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MRgFUS

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https://www.readbyqxmd.com/read/29764258/reference-less-mr-thermometry-on-pre-clinical-thiel-human-cadaver-for-liver-surgery-with-mrgfus
#1
Ioannis Karakitsios, Senay Mihcin, Andreas Melzer
PURPOSE: Reference-less MR thermometry can be a promising technique for temperature mapping during liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS), as it is more robust to breathing motion than Proton Resonance Frequency MR thermometry. However, there is a lack of a pre-clinical model for repeatable testing of reference-less thermometry. The purpose of this work was to verify the explanted Thiel embalmed human liver and whole Thiel embalmed human cadaver for application of a custom made reference-less thermometry algorithm during MRgFUS sonication...
May 15, 2018: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29753957/brainstem-blood-brain-barrier-disruption-using-focused-ultrasound-a-demonstration-of-feasibility-and-enhanced-doxorubicin-delivery
#2
Saira Alli, Carlyn A Figueiredo, Brian Golbourn, Nesrin Sabha, Megan Yijun Wu, Andrew Bondoc, Amanda Luck, Daniel Coluccia, Colin Maslink, Christian Smith, Heiko Wurdak, Kullervo Hynynen, Meaghan O'Reilly, James T Rutka
Magnetic Resonance Image-guided Focused Ultrasound (MRgFUS) has been used to achieve transient BBB opening without tissue injury. Delivery of a targeted ultrasonic wave causes an interaction between administered microbubbles and the capillary bed resulting in enhanced vessel permeability. The use of MRgFUS in the brainstem has not previously been shown but could provide value in the treatment of tumours such as Diffuse Intrinsic Pontine Glioma (DIPG) where the intact BBB has contributed to the limited success of chemotherapy...
May 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29726769/skull-bone-marrow-injury-caused-by-mr-guided-focused-ultrasound-for-cerebral-functional-procedures
#3
Michael L Schwartz, Robert Yeung, Yuexi Huang, Nir Lipsman, Vibhor Krishna, Jennifer D Jain, Martin G Chapman, Andres M Lozano, Kullervo Hynynen
OBJECTIVE One patient for whom an MR-guided focused ultrasound (MRgFUS) pallidotomy was attempted was discovered to have multiple new skull lesions with the appearance of infarcts on the MRI scan 3 months after his attempted treatment. The authors conducted a retrospective review of the first 30 patients treated with MRgFUS to determine the incidence of skull lesions in patients undergoing these procedures and to consider possible causes. METHODS A retrospective review of the MRI scans of the first 30 patients, 1 attempted pallidotomy and 29 ventral intermediate nucleus thalamotomies, was conducted...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29717977/a-study-of-novel-bilateral-thermal-capsulotomy-with-focused-ultrasound-for-treatment-refractory-obsessive-compulsive-disorder-2-year-follow-up
#4
Se Joo Kim, Daeyoung Roh, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Jin Woo Chang
BACKGROUND: Recently, a new thermal lesioning approach using magnetic-resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this approach for treatment-refractory obsessive-compulsive disorder (OCD), and follow-up was short-term. We investigated the efficacy and safety of bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS in patients with treatment-refractory OCD and followed them for 2 years...
