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Resistent pneumococci in childrens

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https://www.readbyqxmd.com/read/28690025/invasive-pneumococcal-disease-caused-by-ceftriaxone-resistant-streptococcus-pneumoniae-in-taiwan
#1
Hao-Yuan Lee, Tsu-Lan Wu, Lin-Hui Su, Hsin-Chieh Li, Rajendra Prasad Janapatla, Chyi-Liang Chen, Cheng-Hsun Chiu
BACKGROUND: Invasive pneumococcal disease (IPD) was associated with mortality, but the risk factors associated with mortality remains controversial. METHODS: A retrospective cohort study was designed. All patients with IPD from 2011 to 2013 admitted in a medical center were screened and collected for their clinical presentations and laboratory characteristics. RESULTS: Approximately half of the 134 IPD isolates derived from these patients belonged to three major serotypes (19A, 6A and 3), which are included in 13-valent pneumococcal conjugate vaccine (PCV13), but not in 7-valent pneumococcal conjugate vaccine (PCV7)...
June 26, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28626738/streptococcus-pneumoniae-serotype-prevalence-and-antibiotic-resistance-among-young-children-with-invasive-pneumococcal-disease-experience-from-a-tertiary-care-center-in-south-india
#2
Savitha Nagaraj, Bhuvanesh Sukhlal Kalal, Anand Manoharan, Anita Shet
INTRODUCTION: We performed a study to describe the clinical profile, antimicrobial susceptibility and prevalent serotypes of pneumococcal isolates from children with suspected invasive pneumococcal disease (IPD) admitted to a tertiary care hospital in South India. METHODS: Hospitalized children, ≤ 5 years with fever (>38 °C); increased respiratory rate or neurological symptoms were recruited, (as part of the Alliance for Surveillance of Invasive Pneumococci - ASIP - project) from January 2011 to March 2013...
June 2017: Germs
https://www.readbyqxmd.com/read/28542565/promiscuous-signaling-by-a-regulatory-system-unique-to-the-pandemic-pmen1-pneumococcal-lineage
#3
Anagha Kadam, Rory A Eutsey, Jason Rosch, Xinyu Miao, Mark Longwell, Wenjie Xu, Carol A Woolford, Todd Hillman, Anfal Shakir Motib, Hasan Yesilkaya, Aaron P Mitchell, N Luisa Hiller
Streptococcus pneumoniae (pneumococcus) is a leading cause of death and disease in children and elderly. Genetic variability among isolates from this species is high. These differences, often the product of gene loss or gene acquisition via horizontal gene transfer, can endow strains with new molecular pathways, diverse phenotypes, and ecological advantages. PMEN1 is a widespread and multidrug-resistant pneumococcal lineage. Using comparative genomics we have determined that a regulator-peptide signal transduction system, TprA2/PhrA2, was acquired by a PMEN1 ancestor and is encoded by the vast majority of strains in this lineage...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28516842/serotype-distribution-antimicrobial-resistance-and-prevalence-of-pilus-islets-in-pneumococci-following-the-use-of-conjugate-vaccines
#4
Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi
PURPOSE: In Japan, the 7-valent pneumococcal vaccine (PCV7) was introduced in 2010 and, in 2013, the PCV7 was replaced with the 13-valent pneumococcal vaccine (PCV13). This study was conducted to investigate serotypes, antimicrobial resistance and prevalence of pilus islets in pneumococcal isolates from inpatients in a Japanese tertiary hospital. METHODOLOGY: From April 2011 to February 2016, 151 isolates [95 (18 children, 77 adults) and 56 (19 children, 37 adults) in the PCV7 and PCV13 periods, respectively] were collected...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28431817/pneumococcal-carriage-among-children-after-four-years-of-routine-10-valent-pneumococcal-conjugate-vaccine-use-in-brazil-the-emergence-of-multidrug-resistant-serotype-6c
#5
Felipe P G Neves, Nayara T Cardoso, Robert E Snyder, Mariel A Marlow, Claudete A A Cardoso, Lúcia M Teixeira, Lee W Riley
BACKGROUND: In 2010, the 10-valent pneumococcal conjugate vaccine (PCV10) was introduced free of charge in Brazil as part of the public immunization program. Here we investigated the carriage prevalence, colonization risk factors, capsular types, and antimicrobial resistance among pneumococcal isolates obtained from children in Brazil four years after routine PCV10 use. METHODS: Between September and December 2014, we conducted a cross-sectional study among children<6years old who attended one public and two private clinics in Niterói, RJ, Brazil to evaluate pneumococcal nasopharyngeal carriage...
