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UTI In childrens

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https://www.readbyqxmd.com/read/29028278/functional-variants-in-intercellular-adhesion-molecule-1-and-toll-like-receptor-4-genes-are-more-frequent-in-children-with-febrile-urinary-tract-infection-with-renal-parenchymal-involvement
#1
Almontaser Hussein, Khaled Saad, Eman Askar, Asmaa M Zahran, Hekma Farghaly, Kotb Metwalley, Ahmad A Elderwy
AIM: We studied the functional polymorphisms of intercellular adhesion molecule-1 and toll-like receptor-4 genes and risk of acute pyelonephritis in children attending Assiut University Children's Hospitals, Egypt from 2011 to 2015. METHODS: Urinary tract infections (UTIs) were diagnosed in 380 children: 98 had acute pyelonephritis and 282 had lower UTIs. Four single-nucleotide polymorphisms in intercellular adhesion molecule-1 and toll-like receptor-4 genes were genotyped in all subjects: ICAM-1 rs1799969 Gly241Arg, ICAM-1 rs5498 Glu469Lys, TLR-4 rs4896791 Thr399Ile and TLR-4 rs4896790 Asp299Gly...
October 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28986090/urinary-tract-infection-in-children-diagnosis-treatment-imaging-comparison-of-current-guidelines
#2
REVIEW
M Okarska-Napierała, A Wasilewska, E Kuchar
BACKGROUND AND OBJECTIVE: Urinary tract infection (UTI) is a frequent disorder of childhood, yet the proper approach for a child with UTI is still a matter of controversy. The objective of this study was to critically compare current guidelines for the diagnosis and management of UTI in children, in light of new scientific data. METHODS: An analysis was performed of the guidelines from: American Academy of Pediatrics (AAP), National Institute for Health and Care Excellence (NICE), Italian Society of Pediatric Nephrology, Canadian Paediatric Society (CPS), Polish Society of Pediatric Nephrology, and European Association of Urology (EAU)/European Society for Pediatric Urology (ESPU)...
September 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28984254/yield-of-imaging-performed-as-per-indian-society-of-pediatric-nephrology-guidelines-in-children-with-urinary-tract-infection
#3
Rajiv Sinha, Devdeep Mukherjee, Jayati Sengupta, Subhasis Saha, Sushmita Banerjee
OBJECTIVE: To assess yield of imaging performed as per Indian Society of Pediatric Nephrology (ISPN) urinary tract infection (UTI) guideline. METHODS: Ultrasonography (USG), voiding cystourethrography (VCUG) and dimercaptosuccinic-acid (DMSA) scintigraphy were performed in 183 children (age 0-5y) with first episode (age 0-1y) of UTI or recurrent (age <5y) UTI, as per ISPN recommendations. RESULTS: Significant abnormalities were detected in 110 (63%), with vesicoureteric reflux (VUR) grades 3-5 in 31% and renal scars in 43%...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28982546/what-did-we-find-from-imaging-studies-in-childhood-uti-and-which-studies-are-mandatory
#4
Prayong Vachvanichsanong, Pornsak Dissaneewate, Edward McNeil
OBJECTIVE: To evaluate the imaging results of childhood UTI in our setting, and examine if it would be appropriate to apply the recent guideline changes regarding imaging studies as routine practice in Thailand. METHODS: Medical records of UTI children aged 0-15 years were reviewed, with focus on renal ultrasound (RUS), cystogram and (99mTc)dimercaptosuccinic acid (DMSA) renal scan results to determine congenital anomalies of the kidney and urinary tract (CAKUT) and renal damage...