May 2, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29701544/safe-and-stable-noninvasive-focal-gene-delivery-to-the-mammalian-brain-following-focused-ultrasound
#5
Mihaela A Stavarache, Nicholas Petersen, Eric M Jurgens, Elizabeth R Milstein, Zachary B Rosenfeld, Douglas J Ballon, Michael G Kaplitt
OBJECTIVE Surgical infusion of gene therapy vectors has provided opportunities for biological manipulation of specific brain circuits in both animal models and human patients. Transient focal opening of the blood-brain barrier (BBB) by MR-guided focused ultrasound (MRgFUS) raises the possibility of noninvasive CNS gene therapy to target precise brain regions. However, variable efficiency and short follow-up of studies to date, along with recent suggestions of the potential for immune reactions following MRgFUS BBB disruption, all raise questions regarding the viability of this approach for clinical translation...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29696431/magnetic-resonance-guided-focused-high-frequency-ultrasound-ablation-for-focal-therapy-in-prostate-cancer-phase-1-trial
#6
Sangeet Ghai, Nathan Perlis, Uri Lindner, Eugen Hlasny, Masoom A Haider, Antonio Finelli, Alexandre R Zlotta, Girish S Kulkarni, Theodorus H van der Kwast, Stuart A McCluskey, Walter Kucharczyk, John Trachtenberg
OBJECTIVES: To evaluate the feasibility and safety of focal therapy for low-intermediate risk prostate cancer (PCa) with magnetic resonance-guided high frequency focused ultrasound (MRgFUS) METHODS: This IRB-approved phase 1 prospective study enrolled eight patients with prostate specific antigen (PSA) ≤ 10 ng/ml, ≤ cT2a and Gleason score ≤ 7 (4 + 3) disease following informed consent. Under MRI guidance, focused high frequency ultrasound energy was delivered to ablate the target tissue...
April 25, 2018: European Radiology
https://www.readbyqxmd.com/read/29628611/updates-on-mr-guided-focused-ultrasound-for-symptomatic-uterine-fibroids
#7
REVIEW
Divya Sridhar, Maureen P Kohi
Magnetic-resonance-guided focused ultrasound (MRgFUS), also called high-intensity focused ultrasound (HIFU) is an effective, noninvasive uterine-preserving treatment for symptomatic uterine fibroids. As the use of this therapeutic modality is not yet widespread, it may remain unfamiliar to many interventional radiologists. The purpose of this review is to discuss MRgFUS, including technology, patient selection, technique, outcomes, complications, and recent data on fertility and comparative effectiveness.
March 2018: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29527503/the-potential-value-of-probabilistic-tractography-based-for-mr-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#8
Evangelia Tsolaki, Angela Downes, William Speier, W Jeff Elias, Nader Pouratian
Magnetic Resonance-guided Focused UltraSound (MRgFUS) offers an incisionless approach to treat essential tremor (ET). Due to lack of evident internal anatomy on traditional structural imaging, indirect targeting must still be used to localize the lesion. Here, we investigate the potential predictive value of probabilistic tractography guided thalamic targeting by defining how tractography-defined targets, lesion size and location, and clinical outcomes interrelate. MR imaging and clinical outcomes from 12 ET patients that underwent MRgFUS thalamotomy in a pilot study at the University of Virginia were evaluated in this analysis...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29511672/percutaneous-high-frequency-microwave-ablation-of-uterine-fibroids-systematic-review
#9
REVIEW
Anna Maria Ierardi, Valeria Savasi, Salvatore Alessio Angileri, Mario Petrillo, Sara Sbaraini, Antonio Pinto, Francesco Hanozet, Anna Maria Marconi, Gianpaolo Carrafiello
Uterine fibroids are the most common benign pelvic tumor of the female genital tract and tend to increase with age; they cause menorrhagia, dysmenorrhea, pelvic pressure symptoms, back pain, and subfertility. Currently, the management is based mainly on medical or surgical approaches. The nonsurgical and minimally invasive therapies are emerging approaches that to the state of the art include uterine artery embolization (UAE), image-guided thermal ablation techniques like magnetic resonance-guided focused ultrasound surgery (MRgFUS) or radiofrequency ablation (RF), and percutaneous microwave ablation (PMWA)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29483853/minimally-invasive-procedures-in-the-management-of-uterine-fibroids
#10
REVIEW
Piotr Szkodziak, Filip Szkodziak, Kamila Trzeciak, Piotr Czuczwar
Uterine fibroids are benign uterine tumors. In women during the reproductive period, uterine fibroids occur in about 25%, whereas after this time, they are observed in more than 40% of women. In the majority of women (about 20-50%), such tumors do not cause discomfort and do not require treatment. Asymptomatic uterine fibroids usually undergo only regular medical control, whereas symptomatic fibroids are an indication for treatment. Current treatment methods include surgical, pharmacological and minimally invasive treatment...
