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https://www.readbyqxmd.com/read/29054877/ontogeny-of-circadian-rhythms-and-synchrony-in-the-suprachiasmatic-nucleus
#1
Vania Carmona-Alcocer, John H Abel, Tao C Sun, Linda R Petzold, Francis J Doyle, Carrie L Simms, Erik D Herzog
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates daily rhythms including sleep-wake, hormone release and gene expression. The cells of the SCN must synchronize to each other to drive these circadian rhythms in the rest of the body. The ontogeny of circadian cycling and intercellular coupling in the SCN remains poorly understood. Recent in vitro studies have recorded circadian rhythms from the whole embryonic SCN. Here, we tracked the onset and precision of rhythms in PERIOD2 (PER2), a clock protein, within the SCN isolated from embryonic and postnatal mice of undetermined sex...
October 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29046786/sedentary-time-among-primary-school-children-in-south-west-germany-amounts-and-correlates
#2
Belinda Hoffmann, Sarah Kettner, Tamara Wirt, Olivia Wartha, Lina Hermeling, Jürgen M Steinacker, Susanne Kobel
BACKGROUND: Sedentary behaviour in children is related to different health consequences such as overweight and cardio-metabolic diseases that can track into adulthood. Previous studies have shown that children spend hours being sedentary, but no data of sedentary time (ST) among German children has been available, yet. Therefore, this study investigated objectively measured amounts and correlates of ST in a sample of German primary school children. METHODS: Children's physical activity (PA) was objectively assessed for 6 days using a multi-sensor device (Actiheart®; CamNtech, Cambridge, UK)...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29038553/a-comparison-of-passive-and-active-estimates-of-sleep-in-a-cohort-with-schizophrenia
#3
Patrick Staples, John Torous, Ian Barnett, Kenzie Carlson, Luis Sandoval, Matcheri Keshavan, Jukka-Pekka Onnela
Sleep abnormalities are considered an important feature of schizophrenia, yet convenient and reliable sleep monitoring remains a challenge. Smartphones offer a novel solution to capture both self-reported and objective measures of sleep in schizophrenia. In this three-month observational study, 17 subjects with a diagnosis of schizophrenia currently in treatment downloaded Beiwe, a platform for digital phenotyping, on their personal Apple or Android smartphones. Subjects were given tri-weekly ecological momentary assessments (EMAs) on their own smartphones, and passive data including accelerometer, GPS, screen use, and anonymized call and text message logs was continuously collected...
October 16, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29035666/examination-of-risk-for-sleep-disordered-breathing-among-college-football-players
#4
Bailey Peck, Timothy Renzi, Hannah Peach, Jane Gaultney, Joseph S Marino
CONTEXT: Professional football linemen are at risk for sleep disordered breathing (SDB) compared to other types of athletes. It is currently unknown whether collegiate football linemen display a similar risk profile. OBJECTIVE: 1) Determine for the first time whether collegiate football linemen show risk for SDB, and 2) Test the hypothesis that SDB risk is higher in collegiate football linemen compared to an athletic comparison group. DESIGN: Descriptive laboratory study...
October 16, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29023563/influence-of-platinum-harmonized-textile-on-neuromuscular-systemic-and-subjective-recovery
#5
Fridolin Zinke, Patrick Bakenecker, Daniel Hahn
The clothing manufacturer Venex Life-Science tracks the strategy to enhance recovery process through implementing platinum harmonized technology (PHT) into their Venex® Regeneration Wear. The proposed mechanisms of the regeneration wear are an increase of parasympathetic activity and an increase of the temperature due far-infrared radiation. The purpose of this study was to investigate potential effects of Venex regeneration wear on the recovery of neuromuscular, systemic and subjective parameters following exercise...
2017: PloS One
https://www.readbyqxmd.com/read/29022943/simultaneous-measurement-of-sleep-and-feeding-in-individual-drosophila
#6
Keith R Murphy, Jin Hong Park, Robert Huber, William W Ja
Drosophila is widely used for the dissection of genetic and neuronal mechanisms of behavior. Recently, flies have emerged as a model for investigating the regulation of feeding and sleep. Although typically studied in isolation, increasing evidence points to a fundamental connection between these behaviors. Thus, a system for measuring sleep and feeding simultaneously in a single integrated system is important for interpreting behavioral shifts of either state. Here, we describe the construction and use of the Activity Recording Capillary Feeder or CAFE (ARC), a machine-vision (automated image tracking)-based system for the integrated measurement of sleep and feeding in individual Drosophila...
November 2017: Nature Protocols
https://www.readbyqxmd.com/read/29021168/functional-ultrasound-imaging-of-brain-activity-in-human-newborns
#7
Charlie Demene, Jérome Baranger, Miguel Bernal, Catherine Delanoe, Stéphane Auvin, Valérie Biran, Marianne Alison, Jérome Mairesse, Elisabeth Harribaud, Mathieu Pernot, Mickael Tanter, Olivier Baud
Functional neuroimaging modalities are crucial for understanding brain function, but their clinical use is challenging. Recently, the use of ultrasonic plane waves transmitted at ultrafast frame rates was shown to allow for the spatiotemporal identification of brain activation through neurovascular coupling in rodents. Using a customized flexible and noninvasive headmount, we demonstrate in human neonates that real-time functional ultrasound imaging (fUSI) is feasible by combining simultaneous continuous video-electroencephalography (EEG) recording and ultrafast Doppler (UfD) imaging of the brain microvasculature...