October 2, 2017: Urology
https://www.readbyqxmd.com/read/28978286/the-clinical-diagnosis-and-management-of-urinary-tract-infections-in-children-and-adolescents
#5
Lindsey Korbel, Marianella Howell, John David Spencer
Urinary tract infections (UTI) are one of the most common and serious bacterial infections encountered by paediatricians and primary care physicians. Although the diagnosis and management of UTI appear simplistic, they remain among the most contentious issues in paediatrics. In part, UTI controversies stem from the absence of classic clinical symptoms, inappropriate urine specimen collection, modified urinary tract imaging recommendations, and diverse treatment and prevention strategies. Recently published guidelines and large clinical trials have attempted to clarify UTI diagnostic and management strategies...
October 5, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28975420/diagnosis-and-management-of-bladder-bowel-dysfunction-in-children-with-urinary-tract-infections-a-position-statement-from-the-international-children-s-continence-society
#6
Stephen Yang, Michael E Chua, Stuart Bauer, Anne Wright, Per Brandström, Piet Hoebeke, Søren Rittig, Mario De Gennaro, Elizabeth Jackson, Eliane Fonseca, Anka Nieuwhof-Leppink, Paul Austin
BACKGROUND: We present a consensus view from the International Children's Continence Society (ICCS) on the evaluation and management of bladder bowel dysfunction (BBD) in children with urinary tract infection (UTI). The statement aims to highlight the importance of BBD in the development and recurrence of childhood UTI and its management to reduce its associated morbidity and sequelae. METHODS: A systematic literature search was done on PubMed, Embase, and Scopus databases until August 15, 2016...
October 3, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28966488/changing-prevalence-and-antibiotic-drug-resistance-pattern-of-pathogens-seen-in-community-acquired-pediatric-urinary-tract-infections-at-a-tertiary-care-hospital-of-north-india
#7
Vrushali Patwardhan, Dinesh Kumar, Varun Goel, Sarman Singh
AIMS AND OBJECTIVES: The aim and objective of this study was to assess the temporal changes in the microbiological profiles and antimicrobial resistance patterns of uropathogens in pediatric community-acquired UTI. MATERIALS AND METHODS: This is a retrospective analysis of data collected over a Scattered period of 5 years. The baseline data collected were from January to December 2009, and the second period considered for comparison was from January to December 2014...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28965960/urinary-tract-infection-in-children-management-in-the-era-of-antibiotic-resistance-a-pediatric-urologist-s-view
#8
REVIEW
Balazs Kutasy, David Coyle, Magdalena Fossum
CONTEXT: Antibiotic resistance to uropathogens has grown significantly worldwide. Today, pediatric urologist experience a situation that needs appropriate action because urinary tract infections are one of the most common bacterial infections in children. OBJECTIVE: In this overview we aimed at presenting the clinical aspects of antibiotic usage in pediatric urology. Our intention was to take part of the important debate regarding future management of bacterial resistance against antibiotics...
September 28, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28961708/enteroaggregative-escherichia-coli-with-uropathogenic-characteristics-are-present-in-feces-of-diarrheic-and-healthy-children
#9
Kamila O Nunes, Adriana C P Santos, Silvia Y Bando, Rosa M Silva, Tânia A T Gomes, Waldir P Elias
Enteroaggregative Escherichia coli (EAEC) has been recently associated with urinary tract infections (UTI). Since EAEC are found in feces of both diarrheic and asymptomatic individuals, their presence in the intestine may be a source of UTI. In this study we detected in feces of diarrheic and healthy children a subset of EAEC strains with genetic markers of extraintestinal pathogenic E. coli (ExPEC). MLST grouped these EAEC(ExPEC+) in three main clusters along with prototypes strains of EAEC, UPEC and UTI-causing EAEC...
September 11, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28956280/management-of-urinary-tract-infection-with-intravesical-amikacin-may-increase-the-risk-of-bladder-oxidative-stress-in-children-with-neurogenic-bladder
#10
Akin Soner Amasyali, Dilek Yilmaz, Mustafa Yilmaz, Faruk Kucukdurmaz, Ferah Sonmez, Haluk Erol
INTRODUCTION: We evaluated the bladder oxidative stress in neurogenic bladder children treated with intravesical amikacin for recurrent UTI and whether urinary isoprostane f2 alpha (F2-IsoP) is a good biomarker in this particular condition. METHODS: This prospectively designed controlled study was approved by the Adnan Menderes University institutional ethics committee (Adnan Menderes University, 2015/649). Between January 2016 and January 2017, twenty-six children with meningomyelocele who had been doing CIC were recruited...