December 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/29471172/enhancing-glioblastoma-treatment-using-cisplatin-gold-nanoparticle-conjugates-and-targeted-delivery-with-magnetic-resonance-guided-focused-ultrasound
#11
Daniel Coluccia, Carlyn A Figueiredo, Megan YiJun Wu, Alexandra N Riemenschneider, Roberto Diaz, Amanda Luck, Christian Smith, Sunit Das, Cameron Ackerley, Meaghan O'Reilly, Kullervo Hynynen, James T Rutka
Glioblastoma (GBM) is the most common and aggressive primary brain tumor resulting in high rates of morbidity and mortality. A strategy to increase the efficacy of available drugs and enhance the delivery of chemotherapeutics through the blood brain barrier (BBB) is desperately needed. We investigated the potential of Cisplatin conjugated gold nanoparticle (GNP-UP-Cis) in combination with MR-guided Focused Ultrasound (MRgFUS) to intensify GBM treatment. Viability assays demonstrated that GNP-UP-Cis greatly inhibits the growth of GBM cells compared to free cisplatin and shows marked synergy with radiation therapy...
February 20, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29467432/printed-receive-coils-with-high-acoustic-transparency-for-magnetic-resonance-guided-focused-ultrasound
#12
Joseph Corea, Patrick Ye, Dongjin Seo, Kim Butts-Pauly, Ana Claudia Arias, Michael Lustig
In magnetic resonance guided focused ultrasound (MRgFUS) therapy sound waves are focused through the body to selectively ablate difficult to access lesions and tissues. A magnetic resonance imaging (MRI) scanner non-invasively tracks the temperature increase throughout the tissue to guide the therapy. In clinical MRI, tightly fitted hardware comprised of multichannel coil arrays are required to capture high quality images at high spatiotemporal resolution. Ablating tissue requires a clear path for acoustic energy to travel but current array materials scatter and attenuate acoustic energy...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29419328/brain-focussed-ultrasound-what-s-the-fus-all-about-a-review-of-current-and-emerging-neurological-applications
#13
Laure Bretsztajn, Wladyslaw Gedroyc
MR-guided focussed ultrasound surgery (MRgFUS) allows for precise non-invasive thermal ablation of target tissues for a wide range of clinical applications. It is an innovative and rapidly expanding technology, which has already established itself as an effective and safe incisionless alternative in the treatment of various soft tissue tumours, with many more research studies underway to extend its therapeutic envelope. The non-invasiveness of the procedure makes FUS particularly attractive in functional neurosurgery, where existing treatment options are not suitable for all patients...
March 6, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29415084/mr-guided-transcranial-focused-ultrasound-safely-enhances-interstitial-dispersion-of-large-polymeric-nanoparticles-in-the-living-brain
#14
David S Hersh, Pavlos Anastasiadis, Ali Mohammadabadi, Ben A Nguyen, Sijia Guo, Jeffrey A Winkles, Anthony J Kim, Rao Gullapalli, Asaf Keller, Victor Frenkel, Graeme F Woodworth
Generating spatially controlled, non-destructive changes in the interstitial spaces of the brain has a host of potential clinical applications, including enhancing the delivery of therapeutics, modulating biological features within the tissue microenvironment, altering fluid and pressure dynamics, and increasing the clearance of toxins, such as plaques found in Alzheimer's disease. Recently we demonstrated that ultrasound can non-destructively enlarge the interstitial spaces of the brain ex vivo. The goal of the current study was to determine whether these effects could be reproduced in the living brain using non-invasive, transcranial MRI-guided focused ultrasound (MRgFUS)...
