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Enterococci infections in childrens

Munehiro Furuichi, Mihoko Furuichi, Yuho Horikoshi, Isao Miyairi
BACKGROUND: Enterococci can cause severe infectious diseases. Delaying appropriate antibiotic therapy for enterococcal bacteremia is associated with increased patient mortality. METHODS: We conducted a retrospective analysis examining the characteristics of children with enterococcal bacteremia at the two largest children's hospitals in Japan. We compared outcomes of enterococcal bacteremia patients who received infectious diseases (ID) consultation with those who did not...
January 29, 2018: Pediatric Infectious Disease Journal
Miniar Tfifha, Asma Ferjani, Manel Mallouli, Nesrine Mlika, Saoussen Abroug, Jalel Boukadida
The pandemic spread of multidrug-resistant (MDR) bacteria (i.e., methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum b-lactamase-producing Enterobacteriaceae (ESBLPE), vancomycin-resistant enterococci, carbapenemase-producing Enterobacteriaceae (CPE), multiresistant Pseudomonas aeruginosa and multiresistant Acinetobacter baumannii) pose a threat to healthcare Worldwide. We found limited data of MDR bacteria in pediatric patients hospitalized in Tunisian tertiary healthcare.The aim of the study is to evaluate the acquisition rate of MDR acquisition during hospitalization and to explore some of the associated risk factors for both carriage and acquisition at the pediatric department, Sahloul University Hospital...
December 2018: Libyan Journal of Medicine
E Costa, M Tejada, P Gaia, M Cornetta, A Moroni, E Carfora, R Valaperta, C De Siena, N Moussaidi, G Isgrò, A Frigiola
Screening on hospital admission to identify multidrug-resistant organism (MDRO) colonization is a frequently discussed topic. We report the results of microbiological screening in 141 Italian and 354 migrant children candidates for cardiac surgery conducted in 2015-2016. In all, 25% of Italian children and more than 65.4% of African and Romanian children carried at least one MDRO (meticillin-resistant Staphylococcus aureus; extended-spectrum β-lactamase enzymes; carbapenemase producers; and vancomycin-resistant enterococci)...
March 2018: Journal of Hospital Infection
M Wagener, M Naidoo, C Aldous
BACKGROUND: Snakebites can produce severe local and systemic septic complications as well as being associated with significant overall morbidity and even mortality. OBJECTIVE: A prospective audit was undertaken to determine the bacterial causation of wound infection secondary to snakebite, and attempt to quantify the burden of disease. METHODS: The audit was undertaken at Ngwelezane Hospital, which provides both regional and tertiary services for north-eastern KwaZulu-Natal Province, South Africa, over a 4-month period...
March 29, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Myrto Eleni Flokas, Spyridon A Karageorgos, Marios Detsis, Michail Alevizakos, Eleftherios Mylonakis
The objective of this study was to estimate the rate and significance of colonisation with vancomycin-resistant enterococci (VRE) among hospitalised children. The PubMed and EMBASE databases were systematically searched (last accessed on 29 May 2016) to identify studies evaluating VRE colonisation of the gastrointestinal tract of hospitalised children in non-outbreak periods. Of 945 non-duplicate citations, 19 studies enrolling 20 234 children were included. The overall and paediatric intensive care unit (PICU) rate of VRE colonisation were both 5% [95% confidence interval (CI) 3-8% overall and 95% CI 2-9% in the PICU] but was 23% in haematology/oncology units (95% CI 18-29%)...
March 20, 2017: International Journal of Antimicrobial Agents
A Dramowski, M Aucamp, A Bekker, S Mehtar
BACKGROUND: Hospitalized neonates are vulnerable to infection, with pathogen exposures occurring in utero, intrapartum, and postnatally. African neonatal units are at high risk of outbreaks owing to overcrowding, understaffing, and shared equipment. METHODS: Neonatal outbreaks attended by the paediatric infectious diseases and infection prevention (IP) teams at Tygerberg Children's Hospital, Cape Town (May 1, 2008 to April 30, 2016) are described, pathogens, outbreak size, mortality, source, and outbreak control measures...
April 2017: International Journal of Infectious Diseases: IJID
Gil Marcus, Samuel Levy, Ghaleb Salhab, Bethlehem Mengesha, Oran Tzuman, Shira Shur, Erica Burke, Rebecca Cruz Mayeda, Lior Cochavi, Idan Perluk, Ronit Zaidenstein, Tsilia Lazarovitch, Mor Dadon, Dror Marchaim
BACKGROUND: Intra-abdominal infections (IAI) constitute a common reason for hospitalization. However, there is lack of standardization in empiric management of (1) anaerobes, (2) enterococci, (3) fungi, and (4) multidrug-resistant organisms (MDRO). The recommendation is to institute empiric coverage for some of these organisms in "high-risk community-acquired" or in "healthcare-associated" infections (HCAI), but exact definitions are not provided. METHODS: Epidemiological study of IAI was conducted at Assaf Harofeh Medical Center (May-November 2013)...
