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https://www.readbyqxmd.com/read/27918991/sample-preparation-of-serum-to-allow-capillary-electrophoresis-analysis-of-prostate-specific-antigen-isoforms
#1
Noemi Farina-Gomez, Silvia Barrabes, Jorge E Gomez-Lopez, Monica Gonzalez, Angel Puerta, Diana Navarro-Calderon, Eduardo Albers-Acosta, Carlos Olivier, Jose C Diez-Masa, Rosa Peracaula, Mercedes de Frutos
Prostate cancer is the second most frequently diagnosed cancer in men worldwide. Currently prostate specific antigen (PSA) serum concentration is the most used prostate cancer marker, but it only shows limited specificity. Because PSA glycosylation is altered by prostate cancer, detecting glycosylation changes could increase PSA specificity as a prostate cancer marker. Changes in PSA glycosylation can modify its electrophoretic- behavior and techniques such as capillary zone electrophoresis (CZE) and two-dimensional electrophoresis (2-DE) could be applied to detect changes in PSA glycosylation...
November 24, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27910728/predictive-factors-associated-with-biochemical-recurrence-following-radical-prostatectomy-for-pathological-t2-prostate-cancer-with-negative-surgical-margins
#2
Fouad Aoun, Simone Albisinni, Benjamin Henriet, Bertrand Tombal, Roland Van Velthoven, Thierry Roumeguère
OBJECTIVE: The aim of this study was to determine factors associated with the development of biochemical recurrence (BCR) following radical prostatectomy in patients with pathological T2 prostate cancer and negative surgical margins. MATERIALS AND METHODS: This retrospective multicentre cohort study included 1252 consecutive patients with pT2 pN0/Nx and negative surgical margins on radical prostatectomy and without any adjuvant treatment, performed in three Belgian centres...
December 2, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27909617/diagnostic-value-of-micrornas-in-prostate-cancer-patients-with-prostate-specific-antigen-psa-levels-between-2-and-10-ng-ml
#3
Serin Akbayır, Necati Muşlu, Sema Erden, Murat Bozlu
OBJECTIVE: Prostate specific antigen (PSA), used for the early diagnosis of prostate cancer (PCa), is one of the best tumour markers known so far. However, in situations when PSA is between 2-10 ng/mL, which is named as grey zone, PSA falls short of distinguishing benign prostate diseases from PCa. On the other hand, it was demonstrated in many previous studies that microRNA (miRNA) could be a marker for cancer. Therefore, in this study, it was aimed to enhance the diagnostic power of PSA, especially with grey zone patients, by the use of miRNA...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27882806/comorbidity-as-a-predictor-of-overall-survival-in-prostate-cancer-patients-treated-with-external-beam-radiotherapy-combined-with-hdr-brachytherapy-boosts
#4
Marie Hjälm-Eriksson, Anders Ullén, Hemming Johansson, Seymoure Levitt, Sten Nilsson, Karl-Mikael Kälkner
BACKGROUND: The risk stratification currently applied prior to curative treatment for localized prostate cancer (PC) does not take into account comorbidity or age. Therefore, we investigated the impact of comorbidity on overall survival (OS) in PC patients treated with external beam radiotherapy (EBRT) and high-dose rate (HDR) brachytherapy boost. MATERIAL AND METHODS: At a single center, 611 consecutive patients diagnosed with localized PC from 1998 to 2004 underwent definitive EBRT (50 Gy) and HDR brachytherapy boosts (2 × 10 Gy) combined with neoadjuvant total androgen blockade...
