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UTI In childrens

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https://www.readbyqxmd.com/read/29198997/a-reanalysis-of-the-rivur-trial-using-a-risk-classification-system
#1
Zhan Tao Wang, Elias Wehbi, Yasaman Alam, Antoine Khoury
PURPOSE: The RIVUR trial showed a 50% reduction in the risk for urinary tract infection (UTI) recurrence in children receiving continuous antibiotic prophylaxis (CAP). We reanalyzed the RIVUR data with the purpose of using a risk classification system to identify children who are more likely to benefit from CAP. METHODS: Data from 607 children enrolled in the RIVUR trial were obtained from the NIDDK central repository and were analyzed. We stratified these children into low and high-risk categories...
November 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29189595/fast-and-sensitive-automated-point-of-care-urine-dips
#2
Laurie Malia, Kaitlin Strumph, Sharon Smith, John Brancato, Stephanie T Johnson, Henry Chicaiza
OBJECTIVE: Point-of-care (POC) urine dipstick is a highly used test in the pediatric emergency department (PED) owing to its fast turn-around time and inexpensive cost. Past studies have shown hand-held urine dipsticks and automated urinalysis in children younger than 48 months to be sensitive predictors for urinary tract infection (UTI). It is hypothesized that POC dip testing is as accurate as laboratory urinalysis in the diagnosis of UTI. METHODS: A retrospective chart review was conducted on patients (aged birth through 18 years) presenting to a PED between January 2015 and December 2015...
November 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29187581/randomized-trials-in-children-with-uti
#3
Alan R Schroeder, Thomas B Newman
No abstract text is available yet for this article.
November 29, 2017: Pediatrics
https://www.readbyqxmd.com/read/29187579/urinary-tract-infection-antibiotic-trial-study-design-a-systematic-review
#4
REVIEW
Romain Basmaci, Konstantinos Vazouras, Julia Bielicki, Laura Folgori, Yingfen Hsia, Theoklis Zaoutis, Mike Sharland
CONTEXT: Urinary tract infections (UTIs) represent common bacterial infections in children. No guidance on the conduct of pediatric febrile UTI clinical trials (CTs) exist. OBJECTIVE: To assess the criteria used for patient selection and the efficacy end points in febrile pediatric UTI CTs. DATA SOURCES: Medline, Embase, Cochrane central databases, and clinicaltrials.gov were searched between January 1, 1990, and November 24, 2016. STUDY SELECTION: We combined Medical Subject Headings terms and free-text terms for "urinary tract infections" and "therapeutics" and "clinical trials" in children (0-18 years), identifying 3086 articles...
November 29, 2017: Pediatrics
https://www.readbyqxmd.com/read/29146619/urinary-neutrophil-gelatinase-associated-lipocalin-for-the-diagnosis-of-urinary-tract-infections
#5
Tamar R Lubell, Jonathan M Barasch, Katherine Xu, Maria Ieni, Keven I Cabrera, Peter S Dayan
OBJECTIVES: To determine the accuracy of the novel biomarker urinary neutrophil gelatinase-associated lipocalin (uNGAL) to diagnose urinary tract infections (UTIs) in febrile infants and young children. METHODS: Prospective cross-sectional study of febrile infants <3 months ( ≥ 38.0°C) and children 3 to 24 months (≥ 39.0°C) evaluated for UTIs. uNGAL levels, urinalysis, Gram-stain and culture were obtained. UTI was defined by colony counts. RESULTS: Of 260 patients, 35 (13...
