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MRgFUS

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https://www.readbyqxmd.com/read/29054252/methodology-on-quantification-of-sonication-duration-for-safe-application-of-mr-guided-focused-ultrasound-for-liver-tumour-ablation
#1
Senay Mihcin, Ioannis Karakitsios, Nhan Le, Jan Strehlow, Daniel Demedts, Michael Schwenke, Sabrina Haase, Tobias Preusser, Andreas Melzer
BACKGROUND AND OBJECTIVE: Magnetic Resonance Guided Focused Ultrasound (MRgFUS) for liver tumour ablation is a challenging task due to motion caused by breathing and occlusion due the ribcage between the transducer and the tumour. To overcome these challenges, a novel system for liver tumour ablation during free breathing has been designed. METHODS: The novel TRANS-FUSIMO Treatment System (TTS, EUFP7) interacts with a Magnetic Resonance (MR) scanner and a focused ultrasound transducer to sonicate to a moving target in liver...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29053074/clinical-improvement-associated-with-targeted-interruption-of-the-cerebellothalamic-tract-following-mr-guided-focused-ultrasound-for-essential-tremor
#2
J Levi Chazen, Harini Sarva, Philip E Stieg, Robert J Min, Douglas J Ballon, Kane O Pryor, Paul M Riegelhaupt, Michael G Kaplitt
OBJECTIVE The objective of this study was to evaluate the utility of diffusion tensor imaging (DTI) tractography-based targeting of the dentatorubrothalamic tract (DRT) for magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in patients with essential tremor (ET) and correlate postprocedural tract disruption with clinical outcomes. METHODS Four patients received preprocedural and immediate postprocedural DTI in addition to traditional anatomical MRI sequences for MRgFUS thalamotomy. Optimal ablation sites were selected based on the patient-specific location of the DRT as demonstrated by DTI (direct targeting) and correlated with traditional atlas-based measurements for thalamic ventral intermediate nucleus (Vim) lesioning (indirect targeting)...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28926387/magnetic-resonance-guided-focused-ultrasound-versus-conventional-radiation-therapy-for-painful-bone-metastasis-a-matched-pair-study
#3
COMPARATIVE STUDY
Hsin-Lun Lee, Chia-Chun Kuo, Jo-Ting Tsai, Chun-You Chen, Meng-Huang Wu, Jeng-Fong Chiou
BACKGROUND: Magnetic resonance-guided focused ultrasound (MRgFUS) is an alternative local therapy for patients with painful bone metastasis for whom standard conventional radiation therapy (RT) has failed. However, the therapeutic effects of MRgFUS as a first-line treatment for bone metastasis remain uncertain. METHODS: A matched-pair study was conducted to compare the therapeutic effects of MRgFUS with those of conventional RT as a first-line treatment for patients with painful bone metastasis...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28917284/neurosurgical-applications-of-high-intensity-focused-ultrasound-with-magnetic-resonance-thermometry
#4
REVIEW
Rivka R Colen, Iman Sahnoune, Jeffrey S Weinberg
Magnetic resonance guided focused ultrasound surgery (MRgFUS) has potential noninvasive effects on targeted tissue. MRgFUS integrates MRI and focused ultrasound surgery (FUS) into a single platform. MRI enables visualization of the target tissue and monitors ultrasound-induced effects in near real-time during FUS treatment. MRgFUS may serve as an adjunct or replace invasive surgery and radiotherapy for specific conditions. Its thermal effects ablate tumors in locations involved in movement disorders and essential tremors...