September 27, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28954556/an-update-on-new-antibiotic-prophylaxis-and-treatment-for-urinary-tract-infections-in-children
#11
Jean Daniel Delbet, Mathie Lorrot, Tim Ulinski
This review focuses on the treatment of urinary tract infections (UTI) in children and in particular its recent changes. Areas covered: Acute pyelonephritis, acute cystitis and asymptomatic bacteriuria or asymptomatic infections have to be clearly distinguished. Prompt treatment is required in pyelonephritis and cystitis, but not in asymptomatic bacteriuria or infection, in order to avoid selection of more virulent strains. This concept should be considered even in immunocompromised or bedridden children. In case of pyelonephritis, there should be no delay in beginning the antibiotic treatment in order to decrease the risk of long term complication, such as renal scars...
October 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28941917/national-trends-in-the-management-of-primary-vesicoureteral-reflux-in-children
#12
Michael Garcia-Roig, Curtis Tavers, Courtney E McCracken, Andrew J Kirsch
OBJECTIVE: In September 2011, the American Academy of Pediatrics(AAP) released updated guidelines for workup of children 2-24 months old with a febrile urinary tract infection(UTI). We aimed to document the guideline's impact on diagnosis and surgical management of VUR at US children's hospitals. We hypothesize that VCUG studies and VUR treatment rate decreased concurrent with national guideline release. METHODS: The Pediatric Health Information System(PHIS) was queried for children(<18 years) with primary VUR, and their anti-reflux surgical history, from January 2004-June 2015...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28906365/the-antibiotic-susceptibility-patterns-of-uropathogens-among-children-with-urinary-tract-infection-in-shiraz
#13
Gholamreza Pouladfar, Mitra Basiratnia, Mojtaba Anvarinejad, Pejman Abbasi, Fatemeh Amirmoezi, Samaneh Zare
Urinary tract infection (UTI) is one of the most common bacterial infections in pediatrics. Delay in diagnosis and treatment can cause significant morbidity. The physicians knowledge regarding the symptoms, microorganisms that caused UTI, and effective antibiotics in a geographical area can help them to select the appropriate antibiotics. This study was performed to determine the prevalence of bacteria that cause UTI and their susceptibility to common antibiotics as well as the common symptoms and associated factors in children of Shiraz, Southern Iran...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28899877/multiresistant-e-coli-urine-infections-in-children-a-case-control-study
#14
Gayathri Raman, Brendan McMullan, Peter Taylor, Kylie-Ann Mallitt, Sean E Kennedy
OBJECTIVE: Urinary tract infections (UTIs) caused by resistant organisms are increasing which poses challenges when selecting empirical antimicrobial therapy. The aim of this study is to determine risk factors for multiresistant Escherichia coliUTIs in children. DESIGN: We included all reported urinary isolates from a children's hospital collected between January 2010 and June 2013. Patients who had multiresistant E. coliUTIs were identified and a retrospective review of medical records performed...
September 12, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28884476/probiotics-for-preventing-urinary-tract-infection-in-people-with-neuropathic-bladder
#15
REVIEW
Swee-Ling Toh, Claire L Boswell-Ruys, Bon San B Lee, Judy M Simpson, Kate R Clezy
BACKGROUND: Neuropathic or neurogenic bladder describes a process of dysfunctional voiding as the result of injury in the brain, spinal cord or nerves innervating the bladder. People with neuropathic bladder, such as from spinal cord injury (SCI), are at significant risk of morbidity from urinary tract infections (UTI). Effective methods to prevent UTI in people with SCI have been sought for many years. Probiotics (micro-organisms that exert beneficial health effects in the host) have been recommended for bacterial interference of the urological tract to reduce colonisation by uropathogen and to manage the dual problems of infection and antibiotic resistance...
