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Sheng-Ling Tung, Ting-Ywan Chou, Hung-Shi Tseng, Chi-Ming Lee
OBJECTIVE: To report our experiences with 40 patients who were treated with magnetic resonance-guided focused ultrasound surgery (MRgFUS) for uterine fibroids and their 6-month follow-up status. MATERIALS AND METHODS: A total of 40 patients with uterine fibroids underwent MRgFUS from January 2009 to November 2011. The Uterine Fibroid Symptoms and Quality of Life Questionnaire was used to determine the patients' Symptom Severity Scores (SSS) prior to and 6 months after treatment...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
Michael Marx, Pejman Ghanouni, Kim Butts Pauly
PURPOSE: MR thermometry is critical for safe and effective transcranial focused ultrasound. The current single-slice MR thermometry sequence cannot achieve all desired treatment monitoring requirements. We propose an approach in which the imaging requirements of different aspects of treatment monitoring are met by optimizing multiple sequences. METHODS: Imaging requirements were determined for three stages of MR-guided focused ultrasound brain treatment: 1) focal spot localization, 2) focal spot monitoring, and 3) background monitoring...
October 4, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
I E Porotikova, L V Adamyan, T Y Gavrilova, E A Kulabukhova
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Nicholas Ellens, Ari Partanen
Effective pre-clinical research is a vital component in the development of MRI-guided focused ultrasound (MRgFUS) and its translation to clinic. In this review we seek to outline the challenges at hand for effective pre-clinical research, survey different solutions, and underline best practices. Furthermore, we summarize efforts to build and characterize dedicated pre-clinical MRgFUS equipment, including lab prototypes and available commercial products. Finally, we discuss constraints and considerations specific to using clinical MRgFUS equipment in preclinical research...
September 13, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Jae-Hyeok Jeong, Gil Pyo Hong, Yu-Ri Kim, Jae-Eun Ha, Kyu-Sup Lee
OBJECTIVES: Magnetic resonance imaging (MRI)-guided high intensity focused ultrasound surgery (MRgFUS) is a newly emerging non-invasive technique for the treatment of uterine fibroids. The purpose of this study is to review the clinical impact of MRgFUS. METHODS: This study examined 157 patients. The high intensity focused ultrasound (HIFU) utilized in this study was Philips Achieva 1.5 Tesla MR (Philips Healthcare, Best, the Netherlands) and Sonalleve HIFU system...
August 2016: Journal of Menopausal Medicine
Megan E Poorman, Vandiver L Chaplin, Ken Wilkens, Mary D Dockery, Todd D Giorgio, William A Grissom, Charles F Caskey
BACKGROUND: MR-guided focused ultrasound or high-intensity focused ultrasound (MRgFUS/MRgHIFU) is a non-invasive therapeutic modality with many potential applications in areas such as cancer therapy, drug delivery, and blood-brain barrier opening. However, the large financial costs involved in developing preclinical MRgFUS systems represent a barrier to research groups interested in developing new techniques and applications. We aim to mitigate these challenges by detailing a validated, open-source preclinical MRgFUS system capable of delivering thermal and mechanical FUS in a quantifiable and repeatable manner under real-time MRI guidance...
2016: Journal of Therapeutic Ultrasound
Karl D Price, Vivian W Sin, Charles Mougenot, Samuel Pichardo, Thomas Looi, Adam C Waspe, James M Drake
PURPOSE: Current treatment of intraventricular hemorrhage (IVH) involves cerebral shunt placement or an invasive brain surgery. Magnetic resonance-guided focused ultrasound (MRgFUS) applied to the brains of pediatric patients presents an opportunity to treat IVH in a noninvasive manner, termed "incision-less surgery." Current clinical and research focused ultrasound systems lack the capability to perform neonatal transcranial surgeries due to either range of motion or dexterity requirements...
September 2016: Medical Physics
Chiara Marigliano, Giovanna Panzironi, Luisa Molisso, Alessandra Pizzuto, Federica Ciolina, Alessandro Napoli, Paolo Ricci
PURPOSE: Definition of the role of real-time elastography (RTE) in the evaluation of response to treatment of uterine fibroids using MRgFUS in symptomatic patients. MATERIALS AND METHODS: 28 women with 34 symptomatic fibroids, selected for MRgFUS, were enrolled. The patients were preliminarily studied with MRI and suprapubic and transvaginal ultrasound examination including RTE; the follow-up was performed immediately after treatment, at 3 months and 12 months with the same technique...