April 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28252438/-sensitivity-study-of-antimicrobial-pneumococci-in-central-kazakhstan
#6
I Belyaev, A Belyaev
To determine the epidemiological pattern of antibiotic resistance strains of S. Pneumoniae studied the sensitivity of nasopharyngeal isolates of pneumococci isolated from healthy children attending sports clubs Karaganda region. The frequency of allocation of pneumococci was 35.57%. In accordance with the values of the minimum inhibitory concentration resistant pneumococci was: penicillin - 5.41%, erythromycin - 8.1%, clindamycin - 4.05%, amoxicillin-6.76%, tetracycline 28.38%. Resistance to beta-lactam antibiotics in the studied children is not a significant problem...
January 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28132873/detection-of-macrolide-resistance-genes-in-culture-negative-specimens-from-bangladeshi-children-with-invasive-pneumococcal-diseases
#7
Md Hasanuzzaman, Roly Malaker, Maksuda Islam, Abdullah H Baqui, Gary L Darmstadt, Cynthia G Whitney, Samir K Saha
OBJECTIVES: In recent years, an increasing prevalence of macrolide resistance among pneumococci in Bangladesh has been observed. However, the scenario remains incomplete, as few isolates (<1%) are available from pneumonia cases and most pneumococcal meningitis cases (>80%) are culture-negative. This study optimised a triplex PCR method to detect macrolide resistance genes (MRGs) (mefA and ermB) and cpsA from culture-negative pneumococcal cases to predict the prevalence and level of macrolide resistance...
January 26, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28056828/pneumococcal-carriage-and-antibiotic-susceptibility-patterns-from-two-cross-sectional-colonization-surveys-among-children-aged-5-years-prior-to-the-introduction-of-10-valent-pneumococcal-conjugate-vaccine-kenya-2009-2010
#8
Miwako Kobayashi, Laura M Conklin, Godfrey Bigogo, Geofrey Jagero, Lee Hampton, Katherine E Fleming-Dutra, Muthoni Junghae, Maria da Gloria Carvalho, Fabiana Pimenta, Bernard Beall, Thomas Taylor, Kayla F Laserson, John Vulule, Chris Van Beneden, Lindsay Kim, Daniel R Feikin, Cynthia G Whitney, Robert F Breiman
BACKGROUND: Pneumococci are spread by persons with nasopharyngeal colonization, a necessary precursor to invasive disease. Pneumococcal conjugate vaccines can prevent colonization with vaccine serotype strains. In 2011, Kenya became one of the first African countries to introduce the 10-valent pneumococcal conjugate vaccine (PCV10) into its national immunization program. Serial cross-sectional colonization surveys were conducted to assess baseline pneumococcal colonization, antibiotic resistance patterns, and factors associated with resistance...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27994923/microbiological-features-of-upper-respiratory-tract-infections-in-bulgarian-children-for-the-period-1998-2014
#9
Raina Tzvetanova Gergova, Guergana Petrova, Stefan Gergov, Petko Minchev, Ivan Mitov, Tanya Strateva
BACKGROUND: Across the globe, upper respiratory tract infections (URTIs) are the most prevalent cause of morbidity in childhood. AIMS: The aim of our study is to analyze the incidence and etiology of bacterial URTIs in Bulgarian children, as well as the increasing antimicrobial resistance to the most common etiologic agents over a period of 17 years. STUDY DESIGN: Retrospective study. METHODS: The study material comprised the data from 4768 patients (aged 1-16 years) with URTI during the period from 1998-2014...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27956163/invasive-pneumococcal-disease-in-children-aged-younger-than-5-years-in-india-a-surveillance-study
#10
Anand Manoharan, Vikas Manchanda, Sundaram Balasubramanian, Sanjay Lalwani, Meera Modak, Sushama Bai, Ajith Vijayan, Anita Shet, Savitha Nagaraj, Sunil Karande, Gita Nataraj, Vijay N Yewale, Shrikrishna A Joshi, Ranganathan N Iyer, Mathuram Santosham, Geoffrey D Kahn, Maria Deloria Knoll