November 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/29138582/once-daily-intramuscular-amikacin-for-outpatient-treatment-of-lower-urinary-tract-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-children
#6
Meltem Polat, Soner Sertan Kara
Background: The rise in community-acquired urinary tract infections (UTIs) with extended-spectrum β-lactamase (ESBL)-producing Escherichia coli strains raises the question of how to treat these infections effectively in pediatric outpatients. Amikacin has shown promising in vitro activity against ESBL-producing urinary isolates of E. coli; however, clinical data are limited. Objective: To investigate the clinical and microbiological outcomes of community-acquired lower UTIs caused by ESBL-producing E...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29135902/should-the-absence-of-urinary-nitrite-influence-empiric-antibiotics-for-urinary-tract-infection-in-young-children
#7
Pradip P Chaudhari, Michael C Monuteaux, Richard G Bachur
OBJECTIVES: Screening for urinary tract infection (UTI) includes urinary nitrite testing by dipstick urinalysis. Gram-negative enteric organisms produce urinary nitrite and represent the most common uropathogens. Enterococcus, a less common uropathogen, does not produce nitrite and has a unique antibiotic resistance pattern. Whether to adjust empiric antibiotics in the absence of urinary nitrite has not been established. Our primary objective was to determine prevalence of enterococcal UTI among young children with a nitrite negative urinalysis...
November 14, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29102297/the-efficacy-of-probiotics-in-prevention-of-urinary-tract-infection-in-children-a-systematic-review-and-meta-analysis
#8
REVIEW
Mostafa Hosseini, Mahmoud Yousefifard, Neamatollah Ataei, Alireza Oraii, Jalaledin Mirzay Razaz, Anahita Izadi
BACKGROUND: A consensus has not been reached yet about the efficacy of probiotics in reducing the incidence of urinary tract infections (UTIs) in children. This systematic review and meta-analysis was designed to assess the efficacy of probiotics in prevention UTI in children. METHODS: The present study was designed based on guidelines for systematic reviews of clinical trials. Two independent reviewers performed an extensive search in the Medline, Embase, Web of Science and Scopus electronic databases up to the end of 2016...
October 9, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29100793/discrimination-of-culture-negative-pyelonephritis-in-children-with-suspected-febrile-urinary-tract-infection-and-negative-urine-culture-results
#9
Jun Ho Lee
BACKGROUND: We investigated whether the C-reactive protein (CRP) level, urine electrolytes, and urine sodium-potassium ratio (uNa/K) could be useful markers for discriminating children with culture negative pyelonephritis (CNP) from children with suspected febrile urinary tract infection (fUTI) and negative urine culture results. METHODS: We examined 264 children experiencing their first fUTI consecutively admitted to our hospital between January 2011 and October 2014...
October 25, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29097611/trends-in-intravenous-antibiotic-duration-for-urinary-tract-infections-in-young-infants
#10
William W Lewis-de Los Angeles, Cary Thurm, Adam L Hersh, Samir S Shah, Michael J Smith, Jeffrey S Gerber, Sarah K Parker, Jason G Newland, Matthew P Kronman, Brian R Lee, Thomas V Brogan, Joshua D Courter, Alicen Spaulding, Sameer J Patel
OBJECTIVES: To assess trends in the duration of intravenous (IV) antibiotics for urinary tract infections (UTIs) in infants ≤60 days old between 2005 and 2015 and determine if the duration of IV antibiotic treatment is associated with readmission. METHODS: Retrospective analysis of infants ≤60 days old diagnosed with a UTI who were admitted to a children's hospital and received IV antibiotics. Infants were excluded if they had a previous surgery or comorbidities, bacteremia, or admission to the ICU...
December 2017: Pediatrics
https://www.readbyqxmd.com/read/29082641/risk-factors-for-urological-complications-following-living-donor-renal-transplantation-in-children
#11
Mohammed S ElSheemy, Waleed Ghoneima, Waseem Aboulela, Kareem Daw, Ahmed M Shouman, Ahmed I Shoukry, Sherif Soaida, Doaa M Salah, Hafez Bazaraa, Fatina I Fadel, Ahmed A Hussein, Enmar Habib, Ismail R Saad, Mohamed El Ghoneimy, Hany A Morsi, Mohammed A Lotfi, Hesham Badawy
The aim of this study was to detect possible risk factors for UC and UTI following pediatric renal Tx and effect of these complications on outcome. One hundred and eight children who underwent living donor Tx between 2009 and 2015 were retrospectively included. Extraperitoneal approach was used with stented tunneled extravesical procedure. Mean recipient age was 9.89 ± 3.46 years while mean weight was 25.22 ± 10.43 kg. Seventy-three (67.6%) recipients were boys while 92 (85.2%) were related to donors...
