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https://www.readbyqxmd.com/read/28441008/simultaneous-detection-of-dual-prostate-specific-antigens-using-surface-enhanced-raman-scattering-based-immunoassay-for-accurate-diagnosis-of-prostate-cancer
#1
Ziyi Cheng, Namhyun Choi, Rui Wang, Sangyeop Lee, Kyung Chul Moon, Soo-Young Yoon, Lingxin Chen, Jaebum Choo
Accurate analysis of specific biomarkers in clinical serum is essential for early diagnosis and treatment of cancer. Here, a surface-enhanced Raman scattering (SERS)-based immunoassay, using magnetic beads and SERS nano tags, was developed for the determination of free to total (f/t) prostate specific antigen (PSA) ratio to improve the diagnostic performance of prostate cancer. To assess the clinical applicability of the proposed method, SERS-based assays for the simultaneous detection of dual PSA markers, free PSA (f-PSA) and complexed PSA (c-PSA), were performed for clinical samples in the gray zone between 4...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28429372/long-term-clinical-impact-of-psa-surge-in-castration-resistant-prostate-cancer-patients-treated-with-abiraterone
#2
Vincenza Conteduca, Orazio Caffo, Cristian Lolli, Michele Aieta, Emanuela Scarpi, Emanuela Bianchi, Francesca Maines, Giuseppe Schepisi, Samanta Salvi, Francesco Massari, Francesco Carrozza, Antonello Veccia, Vincenzo E Chiuri, Enrico Campadelli, Gaetano Facchini, Ugo De Giorgi
BACKGROUND: Early changes in PSA have been evaluated in association to treatment outcome. The aim of this study was to assess PSA surge phenomenon in castration-resistant prostate cancer (CRPC) patients treated with abiraterone and to correlate those variations with long-term treatment outcome. PATIENTS AND METHODS: We retrospectively evaluated 330 CRPC patients in 11 Italian hospitals, monitoring PSA levels at baseline and every 4 weeks. Other clinical, biochemical and molecular parameters were determined at baseline...
April 20, 2017: Prostate
https://www.readbyqxmd.com/read/28427756/human-tissue-kallikreins-blood-levels-and-response-to-radiotherapy-in-intermediate-risk-prostate-cancer
#3
Nicola J Nasser, John Thoms, Antoninus Soosaipillai, Melania Pintilie, Ri Wang, Eleftherios P Diamandis, Robert G Bristow
OBJECTIVES: Kallikreins are serine proteases over expressed in many malignancies. In this study, we measure changes in serum kallikrein (KLKs) levels during intensity-modulated radiotherapy (IMRT) in prostate cancer patients, and find potential correlations between serum kallikrein level and normal tissues toxicity during radiation. METHODS: Forty-nine patients with prostate cancer were recruited as follows: group 1, definitive standard fractionation IMRT (78Gy in 39 fractions, n=15); group 2, definitive hypofractionated IMRT (60Gy in 20 fractions, n=15); and group 3, IMRT postprostatectomy (66Gy in 33 fractions, n=19)...
April 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28427507/is-still-there-a-place-for-orteronel-in-management-of-prostate-cancer-data-from-a-literature-based-meta-analysis-of-randomized-trials
#4
REVIEW
Giandomenico Roviello, Chiara Pacifico, Giorgio Chiriacò, Daniele Generali
Orteronel (TAK-700) is an oral, non-steroidal 17,20-lyase inhibitor with higher specificity for 17,20 lyase over 17 hydroxylase. The first phase III studies showed an advantage with orteronel compared with placebo in terms of progression free survival and response of PSA. Unfortunately orteronel did not significantly prolong the overall survival. In order to assess the efficacy of orteronel in prostate cancer, we evaluated all available data on orteronel in the management of prostate cancer. A total of 2716 patients were evaluated from 3 randomized trials...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28418634/protein-trapping-in-plasmonic-nanoslit-and-nanoledge-cavities-the-behavior-and-sensing
#5
Zheng Zeng, Xiaojun Shi, Taylor Mabe, Shaun Christie, Grant Gilmore, Adam W Smith, Jianjun Wei
A novel plasmonic nanoledge device was presented to explore the geometry-induced trapping of nanoscale biomolecules and examine a generation of surface plasmon resonance (SPR) for plasmonic sensing. To design an optimal plasmonic device, a semi-analytical model was implemented for a quantitative analysis of SPR under plane-wave illumination and a finite-difference time-domain (FDTD) simulation was used to study the optical transmission and refractive index (RI) sensitivity. In addition, total internal reflection fluorescence (TIRF) imaging was used to visualize the migration of fluorescently labeled bovine serum albumin (BSA) into the nanoslits; and fluorescence correlation spectroscopy (FCS) was further used to investigate the diffusion of BSA in the nanoslits...
