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Acinetobacter baumannii infection in childrens

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https://www.readbyqxmd.com/read/29771233/regulation-of-gene-expression-of-hcp-a-core-gene-of-the-type-vi-secretion-system-in-acinetobacter-baumannii-causing-respiratory-tract-infection
#1
Yin-Yin Hu, Cai-Xia Liu, Peng Liu, Zhuo-Ying Wu, Ya-Dong Zhang, Xiao-Shun Xiong, Xiang-Yang Li
PURPOSE: The objective of the current study was to investigate whether hcp plays a role in the process of Acinetobacter baumannii infection and to examine clinically relevant factors that may affect hcp expression. METHODOLOGY: Seventy-seven A. baumannii isolates from patients with a respiratory infection at the Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University (Wenzhou, China) were included in this study. PCR was performed to screen for the presence of hcp...
May 17, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29666685/identifying-risk-factors-for-healthcare-associated-infections-caused-by-carbapenem-resistant-acinetobacter-baumannii-in-a-neonatal-intensive-care-unit
#2
Amira M Sultan, Wael A Seliem
Objectives: Acinetobacter baumannii is a causative pathogen of various healthcare-associated infections (HAIs) and is particularly prevalent in high-risk hospital settings. This study aimed to determine risk factors associated with HAIs caused by carbapenem-resistant A. baumannii (CRAB) in a neonatal intensive care unit (NICU). Methods: This prospective study was performed between January 2013 and June 2014 among NICU patients at the Mansoura University Children's Hospital, Mansoura, Egypt...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29579216/acinetobacter-baumannii-resistance-trends-in-children-in-the-united-states-1999-2012
#3
Latania K Logan, Sumanth Gandra, Anna Trett, Robert A Weinstein, Ramanan Laxminarayan
Background: Acinetobacter baumannii is a common cause of healthcare-associated infections. Carbapenem-resistant (CR) A baumannii is a significant threat globally. We used a large reference laboratory database to study the epidemiology of A baumannii in children in the United States. Methods: Antimicrobial susceptibility data from The Surveillance Network were used to phenotypically identify antibiotic resistance in A baumannii isolates in children 1-17 years of age between January 1999 and July 2012...
March 22, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29474260/high-prevalence-of-extensively-drug-resistant-acinetobacter-baumannii-at-a-children-hospital-in-bolivia
#4
Mónica Cerezales, Alain A Ocampo-Sosa, Laura Álvarez Montes, Catalina Díaz Ríos, Zulema Bustamante, Jazmín Santos, Luis Martínez-Martínez, Paul G Higgins, Lucía Gallego
Acinetobacter baumannii causes serious hospital-acquired infections and has been positioned as a priority organism by the World Health Organization. This study includes 36 A. baumannii isolates from a children hospital recovered between March 2014 and May 2015 in Cochabamba. The majority of the isolates were recovered from blood cultures (n=10, 31.3%) and respiratory samples (n=11, 34.4%); fifty three percent of the patients were younger than one month old. Most of these isolates (n=30, 80.6%) were extremely-drug resistant (XDR) and 8...
February 22, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29277142/carriage-of-multidrug-resistant-bacteria-among-pediatric-patients-before-and-during-their-hospitalization-in-a-tertiary-pediatric-unit-in-tunisia
#5
Miniar Tfifha, Asma Ferjani, Manel Mallouli, Nesrine Mlika, Saoussen Abroug, Jalel Boukadida
The pandemic spread of multidrug-resistant (MDR) bacteria (i.e., methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum b-lactamase-producing Enterobacteriaceae (ESBLPE), vancomycin-resistant enterococci, carbapenemase-producing Enterobacteriaceae (CPE), multiresistant Pseudomonas aeruginosa and multiresistant Acinetobacter baumannii) pose a threat to healthcare Worldwide. We found limited data of MDR bacteria in pediatric patients hospitalized in Tunisian tertiary healthcare.The aim of the study is to evaluate the acquisition rate of MDR acquisition during hospitalization and to explore some of the associated risk factors for both carriage and acquisition at the pediatric department, Sahloul University Hospital...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/28572073/tigecycline-treatment-in-an-infant-with-extensively-drug-resistant-acinetobacter-baumannii-bacteremia
#6
Jiawei Zeng, Lidan Zhang, Min Gao, Jingjing Wu, Haiyan Wu, Jie Chen, Xiao Chen, Wen Tang
The successful use of tigecycline in a 12-month old liver transplant recipient with extensively drug-resistant Acinetobacter baumannii bacteremia is presented. Tigecycline serum concentrations were monitored to help improve antibiotic efficacy and minimize side effects. A literature review identified 11 additional pediatric cases of A. baumannii infection treated with tigecycline since 2011. Tigecycline treatment should be considered in children with extensively drug-resistant bacterial infections.