September 1, 2016: La Radiologia Medica
Michele Anzidei, Alessandro Napoli, Beatrice Sacconi, Fabrizio Boni, Vincenzo Noce, Michele Di Martino, Luca Saba, Carlo Catalano
PURPOSE: To assess the correlation between functional MRI, including ADC values obtained from DWI and DCE, and clinical outcome in patients with bone metastases treated with MRgFUS. METHODS AND MATERIALS: Twenty-three patients with symptomatic bone metastases underwent MRgFUS treatment (ExAblate 2100 system InSightec) for pain palliation. All patients underwent clinical and imaging follow-up examinations at 1, 3 and 6 months after treatment. Visual Analog Scale (VAS) score was used to evaluate treatment efficacy in terms of pain palliation while ADC maps obtained by DWI sequences, and DCE data were used for quantitative assessment of treatment response at imaging...
August 27, 2016: La Radiologia Medica
Hao Wu, Guofeng Shen, Yazhu Chen
This study evaluated an electromagnetic compatibility method for high-intensity focused ultrasound (HIFU) and magnetic resonance (MR) imaging in an MR-guided focused ultrasound surgery using a conductive wire mesh screen. This screen has a good ultrasound transmission and shielding effectiveness. A hybrid acoustic simulation method was developed to analyze the effects of mesh parameters and the HIFU working frequency on the acoustic field. Experiments were performed to measure both acoustic pressure profile and radiated electromagnetic noise...
December 2016: Ultrasonics
Elena A Kaye, Sebastien Monette, Govindarajan Srimathveeravalli, Majid Maybody, Stephen B Solomon, Amitabh Gulati
PURPOSE: About 10-40% of chronic low back pain cases involve facet joints, which are commonly treated with lumbar medial branch (MB) radiofrequency neurotomy. Magnetic resonance imaging-guided focused ultrasound (MRgFUS), a non-invasive, non-ionising ablation modality used to treat tumours, neuropathic pain and painful bone metastasis can also be used to disrupt nerve conduction. This work's purpose was to study the feasibility and safety of direct MRgFUS ablation of the lumbar MB nerve in acute and subacute swine models...
November 2016: International Journal of Hyperthermia
Bryant T Svedin, Michael J Beck, J Rock Hadley, Robb Merrill, Joshua T de Bever, Bradley D Bolster, Allison Payne, Dennis L Parker
PURPOSE: To develop a method for rapid prediction of the geometric focus location in MR coordinates of a focused ultrasound (US) transducer with arbitrary position and orientation without sonicating. METHODS: Three small tracker coil circuits were designed, constructed, attached to the transducer housing of a breast-specific MR-guided focused US (MRgFUS) system with 5 degrees of freedom, and connected to receiver channel inputs of an MRI scanner. A one-dimensional sequence applied in three orthogonal directions determined the position of each tracker, which was then corrected for gradient nonlinearity...
July 15, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Aaron E Bond, Robert Dallapiazza, Diane Huss, Amy L Warren, Scott Sperling, Ryder Gwinn, Binit B Shah, W Jeffrey Elias
INTRODUCTION: Traditional stereotactic radiofrequency thalamotomy has been used with success in medication-refractory tremor-dominant Parkinson disease (PD). Recently, transcranial magnetic resonance-guided focused ultrasound (MRgFUS) has been used to successfully perform thalamotomy for essential tremor. We designed a double-blinded, randomized controlled trial to investigate the effectiveness of MRgFUS thalamotomy in tremor-dominant PD. METHODS: Patients with medication-refractory, tremor-dominant PD were enrolled in the 2-center study and randomly assigned 1:2 to receive either a sham procedure or treatment...
August 2016: Neurosurgery
Y C Shi, D L Parker, C R Dillon
This study evaluates the sensitivity of two magnetic resonance-guided focused ultrasound (MRgFUS) thermal property estimation methods to errors in required inputs and different data inclusion criteria. Using ex vivo pork muscle MRgFUS data, sensitivities to required inputs are determined by introducing errors to ultrasound beam locations (r error  =  -2 to 2 mm) and time vectors (t error  =  -2.2 to 2.2 s). In addition, the sensitivity to user-defined data inclusion criteria is evaluated by choosing different spatial (r fit  =  1-10 mm) and temporal (t fit  =  8...
