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Herpes simplex encephalitis In childrens

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https://www.readbyqxmd.com/read/27218417/clinical-outcomes-in-children-with-herpes-simplex-encephalitis-receiving-steroid-therapy
#1
Hülya Maraş Genç, Emek Uyur Yalçın, Murat Sayan, Asuman Bayhan, Selim Öncel, Emin Sami Arısoy, Bülent Kara
BACKGROUND: Herpes simplex virus encephalitis (HSE) is a significant cause of morbidity and mortality. Neurologic sequelae are common even after early initiation of acyclovir treatment. The host immune response during HSE can also lead to brain damage. There are an increasing number of reports favoring steroid use in HSE. OBJECTIVES: We aimed to compare the prognosis of children with HSE with and without steroid therapy. STUDY DESIGN: We retrospectively screened our hospital archive from 2009 to 2014 for patients diagnosed with HSE with a positive result for herpes simplex virus polymerase chain reaction in cerebrospinal fluid...
July 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27190218/type-i-interferons-in-newborns-neurotoxicity-versus-antiviral-defense
#2
Dusan Bogunovic
In most children and adults, primary infection with herpes simplex virus 1 (HSV-1) is asymptomatic. However, very rarely (incidence of 1 in 1,000,000), it can cause herpes simplex encephalitis (HSE). HSE also occurs in infants but with a much starker incidence of one in three. This age difference in susceptibility to HSV-1-caused HSE is not well understood. In a recent article in mBio, authors have identified the choroid plexus as the anatomical site of robust HSV-1 replication in the brain. They point to low levels of type I interferon (IFN) receptor as causal of the lack of HSV-1 replication control in neonates, in contrast to adults...
2016: MBio
https://www.readbyqxmd.com/read/26748392/cerebral-malaria-in-a-man-with-plasmodium-vivax-mono-infection-a-case-report
#3
Himanshu Gupta, Pushwinder Dhunputh, Ankita N Bhatt, Kapaettu Satyamoorthy, Shashikiran Umakanth
Cerebral malaria (CM) is a diffuse encephalopathy associated with coma and seizures commonly caused by Plasmodium falciparum (P. falciparum) in children with severe malaria. We present a case of a 19-year-old man with CM due to Plasmodium vivax (P. vivax) infection. Cerebrospinal fluid (CSF) was negative for Japanese B encephalitis, enterovirus, herpes simplex 1 and 2, varicella and mumps viruses as determined by real-time polymerase chain reaction (PCR). P. falciparum and P. vivax species were analysed by microscopy, immunochromatography and PCR assays and confirmed mono-infection of P...
January 8, 2016: Tropical Doctor
https://www.readbyqxmd.com/read/26709736/simultaneous-detection-and-genotype-determination-of-hsv-1-and-2-by-real-time-pcr-using-melting-curve-analysis-and-a-unique-pair-of-primers
#4
Mahdi Paryan, Samira Mohammadi-Yeganeh, Houri Rezvan, Vahid Kia, Ardalan Mansouri, Siamak Mirab Samiee
Herpes simplex virus (HSV) is a human pathogen that causes different pathologic manifestations. Rapid and feasible detection and discrimination methods for HSV genotyping is a challenge in clinical laboratories, especially in children suffering from herpetic encephalitis. A quantitative real-time polymerase chain reaction (PCR)-based genotyping assay using SYBR Green I was established. We designed only 1 pair of primer for HSV 1 and 2, targeting thymidine kinase gene conserved region. HSV genotypes were determined by PCR using melting curve analysis with LightCycler...
December 24, 2015: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/26607060/prevalence-type-and-concentration-of-human-enterovirus-and-parechovirus-in-cerebrospinal-fluid-samples-of-pediatric-patients-over-a-10-year-period-a-retrospective-study
#5
Silke Vollbach, Andreas Müller, Jan Felix Drexler, Arne Simon, Christian Drosten, Anna Maria Eis-Hübinger, Marcus Panning
BACKGROUND: Human enterovirus (EV) and parechovirus (HPeV) are significant causes of encephalitis and meningitis in children. The aim of this study was to determine the prevalence, type and viral RNA concentration of EV and HPeV in cerebrospinal fluid (CSF) samples in an unselected cohort of patients <18 years admitted to Bonn university hospital from 1998 to 2008. METHODS: A total of 327 CSF samples from 327 patients were retrospectively tested by real-time reverse-transcriptase PCR (RT-PCR) for EV and HPeV, and by real-time PCR for cytomegalovirus (CMV), herpes simplex virus 1/2 (HSV), and varizella zoster-virus (VZV)...