November 24, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27862863/value-of-111-in-psma-radioguided-surgery-for-salvage-lymphadenectomy-in-recurrent-prostate-cancer-correlation-with-histopathology-and-clinical-follow-up
#5
Isabel Rauscher, Charlotte Düwel, Martina Wirtz, Margret Schottelius, Hans-Jürgen Wester, Kristina Schwamborn, Bernhard Haller, Markus Schwaiger, Jürgen E Gschwend, Matthias Eiber, Tobias Maurer
OBJECTIVES: To evaluate the use of (111) In-labeled PSMA-I&T based radioguided surgery ((111) In-PSMA-RGS) for salvage surgery in recurrent prostate cancer (PC) using comparison of intraoperative γ-probe measurements to histopathological results of dissected specimens. Furthermore, the success of (111) In-PSMA-RGS was determined by postoperative prostate-specific antigen (PSA) responses, PC-specific treatment-free survival as well as postoperative complication rates. PATIENTS AND METHODS: In this study, 31 consecutive patients with localized recurrent PC undergoing salvage surgery with PSMA-targeted RGS using an (111) In-labeled PSMA ligand were retrospectively included from April 2014 to July 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27833172/cranberry-intervention-in-patients-with-prostate-cancer-prior-to-radical-prostatectomy-clinical-pathological-and-laboratory-findings
#6
Vladimir Student, Ales Vidlar, Jan Bouchal, Jana Vrbkova, Zdenek Kolar, Milan Kral, Pavel Kosina, Jitka Vostalova
BACKGROUND AND OBJECTIVES: Recently, we described an inverse association between cranberry supplementation and serum prostate specific antigen (PSA) in patients with negative biopsy for prostate cancer (PCa) and chronic nonbacterial prostatitis. This double blind placebo controlled study evaluates the effects of cranberry consumption on PSA values and other markers in men with PCa before radical prostatectomy. METHODS: Prior to surgery, 64 patients with prostate cancer were randomized to a cranberry or placebo group...
November 10, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27824042/the-role-of-salvage-extended-lymph-node-dissection-in-patients-with-rising-psa-and-pet-ct-scan-detected-nodal-recurrence-of-prostate-cancer
#7
D Porres, D Pfister, A Thissen, T H Kuru, V Zugor, R Buettner, R Knuechel, F A Verburg, A Heidenreich
BACKGROUND: Non-prostatic bed recurrence of prostate cancer (PCa) is usually treated with androgen deprivation therapy (ADT). We analyzed the impact of salvage extended lymph node dissection (sLND) on cancer control in patients with rising PSA and lymph node (LN) metastases. METHODS: Between 2009 and 2016 we performed sLND in 87 patients with biochemical recurrence (BCR) and positive LNs on (18)FEC and (68)Ga-PSMA positron emission tomography/X-ray computer tomography (PET/CT) after primary treatment (PT) of PCa...
November 8, 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27810449/detection-of-high-grade-prostate-cancer-among-plco-participants-using-a-prespecified-four-kallikrein-marker-panel
#8
Eric H Kim, Gerald L Andriole, E David Crawford, Daniel D Sjoberg, Melissa Assel, Andrew J Vickers, Hans Lilja
PURPOSE: To assess the performance of a four-kallikrein panel, with and without microseminoprotein-beta (MSP), to predict high-grade (Gleason 7+, Gleason Grade Group 2+) prostate cancer (PCa) on biopsy in a multiethnic cohort from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. MATERIALS AND METHODS: Levels of free, intact, total prostate-specific antigen (PSA), human kallikrein-2, and MSP were measured blinded to outcome in cryo-preserved serum from men in the intervention arm of PLCO...
October 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27800640/free-testosterone-during-androgen-deprivation-therapy-predicts-castration-resistant-progression-better-than-total-testosterone
#9
Lucas Regis, Jacques Planas, Joan Carles, Xavier Maldonado, Inma Comas, Roser Ferrer, Juan Morote
BACKGROUND: The optimal degree of testosterone suppression in patients with prostate cancer undergoing androgen deprivation therapy remains in question. Furthermore, serum free testosterone, which is the active form of testosterone, seems to correlate with intraprostatic testosterone. Here we compared free and total serum testosterone as predictors of survival free of castration resistance. METHODS: Total testosterone (chemiluminescent assay, lower sensitivity 10 ng/dl) and free testosterone (analogue-ligand radioimmunoassay, lower sensitivity 0...
November 1, 2016: Prostate
https://www.readbyqxmd.com/read/27766004/quantitative-and-qualitative-analysis-of-circulating-cell-free-dna-can-be-used-as-an-adjuvant-tool-for-prostate-cancer-screening-a-meta-analysis
#10
Changqing Yin, Changliang Luo, Wei Hu, Xu Ding, Chunhui Yuan, Fubing Wang
As part of "liquid biopsy," lots of literature indicated the potential diagnostic value of circulating cell-free DNA (cfDNA) in the management of prostate cancer (PCa). However, the literature on the accuracy of cfDNA detection in PCa has been inconsistent. Hence, we performed this meta-analysis to assess the diagnostic value of cfDNA in PCa. A total of 19 articles were included in this analysis according to the inclusion and exclusion criteria. We then investigated two main subgroups in this meta-analysis, including qualitative analysis of abnormal level of cfDNA and qualitative analysis of single-gene methylation alterations...