October 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28819458/focused-ultrasound-hyperthermia-mediated-drug-delivery-using-thermosensitive-liposomes-and-visualized-with-in-vivo-two-photon-microscopy
#5
Marc A Santos, David E Goertz, Kullervo Hynynen
The future of nanomedicines in oncology requires leveraging more than just the passive drug accumulation in tumors through the enhanced permeability and retention effect. Promising results combining mild hyperthermia (HT) with lyso-thermosensitive liposomal doxorubicin (LTSL-DOX) has led to improved drug delivery and potent antitumor effects in pre-clinical studies. The ultimate patient benefit from these treatments can only be realized when robust methods of HT can be achieved clinically. One of the most promising methods of non-invasive HT is the use of focused ultrasound (FUS) with MRI thermometry for anatomical targeting and feedback...
2017: Theranostics
https://www.readbyqxmd.com/read/28810261/comparative-evaluation-of-magnetic-resonance-guided-focused-ultrasound-surgery-for-essential-tremor
#6
Minsoo Kim, Na Young Jung, Chang Kyu Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
BACKGROUND: Treatment options for patients with drug-resistant essential tremor (ET) are limited. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is an emerging technique to treat refractory ET. OBJECTIVES: To present MRgFUS as an alternative to radiofrequency (RF) thalamotomy or deep brain stimulation (DBS) for ET treatment. METHODS: We retrospectively analyzed 59 patients who underwent unilateral surgery for drug-resistant ET...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28747452/mri-guided-focused-ultrasound-thalamotomy-in-non-et-tremor-syndromes
#7
Alfonso Fasano, Maheleth Llinas, Renato P Munhoz, Eugen Hlasny, Walter Kucharczyk, Andres M Lozano
OBJECTIVE: To report the 6-month single-blinded results of unilateral thalamotomy with MRI-guided focused ultrasound (MRgFUS) in patients with tremors other than essential tremor. METHODS: Three patients with tremor due to Parkinson disease, 2 with dystonic tremor in the context of cervicobrachial dystonia and writer's cramp, and 1 with dystonia gene-associated tremor underwent MRgFUS targeting the ventro-intermedius nucleus (Vim) of the dominant hemisphere. The primary endpoint was the reduction of lateralized items of the Tremor Rating Scale of contralateral hemibody assessed by a blinded rater...
August 22, 2017: Neurology
https://www.readbyqxmd.com/read/28723697/the-history-and-future-of-ablative-neurosurgery-for-major-depressive-disorder
#8
Matthew Volpini, Peter Giacobbe, G Rees Cosgrove, Anthony Levitt, Andres M Lozano, Nir Lipsman
BACKGROUND: There is an urgent need to develop safe and effective treatments for patients with treatment-resistant depression (TRD). Several neurosurgical procedures have been developed to treat the dysfunctional brain circuits implicated in major depression. OBJECTIVES: This review describes the most common ablative procedures used to treat major depressive disorder: anterior cingulotomy, subcaudate tractotomy, limbic leucotomy, and anterior capsulotomy. The efficacy and safety of each are discussed and compared with other current and emerging modalities, including deep brain stimulation (DBS) and MR-guided focused ultrasound (MRgFUS)...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28714565/mri-compatible-breast-rib-phantom-for-evaluating-ultrasonic-thermal-exposures
#9
Georgios Menikou, Marinos Yiannakou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
INTRODUCTION: The target of this study was the development of a magnetic resonance imaging (MRI) compatible breast phantom for focused ultrasound which includes plastic (ABS) ribs. The objective of the current study was the evaluation of a focused ultrasound procedure using the proposed phantom that eliminates rib heating. MATERIAL AND METHODS: The proposed phantom was evaluated using two different focused ultrasound exposures. The surrounding breast tissue was mimicked using an agar-silica-evaporation milk gel (2% w/v - 2% w/v - 40% v/v)...
July 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28659546/focused-ultrasound-treatment-present-and-future
#10
Keiichi Abe, Takaomi Taira
The discovery that ultrasound waves could be focused inside the skull and heated to high temperatures at a focal point goes back to 1944. However, because the skull causes the ultrasound waves to attenuate and scatter, it was believed that application of this technology would be difficult, and that it would be impossible to use this approach in the surgical treatment of intracranial diseases. Eventually, magnetic resonance image guided focused ultrasound (MRgFUS) surgery began being used to treat uterine fibroids, breast cancer and bone metastasis and locally confined prostate cancer...