August 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28349005/multidrug-resistant-acinetobacter-meningitis-in-children
#7
Ira Shah, Muznah Kapdi
Acinetobacter species have emerged as one of the most troublesome pathogens for healthcare institutions globally. In more recent times, nosocomial infections involving the central nervous system, skin and soft tissue, and bone have emerged as highly problematic. Acinetobacter species infection is common in intensive care units; however, Acinetobacter baumannii meningitis is rarely reported. Here, we report two cases of Acinetobacter baumannii meningitis which was multidrug resistance and ultimately required the carbapenem group of drugs for the treatment...
October 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28205160/non-fermentative-gram-negative-rods-bacteremia-in-children-with-cancer-a-14-year-single-center-experience
#8
D Averbuch, C Avaky, M Harit, P Stepensky, I Fried, T Ben-Ami, V Temper, Y Peled, H Troen, R Masarwa, W Abu Ahmad, M Weintraub, S Revel-Vilk, D Engelhard
PURPOSE: Data on non-fermentative Gram-negative rods (NFGNR) bacteremia in children with malignancies are limited. The aim of this study was to present clinical picture, antimicrobial susceptibility pattern, risk factors for resistance and outcome in NFGNR bacteremia in children with cancer. METHODS: All episodes of NFGNR bacteremia occurring during 2001-2014 in children with cancer in a tertiary-care hospital were retrospectively analyzed. Pseudomonas and Acinetobacter spp...
June 2017: Infection
https://www.readbyqxmd.com/read/28161461/infectious-disease-exposures-and-outbreaks-at-a-south-african-neonatal-unit-with-review-of-neonatal-outbreak-epidemiology-in-africa
#9
A Dramowski, M Aucamp, A Bekker, S Mehtar
BACKGROUND: Hospitalized neonates are vulnerable to infection, with pathogen exposures occurring in utero, intrapartum, and postnatally. African neonatal units are at high risk of outbreaks owing to overcrowding, understaffing, and shared equipment. METHODS: Neonatal outbreaks attended by the paediatric infectious diseases and infection prevention (IP) teams at Tygerberg Children's Hospital, Cape Town (May 1, 2008 to April 30, 2016) are described, pathogens, outbreak size, mortality, source, and outbreak control measures...
April 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28135233/use-of-colistin-in-a-neonatal-intensive-care-unit-a-cohort-study-of-65-patients
#10
Eren Çağan, Evrim Kıray Baş, Hüseyin Selim Asker
BACKGROUND The emergence of infections related to multidrug-resistant Gram-negative bacilli (MDR-GNB) reintroduced the use of colistin, an antibiotic that was previously abandoned due to adverse effects. However, because of its limited use in neonatal intensive care units, there is very little data about the effectiveness and safety of colistin in children and newborns. In this study, which will be the largest case study in the literature, we aimed to evaluate the effectiveness and safety of colistin in full-term and preterm newborns...