April 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28410986/predictors-of-biochemical-recurrence-after-primary-focal-cryosurgery-hemiablation-for-localized-prostate-cancer-a-multi-institutional-analytic-comparison-of-phoenix-and-stuttgart-criteria
#6
Michael Kongnyuy, Michael J Lipsky, Shahidul Islam, Dennis J Robins, Shaun Hager, Daniel M Halpern, Kaitlin E Kosinski, Jeffrey T Schiff, Anthony T Corcoran, Sven Wenske, Aaron E Katz
BACKGROUND: The Phoenix definition (PD) and Stuttgart definition (SD) designed to determine biochemical recurrence (BCR) in patients with postradiotherapy and high-intensity focused ultrasound organ-confined prostate cancer are being applied to follow patients after cryosurgery. We sought to identify predictors of BCR using the PD and SD criteria in patients who underwent primary focal cryosurgery (PFC). MATERIALS AND METHODS: We performed a retrospective review of patients who underwent PFC (hemiablation) at 2 referral centers from 2000 to 2014...
April 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28399576/local-tumor-control-and-dna-pk-activity-of-peripheral-blood-lymphocytes-in-prostate-cancer-patients-receiving-radiotherapy
#7
Masanori Someya, Tomokazu Hasegawa, Masakazu Hori, Yoshihisa Matsumoto, Kensei Nakata, Naoya Masumori, Koh-Ichi Sakata
Repair of DNA damage is critical for genomic stability, and DNA-dependent protein kinase (DNA-PK) has an important role in repairing double-strand breaks. We examined whether the DNA-PK activity of peripheral blood lymphocytes (PBLs) was related to biochemical (prostate-specific antigen: PSA) relapse and radiation toxicity in prostate cancer patients who have received radiotherapy. A total of 69 patients with localized adenocarcinoma of the prostate participated in this study. Peripheral blood was collected 2 years or later after radiotherapy and centrifuged, then DNA-PK activity was measured by a filter binding assay...
March 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28384926/trus-biopsy-yield-in-indian-population-a-retrospective-analysis
#8
Sunil Raghunath Patil, Prakash Wamanrao Pawar, Ajit Somaji Sawant, Akshay Vijay Patil, Sayalee Suryabhan Narwade, Shankar Tanaji Mundhe, Abhishek Jaysukhbhai Savalia, Ashwin Sunil Tamhankar
INTRODUCTION: The reported cancer detection rate of Trans-Rectal Ultrasonography (TRUS) biopsies (TRUS biopsy yield) has been around 30 percent in western countries. However it is much lower in Asian countries, including India. Hence a larger proportion of patients in India undergo unnecessary biopsies. AIMS: To find out the cancer detection rate of TRUS biopsy (TRUS biopsy yield) in contemporary Indian population. Also, to study the positive predictive values at different serum Prostate-Specific Antigen (PSA)/PSA Density (PSAD) cut off levels and suspicious Digital Rectal Examination (DRE) findings...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28383613/can-psa-reflex-algorithm-be-a-valid-alternative-to-other-psa-based-prostate-cancer-screening-strategies
#9
G Caldarelli, G Troiano, D Rosadini, N Nante
BACKGROUND: The available laboratory tests for the differential diagnosis of prostate cancer, are represented by the total PSA, the free PSA, and the free/total PSA ratio. In Italy most of doctors tend to request both total and free PSA for their patients even in cases where the total PSA doesn't justify the further request of free PSA, with a consequent growth of the costs for the National Health System. The aim of our study was to predict the saving in Euro (due to reagents) and reduction in free PSA tests, applying the "PSA Reflex" algorithm...
May 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28383168/different-free-prostate-specific-antigen-to-total-prostate-specific-antigen-ratios-using-three-detecting-systems
#10
Hui-Qing Huang, Yan Zhang, Hua-Guo Xu
BACKGROUND: Prostate-specific antigen (PSA) is used as an indicative marker of a pathologic condition of the prostate, and the ratio of free PSA (fPSA) to total PSA (tPSA) helps to distinguish benign prostatic hyperplasia (BPH) from prostate cancer (PCa). In this study, we present some reversed ratios of fPSA to tPSA and analyze the possible mechanism. METHODS: Using the UniCel DxI800 Access Immunoassay System, eight reversed fPSA to tPSA ratios were obtained, and then these samples were retested with an Abbott Architect i2000 Immunoassay Analyser and Cobas e602...
