keyword
https://read.qxmd.com/read/38500292/phase-2-study-of-the-efficacy-and-safety-of-ponsegromab-in-patients-with-cancer-cachexia-proacc-1-study-design
#21
JOURNAL ARTICLE
John D Groarke, Jeffrey Crawford, Susie M Collins, Shannon L Lubaczewski, Danna M Breen, Magdalena A Harrington, Ira Jacobs, Ruolun Qiu, James Revkin, Michelle I Rossulek, Aditi R Saxena
BACKGROUND: Cancer cachexia is a multifactorial metabolic wasting syndrome characterized by anorexia, unintentional loss of weight involving both skeletal muscle and adipose tissues, progressive functional impairment and reduced survival. Therapeutic strategies for this serious condition are very limited. Growth differentiation factor 15 (GDF-15) is a cytokine that is implicated in cancer cachexia and may represent both a biomarker of cancer cachexia and a potential therapeutic target...
March 18, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38499546/multimodal-digital-assessment-of-depression-with-actigraphy-and-app-in-hong-kong-chinese
#22
JOURNAL ARTICLE
Jie Chen, Ngan Yin Chan, Chun-Tung Li, Joey W Y Chan, Yaping Liu, Shirley Xin Li, Steven W H Chau, Kwong Sak Leung, Pheng-Ann Heng, Tatia M C Lee, Tim M H Li, Yun-Kwok Wing
There is an emerging potential for digital assessment of depression. In this study, Chinese patients with major depressive disorder (MDD) and controls underwent a week of multimodal measurement including actigraphy and app-based measures (D-MOMO) to record rest-activity, facial expression, voice, and mood states. Seven machine-learning models (Random Forest [RF], Logistic regression [LR], Support vector machine [SVM], K-Nearest Neighbors [KNN], Decision tree [DT], Naive Bayes [NB], and Artificial Neural Networks [ANN]) with leave-one-out cross-validation were applied to detect lifetime diagnosis of MDD and non-remission status...
March 18, 2024: Translational Psychiatry
https://read.qxmd.com/read/38498995/measuring-objective-and-subjective-sleep-during-lisdexamfetamine-treatment-of-acute-methamphetamine-withdrawal-a-feasibility-study
#23
Liam S Acheson, Christopher Gordon, Rebecca McKetin, Jonathan Brett, Michael Christmass, Craig Rodgers, Nicholas Lintzeris, Adrian Dunlop, Michael Farrell, Steven Shoptaw, Nadine Ezard, Krista J Siefried
INTRODUCTION: Sleep disturbance is common during methamphetamine (MA) use and withdrawal; however, the feasibility of combined subjective-objective measurement of sleep-wake has not been shown in this population. Actigraphy is a well-established, non-invasive measure of sleep-wake cycles with good concordance with polysomnography. This study aimed to investigate the feasibility and utility of using actigraphy and sleep diaries to investigate sleep during MA withdrawal. METHODS: We conducted a feasibility and utility study of actigraphy and sleep diaries during a clinical trial of lisdexamfetamine for MA withdrawal...
March 18, 2024: European Addiction Research
https://read.qxmd.com/read/38498321/online-exercise-programs-for-chronic-nonspecific-neck-pain-a-randomized-controlled-trial-reveals-comparable-effects-of-global-local-and-combined-approaches
#24
JOURNAL ARTICLE
Jente Bontinck, Mira Meeus, Lennard Voogt, Marjolein Chys, Iris Coppieters, Barbara Cagnie, Kayleigh De Meulemeester
OBJECTIVE: Specific neck exercises are recommended in the rehabilitation of chronic nonspecific neck pain. They are unfortunately often accompanied by acute pain flare-ups. Global exercises might be a beneficial addition, as they activate endogenous analgesia without overloading painful structures. However, it is still unclear which type of exercise is most effective. This randomized controlled trial was done to evaluate the effect of an online blended program of global and specific neck exercises, compared to programs including only 1 of both types of exercise...
March 18, 2024: Physical Therapy
https://read.qxmd.com/read/38497688/the-role-of-actigraphy-in-detecting-and-characterizing-the-early-phases-of-alzheimer-s-disease
#25
JOURNAL ARTICLE
Joseph R Winer
No abstract text is available yet for this article.
March 18, 2024: Sleep
https://read.qxmd.com/read/38497429/delineating-cognitive-resilience-using-fractal-regulation-cross-sectional-and-longitudinal-evidence-from-the-rush-memory-and-aging-project
#26
JOURNAL ARTICLE
Peng Li, Chenlu Gao, Lei Yu, Lei Gao, Ruixue Cai, David A Bennett, Julie A Schneider, Aron S Buchman, Kun Hu
INTRODUCTION: Degradation of fractal patterns in actigraphy independently predicts dementia risk. Such observations motivated the study to understand the role of fractal regulation in the context of neuropathologies. METHODS: We examined associations of fractal regulation with neuropathologies and longitudinal cognitive changes in 533 older participants who were followed annually with actigraphy and cognitive assessments until death with brain autopsy performed...
