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Acinetobacter baumannii infection in childrens

İlker Devrim, Ahu Kara, Mine Düzgöl, Aytaç Karkıner, Nuri Bayram, Günyüz Temir, Arzu Şencan, Yelda Sorguç, Gamze Gülfidan, Münevver Hoşgör
BACKGROUND: Infections are the leading cause of morbidity and mortality in patients with burns in burn units. Bloodstream infections (BSIs) in patients with burns may result from burn wound infection, use of invasive devices such as central venous catheters, and translocation of the gastrointestinal flora. OBJECTIVE: In this study, we investigated the distribution and antimicrobial drug resistance of causative pathogens in children with burns and the durational changes of microorganisms in the distribution of BSIs in children...
September 8, 2016: Burns: Journal of the International Society for Burn Injuries
Chao Fang, Xuejun Chen, Mingming Zhou
BACKGROUND AND AIM: The present study was aimed at assessing the characteristics of children with nosocomial multidrug-resistant Acinetobacter baumannii complex (MDR ABC) in a tertiary hospital of eastern China. MDR ABC poses a serious threat to public health. However, information on nosocomial MDR ABC in children is lacking. METHOD: This study retrospectively reviewed the cases in a tertiary hospital of eastern China between January 1, 2011, and December 31, 2014 (excluding outpatients)...
2016: PloS One
Avish L Jain, Christian M Harding, Kaivon Assani, Chandra L Shrestha, Mercedees Haga, Amy Leber, Robert S Munson, Benjamin T Kopp
BACKGROUND: Acinetobacter species are associated with increasing mortality due to emerging drug-resistance. Pediatric Acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the Acinetobacter calcoaceticus-baumannii complex, leading to improper identification. Therefore we aimed to determine risk factors for invasive Acinetobacter infections within an academic, pediatric setting as well as defining microbiologic characteristics of predominant strains...
2016: BMC Infectious Diseases
Ngai Kien Le, Wertheim Hf, Phu Dinh Vu, Dung Thi Khanh Khu, Hai Thanh Le, Bich Thi Ngoc Hoang, Vu Thanh Vo, Yen Minh Lam, Dung Tien Viet Vu, Thu Hoai Nguyen, Tung Quang Thai, Lennart E Nilsson, Ulf Rydell, Kinh Van Nguyen, Behzad Nadjm, Louise Clarkson, Håkan Hanberger, Mattias Larsson
There is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals.Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year.A total of 1363 cases (1143 children) were surveyed, 59.9% male, average age 11 months. Admission sources were: other hospital 49.3%, current hospital 36.5%, and community 15.3%. Reasons for admission were: infectious disease (66%), noninfectious (20...
July 2016: Medicine (Baltimore)
Zheng-Yi Zhu, Ju-Fei Yang, Ying-Hua Ni, Wei-Feng Ye, Jue Wang, Miao-Lian Wu
AIM: This study assessed the efficacy and safety of tigecycline in children with life-threatening infections. METHODS: We retrospectively reviewed the clinical records of patients treated with tigecycline from June 2012 to May 2014 in a Chinese tertiary centre. RESULTS: The study comprised 24 patients (14 male) with a median age of four years (range, 50 days-12 years). The most frequently isolated microorganism, most common isolation site and type of infection were Acinetobacter baumannii, tracheal aspirate fluid and ventilator-associated pneumonia, respectively...
October 2016: Acta Paediatrica
Radoslaw Jaworski, Ireneusz Haponiuk, Mariusz Steffens, Elzbieta Arlukowicz, Ninela Irga-Jaworska, Maciej Chojnicki, Ewelina Kwasniak, Jacek Zielinski
INTRODUCTION: The incidence of multidrug resistant microorganisms worldwide is increasing. The aim of the study was to present institutional experience with the multidrug resistant microorganism colonization patterns observed in children with congenital heart diseases hospitalized in a hybrid pediatric cardiac surgery center. MATERIAL AND METHODS: Microbiological samples were routinely collected in all children admitted to our department. All microbiological samples were analyzed with regard to multidrug resistant microorganisms: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Gram-negative rods producing extended-spectrum beta-lactamases (ESBL), multidrug resistant Gram-negative rods (MDR-GNRs), carbapenemase-producing Klebsiella pneumoniae (KPC), carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA)...