January 30, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28088916/an-increasing-threat-in-an-iranian-referral-children-s-hospital-multidrug-resistant-acinetobacter-baumannii
#11
Setareh Mamishi, Reza Habibi, Babak Pourakbari, Shima Mahmoudi, Mohammad Taghi Haghi Ashtiani, Reihaneh Hosseinpour Sadeghi, Mahmoud Khodabandeh
INTRODUCTION: Acinetobacter baumannii has emerged as an important nosocomial pathogen in the past decades. Due to the prevalence of A. baumannii across the world, suitable typing methods to investigate the epidemiological distribution of the organism have been developed. The aim of this study was to investigate the epidemiological and molecular diversity of A. baumannii strains isolated from nosocomial infections of hospitalized children in Children Medical Center Hospital (CMC), an Iranian referral hospital, in Tehran, Iran...
January 13, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27894388/-analysis-of-distribution-and-drug-resistance-of-pathogens-isolated-from-541-hospitalized-children-with-burn-infection
#12
J X Dai, L Li, L Xu, Z H Chen, X Y Li, M Liu, Y Q Wen, X D Chen
Objective: To investigate the distribution and drug resistance of pathogens isolated from hospitalized children with burn infection. Methods: Totally 541 patients were hospitalized in Fujian Medical University Union Hospital, the 180th Hospital of Chinese People's Liberation Army(PLA), the 92th Hospital of PLA, and Longyan First Hospital from January 2013 to December 2015. Totally 848 clinical specimens (blood, catheter tip attachments, wound exudate, etc.) were collected for pathogen detection. After being identified by an automatic microbiological identification system, drug resistance of pathogens to 41 commonly-used antibiotics in clinic including gentamicin, aztreonam, erythromycin, clindamycin, etc...
November 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27615546/burn-associated-bloodstream-infections-in-pediatric-burn-patients-time-distribution-of-etiologic-agents
#13
İlker Devrim, Ahu Kara, Mine Düzgöl, Aytaç Karkıner, Nuri Bayram, Günyüz Temir, Arzu Şencan, Yelda Sorguç, Gamze Gülfidan, Münevver Hoşgör
BACKGROUND: Infections are the leading cause of morbidity and mortality in patients with burns in burn units. Bloodstream infections (BSIs) in patients with burns may result from burn wound infection, use of invasive devices such as central venous catheters, and translocation of the gastrointestinal flora. OBJECTIVE: In this study, we investigated the distribution and antimicrobial drug resistance of causative pathogens in children with burns and the durational changes of microorganisms in the distribution of BSIs in children...
February 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27579592/epidemiology-and-cytokine-levels-among-children-with-nosocomial-multidrug-resistant-acinetobacter-baumannii-complex-in-a-tertiary-hospital-of-eastern-china
#14
Chao Fang, Xuejun Chen, Mingming Zhou
BACKGROUND AND AIM: The present study was aimed at assessing the characteristics of children with nosocomial multidrug-resistant Acinetobacter baumannii complex (MDR ABC) in a tertiary hospital of eastern China. MDR ABC poses a serious threat to public health. However, information on nosocomial MDR ABC in children is lacking. METHOD: This study retrospectively reviewed the cases in a tertiary hospital of eastern China between January 1, 2011, and December 31, 2014 (excluding outpatients)...
2016: PloS One
https://www.readbyqxmd.com/read/27449800/characteristics-of-invasive-acinetobacter-species-isolates-recovered-in-a-pediatric-academic-center
#15
Avish L Jain, Christian M Harding, Kaivon Assani, Chandra L Shrestha, Mercedees Haga, Amy Leber, Robert S Munson, Benjamin T Kopp
BACKGROUND: Acinetobacter species are associated with increasing mortality due to emerging drug-resistance. Pediatric Acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the Acinetobacter calcoaceticus-baumannii complex, leading to improper identification. Therefore we aimed to determine risk factors for invasive Acinetobacter infections within an academic, pediatric setting as well as defining microbiologic characteristics of predominant strains...