March 18, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38497216/wrist-worn-actigraphy-in-agitated-late-stage-dementia-patients-a-feasibility-study-on-digital-inclusion
#27
JOURNAL ARTICLE
Ta-Wei Guu, Anna-Katharine Brem, Christopher P Albertyn, Pooja Kandangwa, Dag Aarsland, Dominic Ffytche
BACKGROUND: Wrist-worn actigraphy can be an objective tool to assess sleep and other behavioral and psychological symptoms in dementia (BPSD). We investigated the feasibility of using wearable actigraphy in agitated late-stage dementia patients. METHODS: Agitated, late-stage Alzheimer's dementia care home residents in Greater London area (n = 29; 14 females, mean age ± SD: 80.8 ± 8.2; 93.1% White) were recruited to wear an actigraphy watch for 4 weeks...
March 18, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38496283/circadian-rhythms-characteristics-of-nurses-providing-direct-patient-care-an-observational-study
#28
JOURNAL ARTICLE
İlknur Dolu, Serap Açıkgöz, Ali Rıza Demirbaş, Erdem Karabulut
BACKGROUND: In today's modern world, longer working hours, shift work, and working at night have become major causes of the disruption of our natural circadian rhythms. This study aimed to investigate the effects of the type of shift work (rotating vs. fixed day), duty period (on-duty vs. off-duty), and working period within each shift (nighttime vs. daytime) on the circadian rhythm characteristics of nurses who provide direct patient care. METHODS: This cross-sectional study used a purposive sampling method...
March 2024: Safety and Health At Work
https://read.qxmd.com/read/38493807/improving-sleep-using-mentored-behavioral-and-environmental-restructuring-slumber
#29
JOURNAL ARTICLE
Jennifer L Martin, Mary Cadogan, Abraham A Brody, Michael N Mitchell, Diana E Hernandez, Michael Mangold, Cathy A Alessi, Yeonsu Song, Joshua Chodosh
OBJECTIVES: To evaluate the impact of a mentoring program to encourage staff-delivered sleep-promoting strategies on sleep, function, depression, and anxiety among skilled nursing facility (SNF) residents. DESIGN: Modified stepped-wedge unit-level intervention. SETTING AND PARTICIPANTS: Seventy-two residents (mean age 75 ± 15 years; 55.9% female, 41% non-Hispanic White, 35% Black, 20% Hispanic, 3% Asian) of 2 New York City urban SNFs...
March 14, 2024: Journal of the American Medical Directors Association
https://read.qxmd.com/read/38492665/physical-activity-and-sedentary-behavior-as-treatable-traits-for-clinical-control-in-moderate-to-severe-asthma
#30
JOURNAL ARTICLE
Fabiano F de Lima, Juliana M B Dos Santos, Adriana C Lunardi, Joice M de Oliveira, Patrícia D Freitas, Fabiana S Kim, Rosana Câmara Agondi, Regina M Carvalho-Pinto, Karina C Furlanetto, Celso R F Carvalho
BACKGROUND: Physical activity and sedentary behavior are treatable traits that may impact asthma control in distinct manners, but this impact remains poorly understood. OBJECTIVE: To evaluate the influence of physical activity and sedentary behavior on clinical control in adults with moderate-to-severe asthma. METHODS: This cross-sectional multicentric study included 426 individuals with moderate-to-severe asthma. Assessments included physical activity and sedentary time (actigraphy), clinical asthma control (Asthma Control Questionnaire [ACQ]), quality of life (Asthma Quality of Life Questionnaire [AQLQ]), anxiety and depression symptoms (Hospital Anxiety and Depression Scale [HADS]), anthropometric data, and lung function...
March 14, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38485134/digital-cognitive-behavioural-therapy-for-insomnia-reduces-insomnia-in-nurses-suffering-from-shift-work-disorder-a-randomised-controlled-pilot-trial
#31
JOURNAL ARTICLE
Johanna Ell, Hanna A Brückner, Anna F Johann, Lisa Steinmetz, Lara J Güth, Bernd Feige, Heli Järnefelt, Annie Vallières, Lukas Frase, Katharina Domschke, Dieter Riemann, Dirk Lehr, Kai Spiegelhalder
Insomnia is a primary symptom of shift work disorder, yet it remains undertreated. This randomised-controlled pilot trial examined the efficacy of a digital, guided cognitive behavioural therapy for insomnia adapted to shift work (SleepCare) in nurses with shift work disorder. The hypothesis was that SleepCare reduces insomnia severity compared with a waitlist control condition. A total of 46 unmedicated nurses suffering from shift work disorder with insomnia (age: 39.7 ± 12.1 years; 80...
