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Papular acantholytic dyskeratosis

Adrienne L K Li, Matthew Cesari, R Michael Shier
No abstract text is available yet for this article.
October 2017: Journal of Lower Genital Tract Disease
Hyun Soo Lee, You Chan Kim
No abstract text is available yet for this article.
June 2017: Annals of Dermatology
C Baliu-Piqué, P Iranzo
No abstract text is available yet for this article.
January 2017: Actas Dermo-sifiliográficas
Maher Al-Muriesh, Bilal Abdul-Fattah, Xia Wang, Mengjie Zhao, Siyuan Chen, Changzheng Huang
BACKGROUND: Papular acantholytic dyskeratosis (PAD) of the anogenital/genitocrural area is described as a rare distinct clinicopathological entity known to dermatopathologists, although its characteristic histopathologic pattern resembles both Hailey-Hailey disease and Darier disease. The objective of this study is to describe the clinical characteristics, histopathologic features and response to treatment of PAD. METHODS: We report in detail six cases of PAD. A literature search of the keyword 'papular acantholytic dyskeratosis' was performed on Google scholar and PubMed, 21 cases of this entity were found...
September 2016: Journal of Cutaneous Pathology
Margaret L Dowd, Leah H Ansell, Sameera Husain, Marc E Grossman
No abstract text is available yet for this article.
March 2016: JAAD Case Reports
J Wesley Fletcher, Arathi Ramamurthi, Palak Parekh
Epidermolytic hyperkeratosis is a histological reaction pattern seen in a variety of disease processes, including epidermolytic ichthyosis, Vorner's epidermolytic palmoplantar keratoderma, epidermal nevus, and solitary epidermolytic acanthoma. Here we present the case of a 59-year-old woman with multiple asymptomatic papules on her vulva. Clinical differential diagnoses included condyloma acuminata, seborrheic keratoses, bowenoid papulosis, adnexal tumors, and papular acantholytic dyskeratosis. Shave biopsy revealed findings consistent with epidermolytic hyperkeratosis...
April 2016: Proceedings of the Baylor University Medical Center
W Y Yu, E Ng, C Hale, S Hu, M K Pomeranz
Papular acantholytic dyskeratosis (PAD) of the vulva is a rare, chronic disorder first described in 1984. It presents in young women as white to skin-coloured smooth papules over the vulva, which are persistent but asymptomatic. Histologically, there is hyperkeratosis and focal parakeratosis with acantholytic and dyskeratotic cells forming corps ronds and grains, placing PAD within Ackerman's spectrum of focal acantholytic dyskeratoses with Hailey-Hailey disease (HHD) and Darier disease. There have been 17 previous reports of PAD of the vulva, to our knowledge...
August 2016: Clinical and Experimental Dermatology
Eleanor A Knopp, Corey Saraceni, Jeremy Moss, Jennifer M McNiff, Keith A Choate
Papular acantholytic dyskeratosis, also known as acantholytic dermatosis of the vulvocrural (or anogenital) area, is an uncommon eruption reported predominantly in women. This entity manifests with pruritic papules in the groin/anogenital area and less commonly on the chest. The pathobiology of papular acantholytic dyskeratosis is uncertain. A 62-year-old woman presented with multiple verrucous-appearing lesions in the groin and on the chest showing acantholytic dyskeratosis on histopathology. Given histological similarity of these papular acantholytic dyskeratosis lesions to Darier disease due to inherited ATP2A2 mutation, we screened affected and normal tissue and peripheral blood in our patient for mutations in ATP2A2...
November 2015: Journal of Cutaneous Pathology
Shyam B Verma
A case of Papular acantholytic dermatosis restricted to the perianal area is being reported in a 26 year old male without involvement of the genitalia, groin and upper thighs for the first time in English literature. The patient presented with long standing grayish white confluent papules with eroded areas in the perianal region which were asymptomatic for a long time before the area got macerated. He did not respond to many weeks of topical steroids but is now showing improvement with topical tacrolimus ointment 0...
September 2013: Indian Journal of Dermatology
María-Teresa Fernández-Figueras, Luis Puig, Pablo Cannata, Miriam Cuatrecases, Ariadna Quer, Carlos Ferrándiz, Aurelio Ariza
Grover disease (GD) is a rather common papular pruritic dermatosis that can be transient, persistent, or asymptomatic. The microscopic diagnosis of clinically suspected lesions can be challenging because GD can adopt different patterns, and involved areas are generally admitted to be mostly focal. The histopathologic hallmark of the disease is acantholysis, frequently combined with dyskeratosis, which confers the lesions an appearance similar to Darier disease, Hailey-Hailey disease, or pemphigus. Eczematous features can be observed as well...
August 2010: American Journal of Dermatopathology
C J Dittmer, A Hornemann, C Rose, K Diedrich, M Thill
BACKGROUND: The papular acantholytic dyskeratosis summarizes a collection of papular skin lesions which occur in intertriginous areas and in the genital area. They show a very characteristic histology without the connection to a syndrome such as the Hailey-Hailey disease or the Darier disease. METHODS: We present the case of an affected 45-year-old woman and evaluate the laser therapy as therapeutic option. RESULTS: A long lasting reduction of the symptoms was achieved by paying special attention to involving the deep tissue layers while performing the laser therapy...