BACKGROUND: Invasive pneumococcal disease continues to be a major cause of morbidity and mortality among children younger than 5 years of age in India. We aimed to provide nationally representative data for the pattern of disease due to Streptococcus pneumoniae, trends in the serotype of invasive pneumococci, and invasive pneumococci antimicrobial resistance patterns, in India. METHODS: In this prospective hospital-based and retrospective laboratory-based surveillance study, we prospectively enrolled children aged younger than 5 years with suspected or proven invasive pneumococcal disease from 18 hospitals or institutional centres and retrospectively included laboratory-confirmed pneumococcal isolates from ten sentinel laboratories, together representing 11 states in India...
March 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27919900/n-acetyl-l-cysteine-and-cysteamine-as-new-strategies-against-mixed-biofilms-of-nonencapsulated-streptococcus-pneumoniae-and-nontypeable-haemophilus-influenzae
#11
Mirian Domenech, Ernesto García
Acute otitis media, a polymicrobial disease of the middle ear cavity of children, is a significant public health problem worldwide. It is most frequently caused by encapsulated Streptococcus pneumoniae and nontypeable Haemophilus influenzae, although the widespread use of pneumococcal conjugate vaccines is apparently producing an increase in the carriage of nonencapsulated S. pneumoniae Frequently, pneumococci and H. influenzae live together in the human nasopharynx, forming a self-produced biofilm. Biofilms present a global medical challenge since the inherent antibiotic resistance of their producers demands the use of large doses of antibiotics over prolonged periods...
February 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27821148/understanding-pneumococcal-serotype-1-biology-through-population-genomic-analysis
#12
Chrispin Chaguza, Jennifer E Cornick, Simon R Harris, Cheryl P Andam, Laura Bricio-Moreno, Marie Yang, Feyruz Yalcin, Sani Ousmane, Shanil Govindpersad, Madikay Senghore, Chinelo Ebruke, Mignon Du Plessis, Anmol M Kiran, Gerd Pluschke, Betuel Sigauque, Lesley McGee, Keith P Klugman, Paul Turner, Jukka Corander, Julian Parkhill, Jean-Marc Collard, Martin Antonio, Anne von Gottberg, Robert S Heyderman, Neil French, Aras Kadioglu, William P Hanage, Dean B Everett, Stephen D Bentley
BACKGROUND: Pneumococcus kills over one million children annually and over 90 % of these deaths occur in low-income countries especially in Sub-Saharan Africa (SSA) where HIV exacerbates the disease burden. In SSA, serotype 1 pneumococci particularly the endemic ST217 clone, causes majority of the pneumococcal disease burden. To understand the evolution of the virulent ST217 clone, we analysed ST217 whole genomes from isolates sampled from African and Asian countries. METHODS: We analysed 226 whole genome sequences from the ST217 lineage sampled from 9 African and 4 Asian countries...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27784937/antibiotic-resistance-patterns-and-related-mobile-genetic-elements-of-pneumococci-and-%C3%AE-hemolytic-streptococci-in-thai-healthy-children
#13
P Tantivitayakul, J Lapirattanakul, T Vichayanrat, T Muadchiengka
Transmission of antibiotic resistance genes among Streptococcus pneumoniae and beta-hemolytic streptococcus (BHS) was generally associated with transmissible genetic elements. The objectives of this study were to investigate carriage rate, antibiotic resistance and related mobile genetic elements of pneumococci and BHS from school-children. The pneumococci and BHS were recovered from 220 Thai school-children, and then tested for antibiotic susceptibility pattern by disc diffusion. Antibiotic resistance genes and related genetic elements were detected by PCR with specific primers...