June 1, 2016: Archives of Medical Science: AMS
Muneeza Anwar, Hassan Ejaz, Aizza Zafar, Hamdan Hamid
Multidrug resistant A. baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of infections especially in neonates and immunocompromised patients because they have least capacity to fight against infections. Carbapenems are used as last resort antibiotics for treating these infections but currently resistance against carbapenems due to MBL production is on the rise. The objective of this study was to determine the frequency of antibiotic resistance in A...
2016: Journal of Pathogens
Yunxing Yang, Jianfeng Wang, Ying Fu, Zhi Ruan, Yunsong Yu
Clinical infections caused by Acinetobacter spp. have increasing public health concerns because of their global occurrence and ability to acquire multidrug resistance. Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex encompasses A. calcoaceticus, A. baumannii, A. pittii (formerly genomic species 3), and A nosocomial (formerly genomic species 13TU), which are predominantly responsible for clinical pathogenesis in the Acinetobacter genus. In our previous study, a putative novel species isolated from 385 non-A...
March 2016: Medicine (Baltimore)
Richard A Murphy, Luba Nisenbaum, Amy S Labar, Robert L Sheridan, Jean-Baptiste Ronat, Kelly Dilworth, Jade Pena, Erin Kilborn, Carrie Teicher
BACKGROUND: Compare to high-income settings, survival in burn units in low-income settings is lower with invasive infections one leading cause of death. Médecins Sans Frontières is involved in the treatment of large burns in adults and children in Haiti. METHODS: In 2014, we performed a review of 228 patients admitted consecutively with burn injury during a 6-month period to determine patient outcomes and infectious complications. Microbiology was available through a linkage with a Haitian organization...
July 2016: World Journal of Surgery
Shu-Hui Wang, Wei Ji, Xin-Xing Zhang, Wen-Jing Gu, Yong-Dong Yan, Wei-Fang Zhou, Li Huang, Mei-Juan Wang, Yun-Zhen Tao
OBJECTIVE: To investigate the bacterial pathogenic characteristics of respiratory tract infection in children. METHODS: The medical data from 14,994 children with respiratory tract infection who were hospitalized in Children's Hospital Affiliated to Soochow University between November 2005 and October 2014 were retrospectively reviewed. RESULTS: Among the 14,994 sputum samples from the children with respiratory tract infection, 3,947 (26.32%) had a positive bacterial culture...
January 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Beatriz Larru, Wu Gong, Neika Vendetti, Kaede V Sullivan, Russell Localio, Theoklis E Zaoutis, Jeffrey S Gerber
BACKGROUND: Bloodstream infection is a major cause of morbidity and mortality. Much of our understanding of the epidemiology and resistance patterns of bloodstream infections comes from studies of hospitalized adults. METHODS: We evaluated the epidemiology and antimicrobial resistance of bloodstream infections occurring during an 11-year period in a large, tertiary care children's hospital in the US. All positive blood cultures were identified retrospectively from clinical microbiology laboratory records...
May 2016: Pediatric Infectious Disease Journal
A Karaaslan, A Soysal, G Altinkanat Gelmez, E Kepenekli Kadayifci, G Söyletir, M Bakir
BACKGROUND: Multidrug-resistant Gram-negative bacilli are responsible for more than 50% of healthcare-associated infections. Colonization dynamics, characteristics, and risk factor data for CR-GNB are scarce in children. AIM: To examine the molecular characteristics of, and risk factors for nosocomial colonization with, carbapenem-resistant Gram-negative bacilli (CR-GNB) in hospitalized paediatric patients in a tertiary university hospital's paediatric units in Turkey...
January 2016: Journal of Hospital Infection
A V Lazareva, L K Katosova, O A Kryzhanovskaya, O A Ponomarenko, O V Karaseva, A L Gorelik, N A Mayanskiy
Nosocomial infections and their rational antibiotic treatment represent a major challenge for the healthcare nowadays. In this context, gramnegative bacteria including Pseudomonas aeruginosa, Acinetobacter baumanii and Enterobacteriaceae spp. are etiologically important and characterized by a significant level of antibiotic resistance. To examine dynamics of the respiratory tract colonization by hospital flora, tracheal aspirates obtained at three time points from 69 children with severe craniocerebral trauma during their stay in ICU were analysed...