March 14, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38483375/the-impact-of-the-double-school-shift-system-on-lifestyle-behaviors-among-mexican-adolescents
#32
JOURNAL ARTICLE
Yujie Peng, Laura Arboleda-Merino, Arturo Arrona-Palacios, Alejandra Cantoral, Martha Maria Tellez Rojo, Karen E Peterson, Libni Olascoaga-Torres, Erica C Jansen
PURPOSE: Early school start times could adversely impact adolescent sleep duration. They could also impact other behaviors like diet and physical activity, either directly or indirectly through effects on sleep. We examined whether the double school shift system was associated with sleep, diet, and physical activity behaviors among Mexican adolescents. METHODS: The analytic sample included 305 Mexican adolescents from a cohort study (on average 14.53 ± 1.75 years old and 51% male)...
March 13, 2024: Journal of Adolescent Health
https://read.qxmd.com/read/38476850/assessment-of-cognitive-function-and-sleep-wake-rhythms-in-community-dwelling-older-adults
#33
JOURNAL ARTICLE
Masato Okuda, Akiko Noda, Kunihiro Iwamoto, Nozomi Hishikawa, Seiko Miyata, Fumihiko Yasuma, Toshiaki Taoka, Norio Ozaki, Julie A Suhr, Soichiro Miyazaki
Disruption of the circadian rhythm and sleep-wake cycles is a consequence of aging and is associated with the cognitive decline and many neurodegenerative conditions. We investigated the bedtime, wake-up time, sleep timing (midpoint between bedtime and wake-up time), and sleep timing standard deviation (SD) using the actigraphy among 80 consecutive volunteers aged ≥ 60 years. Global cognitive function and executive function of detailed cognitive domains were evaluated using the mini-mental state examination (MMSE) and Wisconsin card sorting test (WCST) and subjective daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS)...
January 2024: Sleep and Biological Rhythms
https://read.qxmd.com/read/38472641/tryptophan-kynurenine-metabolic-pathway-and-daytime-dysfunction-in-women-with-hiv
#34
JOURNAL ARTICLE
Eran Frank Shorer, Leah H Rubin, Audrey L French, Kathleen M Weber, Elizabeth Daubert, Tsion Yohannes, Ralph Morack, Clary Clish, Kevin Bullock, Deborah Gustafson, Anjali Sharma, Andrea C Rogando, Qibin Qi, Helen J Burgess, Raha M Dastgheyb
Sleep disturbances are prevalent in women with HIV (WWH). Tryptophan-kynurenine (T-K) pathway metabolites are associated with alterations in actigraphy derived sleep measures in WWH, although may not always correlate with functional impairment. We investigated the relationship between T-K pathway metabolites and self-reported daytime dysfunction in WWH and women without HIV (WWoH). 141 WWH on stable antiretroviral therapy and 140 demographically similar WWoH enrolled in the IDOze Study had targeted plasma T-K metabolites measured using liquid chromatography-tandem mass spectrometry...
March 12, 2024: Journal of Neurovirology
https://read.qxmd.com/read/38471498/disruptions-to-sleep-and-circadian-rhythms-are-associated-with-poorer-athlete-mental-health-in-female-but-not-male-elite-australian-rules-footballers
#35
JOURNAL ARTICLE
Luis Mascaro, Josh Leota, Daniel Hoffman, Shantha M W Rajaratnam, Sean P A Drummond, Elise R Facer-Childs
Elite athletes are vulnerable to sleep and circadian disruption and associated mental health symptoms. This study aimed to investigate sex differences in sleep, circadian rhythms, and mental health, as well as the moderating role of sex in the prediction of mental health, among male professional and female semi-professional elite athletes. Participants were 87 elite Australian Rules football (ARF) athletes (43% female; mean [standard deviation] age 24.0 [4.1] years). Participants completed baseline questionnaires, 2 weeks of sleep/wake monitoring via actigraphy, and a circadian phase assessment (dim-light melatonin onset [DLMO])...
March 12, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38469283/sleep-disturbance-in-adults-with-untreated-primary-brain-tumors-prevalence-and-impact-on-quality-of-life
#36
JOURNAL ARTICLE
Pei-Ching Lin, Pin-Yuan Chen, Kuo-Chen Wei, Jian-Her Lin, Mei-Ru Lin, Huan-Chih Wang, Hsiao-Yean Chiu
PURPOSE: To investigate the frequency of sleep disturbance and its effects on quality of life in adults with untreated primary brain tumors. METHODS: This cross-sectional study recruited 68 and 35 patients with newly diagnosed benign and malignant brain tumors, respectively. All participants completed the Chinese versions of the Athens Insomnia Scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale, Brief Fatigue Inventory, and EORTC-QLQ-BN20 for quality-of-life assessment...