April 6, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28361781/serum-complexed-and-free-prostate-specific-antigen-psa-for-the-diagnosis-of-the-polycystic-ovarian-syndrome-pcos
#11
Eleftherios P Diamandis, Frank Z Stanczyk, Sarah Wheeler, Anu Mathew, Martin Stengelin, Galina Nikolenko, Eli N Glezer, Marshall D Brown, Yingye Zheng, Yen-Hao Chen, Hsiao-Li Wu, Ricardo Azziz
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a common cause of reproductive and metabolic dysfunction. We hypothesized that serum prostate-specific antigen (PSA) may constitute a new biomarker for hyperandrogenism in PCOS. METHODS: We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Serum from these women was analyzed for androgenic steroids and for complexed PSA (cPSA) and free PSA (fPSA) with a novel fifth- generation assay with a sensitivity of ~10 fg/mL for cPSA and 140 fg/mL for fPSA...
March 31, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28358937/abiraterone-acetate-for-metastatic-prostate-cancer-in-patients-with-suboptimal-biochemical-response-to-hormone-induction
#12
Thomas W Flaig, Melissa Plets, Maha H A Hussain, Neeraj Agarwal, Nicholas Mitsiades, Hari A Deshpande, Ulka N Vaishampayan, Ian M Thompson
Importance: Men with metastatic prostate cancer who have a poor response to initial androgen-deprivation therapy (ADT), as reflected by a prostate-specific antigen (PSA) level higher than 4.0 ng/mL after 7 months of ADT, have a poor prognosis, based on historical controls. Objective: To determine the efficacy of abiraterone acetate with prednisone in these high-risk patients with a suboptimal response to hormonal induction. Design, Setting, and Participants: A phase 2 single-arm study was conducted through the National Clinical Trials Network-Southwest Oncology Group...
March 30, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28351193/measurement-of-serum-isoform-2-propsa-derivatives-shows-superior-accuracy-to-magnetic-resonance-imaging-in-the-diagnosis-of-prostate-cancer-in-patients-with-a-total-prostate-specific-antigen-level-of-2-10%C3%A2-ng-ml
#13
Kazuhiro Furuya, Takashi Kawahara, Masaki Narahara, Takashi Tokita, Sachi Fukui, Masashi Imano, Taku Mitome, Yusuke Ito, Koji Izumi, Kimito Osaka, Yumiko Yokomizo, Narihiko Hayashi, Hisashi Hasumi, Shintaro Nawata, Tsuyoshi Kawano, Masahiro Yao, Hiroji Uemura
OBJECTIVE: More accurate diagnostic procedures for prostate cancer are needed to avoid unnecessary biopsy due to the low specificity of prostate-specific antigen (PSA). Recent studies showed that the percentage of serum isoform [-2]proPSA (p2PSA) to free PSA (%p2PSA), the Prostate Health Index (PHI) and magnetic resonance imaging (MRI) were more accurate than PSA. The aim of this study was to test the accuracy of %p2PSA, PHI and MRI in discriminating patients with and without prostate cancer...
March 29, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28336437/overexpression-of-tacc3-is-correlated-with-tumor-aggressiveness-and-poor-prognosis-in-prostate-cancer
#14
Qiji Li, Liping Ye, Wei Guo, Min Wang, Shuai Huang, Xinsheng Peng
Transforming acidic coiled-coil (TACC3), a member of the TACC family, has been shown to be deregulated in various cancers and involved in tumor progression. However, its biological role and molecular mechanism in prostate cancer (PCa) have not been elucidated. Herein, we reported that TACC3 was markedly upregulated in metastatic PCa. The upregulation of TACC3 was significantly associated with the metastasis status, tumor stage, total prostate-specific antigen (PSA) level, and Gleason score in patients with PCa...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28322857/vascular-targeted-photodynamic-therapy-with-padeliporfin-for-low-risk-prostate-cancer-treatment-mid-term-oncological-outcomes
#15
Souhil Lebdai, Pierre Bigot, Pierre-Adrien Leroux, Louis-Paul Berthelot, Pierre Maulaz, Abdel-Rahmene Azzouzi
PURPOSE: To assess the mid-term oncological outcomes of vascular-targeted photodynamic therapy with padeliporfin for low-risk prostate cancer treatment. MATERIAL AND METHODS: We prospectively assessed all patients treated with vascular-targeted photodynamic therapy for low-risk prostate cancer in our center. Patients were followed every 6 months. All patients underwent prostate biopsies 6 months post-treatment or in case of biological or clinical progression. Primary endpoint was the progression-free survival...