July 22, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27399106/high-prevalence-of-hospital-acquired-infections-caused-by-gram-negative-carbapenem-resistant-strains-in-vietnamese-pediatric-icus-a-multi-centre-point-prevalence-survey
#16
MULTICENTER STUDY
Ngai Kien Le, Wertheim Hf, Phu Dinh Vu, Dung Thi Khanh Khu, Hai Thanh Le, Bich Thi Ngoc Hoang, Vu Thanh Vo, Yen Minh Lam, Dung Tien Viet Vu, Thu Hoai Nguyen, Tung Quang Thai, Lennart E Nilsson, Ulf Rydell, Kinh Van Nguyen, Behzad Nadjm, Louise Clarkson, Håkan Hanberger, Mattias Larsson
There is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals.Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year.A total of 1363 cases (1143 children) were surveyed, 59.9% male, average age 11 months. Admission sources were: other hospital 49.3%, current hospital 36.5%, and community 15.3%. Reasons for admission were: infectious disease (66%), noninfectious (20...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27381360/retrospective-analysis-of-tigecycline-shows-that-it-may-be-an-option-for-children-with-severe-infections
#17
Zheng-Yi Zhu, Ju-Fei Yang, Ying-Hua Ni, Wei-Feng Ye, Jue Wang, Miao-Lian Wu
AIM: This study assessed the efficacy and safety of tigecycline in children with life-threatening infections. METHODS: We retrospectively reviewed the clinical records of patients treated with tigecycline from June 2012 to May 2014 in a Chinese tertiary centre. RESULTS: The study comprised 24 patients (14 male) with a median age of four years (range, 50 days-12 years). The most frequently isolated microorganism, most common isolation site and type of infection were Acinetobacter baumannii, tracheal aspirate fluid and ventilator-associated pneumonia, respectively...
October 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27279859/colonization-of-multidrug-resistant-pathogens-in-a-hybrid-pediatric-cardiac-surgery-center
#18
Radoslaw Jaworski, Ireneusz Haponiuk, Mariusz Steffens, Elzbieta Arlukowicz, Ninela Irga-Jaworska, Maciej Chojnicki, Ewelina Kwasniak, Jacek Zielinski
INTRODUCTION: The incidence of multidrug resistant microorganisms worldwide is increasing. The aim of the study was to present institutional experience with the multidrug resistant microorganism colonization patterns observed in children with congenital heart diseases hospitalized in a hybrid pediatric cardiac surgery center. MATERIAL AND METHODS: Microbiological samples were routinely collected in all children admitted to our department. All microbiological samples were analyzed with regard to multidrug resistant microorganisms: methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Gram-negative rods producing extended-spectrum beta-lactamases (ESBL), multidrug resistant Gram-negative rods (MDR-GNRs), carbapenemase-producing Klebsiella pneumoniae (KPC), carbapenem-resistant Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA)...
June 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27123345/phenotypic-detection-of-metallo-beta-lactamases-in-carbapenem-resistant-acinetobacter-baumannii-isolated-from-pediatric-patients-in-pakistan
#19
Muneeza Anwar, Hassan Ejaz, Aizza Zafar, Hamdan Hamid
Multidrug resistant A. baumannii has emerged as an important and problematic human pathogen as it is the causative agent of several types of infections especially in neonates and immunocompromised patients because they have least capacity to fight against infections. Carbapenems are used as last resort antibiotics for treating these infections but currently resistance against carbapenems due to MBL production is on the rise. The objective of this study was to determine the frequency of antibiotic resistance in A...
2016: Journal of Pathogens
https://www.readbyqxmd.com/read/26945401/acinetobacter-seifertii-isolated-from-china-genomic-sequence-and-molecular-epidemiology-analyses
#20
Yunxing Yang, Jianfeng Wang, Ying Fu, Zhi Ruan, Yunsong Yu
Clinical infections caused by Acinetobacter spp. have increasing public health concerns because of their global occurrence and ability to acquire multidrug resistance. Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex encompasses A. calcoaceticus, A. baumannii, A. pittii (formerly genomic species 3), and A nosocomial (formerly genomic species 13TU), which are predominantly responsible for clinical pathogenesis in the Acinetobacter genus. In our previous study, a putative novel species isolated from 385 non-A...
March 2016: Medicine (Baltimore)
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