October 11, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28993311/central-and-peripheral-circadian-clocks-and-their-role-in-alzheimer-s-disease
#8
REVIEW
Ruchi Chauhan, Ko-Fan Chen, Brianne A Kent, Damian C Crowther
Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face. The workings of this internal clock become impaired with age. In this review, we discuss whether such age-related impairments in the circadian clock interact with age-related neurodegenerative disorders, such as Alzheimer's disease. Findings from mouse and fly models of Alzheimer's disease have accelerated our understanding of the interaction between neurodegeneration and circadian biology...
October 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28992746/changes-in-sleep-habits-between-1985-and-2013-among-children-and-adolescents-in-sweden
#9
Annika Norell-Clarke, Curt Hagquist
AIMS: The aim was to investigate changes in child and adolescent sleep habits in Sweden over time. This had not been done previously. METHODS: Cross-sectional questionnaire data over three decades of investigations of the Health Behaviours of School Children study (1985/1986, 2005/2006 and 2013/2014) were used. The sample included 18,682 children and adolescents, aged 11, 13 and 15. Empirically based age-specific sleep duration recommendations were used to operationalise sleep duration...
October 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28987265/performance-and-sleepiness-in-nurses-working-12-h-day-shifts-or-night-shifts-in-a-community-hospital
#10
Marian Wilson, Regan Permito, Ashley English, Sandra Albritton, Carlana Coogle, Hans P A Van Dongen
Hospitals are around-the-clock operations and nurses are required to care for patients night and day. The nursing shortage and desire for a more balanced work-to-home life has popularized 12-h shifts for nurses. The present study investigated sleep/wake cycles and fatigue levels in 22 nurses working 12-h shifts, comparing day versus night shifts. Nurses (11day shift and 11 night shift) were recruited from a suburban acute-care medical center. Participants wore a wrist activity monitor and kept a diary to track their sleep/wake cycles for 2 weeks...
October 5, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28982643/well-being-tracking-via-smartphone-measured-activity-and-sleep-cohort-study
#11
Orianna DeMasi, Sidney Feygin, Aluma Dembo, Adrian Aguilera, Benjamin Recht
BACKGROUND: Automatically tracking mental well-being could facilitate personalization of treatments for mood disorders such as depression and bipolar disorder. Smartphones present a novel and ubiquitous opportunity to track individuals' behavior and may be useful for inferring and automatically monitoring mental well-being. OBJECTIVE: The aim of this study was to assess the extent to which activity and sleep tracking with a smartphone can be used for monitoring individuals' mental well-being...
October 5, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28975672/don-t-let-sleeping-dogmas-lie-new-views-of-peptidoglycan-synthesis-and-its-regulation
#12
REVIEW
Heng Zhao, Vaidehi Patel, John D Helmann, Tobias Dörr
Bacterial cell wall synthesis is the target for some of our most powerful antibiotics and has thus been the subject of intense research focus for more than 50 years. Surprisingly, we still lack a fundamental understanding of how bacteria build, maintain and expand their cell wall. Due to technical limitations, directly testing hypotheses about the coordination and biochemistry of cell wall synthesis enzymes or architecture has been challenging, and interpretation of data has therefore often relied on circumstantial evidence and implicit assumptions...
October 4, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28974586/a-4-week-wait-fast-track-sleep-service-is-effective-at-establishing-vocational-drivers-on-continuous-positive-airway-pressure
#13
Sophie D West, Beatrice Downie, Gillian Olds, Mark Tomlinson, Claire Wotton, Emma Firth, Alison McMillan
We sought to establish whether an expedited or 'fast-track' NHS service to diagnose obstructive sleep apnoea (OSA) and establish vocational drivers on continuous positive airway pressure (CPAP) within 4 weeks of referral was possible. This model is recommended by the OSA Partnership Group. In total, 55 vocational drivers were referred to two sleep services. Assessment showed 73% had moderate or severe OSA on sleep study. Of those commenced on CPAP, review was a mean of 15 days after initiation (range 3-62 days)...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28943083/the-jellyfish-cassiopea-exhibits-a-sleep-like-state
#14
Ravi D Nath, Claire N Bedbrook, Michael J Abrams, Ty Basinger, Justin S Bois, David A Prober, Paul W Sternberg, Viviana Gradinaru, Lea Goentoro
Do all animals sleep? Sleep has been observed in many vertebrates, and there is a growing body of evidence for sleep-like states in arthropods and nematodes [1-5]. Here we show that sleep is also present in Cnidaria [6-8], an earlier-branching metazoan lineage. Cnidaria and Ctenophora are the first metazoan phyla to evolve tissue-level organization and differentiated cell types, such as neurons and muscle [9-15]. In Cnidaria, neurons are organized into a non-centralized radially symmetric nerve net [11, 13, 15-17] that nevertheless shares fundamental properties with the vertebrate nervous system: action potentials, synaptic transmission, neuropeptides, and neurotransmitters [15-20]...
