due to a neoplasm and in patients with mucous membrane trauma using autogenous mucosal grafts from the hard palate. PATIENTS: In this retrospective comparative interventional case series 23 eyes from 19 patients were included in whom upper eyelid reconstruction was undertaken at the University Eye Hospital in Salzburg between 2001 and 2012...
September 2014: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
José Santiago López-García, Luis Rivas, Isabel García-Lozano, Eduardo Conesa, Isabel Elosua, Juan Murube
PURPOSE: To evaluate ocular features and histopathologic changes in patients with toxic epidermal necrolysis (TEN) treated with amniotic membrane transplantation (AMT) in the acute phase. METHODS: A prospective study of 5 eyes (3 patients) with severe ocular involvement and 4 eyes (2 patients) with moderate involvement treated with AMT in the acute phase of TEN was performed. Patients underwent a complete ophthalmic assessment before the intervention and 3, 6, 9, and 12 months postoperatively...
September 2014: European Journal of Ophthalmology
Afshan A Nanji, Christina S Moon, Anat Galor, Julia Sein, Patrick Oellers, Carol L Karp
PURPOSE: Treatment for ocular surface squamous neoplasia (OSSN) has historically been surgery, but nonsurgical interventions are increasingly used. Treatment with interferon is efficacious, but evidence is needed regarding recurrence and complication rates in comparison with surgery. The objective of this study is to compare the recurrence and complication rates of surgical treatment and interferon treatment for OSSN. DESIGN: A matched, case-control study. PARTICIPANTS: Ninety-eight patients with OSSN, 49 of whom were treated with interferon (IFN) α2b therapy and 49 of whom were treated with surgical intervention...
May 2014: Ophthalmology
Rasik B Vajpayee, Himanshu Shekhar, Namrata Sharma, Vishal Jhanji
OBJECTIVE: To review the risk factors, management, and visual outcomes of pediatric chemical eye injuries in a tertiary care hospital in North India. DESIGN: Retrospective hospital-based study. PARTICIPANTS: Patients aged <16 years with ocular chemical burns. METHODS: Case records of patients with ocular chemical injury who presented to the Dr. Rajendra Prasad Centre for Ophthalmic Sciences were reviewed over a 5-year period...
January 2014: Ophthalmology
Sandhya V Subramaniam, Kunjal Sejpal, Anees Fatima, Subhash Gaddipati, Geeta K Vemuganti, Virender S Sangwan
BACKGROUND: Cultivated limbal epithelium for reconstruction of corneal surface is a well-established procedure; however, it is not adequate for damage which also extensively involves the conjunctiva. In severe cases of ocular surface damage that warrant additional conjunctival transplantation apart from cultivated limbal stem cell transplantation, we describe the long-term survival of a novel method of cocultivating autologous limbal and conjunctival epithelium on a single substrate. MATERIALS AND METHODS: Forty eyes of 39 patients with severe limbal stem cell deficiency and conjunctival scarring or symblepharon underwent transplantation of autologous cocultivated epithelium on human amniotic membrane...
May 2013: Indian Journal of Ophthalmology
Chie Sotozono, Tsutomu Inatomi, Takahiro Nakamura, Noriko Koizumi, Norihiko Yokoi, Mayumi Ueta, Kotone Matsuyama, Keiko Miyakoda, Hideaki Kaneda, Masanori Fukushima, Shigeru Kinoshita
PURPOSE: To report the effectiveness, disease-specific outcomes, and safety of cultivated oral mucosal epithelial sheet transplantation (COMET), with the primary objective of visual improvement. DESIGN: Noncomparative, retrospective, interventional case series. PARTICIPANTS: This study involved 46 eyes in 40 patients with complete limbal stem cell deficiency (LSCD) who underwent COMET for visual improvement. These LSCD disorders fell into the following 4 categories: Stevens-Johnson syndrome (SJS; 21 eyes), ocular cicatricial pemphigoid (OCP; 10 eyes), thermal or chemical injury (7 eyes), or other diseases (8 eyes)...
January 2013: Ophthalmology
Ahmad Kheirkhah, Reza Ghaffari, Reza Kaghazkanani, Hassan Hashemi, Mahmoud Jabbarvand Behrouz, Vadrevu K Raju
PURPOSE: To evaluate the results of a combined approach of cicatrix lysis, intraoperative mitomycin C (MMC) application, oral mucosal transplantation (OMT), and amniotic membrane transplantation (AMT) for surgery of severe symblepharon. METHODS: This prospective study included 32 eyes with severe symblepharon in which after cicatrix lysis the residual conjunctiva was not enough to cover the tarsus (grade III symblepharon) or there was no residual conjunctiva (grade IV symblepharon)...
February 2013: Cornea
E Mameletzi, M Hamedani, F Majo, Y Guex-Crosier
Mucous membrane pemphigoid (MMP) is a progressive inflammatory disease of autoimmune etiology. We performed a retrospective analysis of clinical signs and treatment on 16 patients. Conjunctival biopsies were performed in all patients and showed typical immuno-deposits at the basement membrane zone. The mean age at presentation was 69 years, 60 % were female.12 patients demonstrated ocular involvement (11 bilaterally). At the time of referral to our hospital, 92 % had reached an advanced stage III or IV. All patients presented conjunctival fibrosis with resultant fornix foreshortening...
April 2012: Klinische Monatsblätter Für Augenheilkunde
Raman Malhotra, Carmen Yau, Jonathan H Norris
PURPOSE: To report indications and outcomes of a technique for the correction of lower eyelid cicatricial entropion using a lower eyelid gray-line split, inferior retractor recession, lateral-horn lysis, and anterior lamella repositioning. PATIENTS AND METHODS: Retrospective, 5-year, single-center, consecutive case series of patients with lower eyelid cicatricial margin entropion undergoing the above procedure. Patients with significant inferior fornix contraction or symblepharon undergoing concurrent fornix reconstruction with buccal mucosal grafts at the same time as lamella repositioning were excluded...
March 2012: Ophthalmic Plastic and Reconstructive Surgery
Sonal Anchlia, Krishna Shama Rao, Krishnamurthy Bonanthaya, B Anupama, I Vittal Nayak
Cleft lip and palate (CL and P) represents the second most frequently occurring congenital deformity after clubfoot deformity. CL and P could be associated with many other structural abnormalities of the adjacent vital structures of the face. In this study, an attempt was made to identify the abnormalities of the ocular structures seen in patients with isolated CL and P as well as in those with syndromic CL and P. Of the 322 patients with cleft lip and palate screened, 27 (8.3%) had ocular abnormalities. Totally 47 ocular defects were identified in 27 patients...
March 2011: Journal of Maxillofacial and Oral Surgery
Esmeralda Delgado
A 4-month-old crossbred female dog presented with complaints of poor vision and odd appearance of the eyes. At the age of a month, the animal was found lying in a railway road in a very bad condition and was rescued from death. At that time, the patient was presented with severe bilateral ocular discharge, and from both eyes, dipterous fly larvae were extracted. The dog was given symptomatic treatment (deworming, topical and systemic antibiotics, nutritional support) but never regained a normal eye appearance...
May 2012: Veterinary Ophthalmology
Reshma A Mehendale, Linda R Dagi
Amniotic membrane grafts are used extensively for ocular surface reconstruction. We describe the case of a 66-year-old man with traumatic, restrictive strabismus. Amniotic membrane was applied to resolve symblepharon between the globe and lids and also to prevent re-formation of adhesions between extraocular muscles and adjacent titanium plates placed during prior surgery.
August 2011: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
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