October 29, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29080255/how-to-stent-the-ureter-after-kidney-transplantation-in-children-a-comparison-of-two-methods-of-urinary-drainage
#12
Anuradha S Ter Haar, Rulan S Parekh, Ralph W J Leunissen, Joop van den, Armando J Lorenzo, Diane Hebert, Mandy G Keijzer-Veen, Karlien Cransberg
Ureteral stenting after pediatric renal transplantation serves to prevent obstruction and urinary leakage, but can also cause complications. This study compares the complication rates of both methods. Data were retrospectively collected at Erasmus MC, Rotterdam, the Netherlands (splint group, n = 61) and Hospital for Sick Children, Toronto, Canada (JJ catheter group, n = 50). Outcome measures included urological interventions and incidence of UTIs during the first 3 months post-transplantation. The splint was removed after a median of 9 (IQR 8-12), the JJ catheter after 42 (IQR 36-50) days...
October 27, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29071817/urinary-ykl-40-as-a-candidate-biomarker-for-febrile-urinary-tract-infection-in-young-children
#13
Hyun Hee Kim, Mi Hae Chung, Joong Hyun Bin, Kyoung Soon Cho, Juyoung Lee, Jin Soon Suh
BACKGROUND: Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. METHODS: In total, 44 children aged 0 to 24 months with febrile UTI and 35 age- and sex-matched controls with fever from other causes were enrolled in the study. ELISA was performed to determine the level of YKL-40 in urine collected from each child. RESULTS: The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (P<0...
January 2018: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/29028278/functional-variants-in-intercellular-adhesion-molecule-1-and-toll-like-receptor-4-genes-are-more-frequent-in-children-with-febrile-urinary-tract-infection-with-renal-parenchymal-involvement
#14
Almontaser Hussein, Khaled Saad, Eman Askar, Asmaa M Zahran, Hekma Farghaly, Kotb Metwalley, Ahmad A Elderwy
AIM: We studied the functional polymorphisms of intercellular adhesion molecule-1 (ICAM-1) and toll-like receptor-4 (TLR-4) genes and risk of acute pyelonephritis (APN) in children attending Assiut University Children's Hospitals, Egypt, from 2011 to 2015. METHODS: Urinary tract infections (UTIs) were diagnosed in 380 children: 98 had APN and 282 had lower UTIs. Four single-nucleotide polymorphisms in ICAM-1 and TLR-4 genes were genotyped in all subjects: ICAM-1 rs1799969 Gly241Arg, ICAM-1 rs5498 Glu469Lys, TLR-4 rs4896791 Thr399Ile and TLR-4 rs4896790 Asp299Gly...
October 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28986090/urinary-tract-infection-in-children-diagnosis-treatment-imaging-comparison-of-current-guidelines
#15
REVIEW
M Okarska-Napierała, A Wasilewska, E Kuchar
BACKGROUND AND OBJECTIVE: Urinary tract infection (UTI) is a frequent disorder of childhood, yet the proper approach for a child with UTI is still a matter of controversy. The objective of this study was to critically compare current guidelines for the diagnosis and management of UTI in children, in light of new scientific data. METHODS: An analysis was performed of the guidelines from: American Academy of Pediatrics (AAP), National Institute for Health and Care Excellence (NICE), Italian Society of Pediatric Nephrology, Canadian Paediatric Society (CPS), Polish Society of Pediatric Nephrology, and European Association of Urology (EAU)/European Society for Pediatric Urology (ESPU)...