2015: Virology Journal
https://www.readbyqxmd.com/read/26513235/mutations-in-the-tlr3-signaling-pathway-and-beyond-in-adult-patients-with-herpes-simplex-encephalitis
#6
N Mørk, E Kofod-Olsen, K B Sørensen, E Bach, T F Ørntoft, L Østergaard, S R Paludan, M Christiansen, T H Mogensen
Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon production downstream of Toll-like receptor (TLR)3. In the present study, we used whole-exome sequencing to investigate the genetic profile of 16 adult patients with a history of HSE. We identified novel mutations in IRF3, TYK2 and MAVS, molecules involved in generating innate antiviral immune responses, which have not previously been associated with HSE. Moreover, data revealed mutations in TLR3, TRIF, TBK1 and STAT1 known to be associated with HSE in children but not previously described in adults...
December 2015: Genes and Immunity
https://www.readbyqxmd.com/read/26494725/severe-post-influenza-h1n1-encephalitis-involving-pulvinar-nuclei-in-an-adult-patient
#7
José Tomás, Maria Carmo Macário, Elsa Gaspar, Isabel Santana
Neurological complications of H1N1 infections are mostly found in children, but rare cases of acute encephalopathy and post-infectious encephalitis such as acute disseminated encephalomyelitis (ADEM) have been described in adults. We report a case of an adult presenting with a progressive and severe encephalopathy that developed after H1N1 respiratory infection resolution. Cerebrospinal fluid (CSF) analysis was normal, including negative PCR for herpes simplex virus, H1N1, influenza B and JC virus, and absent oligoclonal IgG bands in CSF and serum...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26491084/autoimmune-post-herpes-simplex-encephalitis-of-adults-and-teenagers
#8
MULTICENTER STUDY
Thaís Armangue, Germán Moris, Verónica Cantarín-Extremera, Carlos Enrique Conde, Kevin Rostasy, Maria Elena Erro, Juan Carlos Portilla-Cuenca, Eulàlia Turón-Viñas, Ignacio Málaga, Beatriz Muñoz-Cabello, Carmen Torres-Torres, Sara Llufriu, Luis González-Gutiérrez-Solana, Guillermo González, Ignacio Casado-Naranjo, Myrna Rosenfeld, Francesc Graus, Josep Dalmau
OBJECTIVE: To report 14 patients with immune-mediated relapsing symptoms post-herpes simplex encephalitis (HSE) and to compare the clinical and immunologic features of the teenage and adult group with those of young children. METHODS: Prospective observational study of patients diagnosed between June 2013 and February 2015. Immunologic techniques have been reported previously. RESULTS: Among the teenage and adult group (8 patients, median age 40 years, range 13-69; 5 male), 3 had an acute symptom presentation suggesting a viral relapse, and 5 a presentation contiguous with HSE suggesting a recrudescence of previous deficits...
November 17, 2015: Neurology
https://www.readbyqxmd.com/read/26475868/encephalitis-in-australian-children-contemporary-trends-in-hospitalisation
#9
MULTICENTER STUDY
Philip N Britton, Lynette Khoury, Robert Booy, Nicholas Wood, Cheryl A Jones
OBJECTIVE: The clinical epidemiology of childhood encephalitis in Australia is inadequately understood. We aimed to describe recent trends in childhood encephalitis-related hospitalisation. STUDY DESIGN: We identified encephalitis-related hospital admissions (2000-2012) in national datasets among children ≤14 years using ICD encephalitis codes. We calculated hospitalisation rates and analysed trends by year, age, gender, location, indigenous status and aetiology...
January 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/26216125/functional-irf3-deficiency-in-a-patient-with-herpes-simplex-encephalitis
#10
Line Lykke Andersen, Nanna Mørk, Line S Reinert, Emil Kofod-Olsen, Ryo Narita, Sofie E Jørgensen, Kristian A Skipper, Klara Höning, Hans Henrik Gad, Lars Østergaard, Torben F Ørntoft, Veit Hornung, Søren R Paludan, Jacob Giehm Mikkelsen, Takashi Fujita, Mette Christiansen, Rune Hartmann, Trine H Mogensen
Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon (IFN) production downstream of Toll-like receptor 3. Here, we describe a novel genetic etiology of HSE by identifying a heterozygous loss-of-function mutation in the IFN regulatory factor 3 (IRF3) gene, leading to autosomal dominant (AD) IRF3 deficiency by haploinsufficiency, in an adolescent female patient with HSE. IRF3 is activated by most pattern recognition receptors recognizing viral infections and plays an essential role in induction of type I IFN...