April 2010: Archives of Gynecology and Obstetrics
Mi Ryung Roh, Yoon Jin Choi, Kwang Gil Lee
We describe a 63-year-old woman with an asymptomatic papular eruption on the vulva. Clinically, the lesions showed multiple pin-head-sized whitish papules on the labia major. Histologically, the biopsy specimen showed acantholysis throughout the epidermis with the presence of dyskeratotic cells resembling corps ronds and grains, hyperkeratosis and parakeratosis. These clinical and histological findings were consistent with the diagnosis of papular acantholytic dyskeratosis of the vulva which is a rare disorder, first described in 1984...
July 2009: Journal of Dermatology
Fiona Browne, Helen Keane, Maureen Walsh, Raymond Maw
A 24-year-old woman presented with genital warts which did not respond to treatment. Biopsy confirmed changes in keeping with a diagnosis of Darier's disease. The patient, however, had no other manifestations of Darier's disease, i.e. family history of skin disease, nail changes or other skin site involvement. We propose that this patient has a form of Darier's disease called genital papular acantholytic dyskeratosis.
December 2007: International Journal of STD & AIDS
A T Güneş, T Ilknur, U Pabuççuoğlu, B Lebe, D D Altiner
Acantholytic dyskeratosis is a distinct histological pattern characterized by hyperkeratotic and parakeratotic epidermis with intraepidermal clefts harbouring acantholytic and dyskeratotic keratinocytes. This histopathological pattern is uncommon in dermatoses of the anogenital region. We report a 30-year-old woman who had numerous smooth whitish papules on the labia majora, perineum and perianal region, which coalesced into plaques in some areas. Microscopically, the lesions showed prominent suprabasal and intraspinous acantholysis with dyskeratotic keratinocytes...
May 2007: Clinical and Experimental Dermatology
Fotini Boutli, Maria Voyatzi, Ioanna Lefaki, Giorgos Chaidemenos, Jean Kanitakis
Grover's disease ("transient acantholytic dermatosis") is a transient dermatosis of unknown cause manifesting clinically as a papular skin eruption located usually on the anterior chest and abdomen and histologically with dyskeratosis and acantholysis. Grover's disease has occasionally been reported in patients with chronic renal failure, HIV infection, hematological malignancies and bone-marrow allotransplantation. We report herein a new case of Grover's disease that developed in a renal transplant patient...
March 2006: Journal of Dermatology
Ana María Sáenz, Antonietta Cirocco, Mónica Avendaño, Francisco González, José R Sardi
We describe an 11-year-old girl with a persistent pruritic papular eruption on the vulva. Clinically, the lesions consisted of whitish papules and erosions located on the inner aspect of the labia majora. There was no familial history of skin diseases. Histologically, a biopsy specimen showed difuse hyperkeratosis, parakeratosis, acantholysis throughout the thickness of the epidermis, and the presence of corps ronds. Those findings were consistent with a diagnosis of acantholytic dyskeratosis. At 3 years follow-up, only isolated hyperkeratotic, asymptomatic papules on the same location remained...
May 2005: Pediatric Dermatology
Paula Bergua, Lluís Puig, María-Teresa Fernández-Figueras, Eulalia Baselga, Agustín Alomar
Acantholytic dyskeratosis is a histopathologic pattern defined by a hyperkeratotic and parakeratotic epidermis with intraepidermal clefts containing acantholytic and dyskeratotic keratinocytes. These typical features are distinctive but not entirely pathognomonic of Darier disease, since they may occur at cutaneous and mucocutaneous sites in other conditions such as Grover disease, acantholytic and dyskeratotic epidermal nevus (nevus of Starink), warty dyskeratoma, or acantholytic papular dermatosis localized to the vulvocrural area...
May 2003: Pediatric Dermatology
H L de Almeida Júnior, M Wolter, L A Castro, N E Rocha
Papular acantholytic dyskeratosis is a very rare skin disease, which shows a suprabasilar cleft with acantholytic and dyskeratotic cells, simulating the light microscopic picture of Darier disease. In this condition, the lesions are acquired without a genetic basis. We observed a 40-year-old woman with about 200 papules on the lower aspects of her legs; histological examination showed changes similar to Darier disease. Transmission electron microscopy showed a reduced number of desmosomes and perinuclear distribution of tonofilaments...
December 2001: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
H K Bell, C W Farrar, R K Curley
We describe two patients with unusual asymptomatic, papular lesions on the vulva, clinically resembling lichen planus, the histology of which revealed unexpected findings of suprabasilar clefting, acantholysis and dyskeratotic cells giving rise to corps ronds and grains together with hyperkeratosis and parakeratosis, features originally associated with a diagnosis of Darier's disease. Focal acantholytic dyskeratosis has been described in a wide variety of inflammatory and neoplastic processes including those involving mucous membranes and has been attributed various diagnostic labels...
July 2001: Clinical and Experimental Dermatology
H E Peştereli, S Karaveli, S Oztekin, G Zorlu
We report a case of 44-year-old woman with persistent pruritic papules on the left and right labium majus of the vulva. Histopathologic examination of the vulvar biopsy specimen revealed a suprabasal separation of the epidermis with acantholysis and dyskeratosis.
October 2000: International Journal of Gynecological Pathology
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