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https://www.readbyqxmd.com/read/28099559/pain-induced-depression-is-related-to-overestimation-of-sleep-quality-in-a-very-elderly-population-with-pain
#1
Ricardo Humberto Felix, Carla Bezerra Lopes Almeida, Renata Carvalho Cremaschi, Fernando Morgadinho Coelho, Fânia Cristina Santos
Objective: To study the quality of sleep in very elderly people with chronic pain. Methods: We investigated 51 very elderly people without dementia and with chronic pain according to the Geriatric Pain Measure. Katz and Lawton questionnaires were used to evaluate functionality. The Geriatric Depression Scale and Geriatric Psychosocial Assessment of Pain-induced Depression were also used. Self-perceptions of sleep and quality of sleep were checked using the Pittsburgh Sleep Quality Index...
January 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28087891/physical-activity-and-exercise-for-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#2
REVIEW
Louise J Geneen, R Andrew Moore, Clare Clarke, Denis Martin, Lesley A Colvin, Blair H Smith
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning...
January 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28076377/comparative-analysis-of-vertebrate-diurnal-circadian-transcriptomes
#3
Greg Boyle, Kerstin Richter, Henry D Priest, David Traver, Todd C Mockler, Jeffrey T Chang, Steve A Kay, Ghislain Breton
From photosynthetic bacteria to mammals, the circadian clock evolved to track diurnal rhythms and enable organisms to anticipate daily recurring changes such as temperature and light. It orchestrates a broad spectrum of physiology such as the sleep/wake and eating/fasting cycles. While we have made tremendous advances in our understanding of the molecular details of the circadian clock mechanism and how it is synchronized with the environment, we still have rudimentary knowledge regarding its connection to help regulate diurnal physiology...
2017: PloS One
https://www.readbyqxmd.com/read/28047298/tu-h-campus-tep2-01-a-comparison-of-noninvasive-techniques-to-assess-radiation-induced-lung-damage-in-mice
#4
A Rubinstein, C Kingsley, A Melancon, R Tailor, J Pollard, M Guindani, D Followill, J Hazle, L Court
PURPOSE: To evaluate the use of post-irradiation changes in respiratory rate and CBCT-based morphology as predictors of survival in mice. METHODS: C57L/J mice underwent whole-thorax irradiation with a Co-60 beam to four different doses [0Gy (n=3), 9Gy (n=5), 11Gy (n=7), and 13Gy (n=5)] in order to induce varying levels of pneumonitis. Respiratory rate measurements, breath-hold CBCTs, and free-breathing CBCTs were acquired pre-irradiation and at six time points between two and seven months post-irradiation...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27991464/tram-squealing-noise-and-its-impact-on-human-health
#5
Eva Panulinova, Slávka Harabinová, Lubica Argalášová
INTRODUCTION: Tramway has become a serious urban noise source in densely populated areas. The disturbance from squealing noise is significant. Curve squeal is the very loud, tonal noise emitted by tram operation in tight radius curves. Studies had reported a relationship between noise levels and health effects, such as annoyance, sleep disturbance, and elevated systolic and diastolic blood pressure. MATERIALS AND METHODS: This study aimed to analyze the wheel squeal noise along the tramway line in Košice, Slovakia, review the effects on human health, and discuss its inclusion in the design method...
November 2016: Noise & Health
https://www.readbyqxmd.com/read/27928029/local-changes-in-network-structure-contribute-to-late-communication-recovery-after-severe-brain-injury
#6
Daniel J Thengone, Henning U Voss, Esteban A Fridman, Nicholas D Schiff
Spontaneous recovery of brain function after severe brain injury may evolve over a long time period and is likely to involve both structural and functional reorganization of brain networks. We longitudinally tracked the recovery of communication in a patient with severe brain injury using multimodal brain imaging techniques and quantitative behavioral assessments measured at the bedside over a period of 2 years and 9 months (21 months after initial injury). Structural diffusion tensor imaging revealed changes in brain structure across interhemispheric connections and in local brain regions that support language and visuomotor function...
December 7, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27911798/stretchable-multichannel-antennas-in-soft-wireless-optoelectronic-implants-for-optogenetics
#7
Sung Il Park, Gunchul Shin, Jordan G McCall, Ream Al-Hasani, Aaron Norris, Li Xia, Daniel S Brenner, Kyung Nim Noh, Sang Yun Bang, Dionnet L Bhatti, Kyung-In Jang, Seung-Kyun Kang, Aaron D Mickle, Gregory Dussor, Theodore J Price, Robert W Gereau, Michael R Bruchas, John A Rogers
Optogenetic methods to modulate cells and signaling pathways via targeted expression and activation of light-sensitive proteins have greatly accelerated the process of mapping complex neural circuits and defining their roles in physiological and pathological contexts. Recently demonstrated technologies based on injectable, microscale inorganic light-emitting diodes (μ-ILEDs) with wireless control and power delivery strategies offer important functionality in such experiments, by eliminating the external tethers associated with traditional fiber optic approaches...