August 24, 2015: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/26184485/role-of-autoantibodies-to-n-methyl-d-aspartate-nmda-receptor-in-relapsing-herpes-simplex-encephalitis-a-retrospective-one-center-experience
#11
Murat Sutcu, Hacer Akturk, Ayper Somer, Burak Tatli, Selda Hancerli Torun, Edibe Pembegul Yıldız, Guntulu Şık, Agop Citak, Ali Agacfidan, Nuran Salman
Post-herpes simplex virus encephalitis relapses have been recently associated with autoimmunity driven by autoantibodies against N-methyl-d-aspartate (NMDA) receptors. Because it offers different treatment options, determination of this condition is important. Between 2011 and 2014, 7 children with proven diagnosis of herpes simplex virus encephalitis were identified in a university hospital of Istanbul. Two patients had neurologic relapse characterized mainly by movement disorders 2 to 3 weeks after initial encephalitis...
March 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/26181499/acute-childhood-encephalitis-at-2-tertiary-care-children-s-hospitals-in-israel-etiology-and-clinical-characteristics
#12
Nili Yanai Milshtein, Gideon Paret, Shimon Reif, Ora Halutz, Galia Grisaru-Soen
OBJECTIVES: The clinical characteristics, pathogens, and outcome were analyzed to investigate the etiology of acute pediatric encephalitis in 2 tertiary pediatric medical centers in Israel. METHODS: A retrospective study among children aged 1 month to 18 years hospitalized with the diagnosis of acute encephalitis between January 1999 and December 2009. Data on presenting symptoms, clinical findings, microbiological, virologic, electroencephalographic and neuroimaging studies, laboratory results, and hospital course were retrieved from the medical records and the computerized microbiology database...
February 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/26139017/hsv-encephalitis-induced-anti-nmdar-encephalitis-in-a-67-year-old-woman-report-of-a-case-and-review-of-the-literature
#13
Nicholas A Morris, Tamara B Kaplan, Jenny Linnoila, Tracey Cho
Herpes simplex virus (HSV) encephalitis can induce an autoimmune encephalitis mediated by autoantibodies against the N-methyl-D-aspartate receptor (NMDAR). Post-HSV NMDAR encephalitis and de novo NMDAR encephalitis have been more commonly described in children and young adults. We describe the case of a 67-year-old woman with post-HSV NMDAR encephalitis and review the relevant literature. Clinical, serological, neurophysiological, and imaging evaluations were undertaken in the evaluation of this patient. A literature review was performed...
February 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/26110804/a-field-guide-to-current-advances-in-paediatric-movement-disorders
#14
REVIEW
Laura Silveira-Moriyama, Jean-Pierre Lin
PURPOSE OF REVIEW: Recent advances in neurogenetics, neuroimmunology and nonpharmacological treatments have reshaped the field of paediatric movement disorders. In this review, we put recent findings into context providing a framework to enable navigation of the expanding literature in this field. RECENT FINDINGS: Anti-NMDA receptor encephalitis has proven to be a significant cause of treatable movement disorder in children and to present a multifaceted link with herpes simplex encephalitis...
August 2015: Current Opinion in Neurology
https://www.readbyqxmd.com/read/26108903/-etiology-clinical-presentation-and-outcome-of-severe-viral-acute-childhood-encephalitis-ecove-study
#15
MULTICENTER STUDY
José C Flores-Gonzalez, Iolanda Jordan-Garcia, Eulàlia Turon-Vinas, Cristina Montero-Valladares, Cinta Tellez-Gonzalez, Francisco Fernandez-Carrion, Juan P Garcia-Iniguez, Eider Onate-Vergara, Antonio Rodriguez-Nunez
INTRODUCTION: Viral encephalitis are rare and potentially serious conditions with different etiologist, and not always identifiable. Our aim is to describe the etiological, clinical presentation and neurological outcome of viral encephalitis admitted in Paediatrics Intensive Care Units (PICUs) in Spain. PATIENTS AND METHODS: Observational prospective multicenter study. Children with viral encephalitis admitted to 14 PICUs, for a period of 3 years (2010-2013) were included...
July 1, 2015: Revista de Neurologia
https://www.readbyqxmd.com/read/25983131/acute-meningoencephalitis-associated-with-echovirus-9-infection-in-sri-lanka-2009
#16
Nayomi Danthanarayana, David T Williams, Simon Hedley Williams, Vasanthi Thevanesam, David J Speers, M S S Fernando
The aetiology of acute meningoencephalitis in Sri Lankan children and adults is poorly understood. This study was carried out to determine pathogens responsible for meningoencephalitis in Sri Lanka. A hospital-based cross-sectional study was performed using cerebrospinal fluid samples (22 adult and 17 pediatric) collected from August to December 2009 from patients clinically diagnosed with acute meningoencephalitis at two tertiary care hospitals in Sri Lanka. Routine microbiology for bacterial pathogens together with in-house RT-PCR and PCR assays for the detection of dengue viruses, Japanese encephalitis virus, West Nile virus, chikungunya virus, enteroviruses, mumps virus, measles virus, herpes simplex viruses types 1 and 2, and varicella zoster virus were performed...