2014: Antibiotiki i Khimioterapii︠a︡, Antibiotics and Chemoterapy [sic]
N Rabirad, M Mohammadpoor, A Rastegar Lari, A Shojaie, R Bayat, M Alebouyeh
INTRODUCTION: The choice of antimicrobial treatment for septicemia is often empirical and based on the knowledge of local anti-microbial activity patterns of the most common bacteria causing such bloodstream infections. The current study aimed to study the prevalence of bacterial pathogens causing septicemia and their antimicrobial resistant profiles in hospital admitted patients. METHODS: This cross sectional study done at Children's Medical Center, Tehran, Iran...
March 2014: Journal of Preventive Medicine and Hygiene
Angela Dramowski, Mark F Cotton, Helena Rabie, Andrew Whitelaw
BACKGROUND: The epidemiology of paediatric bloodstream infection (BSI) in Sub-Saharan Africa is poorly documented with limited data on hospital-acquired sepsis, impact of HIV infection, BSI trends and antimicrobial resistance. METHODS: We retrospectively reviewed paediatric BSI (0-14 years) at Tygerberg Children's Hospital between 1 January 2008 and 31 December 2013 (excluding neonatal wards). Laboratory and hospital data were used to determine BSI rates, blood culture contamination, pathogen profile, patient demographics, antimicrobial resistance and factors associated with mortality...
2015: BMC Pediatrics
Özlem Özgür Gündeşlioğlu, Tülin Güven Gökmen, Özden Özgür Horoz, Necmi Aksaray, Fatih Köksal, Akgün Yaman, Rıza Dinçer Yıldızdaş, Emre Alhan, Emine Kocabaş, Derya Alabaz
The aim of the present study is to investigate the types of healthcare-associated infections (HC-AIs) caused by Acinetobacter baumannii and the related antibiotic susceptibility patterns as well as the genotypic characteristics of the Acinetobacter baumannii isolates from our center. Sixty-nine Acinetobacter baumannii isolates originating from various samples collected from 69 pediatric patients during their hospital stays were included in the study. The types of healthcare-associated infections caused by these isolates were evaluated, and the antibiotic susceptibility pattern and the genotypic characteristics of the isolates were determined using the pulsed-field gel electrophoresis (PFGE) method...
July 2014: Turkish Journal of Pediatrics
Kapil Kapoor, Sumidha Jain, Mamta Jajoo, Swati Dublish, Vikas Dabas, Vikas Manchanda
OBJECTIVE: Acinetobacter baumannii is an important emerging cause for extensively-drug resistant (XDR) hospital associated infections (HAIs) in pediatric intensive care units (PICU). The study was done to evaluate the risk factors, outcome, antibiotic sensitivity pattern, and predictors of mortality in critically ill children with XDR A. baumannii infection. METHODS: Retrospective case control study, done in the PICU of a tertiary care pediatric hospital of India from April 2010 to March 2012...
October 2014: Iranian Journal of Pediatrics
Xinting Zhang, Junying Zhang, Aihua Cao
OBJECTIVE: To analyze the characteristics of respiratory diseases and to provide scientific basis for developing relevant control measures. METHODS: 1 300 children with respiratory diseases were treated in hospitals, from Jan. 2013 to May 2014, in the city of Jinan. Characteristics of respiratory diseases were analyzed. RESULTS: The distribution of respiratory diseases in children appeared as: 373 cases of pneumonia (28.7%), 3 cases of pulmonary tuberculosis (0...
November 2014: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Jeong A Park, Byoung-Ju Kim
Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients with hematologic malignancies or autoimmune disorders, and it has a high mortality rate. The current treatment options of corticosteroids, transfusions, and immunosuppressants have been limited and largely unsuccessful, and they can be accompanied by multiple complications. Intrapulmonary administration of recombinant activated factor VII (rFVIIa) has been reported in adults, but there are scarce data on its use in children...
January 2015: Pediatrics
Warunee Punpanich Vandepitte, Josef Berge, Rune Andersson
BACKGROUND: A relentless increase in the rate of carbapenem-resistant among Acinetobacter baumannii has substantially reduced the access to effective antimicrobial regimens. Currently limited information is available regarding the prognosis or outcomes of children with blood stream infection caused by carbapenem resistant A. baumanii. OBJECTIVE: To determine the clinical outcomes and predictors for fatality among children with carbapenem-resistant A. baumannii (CRAB) bloodstream infection (BSI)...
November 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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