August 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28659052/magnetic-resonance-guided-focused-ultrasound-for-treatment-of-bone-tumors
#11
Vivek Ajit Singh, Syed Usman Shah, Nor Faissal Yasin, Basri Johan Jeet Abdullah
AIMS: Magnetic resonance guided focused ultrasound (MRgFUS) is a new modality in the management of primary and secondary bone tumors. We aimed to investigate the safety, efficacy, and feasibility of using MRgFUS for the treatment of (1) benign bone tumors with the intent of complete tumor ablation, (2) primary malignant bone tumors with the intent to assess its effectiveness in causing tumor necrosis, and (3) metastatic bone disease with the intent of pain relief. METHOD: Twenty-four patients with benign bone tumors, primary malignant bone tumors, and metastatic bone disease were treated with one session of MRgFUS...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28616236/effect-of-applied-energy-in-renal-sympathetic-denervation-with-magnetic-resonance-guided-focused-ultrasound-in-a-porcine-model
#12
Jill Shea, Joshua de Bever, Eugene Kholmovski, Hannah Beal, J Rock Hadley, Emilee Minalga, Mohamed E Salama, Nassir F Marrouche, Allison Payne
BACKGROUND: Past catheter-based and focused ultrasound renal denervation studies have indicated that procedure efficacy is related to the number of ablations performed or the amount of energy used for the ablation. This study extends those prior results and investigates energy level effects on the efficacy of MR guided focused ultrasound renal denervation performed in a porcine model. METHODS: Twenty-four normotensive pigs underwent unilateral denervation at three intensity levels...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28595499/thermal-diffusivity-and-perfusion-constants-from-in-vivo-mr-guided-focused-ultrasound-treatments-a-feasibility-study
#13
Christopher R Dillon, Viola Rieke, Pejman Ghanouni, Allison Payne
PURPOSE: This study investigates the feasibility of non-invasively determining thermal diffusivity (α) and the Pennes perfusion parameter (w) from preclinical and clinical magnetic resonance-guided focused ultrasound (MRgFUS) temperature data. MATERIALS AND METHODS: Pre-clinical MRgFUS experiments were performed in rabbit muscle (N = 3, 28 sonications) using three-dimensional MR thermometry. 8 sonications were made in a clinical QA phantom with two-dimensional thermometry...
June 8, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28560040/spatially-segmented-undersampled-mri-temperature-reconstruction-for-transcranial-mr-guided-focused-ultrasound
#14
Pooja Gaur, Beat Werner, Xue Feng, Samuel W Fielden, Craig H Meyer, William A Grissom
BACKGROUND: Volumetric thermometry with fine spatiotemporal resolution is desirable to monitor MR-guided focused ultrasound (MRgFUS) procedures in the brain, but requires some form of accelerated imaging. Accelerated MR temperature imaging methods have been developed that undersample k-space and leverage signal correlations over time to suppress the resulting undersampling artifacts. However, in transcranial MRgFUS treatments, the water bath surrounding the skull creates signal variations that do not follow those correlations, leading to temperature errors in the brain due to signal aliasing...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28553555/magnetic-resonance-imaging-guided-focused-ultrasound-surgery-for-the-treatment-of-symptomatic-uterine-fibroids
#15
Laura Geraci, Alessandro Napoli, Carlo Catalano, Massimo Midiri, Cesare Gagliardo
Uterine fibroids, the most common benign tumor in women of childbearing age, may cause symptoms including pelvic pain, menorrhagia, dysmenorrhea, pressure, urinary symptoms, and infertility. Various approaches are available to treat symptomatic uterine fibroids. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) represents a recently introduced noninvasive safe and effective technique that can be performed without general anesthesia, in an outpatient setting. We review the principles of MRgFUS, describing patient selection criteria for the treatments performed at our center and we present a series of five selected patients with symptomatic uterine fibroids treated with this not yet widely known technique, showing its efficacy in symptom improvement and fibroid volume reduction...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/28509682/new-neurosurgical-approaches-for-tremor-and-parkinson-s-disease
#16
Alfonso Fasano, Andres M Lozano, Esther Cubo
PURPOSE OF REVIEW: The objective of this review is to gather the newest advances in the surgical treatment of tremor and Parkinson's disease. We will briefly discuss the potential applications of the new technologies of deep brain stimulation (DBS), and we will focus on MRI-guided focused ultrasound (MRgFUS). RECENT FINDINGS: Novel DBS devices are being progressively adopted, particularly electrodes allowing a longer stimulating surface (suitable for multiple targets stimulation) and current radial steering (to minimize side effects of stimulation)...