2016: Disease Markers
https://www.readbyqxmd.com/read/27762145/elevated-prostate-specific-antigen-and-reduced-10-year-survival-among-a-cohort-of-danish-men-consecutively-referred-from-primary-care-to-an-urological-department-during-2005-2006
#11
Thore Hillig, Torben Kjær Nielsen, Steen Ingemann Hansen, Ann-Britt Nygaard, György Sölétormos
It remains unclear whether total prostate specific antigen (tPSA) or complex PSA (cPSA) has the best diagnostic performance. Additionally, the utility of percentage free PSA (%fPSA) is still debated. Our objectives were to compare the diagnostic performances of tPSA, cPSA, and %fPSA among patients referred from GP to an Urological Specialist and to investigate prognostic factors and survival in the cohort. A total of 1261 consecutive male patients without previously known prostate cancer (PCa) were referred to the same Department of Urology during June 2005 to August 2006...
October 20, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27756383/abiraterone-acetate-after-progression-with-enzalutamide-in-chemotherapy-na%C3%A3-ve-patients-with-metastatic-castration-resistant-prostate-cancer-a-multi-center-retrospective-analysis
#12
Yoko Yamada, Nobuaki Matsubara, Ken-Ichi Tabata, Takefumi Satoh, Naoto Kamiya, Hiroyoshi Suzuki, Takashi Kawahara, Hiroji Uemura, Akihiro Yano, Satoru Kawakami
BACKGROUND: Both abiraterone acetate (AA) and enzalutamide are promising agents for patients with pre- and post-chemotherapy metastatic castration-resistant prostate cancer (mCRPC). Several retrospective analysis suggested clinical cross-resistance between these agents in patients previously treated with docetaxel. However, data on the antitumor activity of AA as a second androgen receptor-targeting new agent after the failure of enzalutamide in chemotherapy-naive mCRPC patients is unavailable...
October 18, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27749150/development-and-validation-of-an-infection-risk-model-for-bacterial-canker-of-kiwifruit-using-a-multiplication-and-dispersal-concept-for-forecasting-bacterial-diseases
#13
R M Beresford, J L Tyson, W R Henshall
A weather-based disease prediction model for bacterial canker of kiwifruit (known worldwide as Psa; Pseudomonas syringae pv. actinidiae biovar 3) was developed using a new mechanistic scheme for bacterial disease forecasters, the multiplication and dispersal concept. Bacterial multiplication is estimated from a temperature function, the M index, accumulated from hourly air temperature over 3 days for hours when the leaf canopy is wet. Rainfall provides free water to move inoculum to infection sites, and the daily risk indicator, the R index, is the 3-day accumulation of the M index output on days with total rainfall >1 mm; otherwise, R is zero...
November 30, 2016: Phytopathology
https://www.readbyqxmd.com/read/27743493/adjuvant-radiation-therapy-is-associated-with-better-oncological-outcome-compared-with-salvage-radiation-therapy-in-patients-with-pn1-prostate-cancer-treated-with-radical-prostatectomy
#14
Derya Tilki, Felix Preisser, Pierre Tennstedt, Patrick Tober, Philipp Mandel, Thorsten Schlomm, Thomas Steuber, Hartwig Huland, Rudolf Schwarz, Cordula Petersen, Markus Graefen, Sascha Ahyai
OBJECTIVE: To analyse the comparative effectiveness of no treatment (NT) or salvage radiation therapy (sRT) at biochemical recurrence (BCR) vs adjuvant radiation therapy (aRT) in patients with lymph node (LN)-positive prostate cancer (PCa) after radical prostatectomy (RP). PATIENTS AND METHODS: A total of 773 patients with LN-positive PCa at RP, with or without additional radiation therapy (RT), in the period 2005-2013, were retrospectively analysed. Cox regression analysis was used to assess factors influencing BCR and metastasis-free survival (MFS)...