December 2015: Journal of Medical Virology
https://www.readbyqxmd.com/read/25957806/virus-and-immune-mediated-encephalitides-epidemiology-diagnosis-treatment-and-prevention
#17
REVIEW
James F Bale
Virus encephalitis remains a major cause of acute neurological dysfunction and permanent disability among children worldwide. Although some disorders, such as measles encephalomyelitis, subacute sclerosing panencephalitis, and varicella-zoster virus-associated neurological conditions, have largely disappeared in resource-rich regions because of widespread immunization programs, other disorders, such as herpes simplex virus encephalitis, West Nile virus-associated neuroinvasive disease, and nonpolio enterovirus-induced disorders of the nervous system, cannot be prevented...
July 2015: Pediatric Neurology
https://www.readbyqxmd.com/read/25802349/infectious-and-autoantibody-associated-encephalitis-clinical-features-and-long-term-outcome
#18
Sekhar C Pillai, Yael Hacohen, Esther Tantsis, Kristina Prelog, Vera Merheb, Alison Kesson, Elizabeth Barnes, Deepak Gill, Richard Webster, Manoj Menezes, Simone Ardern-Holmes, Sachin Gupta, Peter Procopis, Christopher Troedson, Jayne Antony, Robert A Ouvrier, Yann Polfrit, Nicholas W S Davies, Patrick Waters, Bethan Lang, Ming J Lim, Fabienne Brilot, Angela Vincent, Russell C Dale
BACKGROUND AND OBJECTIVES: Pediatric encephalitis has a wide range of etiologies, clinical presentations, and outcomes. This study seeks to classify and characterize infectious, immune-mediated/autoantibody-associated and unknown forms of encephalitis, including relative frequencies, clinical and radiologic phenotypes, and long-term outcome. METHODS: By using consensus definitions and a retrospective single-center cohort of 164 Australian children, we performed clinical and radiologic phenotyping blinded to etiology and outcomes, and we tested archived acute sera for autoantibodies to N-methyl-D-aspartate receptor, voltage-gated potassium channel complex, and other neuronal antigens...
April 2015: Pediatrics
https://www.readbyqxmd.com/read/25369023/etiologic-agents-of-central-nervous-system-infections-among-febrile-hospitalized-patients-in-the-country-of-georgia
#19
Tamar Akhvlediani, Christian T Bautista, Roman Shakarishvili, Tengiz Tsertsvadze, Paata Imnadze, Nana Tatishvili, Tamar Davitashvili, Tamar Samkharadze, Rusudan Chlikadze, Natia Dvali, Lela Dzigua, Mariam Karchava, Lana Gatserelia, Nino Macharashvili, Nana Kvirkvelia, Engy Emil Habashy, Margaret Farrell, Emily Rowlinson, James Sejvar, Matthew Hepburn, Guillermo Pimentel, Erica Dueger, Brent House, Robert Rivard
OBJECTIVES: There is a large spectrum of viral, bacterial, fungal, and prion pathogens that cause central nervous system (CNS) infections. As such, identification of the etiological agent requires multiple laboratory tests and accurate diagnosis requires clinical and epidemiological information. This hospital-based study aimed to determine the main causes of acute meningitis and encephalitis and enhance laboratory capacity for CNS infection diagnosis. METHODS: Children and adults patients clinically diagnosed with meningitis or encephalitis were enrolled at four reference health centers...
2014: PloS One
https://www.readbyqxmd.com/read/25340058/nmda-receptor-antibodies-associated-with-distinct-white-matter-syndromes
#20
Yael Hacohen, Michael Absoud, Cheryl Hemingway, Leslie Jacobson, Jean-Pierre Lin, Mike Pike, Sunil Pullaperuma, Ata Siddiqui, Evangeline Wassmer, Patrick Waters, Sarosh R Irani, Camilla Buckley, Angela Vincent, Ming Lim
OBJECTIVE: To report the clinical and radiologic findings of children with NMDA receptor (NMDAR) antibodies and white matter disorders. METHOD: Ten children with significant white matter involvement, with or without anti-NMDAR encephalitis, were identified from 46 consecutive NMDAR antibody-positive pediatric patients. Clinical and neuroimaging features were reviewed and the treatment and outcomes of the neurologic syndromes evaluated. RESULTS: THREE DISTINCT CLINICORADIOLOGIC PHENOTYPES WERE RECOGNIZED: brainstem encephalitis (n = 3), leukoencephalopathy following herpes simplex virus encephalitis (HSVE) (n = 2), and acquired demyelination syndromes (ADS) (n = 5); 3 of the 5 with ADS had myelin oligodendrocyte glycoprotein as well as NMDAR antibodies...
June 2014: Neurology® Neuroimmunology & Neuroinflammation
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