December 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27909008/trajectory-of-parvalbumin-cell-impairment-and-loss-of-cortical-inhibition-in-traumatic-brain-injury
#8
Tsung-Hsun Hsieh, Henry Hing Cheong Lee, Mustafa Qadir Hameed, Alvaro Pascual-Leone, Takao K Hensch, Alexander Rotenberg
Many neuropsychiatric symptoms that follow traumatic brain injury (TBI), including mood disorders, sleep disturbance, chronic pain, and posttraumatic epilepsy (PTE) are attributable to compromised cortical inhibition. However, the temporal trajectory of cortical inhibition loss and its underlying mechanisms are not known. Using paired-pulse transcranial magnetic stimulation (ppTMS) and immunohistochemistry, we tracked functional and cellular changes of cortical inhibitory network elements after fluid-percussion injury (FPI) in rats...
November 30, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27898460/a-pilot-comparison-of-a-smartphone-app-with-or-without-2-way-messaging-among-chronic-pain-patients-who-benefits-from-a-pain-app
#9
Robert N Jamison, Dylan C Jurcik, Robert R Edwards, Chuan-Chin Huang, Edgar L Ross
OBJECTIVES: The overall aim of this study was to determine the effect of introducing a smartphone pain app, for both Android and iPhone devices that enables chronic pain patients to assess, monitor, and communicate their status to their providers. METHODS: This study recruited 105 chronic pain patients to use a smartphone pain app and half of the subjects (N=52) had 2-way messaging available through the app. All subjects completed baseline measures and were asked to record their progress every day for 3 months, with the opportunity to continue for 6 months...
November 24, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27895577/fus1-ko-mouse-as-a-model-of-oxidative-stress-mediated-sporadic-alzheimer-s-disease-circadian-disruption-and-long-term-spatial-and-olfactory-memory-impairments
#10
Guillermo Coronas-Samano, Keeley L Baker, Winston J T Tan, Alla V Ivanova, Justus V Verhagen
Insufficient advances in the development of effective therapeutic treatments of sporadic Alzheimer's Disease (sAD) to date are largely due to the lack of sAD-relevant animal models. While the vast majority of models do recapitulate AD's hallmarks of plaques and tangles by virtue of tau and/or beta amyloid overexpression, these models do not reflect the fact that in sAD (unlike familial AD) these genes are not risk factors per se and that other mechanisms like oxidative stress, metabolic dysregulation and inflammation play key roles in AD etiology...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27882272/the-impact-of-wearable-device-enabled-health-initiative-on-physical-activity-and-sleep
#11
Olga Crowley, Laura Pugliese, Stan Kachnowski
OBJECTIVES: The Personal Health Management Study (PHMS) is an assessment of the effect of a voluntary employee-facing health initiative using a commercially-available wearable device implemented among 565 employees of Boehringer Ingelheim Pharmaceuticals, Inc. The results of the initiative on physical activity (measured as steps) and sleep is reported. METHODS: This was a 12-month, prospective, single-cohort intervention study using a wearable activity-measuring device tracking steps and sleep (entire study period) and a system of health-promoting incentives (first nine months of study period)...
October 11, 2016: Curēus
https://www.readbyqxmd.com/read/27870840/single-nanotube-tracking-reveals-the-nanoscale-organization-of-the-extracellular-space-in-the-live-brain
#12
Antoine G Godin, Juan A Varela, Zhenghong Gao, Noémie Danné, Julien P Dupuis, Brahim Lounis, Laurent Groc, Laurent Cognet
The brain is a dynamic structure with the extracellular space (ECS) taking up almost a quarter of its volume. Signalling molecules, neurotransmitters and nutrients transit via the ECS, which constitutes a key microenvironment for cellular communication and the clearance of toxic metabolites. The spatial organization of the ECS varies during sleep, development and aging and is probably altered in neuropsychiatric and degenerative diseases, as inferred from electron microscopy and macroscopic biophysical investigations...
November 21, 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27855740/orthosomnia-are-some-patients-taking-the-quantified-self-too-far
#13
Kelly Glazer Baron, Sabra Abbott, Nancy Jao, Natalie Manalo, Rebecca Mullen
The use of wearable sleep tracking devices is rapidly expanding and provides an opportunity to engage individuals in monitoring of their sleep patterns. However, there are a growing number of patients who are seeking treatment for self-diagnosed sleep disturbances such as insufficient sleep duration and insomnia due to periods of light or restless sleep observed on their sleep tracker data. The patients' inferred correlation between sleep tracker data and daytime fatigue may become a perfectionistic quest for the ideal sleep in order to optimize daytime function...