December 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27756235/an-outbreak-of-pneumococcal-meningitis-among-older-children-%C3%A2-5%C3%A2-years-and-adults-after-the-implementation-of-an-infant-vaccination-programme-with-the-13-valent-pneumococcal-conjugate-vaccine-in-ghana
#14
Brenda Anna Kwambana-Adams, Franklin Asiedu-Bekoe, Badu Sarkodie, Osei Kuffour Afreh, George Khumalo Kuma, Godfred Owusu-Okyere, Ebenezer Foster-Nyarko, Sally-Ann Ohene, Charles Okot, Archibald Kwame Worwui, Catherine Okoi, Madikay Senghore, Jacob Kweku Otu, Chinelo Ebruke, Richard Bannerman, Kwame Amponsa-Achiano, David Opare, Gemma Kay, Timothy Letsa, Owen Kaluwa, Ebenezer Appiah-Denkyira, Victor Bampoe, Syed M A Zaman, Mark J Pallen, Umberto D'Alessandro, Jason M Mwenda, Martin Antonio
BACKGROUND: An outbreak of pneumococcal meningitis among non-infant children and adults occurred in the Brong-Ahafo region of Ghana between December 2015 and April 2016 despite the recent nationwide implementation of a vaccination programme for infants with the 13-valent pneumococcal conjugate vaccine (PCV13). METHODS: Cerebrospinal fluid (CSF) specimens were collected from patients with suspected meningitis in the Brong-Ahafo region. CSF specimens were subjected to Gram staining, culture and rapid antigen testing...
October 18, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27677790/recombination-in-streptococcus-pneumoniae-lineages-increase-with-carriage-duration-and-size-of-the-polysaccharide-capsule
#15
Chrispin Chaguza, Cheryl P Andam, Simon R Harris, Jennifer E Cornick, Marie Yang, Laura Bricio-Moreno, Arox W Kamng'ona, Julian Parkhill, Neil French, Robert S Heyderman, Aras Kadioglu, Dean B Everett, Stephen D Bentley, William P Hanage
Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many bacteria, the pneumococcus can import DNA from other strains or even species by transformation and homologous recombination, which has allowed the pneumococcus to evade clinical interventions such as antibiotics and pneumococcal conjugate vaccines (PCVs). Pneumococci are enclosed in a complex polysaccharide capsule that determines the serotype; the capsule varies in size and is associated with properties including carriage prevalence and virulence...
September 27, 2016: MBio
https://www.readbyqxmd.com/read/27649366/prevalence-of-pneumococcal-nasopharyngeal-carriage-among-children-2-18-months-of-age-baseline-study-pre-introduction-of-pneumococcal-vaccination-in-cuba
#16
María E Toledo, Maria F Casanova, Nivaldo Linares-Pérez, Dagmar García-Rivera, Gilda Toraño Peraza, Indira Barcos Pina, Martha Montes de Oca, Laura M Rodriguez-Noda, Mayelín Mirabal, Beatriz Paredes, Dunia M Chávez Amaro, Darielys Santana Mederos, Yury Valdés-Balbín, Vicente Verez-Bencomo
BACKGROUND: A new vaccine candidate against pneumococcus is being developed in Cuba, and it is a priority of the national health system. There is limited information on nasopharyngeal colonization burden, though it is essential for monitoring the impact of the vaccine. The study aims to estimate the prevalence of nasopharyngeal colonization in children 2-18 months of age and identify circulating serotypes, antimicrobial resistance and its association with selected risk factors. METHODS: A cross-sectional study was conducted between October and December 2013 in Cienfuegos municipality...
