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Enterococci infections in childrens

Edson Yukio Komiyama, Laura Soares Souto Lepesqueur, Cinthia Gomes Yassuda, Lakshman P Samaranayake, Nipuna B Parahitiyawa, Ivan Balducci, Cristiane Yumi Koga-Ito
Enterococci are considered as transient constituent components of the oral microbiome that may cause a variety of oral and systemic infections. As there is sparse data on the oral enterococcal prevalence, we evaluated the Enterococcus spp. and their virulence attributes including antimicrobial resistance in a healthy Brazilian cohort. A total of 240 individuals in different age groups were studied (children 4-11 yrs, adolescents 12-17 yrs, young adults 18-29 yrs, adults 30-59 yrs, elderly over 60 yrs). Oral rinses were collected and isolates were identified by API 20 Strep and confirmed by 16S rDNA sequencing...
2016: PloS One
Tobias Tenenbaum, Klaus-Peter Becker, Bettina Lange, Anka Martin, Peter Schäfer, Stefan Weichert, Horst Schroten
OBJECTIVE To determine the prevalence of multidrug-resistant organisms (MDROs) colonizing in pediatric refugees admitted to a University Children Hospital in Germany. DESIGN Retrospective observational study. SETTING General pediatric and pediatric surgery units. PATIENTS In Germany, recommendations for MDRO screening of pediatric refugees were recently published. According to these and institutional recommendations, all hospitalized pediatric refugees were screened for MDROs between October 2015 and March 2016...
November 2016: Infection Control and Hospital Epidemiology
Radoslaw Jaworski, Ireneusz Haponiuk, Mariusz Steffens, Elzbieta Arlukowicz, Ninela Irga-Jaworska, Maciej Chojnicki, Ewelina Kwasniak, Jacek Zielinski
INTRODUCTION: The incidence of multidrug resistant microorganisms worldwide is increasing. The aim of the study was to present institutional experience with the multidrug resistant microorganism colonization patterns observed in children with congenital heart diseases hospitalized in a hybrid pediatric cardiac surgery center. MATERIAL AND METHODS: Microbiological samples were routinely collected in all children admitted to our department. All microbiological samples were analyzed with regard to multidrug resistant microorganisms: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Gram-negative rods producing extended-spectrum beta-lactamases (ESBL), multidrug resistant Gram-negative rods (MDR-GNRs), carbapenemase-producing Klebsiella pneumoniae (KPC), carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA)...
June 1, 2016: Archives of Medical Science: AMS
Alireza Nateghian, Fatemeh Fallah, Zahra Daghighi, Hossein Goudarzi, Ali Hashemi, Joan L Robinson
BACKGROUND: The study of virulence genes carried by enterococci has become of greater relevance as nosocomial enterococcal infections have become more prevalent and possibly more severe. METHODS: Surveillance swabs were performed on children less than 18 months of age in an intensive care unit in Iran in 2012-2013. Multiplex PCR and sequencing methods were used to detect gelE, esp and asa1 genes in enterococci with intermediate or full resistance to vancomycin. RESULTS: The rate of carriage of the genes was gelE (91%), esp (79%) and asa1 (87%)...
June 2016: Diagnostic Microbiology and Infectious Disease
Hacer Aktürk, Murat Sütçü, Ayper Somer, Serap Karaman, Manolya Acar, Ayşegül Ünüvar, Sema Anak, Zeynep Karakaş, Aslı Özdemir, Kutay Sarsar, Derya Aydın, Nuran Salman
OBJECTIVE: To investigate the clinical impact of vancomycin-resistant enterococci (VRE) colonization in patients with hematologic malignancies and associated risk factors. MATERIALS AND METHODS: Patients colonized and infected with VRE were identified from an institutional surveillance database between January 2010 and December 2013. A retrospective case-control study was performed to identify the risk factors associated with development of VRE infection in VRE-colonized patients...
September 5, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Valerie P O'Brien, Thomas J Hannan, Hailyn V Nielsen, Scott J Hultgren
Urinary tract infections (UTI) are among the most common bacterial infections in humans, affecting millions of people every year. UTI cause significant morbidity in women throughout their lifespan, in infant boys, in older men, in individuals with underlying urinary tract abnormalities, and in those that require long-term urethral catheterization, such as patients with spinal cord injuries or incapacitated individuals living in nursing homes. Serious sequelae include frequent recurrences, pyelonephritis with sepsis, renal damage in young children, pre-term birth, and complications of frequent antimicrobial use including high-level antibiotic resistance and Clostridium difficile colitis...