April 2023: Sleep and Biological Rhythms
https://read.qxmd.com/read/38466984/design-and-rationale-of-prolonged-nightly-fasting-for-multiple-myeloma-prevention-profast-protocol-for-a-randomized-controlled-pilot-trial
#37
JOURNAL ARTICLE
David J Lee, Elizabeth K O'Donnell, Noopur Raje, Cristina Panaroni, Robert Redd, Jennifer Ligibel, Dorothy D Sears, Omar Nadeem, Irene M Ghobrial, Catherine R Marinac
BACKGROUND: Obesity is an established, modifiable risk factor of multiple myeloma (MM); yet, no lifestyle interventions are routinely recommended for patients with overweight or obesity with MM precursor conditions. Prolonged nightly fasting is a simple, practical dietary regimen supported by research, suggesting that the synchronization of feeding-fasting timing with sleep-wake cycles favorably affects metabolic pathways implicated in MM. We describe the design and rationale of a randomized controlled pilot trial evaluating the efficacy of a regular, prolonged nighttime fasting schedule among individuals with overweight or obesity at high risk for developing MM or a related lymphoid malignancy...
March 11, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38464344/actigraphy-methodology-in-the-kids-mod-pah-trial-physical-activity-as-a-functional-endpoint-in-pediatric-clinical-trials
#38
JOURNAL ARTICLE
Catherine M Avitabile, Usha S Krishnan, Delphine Yung, Stephanie S Handler, Nidhy Varghese, Angela Bates, Jeff Fineman, Rachel Sullivan, Grace Friere, Eric Austin, Mary P Mullen, Carol Pereira, Eric J Christensen, Gayane Yenokyan, Joseph M Collaco, Steven H Abman, Lew Romer, D Dunbar Ivy, Erika B Rosenzweig
Pulmonary vasodilator treatment can improve hemodynamics, right ventricular function, symptoms, and survival in pediatric pulmonary hypertension (PH). However, clinical trial data are lacking due to many constraints. One major limitation is the lack of relevant trial endpoints reflective of hemodynamics or functional status in patients in whom standard exercise testing is impractical, unreliable, or not reproducible. The Kids Mod PAH trial (Mono- vs. Duo Therapy for Pediatric Pulmonary Arterial Hypertension) is an ongoing multicenter, Phase III, randomized, open-label, pragmatic trial to compare the safety and efficacy of first-line combination therapy (sildenafil and bosentan) to first-line monotherapy (sildenafil alone) in 100 pediatric patients with PH across North America...
January 2024: Pulmonary Circulation
https://read.qxmd.com/read/38463828/reducing-crash-risk-for-young-drivers-protocol-for-a-pragmatic-randomised-controlled-trial-to-improve-young-driver-sleep
#39
JOURNAL ARTICLE
Simon S Smith, Kalina R Rossa, Shamsi Shekari Soleimanloo, Cassandra L Pattinson, Dwayne L Mann, Shannon L Edmed, Paul M Salmon, Karen A Sullivan
BACKGROUND: Road trauma is a leading cause of death and disability for young Australians (15-24 years). Young adults are overrepresented in crashes due to sleepiness, with two-thirds of their fatal crashes attributed to sleepy driving. This trial aims to examine the effectiveness of a sleep extension and education program for improved road safety in young adults. METHODS: Young adults aged 18-24 years (n = 210) will be recruited for a pragmatic randomised controlled trial employing a placebo-controlled, parallel-groups design...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38462491/the-effectiveness-of-exercise-interventions-targeting-sleep-in-older-adults-with-cognitive-impairment-or-alzheimer-s-disease-and-related-dementias-ad-adrd-a-systematic-review-and-meta-analysis
#40
REVIEW
Arsenio Páez, Emmanuel Frimpong, Melodee Mograss, Thien Thanh Dang-Vu
Sleep loss is associated with reduced health and quality of life, and increased risk of Alzheimer's disease and related dementias. Up to 66% of persons with Alzheimer's disease and related dementias experience poor sleep, which can predict or accelerate the progression of cognitive decline. Exercise is a widely accessible intervention for poor sleep that can protect against functional and cognitive decline. No previous systematic reviews have investigated the effectiveness of exercise for sleep in older adults with mild cognitive impairment or Alzheimer's disease and related dementias...
March 10, 2024: Journal of Sleep Research
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