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27546875/emergence-of-antibiotic-resistant-non-vaccine-serotype-pneumococci-in-nasopharyngeal-carriage-in-children-after-the-use-of-extended-valency-pneumococcal-conjugate-vaccines-in-korea
#17
Young June Choe, Hoan Jong Lee, Hyunju Lee, Chi Eun Oh, Eun Young Cho, Jae Hong Choi, Hyun Mi Kang, In Ae Yoon, Hyun Joo Jung, Eun Hwa Choi
BACKGROUND: This study was performed to assess the serotype distribution and antibiotic nonsusceptibility of pneumococcal carriage isolates from children in Korea following the introduction of extended-valency pneumococcal conjugate vaccines (PCVs). METHODS: From April to June 2014, nasopharyngeal swabs were collected from children who were attending daycare centers in Korea. The collection was conducted in accordance with the World Health Organization Pneumococcal Carriage Working Group standards...
September 14, 2016: Vaccine
https://www.readbyqxmd.com/read/27540112/density-serotype-diversity-and-fitness-of-streptococcus-pneumoniae-in-upper-respiratory-tract-cocolonization-with-nontypeable-haemophilus-influenzae
#18
Joseph A Lewnard, Amit Huppert, Noga Givon-Lavi, Melinda M Pettigrew, Gili Regev-Yochay, Ron Dagan, Daniel M Weinberger
BACKGROUND:  Coinfections by Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) are frequently implicated in complex otitis media. Whereas upper respiratory tract carriage precedes disease for both pathogens, interactions between species in cocolonized hosts are poorly understood. We compared colonization densities and the diversity and fitness of pneumococcal serotypes in single-species and mixed-species colonization. METHODS:  We analyzed nasopharyngeal pneumococcal carriage and nasopharyngeal and oropharyngeal NTHi carriage in 13 541 samples collected over 6909 study visits from 769 children 2-30 months old in a 7-valent pneumococcal conjugate vaccine dosing trial...
November 1, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27257915/multidrug-resistance-in-non-pcv13-serotypes-of-streptococcus-pneumoniae-in-northern-japan-2014
#19
Mitsuyo Kawaguchiya, Noriko Urushibara, Nobumichi Kobayashi
Since the implementation of routine PCV13 immunization in Japan, nonvaccine serotypes (NVTs) have been increasing among clinical isolates of Streptococcus pneumoniae. In this study, susceptibility to 18 antibiotics was tested for all the 231 isolates with NVTs, which were collected from children <16 years of age in northern Japan in 2014 (July-November). High resistance rates were observed for macrolides (>90.9%), tetracycline (91.3%), and clindamycin (75.3%), while penicillin (PEN) nonsusceptibility (PNSP; MIC ≥0...
March 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27206423/antibiotic-resistance-of-streptococcus-pneumoniae-isolated-from-nasopharynx-of-preschool-children-with-acute-respiratory-tract-infection-in-lithuania
#20
Indrė Stacevičienė, Sigita Petraitienė, Daiva Vaičiūnienė, Tomas Alasevičius, Jūratė Kirslienė, Vytautas Usonis
BACKGROUND: Increasing pneumococcal resistance to commonly used antibiotics and multidrug resistance is a serious public health concern. Data on distribution of resistant Streptococcus pneumoniae (SPn) strains among children in Lithuania are limited. We evaluated the circulation of SPn serotypes and antimicrobial susceptibility among preschool children in Lithuania before the introduction of universal infant pneumococcal vaccination. METHODS: A prospective study was carried out from February 2012 to March 2013 in five cities of Lithuania...
May 20, 2016: BMC Infectious Diseases
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