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https://www.readbyqxmd.com/read/28225581/effect-of-sonication-duration-and-power-on-ablation-depth-during-mr-guided-focused-ultrasound-of-bone
#1
Matthew D Bucknor, Eugene Ozhinsky, Rutwik Shah, Roland Krug, Viola Rieke
PURPOSE: To evaluate the effect of differences in sonication duration and power on the size of postcontrast ablation zone following magnetic resonance-guided focused ultrasound (MRgFUS) of bone in a swine femoral bone model. MATERIALS AND METHODS: Experimental procedures received approval from the Institutional Committee on Animal Research. MRgFUS was used to create two thermal lesions in the left femur of six pigs. Each target was subjected to six sonications. 400J of energy was used for each sonication...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28217678/usefulness-of-modified-brb-technique-in-treatment-to-ablate-uterine-fibroids-with-magnetic-resonance-image-guided-high-intensity-focused-ultrasound
#2
Jae-Heok Jeong, Kil-Pyo Hong, Yu-Ri Kim, Jae-Eun Ha, Kyu-Sup Lee
OBJECTIVE: If bowels and other structures are in the pathway of high-intensity focused ultrasound (HIFU) beam during magnetic resonance image-guided HIFU (MRgFUS) therapy, filling to the bladder and the rectum and then emptying the bladder (i.e., the BRB technique) is used to avoid them. A modified BRB technique might be useful method to using a uterine elevator method or by inducing uterus downward traction to lower the position of the uterus. METHODS: A total of 156 patients who had undergone MRgFUS surgery treatment for uterine fibroids from March 2015 to February 2016 were included in this retrospective study...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28211622/mri-guided-focused-ultrasound-robotic-system-for-animal-experiments
#3
Marinos Yiannakou, Georgios Menikou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
BACKGROUND: In this paper an MRI-guided focused ultrasound (MRgFUS) robotic system was developed that can be used for conducting experiments in small animals.The target for this robotic system regarding motion was to move a therapeutic ultrasound transducer in two Cartesian axes. METHODS: A single element spherically focused transducer of 3 cm diameter, focusing at 7 cm and operating at 0.4 MHz was used. The positioning device incorporates only MRI compatible materials...
February 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28174660/mrgfus-for-desmoid-tumors-within-the-thigh-early-clinical-experiences
#4
Matthew D Bucknor, Viola Rieke
BACKGROUND: Desmoid tumors are benign but locally aggressive non-malignant tumors derived from fibroblasts. Surgery, chemotherapy, and radiation therapy have been the mainstay of treatment, but recurrence is common and side effects can result in significant morbidity. In this case series, we highlight our experiences performing treatments in the thigh, including strategies for optimizing ablation size and safety. CASE PRESENTATION: Since December 2014, 14 magnetic resonance-guided focused ultrasound (MRgFUS) treatments for desmoid tumors were performed at our institution in seven patients...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28120053/restoring-neurological-physiology-the-innovative-role-of-high-energy-mr-guided-focused-ultrasound-himrgfus-preliminary-data-from-a-new-method-of-lesioning-surgery
#5
Antonella Giugno, Rosario Maugeri, Francesca Graziano, Cesare Gagliardo, Angelo Franzini, Carlo Catalano, Massimo Midiri, Domenico Gerardo Iacopino
BACKGROUND: Tremor is a disabling condition, common to several neurodegenerative diseases. Lesioning procedures and deep brain stimulation, respectively, of the ventralis intermedius nucleus for intentional tremor, and of the subthalamic nucleus for parkinsonian resting tremor, have been introduced in clinical practice for patients refractory to medical treatment. The combination of high-energy focused ultrasound (HIFUS) with sophisticated magnetic resonance (MR) instrumentation, together with accurate knowledge of the stereotactic brain coordinates, represents a revolution in neuromodulation...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28119893/expulsion-of-fibroids-to-the-endometrial-cavity-after-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-surgery-mrgfus-treatment-of-intramural-uterine-fibroids
#6
Jae-Hyeok Jeong, Gil Pyo Hong, Yu-Ri Kim, Da Gyo Hong, Jae-Eun Ha, Jung In Yeom, Eun-Jeong Kim, Hyung-Il Kim, Kyu-Sup Lee
OBJECTIVES: This report seeks to introduce some cases of the patients who received magnetic resonance imaging (MRI)-guided high intensity focused ultrasound (HIFU) surgery (MRgFUS)-based intramural uterine fibroids treatment where the post-MRgFUS intramural uterine fibroids decreased in its volume and protruded towards the endometrial cavity to be expelled by hysteroscopy. METHODS: Of the 157 patients who had received MRgFUS treatment in the Obstetrics and Gynecology of the Hospital from March, 2015 to February, 2016; this study examined 6 of the cases where, after high intensity focused ultrasound treatment, intramural uterine fibroids protruded towards the endometrial cavity to be removed by hysteroscopic myomectomy...