March 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28322234/propsa-and-the-prostate-health-index-as-predictive-markers-for-aggressiveness-in-low-risk-prostate-cancer-results-from-an-international-multicenter-study
#16
I Heidegger, H Klocker, R Pichler, A Pircher, W Prokop, E Steiner, C Ladurner, E Comploj, A Lunacek, D Djordjevic, A Pycha, E Plas, W Horninger, J Bektic
BACKGROUND: One of the major challenges in prostate cancer (PCa) treatment is distinguishing insignificant PCa from those forms that need active treatment. We evaluated the impact of PSA isoforms on risk stratification in patients with low-risk PCa as well as in active surveillance (AS) candidates who underwent radical prostatectomy. METHODS: A total of 112 patients with biopsy confirmed Gleason score (GS) 6 PCa of four different international institutions were prospectively enrolled in the study...
March 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28314320/the-clinical-efficacy-of-enzalutamide-in-metastatic-prostate-cancer-prospective-single-center-study
#17
Giuseppe Cicero, Rossella DE Luca, Patrizia Dorangricchia, Francesco Dieli
BACKGROUND/AIM: To evaluate the effectiveness of enzalutamide in Italian patients with hormone-refractory metastatic castration-resistant prostate cancer, progressing after chemotherapy with docetaxel plus prednisone. PATIENTS AND METHODS: A total of 60 patients were enrolled. Reduction in serum prostate-specific antigen (PSA) was assessed as the primary endpoint, while reduction in pain, safety, progression-free survival and overall survival represented secondary endpoints...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28296726/the-establishment-and-evaluation-of-a-new-model-for-the-prediction-of-prostate-cancer
#18
Qi Wang, Yan-Feng Li, Jun Jiang, Yong Zhang, Xu-Dong Liu, Ke Li
To develop a new prostate cancer predictor (PCP) model using the combination of total prostate-specific antigen (tPSA), free PSA (fPSA), and complexed PSA (cPSA).The diagnoses of all the included patients were confirmed pathologically in Daping Hospital between December 1, 2011 and December 1, 2014. There were 54 PCa cases and 579 benign prostatic hyperplasia (BPH) cases with tPSA levels of 2 to 10 ng/mL, and 48 PCa cases and 147 BPH cases with tPSA levels of 10 to 20 ng/mL. Logistic regression and receiver operating characteristic curve (ROC) analyses were employed to compare the value of PCP (PCP = tPSA / fPSA × √cPSA) with tPSA, fPSA, the ratio of fPSA to tPSA (%fPSA), and cPSA for the differential diagnosis of PCa and BPH...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28289065/gleason-grade-grouping-of-prostate-cancer-is-of-prognostic-value-in-asian-men
#19
Joe Yeong, Rehena Sultana, Jonathan Teo, Hong Hong Huang, John Yuen, Puay Hoon Tan, Li Yan Khor
AIM: The International Society of Urological Pathology made recommendations for the use of Grade Groups (GG) originally described by Epstein and colleagues over Gleason score (GS) alone in 2014, which was subsequently adopted by the WHO classification in 2016. The majority of studies validating this revision have been in Caucasian populations. We therefore asked whether the new GG system was retrospectively associated with biochemical disease-free survival in a mixed-ethnicity cohort of Asian men...
March 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28271215/moderate-hypofractionated-radiotherapy-with-volumetric-modulated-arc-therapy-and-simultaneous-integrated-boost-for-pelvic-irradiation-in-prostate-cancer
#20
C Franzese, A Fogliata, G R D'Agostino, L Di Brina, T Comito, P Navarria, L Cozzi, M Scorsetti
PURPOSE: The optimal treatment for unfavourable intermediate/high-risk prostate cancer is still debated. In the present study, the pattern of toxicity and early clinical outcome of patients with localized prostate cancer was analyzed. METHODS: A cohort of 90 patients treated on pelvic lymph nodes from 2010 to 2015 was selected. All patients were treated with Volumetric Modulated Arc Therapy (VMAT), and Simultaneous integrated boost (SIB) in 28 fractions; the prostate, the seminal vesicle and the pelvic lymph node received total doses of 74...
March 8, 2017: Journal of Cancer Research and Clinical Oncology
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