October 15, 2016: BJU International
https://www.readbyqxmd.com/read/27740614/enhanced-detection-sensitivity-of-prostate-specific-antigen-via-psa-conjugated-gold-nanoparticles-based-on-localized-surface-plasmon-resonance-gnp-coated-anti-psa-lspr-as-a-novel-approach-for-the-identification-of-prostate-anomalies
#15
M H Jazayeri, H Amani, A A Pourfatollah, A Avan, G A Ferns, H Pazoki-Toroudi
Prostate-specific antigen (PSA) is used to screen for prostate disease, although it has several limitations in its application as an organ-specific or cancer-specific marker. Furthermore, a highly specific/sensitive and/or label-free identification of PSA still remains a challenge in the diagnosis of prostate anomalies. We aimed to develop a gold nanoparticle (GNP)-conjugated anti-PSA antibody-based localized surface plasmon resonance (LSPR) as a novel approach to detect prostatic disease. A total of 25 nm colloidal gold particles were prepared followed by conjugation with anti-PSA pAb (GNPs-PSA pAb)...
October 14, 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/27733065/photoselective-vaporization-of-the-prostate-long-term-outcomes-and-safety-during-10-years-of-follow-up
#16
Yasushi Yamada, Jun Furusawa, Yoshiki Sugimura, Isao Kuromatsu
PURPOSE: To evaluate the long-term outcomes and safety photoselective vaporization of the prostate (PVP). PATIENTS AND METHODS: From April 2005 to December 2015, a total of 1154 patients with benign prostatic hyperplasia underwent PVP. The type of Green Light laser was an 80 W potassium-titanyl-phosphate laser and later a 120 W lithium triborate laser. Before and after surgery, the International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post-voiding volume of residual urine (PVR), prostate-specific antigen (PSA) level, and prostate volume were assessed regularly...
December 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27725614/determining-the-ratio-of-two-types-of-prostate-specific-antigens-with-biochips-and-gold-nanoparticles-for-accurate-prostate-cancer-diagnosis
#17
Minyoung Yoo, Woon-Seok Yeo
Prostate-specific antigen (PSA) is a well-known biomarker for prostate-cancer diagnosis. However, the serum PSA measurement alone is insufficient for accurate diagnoses because the correlation with cancer is weak within the gray zone-the biomarker level range wherein a clear-cut diagnosis is impossible. As such, accurate prostate cancer diagnosis has been supplemented by measurements of the ratio of two types of PSA: free PSA (fPSA) and complexed PSA (cPSA; α-1-antichymotrypsin-bound PSA). Herein, we describe a new method for measuring the ratio of these two types of PSA by using gold nanoparticles (AuNPs) and biochips...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27703291/actual-contribution-of-free-to-total-psa-ratio-in-prostate-diseases-differentiation
#18
Alden Prcic, Edin Begic, Mustafa Hiros
OBJECTIVES: To determine significance and sensitivity of the Free to Total prostate specific antigen (PSA) ratio (%fPSA) in diagnosis of prostate cancer and to correlate its sensitivity and specificity with diagnosis. METHODS: Research included 220 patients, who had indication for biopsy (Clinic for Urology, University Clinical Center Sarajevo). RESULTS: Average age of patients was 64.6 ± 8.1 years. Kruskal Wallis test indicates that there is a significant difference in age in relation to the diagnosis (KW χ(2)=12...
July 27, 2016: Medical Archives
https://www.readbyqxmd.com/read/27692697/low-dose-oral-ethinylestradiol-with-concomitant-low-dose-acetylsalicylic-acid-for-advanced-castrate-resistant-prostate-cancer
#19
Giandomenico Roviello, Laura Zanotti, Angela Gobbi, Martina Dester, Daniele Generali, Chiara Pacifico, Maria Rosa Cappelletti, Alberto Bonetta
BACKGROUND: The aim of the present study was to evaluate the activity and tolerability of low-dose oral ethinylestradiol (EE) and luteinizing hormone-releasing hormone analogue with concomitant low-dose acetylsalicylic acid (ASA) as a thromboprophylactic agent for advanced castrate-resistant prostate cancer (CRPC). PATIENTS AND METHODS: The patients received an EE dose of 150 μg daily (50 μg 3 times daily) and an ASA dose of 100 mg once daily. The primary endpoint was the prostate-specific antigen response...
September 8, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27665407/-urologic-malignancies-in-renal-transplant-candidates-and-recipients
#20
F Kleinclauss, R Thuret, T Murez, M O Timsit
OBJECTIVE: To review epidemiology and management of urologic neoplasms in renal transplant candidates and recipients. MATERIAL AND METHODS: Relevant publications were identified through Medline (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) database using the following keywords, alone or in association, "neoplasms"; "prostate cancer"; "renal carcinoma"; "renal transplantation"; "transitional carcinoma"; "waiting list". Articles were selected according to methods, language of publication and relevance...
September 21, 2016: Progrès en Urologie
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