October 2016: Open Forum Infectious Diseases
Edson Yukio Komiyama, Laura Soares Souto Lepesqueur, Cinthia Gomes Yassuda, Lakshman P Samaranayake, Nipuna B Parahitiyawa, Ivan Balducci, Cristiane Yumi Koga-Ito
Enterococci are considered as transient constituent components of the oral microbiome that may cause a variety of oral and systemic infections. As there is sparse data on the oral enterococcal prevalence, we evaluated the Enterococcus spp. and their virulence attributes including antimicrobial resistance in a healthy Brazilian cohort. A total of 240 individuals in different age groups were studied (children 4-11 yrs, adolescents 12-17 yrs, young adults 18-29 yrs, adults 30-59 yrs, elderly over 60 yrs). Oral rinses were collected and isolates were identified by API 20 Strep and confirmed by 16S rDNA sequencing...
2016: PloS One
Tobias Tenenbaum, Klaus-Peter Becker, Bettina Lange, Anka Martin, Peter Schäfer, Stefan Weichert, Horst Schroten
OBJECTIVE To determine the prevalence of multidrug-resistant organisms (MDROs) colonizing in pediatric refugees admitted to a University Children Hospital in Germany. DESIGN Retrospective observational study. SETTING General pediatric and pediatric surgery units. PATIENTS In Germany, recommendations for MDRO screening of pediatric refugees were recently published. According to these and institutional recommendations, all hospitalized pediatric refugees were screened for MDROs between October 2015 and March 2016...
November 2016: Infection Control and Hospital Epidemiology
Radoslaw Jaworski, Ireneusz Haponiuk, Mariusz Steffens, Elzbieta Arlukowicz, Ninela Irga-Jaworska, Maciej Chojnicki, Ewelina Kwasniak, Jacek Zielinski
INTRODUCTION: The incidence of multidrug resistant microorganisms worldwide is increasing. The aim of the study was to present institutional experience with the multidrug resistant microorganism colonization patterns observed in children with congenital heart diseases hospitalized in a hybrid pediatric cardiac surgery center. MATERIAL AND METHODS: Microbiological samples were routinely collected in all children admitted to our department. All microbiological samples were analyzed with regard to multidrug resistant microorganisms: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Gram-negative rods producing extended-spectrum beta-lactamases (ESBL), multidrug resistant Gram-negative rods (MDR-GNRs), carbapenemase-producing Klebsiella pneumoniae (KPC), carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA)...
June 1, 2016: Archives of Medical Science: AMS
Alireza Nateghian, Fatemeh Fallah, Zahra Daghighi, Hossein Goudarzi, Ali Hashemi, Joan L Robinson
BACKGROUND: The study of virulence genes carried by enterococci has become of greater relevance as nosocomial enterococcal infections have become more prevalent and possibly more severe. METHODS: Surveillance swabs were performed on children less than 18 months of age in an intensive care unit in Iran in 2012-2013. Multiplex PCR and sequencing methods were used to detect gelE, esp and asa1 genes in enterococci with intermediate or full resistance to vancomycin. RESULTS: The rate of carriage of the genes was gelE (91%), esp (79%) and asa1 (87%)...
June 2016: Diagnostic Microbiology and Infectious Disease
Hacer Aktürk, Murat Sütçü, Ayper Somer, Serap Karaman, Manolya Acar, Ayşegül Ünüvar, Sema Anak, Zeynep Karakaş, Aslı Özdemir, Kutay Sarsar, Derya Aydın, Nuran Salman
OBJECTIVE: To investigate the clinical impact of vancomycin-resistant enterococci (VRE) colonization in patients with hematologic malignancies and associated risk factors. MATERIALS AND METHODS: Patients colonized and infected with VRE were identified from an institutional surveillance database between January 2010 and December 2013. A retrospective case-control study was performed to identify the risk factors associated with development of VRE infection in VRE-colonized patients...
September 5, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Valerie P O'Brien, Thomas J Hannan, Hailyn V Nielsen, Scott J Hultgren
Urinary tract infections (UTI) are among the most common bacterial infections in humans, affecting millions of people every year. UTI cause significant morbidity in women throughout their lifespan, in infant boys, in older men, in individuals with underlying urinary tract abnormalities, and in those that require long-term urethral catheterization, such as patients with spinal cord injuries or incapacitated individuals living in nursing homes. Serious sequelae include frequent recurrences, pyelonephritis with sepsis, renal damage in young children, pre-term birth, and complications of frequent antimicrobial use including high-level antibiotic resistance and Clostridium difficile colitis...