December 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28113664/pre-clinical-mri-guided-focused-ultrasound-a-review-of-systems-and-current-practices
#7
Nicholas Ellens, Ari Partanen
Effective pre-clinical research is a vital component in the development of MRI-guided focused ultrasound (MRgFUS) and its translation to clinic. In this review we seek to outline the challenges at hand for effective pre-clinical research, survey different solutions, and underline best practices. Furthermore, we summarize efforts to build and characterize dedicated pre-clinical MRgFUS equipment, including lab prototypes and available commercial products. Finally, we discuss constraints and considerations specific to using clinical MRgFUS equipment in preclinical research...
September 13, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27882240/t2-based-temperature-monitoring-in-bone-marrow-for-mr-guided-focused-ultrasound
#8
Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug, Viola Rieke
BACKGROUND: Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the temperature of the bone. The goal of this study was to determine if T2-based thermometry could be used to monitor the temperature change in bone marrow during focused ultrasound ablation of bone lesions. METHODS: We investigated the dependence of T2 on temperature in ex vivo bovine yellow bone marrow at 3T and studied the influence of acquisition parameters on the T2 measurements...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27790950/magnetic-resonance-texture-parameters-are-associated-with-ablation-efficiency-in-mr-guided-high-intensity-focussed-ultrasound-treatment-of-uterine-fibroids
#9
Arnaud Hocquelet, Baudouin Denis de Senneville, Nora Frulio, Cécile Salut, Mounir Bouzgarrou, Panteleimon Papadopoulos, Hervé Trillaud
OBJECTIVES: The objective of this study is to assess the association between texture parameter analysis derived from T2-weighted images and efficiency of magnetic resonance-guided focussed ultrasound (MRgFUS) ablation for the treatment of uterine fibroids. MATERIALS AND METHODS: Fifty-five women treated by MRgFUS were included in this retrospective analysis. Texture parameters were calculated using three 2D regions of interest placed on three consecutive slices on the same sagittal 3D T2-weighted images obtained at the beginning of MRgFUS ablation...
October 28, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27784190/acoustic-characterization-of-thiel-liver-for-magnetic-resonance-guided-focused-ultrasound-treatment
#10
Ioannis Karakitsios, Joyce Joy, Senay Mihcin, Andreas Melzer
BACKGROUND: The purpose of this work was to measure the essential acoustic parameters, i.e. acoustic impedance, reflection coefficient, attenuation coefficient, of Thiel embalmed human and animal liver. The Thiel embalmed tissue can be a promising, pre-clinical model to study liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS). MATERIAL AND METHODS: Using a single-element transducer and the contact pulse-echo method, the acoustic parameters, i...
October 27, 2016: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/27751409/a-retrospective-study-of-magnetic-resonance-guided-focused-ultrasound-ablation-for-uterine-myoma-in-taiwan
#11
Sheng-Ling Tung, Ting-Ywan Chou, Hung-Shi Tseng, Chi-Ming Lee
OBJECTIVE: To report our experiences with 40 patients who were treated with magnetic resonance-guided focused ultrasound surgery (MRgFUS) for uterine fibroids and their 6-month follow-up status. MATERIALS AND METHODS: A total of 40 patients with uterine fibroids underwent MRgFUS from January 2009 to November 2011. The Uterine Fibroid Symptoms and Quality of Life Questionnaire was used to determine the patients' Symptom Severity Scores (SSS) prior to and 6 months after treatment...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27699844/specialized-volumetric-thermometry-for-improved-guidance-of-mrgfus-in-brain
#12
Michael Marx, Pejman Ghanouni, Kim Butts Pauly
PURPOSE: MR thermometry is critical for safe and effective transcranial focused ultrasound. The current single-slice MR thermometry sequence cannot achieve all desired treatment monitoring requirements. We propose an approach in which the imaging requirements of different aspects of treatment monitoring are met by optimizing multiple sequences. METHODS: Imaging requirements were determined for three stages of MR-guided focused ultrasound brain treatment: 1) focal spot localization, 2) focal spot monitoring, and 3) background monitoring...
October 4, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27679142/intraoperative-monitoring-and-evaluation-of-mri-in-women-of-reproductive-age-after-previously-performed-uterine-artery-embolization-uae-and-mrgfus-ablation-of-fibroids
#13
I E Porotikova, L V Adamyan, T Y Gavrilova, E A Kulabukhova
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27662675/preclinical-mri-guided-focused-ultrasound-a-review-of-systems-and-current-practices
#14
Nicholas P K Ellens, Ari Partanen
Effective preclinical research is a vital component in the development of MRI-guided focused ultrasound (MRgFUS) and its translation to clinic. In this review, we seek to outline the challenges at hand for effective preclinical research, survey different solutions, and underline best practices. Furthermore, we summarize efforts to build and characterize dedicated preclinical MRgFUS equipment, including lab prototypes and available commercial products. Finally, we discuss constraints and considerations specific to using clinical MRgFUS equipment in preclinical research...
