Salma Adeeb, Tarek Ziad Arabi, Hassan Shah, Sulaiman Alsalameh, Mylia Abu-Shaar, Abduljalil Mohamed El-Sibai, Khaled Alkattan, Ahmed Yaqinuddin
Neutrophil extracellular traps (NETs) play an essential role in antimicrobial defense. However, NETs have also been shown to promote and mediate a wide spectrum of diseases, including cancer, diabetes mellitus, cardiovascular diseases, and ocular diseases. Data regarding NETs in ocular diseases remain limited. In physiological conditions, NETs protect the eye from debris and cleave proinflammatory cytokines, including several interleukins. On the other hand, NETs play a role in corneal diseases, such as dry eye disease and ocular graft-versus-host disease, where they promote acinar atrophy and delayed wound healing...
January 17, 2024: Journal of Clinical Medicine