September 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28882930/renal-scar-formation-and-kidney-function-following-antibiotic-treated-murine-pyelonephritis
#16
Patrick D Olson, Lisa K McLellan, Alice Liu, Kelleigh L Briden, Kristin M Tiemann, Allyssa L Daugherty, Keith A Hruska, David A Hunstad
We present a new preclinical model to study treatment, resolution, and sequelae of severe ascending pyelonephritis. Urinary tract infection (UTI), primarily caused by uropathogenic Escherichia coli (UPEC), is a common disease in children. Severe pyelonephritis is the primary cause of acquired renal scarring in childhood, which may eventually lead to hypertension and chronic kidney disease in a small but important fraction of patients. Preclinical modeling of UTI utilizes almost exclusively females, which (in most mouse strains) exhibit inherent resistance to severe ascending kidney infection; consequently, no existing preclinical model has assessed the consequences of recovery from pyelonephritis following antibiotic treatment...
September 7, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28855226/antibiotics-for-performing-voiding-cystourethrogram-a-randomised-control-trial
#17
Rajiv Sinha, Subhasis Saha, Biplab Maji, Yincent Tse
OBJECTIVE: To assess whether antibiotic reduces voiding cystourethrogram (VCUG)-associated urinary tract infection (UTI). DESIGN: Open-labelled randomised controlled trial. SETTING: Tertiary paediatric nephrology centre. PATIENTS: 120 children (age 2 months-5 years) undergoing VCUG. INTERVENTIONS: Children were randomised into group A (antibiotic, n=72) or group B (no antibiotic, n=48) in 3:2 ratio...
August 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28827494/urinary-tract-infection-in-children-with-nephrotic-syndrome
#18
Upma Narain, Arvind Gupta
BACKGROUND: The occurrence of urinary tract infection (UTI) in nephrotic syndrome has been reported. However, the only causes for the infection reported to date are bacteria and prior reported series did not identify yeast or fungi as causative organisms. METHODS: A retrospective study of 2880 children with nephrotic syndrome was made to determine the incidence of UTI, predisposing factor and bacterial and fungal etiologies. RESULTS: Between January 2000 and November 2016 we identified that 15% of the children developed urinary tract infection...
August 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28814261/recent-studies-on-the-care-of-first-febrile-urinary-tract-infection-in-infants-and-children-for-the-pediatric-hospitalist
#19
Ashley G Sutton, Nicole Chandler, Kenneth B Roberts
BACKGROUND: Urinary tract infection (UTI) is a common cause of bacterial infection in young children, and accounts for a significant number of pediatric hospitalizations. OBJECTIVE: To review recent publications focusing on the care of children hospitalized with their first febrile UTI Methods: A PubMed search was performed including publications from 2011-2016 on first febrile UTI in childhood. Abstracts were reviewed for being relevant to the care of hospitalized children and their follow-up...
August 16, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28798828/dimercaptosuccinic-acid-scintigraphy-vs-ultrasound-for-renal-parenchymal-defects-in-children
#20
Maryse Marceau-Grimard, Audrey Marion, Christian Côté, Stephane Bolduc, Marcel Dumont, Katherine Moore
INTRODUCTION: Dimercaptosuccinic acid (DMSA) scintigraphy is the gold standard in the evaluation of renal parenchymal defects and is widely used in the pediatric population. As more recent ultrasound equipment was purchased at our tertiary pediatric centre, our objective was to evaluate if renal ultrasound (US) results are equivalent or sufficient when compared to DMSA scintigraphy in the assessment of renal anomalies. METHODS: The charts of all 463 patients who underwent DMSA scintigraphy between January 2009 and May 2014 at our pediatric tertiary centre were reviewed...
August 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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