August 7, 2016: Physics in Medicine and Biology
Georgios Menikou, Marinos Yiannakou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
OBJECTIVE: The goal of the proposed study was the development of a magnetic resonance imaging (MRI) compatible bone phantom suitable for evaluating focused ultrasound protocols. MATERIALS AND METHODS: High resolution CT images were used to segment femur bone. The segmented model was manufactured with (Acrylonitrile Butadiene Styrene) ABS plastic using a 3-D printer. The surrounding skeletal muscle tissue was mimicked using an agar-silica-evaporated milk gel (2% w/v-2% w/v-40% v/v)...
September 2016: Ultrasonics
Michael J Temple, Adam C Waspe, Joao G Amaral, Alessandro Napoli, Suzanne LeBlang, Pejman Ghanouni, Matthew D Bucknor, Fiona Campbell, James M Drake
Recent studies have demonstrated the effectiveness of magnetic resonance-guided focused ultrasound (MRgFUS) in the treatment of osteoid osteoma (OO), a painful, benign bone tumor. As MRgFUS is a noninvasive and radiation-free treatment, it stands to replace the current standard of care, percutaneous radiofrequency, or laser thermal ablation. Within an institution, creation of a clinical OO MRgFUS treatment program would not only provide cutting edge medical treatment at the current time but would also establish the foundation for an MRgFUS clinical service to introduce treatments currently under development into clinical practice in the future...
2016: Journal of Therapeutic Ultrasound
Carlo Masciocchi, Francesco Arrigoni, Alice La Marra, Silvia Mariani, Luigi Zugaro, Antonio Barile
The objective of this study was to evaluate the role of MR-guided focused ultrasound surgery and radiofrequency ablation in the management of bone and soft-tissue lesions. Musculoskeletal interventional radiology represents an interesting option for the treatment of benign bone and soft-tissue lesions to avoid the invasiveness of surgery and related risks. The imaging techniques now available, besides representing an optimal guide, allow control of the temperature reached in the region of interest, avoiding or minimizing damage to the sensitive structures surrounding the lesion...
October 2016: British Journal of Radiology
Pejman Ghanouni, Andrew Dobrotwir, Alberto Bazzocchi, Matthew Bucknor, Rachelle Bitton, Jarrett Rosenberg, Kristen Telischak, Maurizio Busacca, Stefano Ferrari, Ugo Albisinni, Shannon Walters, Garry Gold, Kristen Ganjoo, Alessandro Napoli, Kim Butts Pauly, Raffi Avedian
OBJECTIVES: To assess the feasibility, safety and preliminary efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) for the treatment of extra-abdominal desmoid tumours. METHODS: Fifteen patients with desmoid fibromatosis (six males, nine females; age range, 7-66 years) were treated with MRgFUS, with seven patients requiring multiple treatments (25 total treatments). Changes in viable and total tumour volumes were measured after treatment. Efficacy was evaluated using an exact one-sided Wilcoxon test to determine if the median reduction in viable tumour measured immediately after initial treatment exceeded a threshold of 50 % of the targeted volume...
May 5, 2016: European Radiology
C Tanner, Y Zur, K French, G Samei, J Strehlow, G Sat, H McLeod, G Houston, S Kozerke, G Székely, A Melzer, T Preusser
PURPOSE: Magnetic resonance-guided focused ultrasound (MRgFUS) of the liver during free-breathing requires spatio-temporal prediction of the liver motion from partial motion observations. The study purpose is to evaluate the prediction accuracy for a realistic MRgFUS therapy scenario, namely for human in vivo data, tracking based on MR images routinely acquired during MRgFUS and in vivo deformations caused by the FUS probe. METHODS: In vivo validation of the motion model was based on a 3D breath-hold image and an interleaved acquisition of two MR slices...
June 2016: International Journal of Computer Assisted Radiology and Surgery
Roland Krug, Loi Do, Viola Rieke, Mark W Wilson, Maythem Saeed
BACKGROUND: MR-guided focused ultrasound (MRgFUS) might be a very safe and effective minimally invasive technique to treat facet joint pain caused by arthritis and other degenerative changes. However, there are still safety concerns for this treatment and challenges regarding MR imaging and temperature mapping due to susceptibility effects between the bone and soft tissue near the joint, which has resulted in poor MR image quality. The goal of this research was to evaluate multiple magnetic resonance imaging (MRI) pulse sequences for characterizing ablated lumbar facet joint lesions created by high-intensity focused ultrasound (FUS) and compare the findings to histological tissue assessment...
2016: Journal of Therapeutic Ultrasound
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