2018: PloS One
https://www.readbyqxmd.com/read/29385928/effects-on-cognition-and-quality-of-life-with-unilateral-magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#15
Na Young Jung, Chang Kyu Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
OBJECTIVE Although neurosurgical procedures are effective treatments for controlling involuntary tremor in patients with essential tremor (ET), they can cause cognitive decline, which can affect quality of life (QOL). The purpose of this study is to assess the changes in the neuropsychological profile and QOL of patients following MR-guided focused ultrasound (MRgFUS) thalamotomy for ET. METHODS The authors prospectively analyzed 20 patients with ET who underwent unilateral MRgFUS thalamotomy at their institute in the period from March 2012 to September 2014...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385922/a-review-of-potential-applications-of-mr-guided-focused-ultrasound-for-targeting-brain-tumor-therapy
#16
Layton Lamsam, Eli Johnson, Ian D Connolly, Max Wintermark, Melanie Hayden Gephart
Magnetic resonance-guided focused ultrasound (MRgFUS) has been used extensively to ablate brain tissue in movement disorders, such as essential tremor. At a lower energy, MRgFUS can disrupt the blood-brain barrier (BBB) to allow passage of drugs. This focal disruption of the BBB can target systemic medications to specific portions of the brain, such as for brain tumors. Current methods to bypass the BBB are invasive, as the BBB is relatively impermeable to systemically delivered antineoplastic agents. Multiple healthy and brain tumor animal models have suggested that MRgFUS disrupts the BBB and focally increases the concentration of systemically delivered antitumor chemotherapy, immunotherapy, and gene therapy...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385921/volumetric-analysis-of-magnetic-resonance-guided-focused-ultrasound-thalamotomy-lesions
#17
Maya Harary, Walid I Essayed, Pablo A Valdes, Nathan McDannold, G Rees Cosgrove
OBJECTIVE Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy was recently approved for use in the treatment of medication-refractory essential tremor (ET). Previous work has described lesion appearance and volume on MRI up to 6 months after treatment. Here, the authors report on the volumetric segmentation of the thalamotomy lesion and associated edema in the immediate postoperative period and 1 year following treatment, and relate these radiographic characteristics with clinical outcome. METHODS Seven patients with medication-refractory ET underwent MRgFUS thalamotomy at Brigham and Women's Hospital and were monitored clinically for 1 year posttreatment...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385919/focused-ultrasound-in-neurosurgery-a-historical-perspective
#18
Maya Harary, David J Segar, Kevin T Huang, Ian J Tafel, Pablo A Valdes, G Rees Cosgrove
Focused ultrasound (FUS) has been under investigation for neurosurgical applications since the 1940s. Early experiments demonstrated ultrasound as an effective tool for the creation of intracranial lesions; however, they were limited by the need for craniotomy to avoid trajectory damage and wave distortion by the skull, and they also lacked effective techniques for monitoring. Since then, the development and hemispheric distribution of phased arrays has resolved the issue of the skull and allowed for a completely transcranial procedure...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385917/a-meta-analysis-of-outcomes-and-complications-of-magnetic-resonance-guided-focused-ultrasound-in-the-treatment-of-essential-tremor
#19
Nasser Mohammed, Devi Patra, Anil Nanda
OBJECTIVE Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel technique that uses high-intensity focused ultrasound to achieve target ablation. Like a lens focusing the sun's rays, the ultrasound waves are focused to generate heat. This therapy combines the noninvasiveness of Gamma Knife thalamotomy and the real-time ablation of deep brain stimulation with acceptable complication rates. The aim of this study was to analyze the overall outcomes and complications of MRgFUS in the treatment of essential tremor (ET)...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29343660/mr-guided-focused-ultrasound-for-uterine-fibroids-a-preliminary-study-of-relationship-between-the-treatment-outcomes-and-factors-of-mr-images-including-elastography
#20
Shintaro Ichikawa, Utaroh Motosugi, Makiko Omori, Katsuhiro Sano, Yoshie Omiya, Shuji Hirata, Hiroshi Onishi
We evaluated the value of magnetic resonance elastography (MRE) for the prediction of response to magnetic resonance-guided focused ultrasound (MRgFUS) for uterine fibroids. Eleven patients were enrolled. A fractional change of >30% in Symptoms Severity Score (SSS) was defined as a 'substantial symptomatic improvement' at 12 months after treatment. The fractional stiffness value reduction in the patients with a substantial improvement in SSS was significantly higher than that in those without (P = 0.0446)...
January 18, 2018: Magnetic Resonance in Medical Sciences: MRMS
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