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Acantholytic dyskeratotic dermatoses

Hemlata Panwar, Deepti Joshi, Garima Goel, Dinesh Asati, Kaushik Majumdar, Neelkamal Kapoor
Aims: Tzanck smear is an old but useful test for diagnosis of cutaneous dermatoses. The aim of this study was to highlight the potential usefulness and diagnostic pitfalls of Tzanck smear for diagnosis of cutaneous dermatoses and infections. Materials and Methods: This hospital based cross-sectional study was carried out on all Tzanck smears received for a period of twenty months (January 2014-August 2015). The smears were assessed to establish the utility of Tzanck smears in corroborating or excluding a diagnosis of immunobullous lesion or herpetic infection...
October 2017: Journal of Cytology
C Hamsch, E Hadaschik
Focal, mostly suprabasal acantholyis with development of dyskeratotic keratinocytes are typical histological features of Grover's disease. The histological distinction between other forms of acantholytic dermatoses is often difficult. A combined assessment of the histological findings and the clinical symptoms often allows a clear diagnosis. The disease is self-limiting but treatment is necessary in some cases due to the sometimes excessive pruritis.
June 2012: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
R Baran
Red nail is a common disorder. However, a thorough examination of the patient's nails allows one to distinguish different diseases. For example, longitudinal erythronychia may be monodactylous or polydactylous. Only the former type can show histologically Bowen's disease or an amelanotic melanoma. Among the polydactylous type, the nosologic position of the acantholytic and dyskeratotic naevus versus Darier's disease is still controversial. Acantholytic epidermolysis bullosa looks like bullous Darier's disease, and acrokeratosis of Hopf may present also red longitudinal streaks...
November 2009: Actas Dermo-sifiliográficas
A T Güneş, T Ilknur, U Pabuççuoğlu, B Lebe, D D Altiner
Acantholytic dyskeratosis is a distinct histological pattern characterized by hyperkeratotic and parakeratotic epidermis with intraepidermal clefts harbouring acantholytic and dyskeratotic keratinocytes. This histopathological pattern is uncommon in dermatoses of the anogenital region. We report a 30-year-old woman who had numerous smooth whitish papules on the labia majora, perineum and perianal region, which coalesced into plaques in some areas. Microscopically, the lesions showed prominent suprabasal and intraspinous acantholysis with dyskeratotic keratinocytes...
May 2007: Clinical and Experimental Dermatology
Kenneth S Resnik, Gary R Kantor, Mario DiLeonardo
Granular parakeratosis was originally described as a dermatosis confined to the axillae that histopathologically shows characteristic findings in the cornified layer consisting of parakeratotic corneocytes housing keratohyaline granules. Since the original description of this entity, non-intertriginous examples and even incidental foci of granular parakeratotic corneocytes in association with other dermatoses have been recognized. This report details the findings of a previously unreported entity that we are naming granular parakeratotic acanthoma, which is fundamentally akin to acantholytic dyskeratotic acanthoma and epidermolytic acanthoma (ie, a solitary keratosis that histopathologically displays features indicated in its name)...
October 2005: American Journal of Dermatopathology
H L de Almeida Júnior, M Wolter, L A Castro, N E Rocha
Papular acantholytic dyskeratosis is a very rare skin disease, which shows a suprabasilar cleft with acantholytic and dyskeratotic cells, simulating the light microscopic picture of Darier disease. In this condition, the lesions are acquired without a genetic basis. We observed a 40-year-old woman with about 200 papules on the lower aspects of her legs; histological examination showed changes similar to Darier disease. Transmission electron microscopy showed a reduced number of desmosomes and perinuclear distribution of tonofilaments...
December 2001: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
M Akiyama, Y Hata, T Nishikawa
A case of keratoacanthoma (KA) with glandular proliferation was reported. The tumor was a firm, dome-shaped, elevated nodule on the cheek of an 82-year-old Japanese male. Generally, the tumor showed the typical histopathological features of KA; slight nuclear atypia and mitotic figures were present in a cup-shaped proliferation of keratinocytes and, in the center of the lesion, a keratin-filled crater with nests of dyskeratotic and acantholytic cells was seen. In the bottom of the lesion, a glandular structure forming branching, thin lumina was observed...
February 1993: Journal of Dermatology
M Raff, J Szilvassy
Palmar and finger prints were obtained in patients with acantholytic dyskeratotic dermatoses. Identical patterns were found with Darier's disease, Grover's disease, Galli-Galli disease, acrokeratosis verruciformis of Hopf, and warty dyskeratoma. Because dermatoglyphic patterns are a genetically determined individual characteristic, we propose that acantholytic dyskeratotic dermatoses with identical dermatoglyphic patterns are variable manifestations of a single disorder, despite their broad spectrum of clinical manifestations...
November 1989: Journal of the American Academy of Dermatology
G F Kao, V I Sulica
Focal acantholytic dyskeratosis (FAD) is a distinctive histologic pattern characterized by suprabasilar clefts surrounding dermal papillae (villi), acantholytic and dyskeratotic cells at all levels of the epidermis, hyperkeratosis, and parakeratosis. The features of FAD are typically seen in Darier's disease, warty dyskeratoma, and transient acantholytic dermatosis; they are also present in a variety of cutaneous neoplastic and nonneoplastic lesions. FAD, however, has not been previously described in lesions of inflammatory dermatoses...
April 1989: American Journal of Dermatopathology
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