November 14, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27847686/parkinson-disease-and-cognitive-impairment-five-new-things
#14
REVIEW
Albert A Davis, Brad Racette
PURPOSE OF REVIEW: While the distinctive motor symptoms of Parkinson disease (PD) have been described for centuries, cognitive impairment has only recently been recognized as a central feature. Studies have yielded clues to the etiology and natural history of cognitive impairment in PD, but much remains unclear and effective therapies are needed. RECENT FINDINGS: Longitudinal cohort studies demonstrate that almost all patients with PD will develop dementia if they live long enough...
October 2016: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/27835632/nonlinear-dynamics-forecasting-of-obstructive-sleep-apnea-onsets
#15
Trung Q Le, Satish T S Bukkapatnam
Recent advances in sensor technologies and predictive analytics are fueling the growth in point-of-care (POC) therapies for obstructive sleep apnea (OSA) and other sleep disorders. The effectiveness of POC therapies can be enhanced by providing personalized and real-time prediction of OSA episode onsets. Previous attempts at OSA prediction are limited to capturing the nonlinear, nonstationary dynamics of the underlying physiological processes. This paper reports an investigation into heart rate dynamics aiming to predict in real time the onsets of OSA episode before the clinical symptoms appear...
2016: PloS One
https://www.readbyqxmd.com/read/27826247/modulations-of-heart-rate-ecg-and-cardio-respiratory-coupling-observed-in-polysomnography
#16
REVIEW
Thomas Penzel, Jan W Kantelhardt, Ronny P Bartsch, Maik Riedl, Jan F Kraemer, Niels Wessel, Carmen Garcia, Martin Glos, Ingo Fietze, Christoph Schöbel
The cardiac component of cardio-respiratory polysomnography is covered by ECG and heart rate recordings. However, their evaluation is often underrepresented in summarizing reports. As complements to EEG, EOG, and EMG, these signals provide diagnostic information for autonomic nervous activity during sleep. This review presents major methodological developments in sleep research regarding heart rate, ECG, and cardio-respiratory couplings in a chronological (historical) sequence. It presents physiological and pathophysiological insights related to sleep medicine obtained by new technical developments...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27815231/sleep-quality-prediction-from-wearable-data-using-deep-learning
#17
Aarti Sathyanarayana, Shafiq Joty, Luis Fernandez-Luque, Ferda Ofli, Jaideep Srivastava, Ahmed Elmagarmid, Teresa Arora, Shahrad Taheri
BACKGROUND: The importance of sleep is paramount to health. Insufficient sleep can reduce physical, emotional, and mental well-being and can lead to a multitude of health complications among people with chronic conditions. Physical activity and sleep are highly interrelated health behaviors. Our physical activity during the day (ie, awake time) influences our quality of sleep, and vice versa. The current popularity of wearables for tracking physical activity and sleep, including actigraphy devices, can foster the development of new advanced data analytics...
November 4, 2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27793703/sleep-duration-predicts-behavioral-and-neural-differences-in-adult-speech-sound-learning
#18
F Sayako Earle, Nicole Landi, Emily B Myers
Sleep is important for memory consolidation and contributes to the formation of new perceptual categories. This study examined sleep as a source of variability in typical learners' ability to form new speech sound categories. We trained monolingual English speakers to identify a set of non-native speech sounds at 8PM, and assessed their ability to identify and discriminate between these sounds immediately after training, and at 8AM on the following day. We tracked sleep duration overnight, and found that light sleep duration predicted gains in identification performance, while total sleep duration predicted gains in discrimination ability...
January 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27793075/does-modafinil-improve-the-level-of-consciousness-for-people-with-a-prolonged-disorder-of-consciousness-a-retrospective-pilot-study
#19
Samira Kashinath Dhamapurkar, Barbara A Wilson, Anita Rose, Peter Watson, Agnes Shiel
BACKGROUND AND AIM: Modafinil is best known as a sleep regulator among healthy individuals, but studies suggest that it reduces excessive daytime sleepiness in patients with brain injury. This retrospective pilot study evaluated the effectiveness of Modafinil for people with a prolonged disorder of consciousness and whether those with a traumatic brain injury did better than those with a non-traumatic brain injury. METHOD: Twenty four prolonged disorder of consciousness patients who were prescribed Modafinil, were assessed at least four times both before and during treatment...
October 28, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27784416/a-randomized-crossover-trial-of-a-novel-sound-to-sleep-mattress-technology-in-children-with-autism-and-sleep-difficulties
#20
Thomas W Frazier, Jyoti Krishna, Eric Klingemier, Mary Beukemann, Rawan Nawabit, Sally Ibrahim
STUDY OBJECTIVES: This preliminary study investigated the tolerability and efficacy of a novel mattress technology - the Sound-To-Sleep (STS) system - in the treatment of sleep problems in children with autism. METHODS: After screening, 45 children, ages 2.5 to 12.9 years, were randomized to order of mattress technology use (On-Off vs. Off-On). Treatment conditions (On vs. Off) lasted two weeks with immediate crossover. Tolerability, including study discontinuation and parent-report of mattress tolerance and ease of use, was tracked throughout the study...
October 20, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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