August 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28505539/revisiting-bilateral-thalamotomy-for-tremor
#17
REVIEW
Jumana Alshaikh, Paul S Fishman
MRI guided focused ultrasound surgery (MRgFUS) has been FDA approved for unilateral treatment of essential tremor (ET). Before this non-incisional lesioning method can be applied to the treatment of both hemispheres the previous experience with bilateral thalamic ablation must be addressed. In particular, the high incidence of worsening of speech and balance associated with bilateral surgical thalamotomy, a rationale for the development of deep brain stimulation. The highest incidence of these complication occurred in the early years of surgery for movement disorders, when neither MRI nor current stereotactic methods were available...
July 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28503363/focused-ultrasound-for-essential-tremor-review-of-the-evidence-and-discussion-of-current-hurdles
#18
REVIEW
Mohammad Rohani, Alfonso Fasano
BACKGROUND: While there is no breakthrough progress in the medical treatment of essential tremor (ET), in the past decades several remarkable achievements happened in the surgical field, such as radiofrequency thalamotomy, thalamic deep brain stimulation, and gamma knife thalamotomy. The most recent advance in this area is magnetic resonance-guided focused ultrasound (MRgFUS). METHODS: The purpose of this review is to discuss the new developments and trials of MRgFUS in the treatment of ET and other tremor disorders...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28437003/high-intensity-focused-ultrasound-for-the-treatment-of-adenomyosis-selection-criteria-efficacy-safety-and-fertility
#19
REVIEW
Lian Zhang, Fangwen Rao, Raymond Setzen
Adenomyosis is a disorder of uterus in which endometrial glands and stroma are present within the uterine musculature. The main clinical manifestations are dysmenorrhea and menorrhagia. Adenomyosis has a great impact on both the quality of life and fertility of women. The treatment of adenomyosis remains an immense challenge. Relevant articles were searched through MEDLINE and PubMed between 2000 and March 2017. The search terms of adenomyosis, magnetic resonance imaging (MRI) features of adenomyosis, high intensity focused ultrasound (HIFU), ultrasound-guided HIFU and MRgFUS were used...
June 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28341966/efficacy-of-single-dose-gonadotropin-releasing-hormone-agonist-administration-prior-to-magnetic-resonance-guided-focused-ultrasound-surgery-for-symptomatic-uterine-fibroids
#20
Hyun Park, Sang Wook Yoon
PURPOSE: To investigate the effects of a single-dose GnRHa on the thermal ablation of MRgFUS in women with symptomatic fibroids. MATERIALS AND METHOD: In this pilot study, a single-dose GnRHa was administered in 17 patients with a total of 20 fibroids. Volume and scaled signal intensity (SSI) as an objective marker of fluid contents were prospectively followed up with serial MR scans. The control group of 17 patients with 19 fibroids were retrospectively enrolled and compared with GnRHa group in terms of non-perfused volume (NPV) and thermal dosimetry to assess the efficiency of thermal ablation...
August 2017: La Radiologia Medica
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