September 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28984254/yield-of-imaging-performed-as-per-indian-society-of-pediatric-nephrology-guidelines-in-children-with-urinary-tract-infection
#16
Rajiv Sinha, Devdeep Mukherjee, Jayati Sengupta, Subhasis Saha, Sushmita Banerjee
OBJECTIVE: To assess yield of imaging performed as per Indian Society of Pediatric Nephrology (ISPN) urinary tract infection (UTI) guideline. METHODS: Ultrasonography (USG), voiding cystourethrography (VCUG) and dimercaptosuccinic-acid (DMSA) scintigraphy were performed in 183 children (age 0-5y) with first episode (age 0-1y) of UTI or recurrent (age <5y) UTI, as per ISPN recommendations. RESULTS: Significant abnormalities were detected in 110 (63%), with vesicoureteric reflux (VUR) grades 3-5 in 31% and renal scars in 43%...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28982546/what-did-we-find-from-imaging-studies-in-childhood-uti-and-which-studies-are-mandatory
#17
Prayong Vachvanichsanong, Pornsak Dissaneewate, Edward McNeil
OBJECTIVE: To evaluate the imaging results of childhood UTI in our setting, and examine if it would be appropriate to apply the recent guideline changes regarding imaging studies as routine practice in Thailand. METHODS: Medical records of UTI children aged 0-15 years were reviewed, with focus on renal ultrasound (RUS), cystogram and (99mTc)dimercaptosuccinic acid (DMSA) renal scan results to determine congenital anomalies of the kidney and urinary tract (CAKUT) and renal damage...
October 2, 2017: Urology
https://www.readbyqxmd.com/read/28978286/the-clinical-diagnosis-and-management-of-urinary-tract-infections-in-children-and-adolescents
#18
Lindsey Korbel, Marianella Howell, John David Spencer
Urinary tract infections (UTI) are one of the most common and serious bacterial infections encountered by paediatricians and primary care physicians. Although the diagnosis and management of UTI appear simplistic, they remain among the most contentious issues in paediatrics. In part, UTI controversies stem from the absence of classic clinical symptoms, inappropriate urine specimen collection, modified urinary tract imaging recommendations, and diverse treatment and prevention strategies. Recently published guidelines and large clinical trials have attempted to clarify UTI diagnostic and management strategies...
October 5, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28975420/diagnosis-and-management-of-bladder-bowel-dysfunction-in-children-with-urinary-tract-infections-a-position-statement-from-the-international-children-s-continence-society
#19
Stephen Yang, Michael E Chua, Stuart Bauer, Anne Wright, Per Brandström, Piet Hoebeke, Søren Rittig, Mario De Gennaro, Elizabeth Jackson, Eliane Fonseca, Anka Nieuwhof-Leppink, Paul Austin
BACKGROUND: We present a consensus view from the International Children's Continence Society (ICCS) on the evaluation and management of bladder bowel dysfunction (BBD) in children with urinary tract infection (UTI). The statement aims to highlight the importance of BBD in the development and recurrence of childhood UTI and its management to reduce its associated morbidity and sequelae. METHODS: A systematic literature search was done on PubMed, Embase, and Scopus databases until August 15, 2016...
October 3, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28966488/changing-prevalence-and-antibiotic-drug-resistance-pattern-of-pathogens-seen-in-community-acquired-pediatric-urinary-tract-infections-at-a-tertiary-care-hospital-of-north-india
#20
Vrushali Patwardhan, Dinesh Kumar, Varun Goel, Sarman Singh
AIMS AND OBJECTIVES: The aim and objective of this study was to assess the temporal changes in the microbiological profiles and antimicrobial resistance patterns of uropathogens in pediatric community-acquired UTI. MATERIALS AND METHODS: This is a retrospective analysis of data collected over a Scattered period of 5 years. The baseline data collected were from January to December 2009, and the second period considered for comparison was from January to December 2014...
October 2017: Journal of Laboratory Physicians
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