October 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28942270/tracking-dynamic-tongue-motion-in-ultrasound-images-for-obstructive-sleep-apnea
#15
Chih-Yen Chien, Jeng-Wen Chen, Chun-Hsiang Chang, Chih-Chung Huang
Obstructive sleep apnea (OSA), a breathing disorder characterized by repetitive collapse of the pharyngeal airway during sleep, can cause intermittent hypoxemia and frequent arousal. The evaluation of dynamic tongue motion not only provides the biomechanics and pathophysiology for OSA diagnosis, but also helps doctors to determine treatment strategies for these patients with OSA. The purpose of this study was to develop and verify a dedicated tracking algorithm, called the modified optical flow (OF)-based method, for monitoring the dynamic motion of the tongue base in ultrasound image sequences derived from controls and patients with OSA...
September 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28916400/assessing-changes-in-the-activity-levels-of-breast-cancer-patients-during-radiation-therapy
#16
Colin E Champ, Nitin Ohri, Rainer J Klement, Matthew Cantor, Sushil Beriwal, Scott M Glaser, Ryan P Smith
BACKGROUND: Radiation therapy (RT) is often delivered after lumpectomy for women with breast cancer. A common perceived side effect of RT is fatigue, yet its exact effect on activity levels and sleep is unknown. In this study we analyzed the change in activity levels and sleep using an activity tracking device before, during, and after RT for women with early stage breast cancer and ductal carcinoma in situ who underwent adjuvant RT. PATIENTS AND METHODS: After institutional review board approval, activity levels were quantified before, during, and after RT with measurements of steps, miles walked, calories burned, and sleep metrics in 10 women fitted with activity trackers...
August 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28892057/reactivations-of-emotional-memory-in-the-hippocampus-amygdala-system-during-sleep
#17
Gabrielle Girardeau, Ingrid Inema, György Buzsáki
The consolidation of context-dependent emotional memory requires communication between the hippocampus and the basolateral amygdala (BLA), but the mechanisms of this process are unknown. We recorded neuronal ensembles in the hippocampus and BLA while rats learned the location of an aversive air puff on a linear track, as well as during sleep before and after training. We found coordinated reactivations between the hippocampus and the BLA during non-REM sleep following training. These reactivations peaked during hippocampal sharp wave-ripples (SPW-Rs) and involved a subgroup of BLA cells positively modulated during hippocampal SPW-Rs...
September 11, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28869230/three-decades-of-transtracheal-oxygen-therapy-a-review-of-the-associated-complications-with-an-illustrative-case-presentation
#18
REVIEW
Faisal Mujib Siddiqui, Sabrina Campbell, Susanti Ie, Frank Biscardi, Edmundo Rubio
Transtracheal oxygen therapy is a well-established modality for improving oxygenation in patients with chronic obstructive pulmonary disease, sleep apnea, pulmonary fibrosis, and other conditions causing hypoxic respiratory failure. In spite of its proven track record, the device remains underutilized. This article reviews benefits and complications related to the use of this modality with an illustrative case presentation.
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28865707/effect-of-airway-surface-liquid-on-the-forces-on-the-pharyngeal-wall-experimental-fluid-structure-interaction-study
#19
Jernej Pirnar, Brane Širok, Andrej Bombač
Obstructive sleep apnoea syndrome (OSAS) is a breathing disorder with a multifactorial etiology. The respiratory epithelium is lined with a thin layer of airway surface liquid preventing interactions between the airflow and epithelium. The effect of the liquid lining in OSAS pathogenesis remains poorly understood despite clinical research. Previous studies have shown that the physical properties of the airway surface liquid or altered stimulation of the airway mechanoreceptors could alleviate or intensify OSAS; however, these studies do not provide a clear physical interpretation...
August 24, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28842597/intrinsic-brain-connectivity-after-partial-sleep-deprivation-in-young-and-older-adults-results-from-the-stockholm-sleepy-brain-study
#20
Gustav Nilsonne, Sandra Tamm, Johanna Schwarz, Rita Almeida, Håkan Fischer, Göran Kecklund, Mats Lekander, Peter Fransson, Torbjörn Åkerstedt
Sleep deprivation has been reported to affect intrinsic brain connectivity, notably reducing connectivity in the default mode network. Studies to date have however shown inconsistent effects, in many cases lacked monitoring of wakefulness, and largely included young participants. We investigated effects of sleep deprivation on intrinsic brain connectivity in young and older participants. Participants aged 20-30 (final n = 30) and 65-75 (final n = 23) years underwent partial sleep deprivation (3 h sleep) in a cross-over design, with two 8-minutes eyes-open resting state functional magnetic resonance imaging (fMRI) runs in each session, monitored by eye-tracking...
August 25, 2017: Scientific Reports
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