February 2016: Microbiology Spectrum
M Jahan, R A Holley
UNLABELLED: Listeria monocytogenes is an important foodborne pathogen that can cause infection in children, pregnant women, the immunocompromised and the elderly. Antibiotic resistance in this species would represent a significant public health problem since the organism has a high fatality/case ratio and resistance may contribute to failure of therapeutic treatment. This study was designed to explore whether the in vitro transferability of antibiotic resistance from enterococci to Listeria spp...
April 2016: Letters in Applied Microbiology
Murat Sutcu, Hacer Akturk, Manolya Acar, Nuran Salman, Derya Aydın, Bahar Akgun Karapınar, Aslı Ozdemir, Rukiye Cihan, Agop Citak, Ayper Somer
BACKGROUND: We aimed to determine the frequency of vancomycin-resistant enterococci (VRE) infection occurrence in previously VRE-colonized children in a pediatric intensive care unit (PICU) and to identify associated risk factors. METHODS: Infection control nurses have performed prospective surveillance of health care-associated infections and rectal VRE carriage in PICUs from January 2010-December 2014. This database was reviewed to obtain information about VRE-colonized and subsequently infected patients...
May 1, 2016: American Journal of Infection Control
Noah Obeng-Nkrumah, Appiah-Korang Labi, Michael Ebo Acquah, Eric S Donkor
BACKGROUND: Bloodstream infections (BSI) remain a major cause of mortality in patients with malignancies. We present the first report on the microbiological profile of bacteraemia and fungaemia among cancer patients in Ghana. METHODS: From January 2010 through December 2013, we retrospectively analyzed the spectrum of bloodstream pathogens in cancer patients from Korle-Bu Teaching Hospital, Ghana--focusing on multidrug resistant isolates (MDRs). RESULTS: Overall BSI were confirmed in 22% (n = 93/453) of total blood cultures...
2015: BMC Research Notes
M V Sycheva, O L Kartashova
AIM: Study the prevalence and intensity of anti-hemoglobin and anti-lactoferrin activity in enterococci as representatives of symbiotic intestine microflora and causative agents of infection-inflammatory diseases in children. MATERIALS AND METHODS: 95 strains of enterococci were used in the study, that were isolated from intestines of children during examination for dysbiosis, and 34 clinical isolates. Strain identification was carried out by using multiplex PCR...
July 2015: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Aslınur Özkaya-Parlakay, Ali Bülent Cengiz, Mehmet Ceyhan, Arzu Bağdat, Çağrı Barın-Kurtoğlu, Venhar Gürbüz, Ahmet Emre Aycan, Ateş Kara
Vancomycin-resistant enterococci (VRE) have become a major concern in medical practice. Asymptomatic VRE colonization of the gastrointestinal tract may lead to infection. In this study, which included patients who stayed in our hospital between 2006 and 2011, we looked at the cases of 342 patients with VRE colonization and 19 patients with VRE infection. Vancomycin and carbapenem exposure and intestinal disorders were significantly more common in patients with VRE infection than in those with VRE colonization (p=0...
November 2014: Turkish Journal of Pediatrics
Philippe Montravers, Hervé Dupont, Marc Leone, Jean-Michel Constantin, Paul-Michel Mertes, Pierre-Francois Laterre, Benoit Misset, Jean-Pierre Bru, Rémy Gauzit, Albert Sotto, Cecile Brigand, Antoine Hamy, Jean-Jacques Tuech
Intra-abdominal infections are one of the most common gastrointestinal emergencies and a leading cause of septic shock. A consensus conference on the management of community-acquired peritonitis was published in 2000. A new consensus as well as new guidelines for less common situations such as peritonitis in paediatrics and healthcare-associated infections had become necessary. The objectives of these Clinical Practice Guidelines (CPGs) were therefore to define the medical and surgical management of community-acquired intra-abdominal infections, define the specificities of intra-abdominal infections in children and describe the management of healthcare-associated infections...
April 2015: Anaesthesia, Critical Care & Pain Medicine
Håvard Aamodt, Stein Christian Mohn, Samuel Maselle, Karim P Manji, Rob Willems, Roland Jureen, Nina Langeland, Bjørn Blomberg
BACKGROUND: While enterococci resistant to multiple antimicrobials are spreading in hospitals worldwide, causing urinary tract, wound and bloodstream infections, there is little published data on these infections from Africa. METHODS: We assessed the prevalence, susceptibility patterns, clinical outcome and genetic relatedness of enterococcal isolates causing bloodstream infections in children in a tertiary hospital in Tanzania, as part of a prospective cohort study of bloodstream infections among 1828 febrile children admitted consecutively from August 2001 to August 2002...
2015: BMC Infectious Diseases
Minli Zhu, Qianhong Hu, Jingyun Mai, Zhenlang Lin
OBJECTIVE: To study the clinical characteristics, pathogenic bacteria, and antibiotics resistance of neonatal purulent meningitis in order to provide the guide for early diagnosis and appropriate treatment. METHOD: A retrospective review was performed and a total of 112 cases of neonatal purulent meningitis (male 64, female 58) were identified in the neonatal intensive care unit of Yuying Children's Hospital of Wenzhou Medical University seen from January 1, 2004 to December 31, 2013...