February 2016: Microbiology Spectrum
M Jahan, R A Holley
UNLABELLED: Listeria monocytogenes is an important foodborne pathogen that can cause infection in children, pregnant women, the immunocompromised and the elderly. Antibiotic resistance in this species would represent a significant public health problem since the organism has a high fatality/case ratio and resistance may contribute to failure of therapeutic treatment. This study was designed to explore whether the in vitro transferability of antibiotic resistance from enterococci to Listeria spp...
April 2016: Letters in Applied Microbiology
Murat Sutcu, Hacer Akturk, Manolya Acar, Nuran Salman, Derya Aydın, Bahar Akgun Karapınar, Aslı Ozdemir, Rukiye Cihan, Agop Citak, Ayper Somer
BACKGROUND: We aimed to determine the frequency of vancomycin-resistant enterococci (VRE) infection occurrence in previously VRE-colonized children in a pediatric intensive care unit (PICU) and to identify associated risk factors. METHODS: Infection control nurses have performed prospective surveillance of health care-associated infections and rectal VRE carriage in PICUs from January 2010-December 2014. This database was reviewed to obtain information about VRE-colonized and subsequently infected patients...
May 1, 2016: American Journal of Infection Control
Noah Obeng-Nkrumah, Appiah-Korang Labi, Michael Ebo Acquah, Eric S Donkor
BACKGROUND: Bloodstream infections (BSI) remain a major cause of mortality in patients with malignancies. We present the first report on the microbiological profile of bacteraemia and fungaemia among cancer patients in Ghana. METHODS: From January 2010 through December 2013, we retrospectively analyzed the spectrum of bloodstream pathogens in cancer patients from Korle-Bu Teaching Hospital, Ghana--focusing on multidrug resistant isolates (MDRs). RESULTS: Overall BSI were confirmed in 22% (n = 93/453) of total blood cultures...
2015: BMC Research Notes
M V Sycheva, O L Kartashova
AIM: Study the prevalence and intensity of anti-hemoglobin and anti-lactoferrin activity in enterococci as representatives of symbiotic intestine microflora and causative agents of infection-inflammatory diseases in children. MATERIALS AND METHODS: 95 strains of enterococci were used in the study, that were isolated from intestines of children during examination for dysbiosis, and 34 clinical isolates. Strain identification was carried out by using multiplex PCR...
July 2015: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Aslınur Özkaya-Parlakay, Ali Bülent Cengiz, Mehmet Ceyhan, Arzu Bağdat, Çağrı Barın-Kurtoğlu, Venhar Gürbüz, Ahmet Emre Aycan, Ateş Kara
Vancomycin-resistant enterococci (VRE) have become a major concern in medical practice. Asymptomatic VRE colonization of the gastrointestinal tract may lead to infection. In this study, which included patients who stayed in our hospital between 2006 and 2011, we looked at the cases of 342 patients with VRE colonization and 19 patients with VRE infection. Vancomycin and carbapenem exposure and intestinal disorders were significantly more common in patients with VRE infection than in those with VRE colonization (p=0...
November 2014: Turkish Journal of Pediatrics
Philippe Montravers, Hervé Dupont, Marc Leone, Jean-Michel Constantin, Paul-Michel Mertes, Pierre-Francois Laterre, Benoit Misset, Jean-Pierre Bru, Rémy Gauzit, Albert Sotto, Cecile Brigand, Antoine Hamy, Jean-Jacques Tuech
Intra-abdominal infections are one of the most common gastrointestinal emergencies and a leading cause of septic shock. A consensus conference on the management of community-acquired peritonitis was published in 2000. A new consensus as well as new guidelines for less common situations such as peritonitis in paediatrics and healthcare-associated infections had become necessary. The objectives of these Clinical Practice Guidelines (CPGs) were therefore to define the medical and surgical management of community-acquired intra-abdominal infections, define the specificities of intra-abdominal infections in children and describe the management of healthcare-associated infections...
April 2015: Anaesthesia, Critical Care & Pain Medicine
Håvard Aamodt, Stein Christian Mohn, Samuel Maselle, Karim P Manji, Rob Willems, Roland Jureen, Nina Langeland, Bjørn Blomberg
BACKGROUND: While enterococci resistant to multiple antimicrobials are spreading in hospitals worldwide, causing urinary tract, wound and bloodstream infections, there is little published data on these infections from Africa. METHODS: We assessed the prevalence, susceptibility patterns, clinical outcome and genetic relatedness of enterococcal isolates causing bloodstream infections in children in a tertiary hospital in Tanzania, as part of a prospective cohort study of bloodstream infections among 1828 febrile children admitted consecutively from August 2001 to August 2002...
February 28, 2015: BMC Infectious Diseases
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