January 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27617244/clinical-consideration-of-treatment-to-ablate-uterine-fibroids-with-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-mrgfus-sonalleve
#15
Jae-Hyeok Jeong, Gil Pyo Hong, Yu-Ri Kim, Jae-Eun Ha, Kyu-Sup Lee
OBJECTIVES: Magnetic resonance imaging (MRI)-guided high intensity focused ultrasound surgery (MRgFUS) is a newly emerging non-invasive technique for the treatment of uterine fibroids. The purpose of this study is to review the clinical impact of MRgFUS. METHODS: This study examined 157 patients. The high intensity focused ultrasound (HIFU) utilized in this study was Philips Achieva 1.5 Tesla MR (Philips Healthcare, Best, the Netherlands) and Sonalleve HIFU system...
August 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27597889/open-source-small-animal-magnetic-resonance-guided-focused-ultrasound-system
#16
Megan E Poorman, Vandiver L Chaplin, Ken Wilkens, Mary D Dockery, Todd D Giorgio, William A Grissom, Charles F Caskey
BACKGROUND: MR-guided focused ultrasound or high-intensity focused ultrasound (MRgFUS/MRgHIFU) is a non-invasive therapeutic modality with many potential applications in areas such as cancer therapy, drug delivery, and blood-brain barrier opening. However, the large financial costs involved in developing preclinical MRgFUS systems represent a barrier to research groups interested in developing new techniques and applications. We aim to mitigate these challenges by detailing a validated, open-source preclinical MRgFUS system capable of delivering thermal and mechanical FUS in a quantifiable and repeatable manner under real-time MRI guidance...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27587029/design-and-validation-of-an-mr-conditional-robot-for-transcranial-focused-ultrasound-surgery-in-infants
#17
Karl D Price, Vivian W Sin, Charles Mougenot, Samuel Pichardo, Thomas Looi, Adam C Waspe, James M Drake
PURPOSE: Current treatment of intraventricular hemorrhage (IVH) involves cerebral shunt placement or an invasive brain surgery. Magnetic resonance-guided focused ultrasound (MRgFUS) applied to the brains of pediatric patients presents an opportunity to treat IVH in a noninvasive manner, termed "incision-less surgery." Current clinical and research focused ultrasound systems lack the capability to perform neonatal transcranial surgeries due to either range of motion or dexterity requirements...
September 2016: Medical Physics
https://www.readbyqxmd.com/read/27586131/first-experience-of-real-time-elastography-with-transvaginal-approach-in-assessing-response-to-mrgfus-treatment-of-uterine-fibroids
#18
Chiara Marigliano, Giovanna Panzironi, Luisa Molisso, Alessandra Pizzuto, Federica Ciolina, Alessandro Napoli, Paolo Ricci
PURPOSE: Definition of the role of real-time elastography (RTE) in the evaluation of response to treatment of uterine fibroids using MRgFUS in symptomatic patients. MATERIALS AND METHODS: 28 women with 34 symptomatic fibroids, selected for MRgFUS, were enrolled. The patients were preliminarily studied with MRI and suprapubic and transvaginal ultrasound examination including RTE; the follow-up was performed immediately after treatment, at 3 months and 12 months with the same technique...
December 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27567615/magnetic-resonance-guided-focused-ultrasound-for-the-treatment-of-painful-bone-metastases-role-of-apparent-diffusion-coefficient-adc-and-dynamic-contrast-enhanced-dce-mri-in-the-assessment-of-clinical-outcome
#19
Michele Anzidei, Alessandro Napoli, Beatrice Sacconi, Fabrizio Boni, Vincenzo Noce, Michele Di Martino, Luca Saba, Carlo Catalano
PURPOSE: To assess the correlation between functional MRI, including ADC values obtained from DWI and DCE, and clinical outcome in patients with bone metastases treated with MRgFUS. METHODS AND MATERIALS: Twenty-three patients with symptomatic bone metastases underwent MRgFUS treatment (ExAblate 2100 system InSightec) for pain palliation. All patients underwent clinical and imaging follow-up examinations at 1, 3 and 6 months after treatment. Visual Analog Scale (VAS) score was used to evaluate treatment efficacy in terms of pain palliation while ADC maps obtained by DWI sequences, and DCE data were used for quantitative assessment of treatment response at imaging...
December 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27448456/feasibility-of-an-electromagnetic-compatibility-method-for-mrgfus-using-a-wire-mesh-screen
#20
Hao Wu, Guofeng Shen, Yazhu Chen
This study evaluated an electromagnetic compatibility method for high-intensity focused ultrasound (HIFU) and magnetic resonance (MR) imaging in an MR-guided focused ultrasound surgery using a conductive wire mesh screen. This screen has a good ultrasound transmission and shielding effectiveness. A hybrid acoustic simulation method was developed to analyze the effects of mesh parameters and the HIFU working frequency on the acoustic field. Experiments were performed to measure both acoustic pressure profile and radiated electromagnetic noise...
December 2016: Ultrasonics
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