January 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Ahu Kara, İlker Devrim, Nuri Bayram, Nagehan Katipoğlu, Ezgi Kıran, Yeliz Oruç, Nevbahar Demiray, Hurşit Apa, Gamze Gülfidan
BACKGROUND: Vancomycin-resistant enterococci colonization has been reported to increase the risk of developing infections, including bloodstream infections. AIM: In this study, we aimed to share our experience with the vancomycin-resistant enterococci bloodstream infections following gastrointestinal vancomycin-resistant enterococci colonization in pediatric population during a period of 18 months. METHOD: A retrospective cohort of children admitted to a 400-bed tertiary teaching hospital in Izmir, Turkey whose vancomycin-resistant enterococci colonization was newly detected during routine surveillances for gastrointestinal vancomycin-resistant enterococci colonization during the period of January 2009 and December 2012 were included in this study...
January 2015: Brazilian Journal of Infectious Diseases
Hiroaki Kanai, Hiroki Sato, Yoshichika Takei
INTRODUCTION: Staphylococcus epidermidis is currently the most frequent pathogen of opportunistic and nosocomial infections worldwide. Most cases of Staphylococcus epidermidis infections are associated with indwelling medical devices and/or immunocompromised conditions. Community-acquired urinary tract infections are rare, particularly among pediatric populations, and clinicians often do not consider Staphylococcus epidermidis as a uropathogen. CASE PRESENTATION: A previously healthy Japanese boy developed pyelonephritis caused by Enterococcus faecalis at 10 months of age...
2014: Journal of Medical Case Reports
Aslinur Ozkaya-Parlakay, Ates Kara, Melda Celik, Yasemin Ozsurekci, Eda Karadag Oncel, Mehmet Ceyhan, Ali Bulent Cengiz
Linezolid, an oxazolidinone class antibiotic, is used to treat Gram-positive infections, including those due to meticillin-resistant staphylococci and vancomycin-resistant enterococci. In paediatric clinical trials, the frequency of possible linezolid-related adverse events ranged from 18.8% to 25.6%. The most commonly reported side effects are gastrointestinal disturbances, headache, rash and liver function alterations. Lactic acidosis has been reported as a side effect of linezolid treatment, and limited data suggest it may be more common in children...
October 2014: International Journal of Antimicrobial Agents
Walter Q Betancourt, Diana C Duarte, Rosa C Vásquez, Patrick L Gurian
Sewage is a major contributor to pollution problems involving human pathogens in tropical coastal areas. This study investigated the occurrence of intestinal protozoan parasites (Giardia and Cryptosporidium) in tropical recreational marine waters contaminated with sewage. The potential risks of Cryptosporidium and Giardia infection from recreational water exposure were estimated from the levels of viable (oo) cysts (DIC+, DAPI+, PI-) found in near-shore swimming areas using an exponential dose response model...
August 15, 2014: Marine Pollution Bulletin
Hiroaki Kanai, Hiroki Sato, Yoshichika Takei
Autoimmune neutropenia of infancy is characterized by minor intercurrent infections despite severe neutropenia; severe bacterial infections are uncommon. An infant developed recurrent urinary tract infections at 9 and 11 months of age. The identified uropathogens were Escherichia coli and Enterococcus faecalis, respectively. Empirical treatment with carbapenems, as broad-spectrum antibiotics, promptly resolved the infection without sequelae. Febrile neutropenic children with cancer and autoimmune neutropenia can develop urinary tract infections; therefore, in such infants, urine culture should be obtained through catheterization...
March 2015: Journal of Pediatric Hematology/oncology
Hiroto Inaba, Aditya H Gaur, Xueyuan Cao, Patricia M Flynn, Stanley B Pounds, Viswatej Avutu, Lindsay N Marszal, Scott C Howard, Ching-Hon Pui, Raul C Ribeiro, Randall T Hayden, Jeffrey E Rubnitz
BACKGROUND: Intensive chemotherapy for pediatric acute myeloid leukemia incurs the risk of infectious complications, but the benefits of antibiotic prophylaxis remain unclear. METHODS: In the current study, among 103 children treated on the AML02 protocol between October 2002 and October 2008 at St. Jude Children's Research Hospital, the authors retrospectively assessed the effect of antibiotic prophylaxis on the frequency of febrile neutropenia, clinically or microbiologically confirmed infections (including bacteremia), and antibiotic resistance, as well as on the results of nasal and rectal surveillance cultures...
July 1, 2014: Cancer
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