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https://www.readbyqxmd.com/read/28646666/detection-of-mycobacterium-avium-subspecies-paratuberculosis-in-powdered-infant-formula-using-is900-quantitative-pcr-and-liquid-culture-media
#1
Kamal R Acharya, Navneet K Dhand, Richard J Whittington, Karren M Plain
Mycobacterium avium subspecies paratuberculosis (MAP) has been implicated in Crohn's disease in humans resulting in public concern over the presence of MAP in powdered infant formula, which could contribute towards early human exposure to MAP or MAP components. Testing of representative powdered infant formula samples using effective tests is required to provide information on contamination of infant formula with MAP, so that consumers can make informed decisions. This study aimed to test representative powdered infant formula samples for the presence of MAP using a quantitative PCR and liquid culture method...
June 8, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28646180/sustained-release-from-a-metal-analgesics-entrapped-within-biocidal-silver
#2
Barak Menagen, Rami Pedahzur, David Avnir
Matrices for sustained release of drugs have been based on polymers, biomaterials and oxides. The use of the major family of metals as matrices for sustained release is, to the best of our knowledge, unknown. In this context we describe a new family of bio-composites for sustained release of drugs, namely analgesic drugs entrapped within metallic silver. Synthetic methodologies were developed for the preparation of ibuprofen@Ag, naproxen@Ag, tramadol@Ag and bupivacaine@Ag composites. Detailed kinetic analysis of the release of the drugs from within the metal, is provided, demonstrating that metals can indeed serve as reservoirs for drug release...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28644842/investigation-of-discriminant-metabolites-in-tamoxifen-resistant-and-choline-kinase-alpha-downregulated-breast-cancer-cells-using-1h-nuclear-magnetic-resonance-spectroscopy
#3
Hoe Suk Kim, Lianji Tian, Hyeonjin Kim, Woo Kyung Moon
Metabolites linked to changes in choline kinase-α (CK-α) expression and drug resistance, which contribute to survival and autophagy mechanisms, are attractive targets for breast cancer therapies. We previously reported that autophagy played a causative role in driving tamoxifen (TAM) resistance of breast cancer cells (BCCs) and was also promoted by CK-α knockdown, resulting in the survival of TAM-resistant BCCs. There is no comparative study yet about the metabolites resulting from BCCs with TAM-resistance and CK-α knockdown...
2017: PloS One
https://www.readbyqxmd.com/read/28644680/exploring-the-factor-structure-of-the-social-cognition-and-object-relations-global-rating-method-support-for-two-and-three-factor-models
#4
Caleb J Siefert, Michelle Stein, Jenelle Slavin-Mulford, Greg Haggerty, Samuel J Sinclair, Danielle Funke, Mark A Blais
The Social Cognition and Object Relations Scales-Global Rating Method (SCORS-G) contains 8 scales for coding narrative content. This study explores the factor structure of this measure using college (n = 171), outpatient (n = 239), and inpatient (n = 78) samples. Participants told stories to the Thematic Apperception Test (TAT; Murray, 1943) cards. Stories were transcribed and coded by blind raters using the SCORS-G. Cases were randomly assigned to an exploratory or validation group. Exploratory factor analysis with the exploratory group suggested 2- and 3-factor models...
June 23, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28644403/assessment-of-vulnerability-to-coccidioidomycosis-in-arizona-and-california
#5
Jennifer Shriber, Kathryn C Conlon, Kaitlin Benedict, Orion Z McCotter, Jesse E Bell
Coccidioidomycosis is a fungal infection endemic to the southwestern United States, particularly Arizona and California. Its incidence has increased, potentially due in part to the effects of changing climatic variables on fungal growth and spore dissemination. This study aims to quantify the county-level vulnerability to coccidioidomycosis in Arizona and California and to assess the relationships between population vulnerability and climate variability. The variables representing exposure, sensitivity, and adaptive capacity were combined to calculate county level vulnerability indices...
June 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28642876/magnetic-separation-methods-for-the-detection-of-mycobacterium-avium-subsp-paratuberculosis-in-various-types-of-matrices-a-review
#6
REVIEW
Marketa Husakova, Radka Dziedzinska, Iva Slana
The main reasons to improve the detection of Mycobacterium avium subsp. paratuberculosis (MAP) are animal health and monitoring of MAP entering the food chain via meat, milk, and/or dairy products. Different approaches can be used for the detection of MAP, but the use of magnetic separation especially in conjunction with PCR as an end-point detection method has risen in past years. However, the extraction of DNA which is a crucial step prior to PCR detection can be complicated due to the presence of inhibitory substances...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28640625/dust-effects-on-nucleation-kinetics-and-nanoparticle-product-size-distributions-illustrative-case-study-of-a-prototype-ir-0-n-transition-metal-nanoparticle-formation-system
#7
Saim Özkar, Richard G Finke
The question is addressed if dust is kinetically important in the nucleation and growth of Ir(0)n nanoparticles formed from [Bu4N]5Na3(1,5-COD)Ir(I)·P2W15Nb3O62 (hereafter [(COD)Ir·POM](8-)), reduced by H2 in propylene carbonate solvent. Following a concise review of the (often-neglected) literature addressing dust in nucleation phenomena dating back to the late 1800s, the nucleation and growth kinetics of the [(COD)Ir·POM](8-) precatalyst system are examined for the effects of 0.2 μm microfiltration of the solvent and precatalyst solution, of rinsing the glassware with that microfiltered solvent, of silanizing the glass reaction vessel, for the addition of <0...
June 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28640603/changes-in-light-absorptivity-of-molecular-weight-separated-brown-carbon-due-to-photolytic-aging
#8
Jenny Pui Shan Wong, Athanasios Nenes, Rodney J Weber
Brown carbon (BrC) are those organic compounds in atmospheric aerosols that absorb solar radiation and may play an important role on planetary radiative forcing and climate. However, little is known about the production and loss mechanisms of BrC in the atmosphere. Here, we study how the light absorptivity of BrC from wood smoke and secondary BrC generated from reaction of ammonium sulfate with methylglyoxal changes under photolytic aging by UVA radiation in the aqueous phase. Owing to its chemical complexity, BrC is separated by molecular weight using size exclusion chromatography and the response of each molecular weight fraction to aging is studied...
June 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28639601/faecal-microbiota-of-healthy-adults-in-south-india-comparison-of-a-tribal-a-rural-population
#9
Balamurugan Ramadass, B Sandya Rani, Srinivasan Pugazhendhi, K R John, Balakrishnan S Ramakrishna
BACKGROUND & OBJECTIVES: The relevance of the gut microbiota to human health is increasingly appreciated. The objective of this study was to compare the gut microbiota of a group of adult tribals with that of healthy adult villagers in Tamil Nadu, India. METHODS: Faeces were collected from 10 healthy tribal adults (TAs) in the Jawadhi hills and from 10 healthy villagers [rural adults (RAs)] in Vellore district, Tamil Nadu. DNA was extracted, and 456 bp segments comprising hypervariable regions 3 and 4 of the 16S rRNA gene were amplified, barcoded and 454 sequenced...
February 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28638597/rest-tremor-revisited-parkinson-s-disease-and-other-disorders
#10
REVIEW
Wei Chen, Franziska Hopfner, Jos Steffen Becktepe, Günther Deuschl
Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is challenging to make an accurate diagnosis. This applies particularly for tremor at rest. This entity was only rarely studied in the past, although a multitude of clinical studies on prevalence and clinical features of tremor in Parkinson's disease (PD), essential tremor and dystonia, have been carried out...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28637811/bayesian-networks-illustrate-genomic-and-residual-trait-connections-in-maize-zea-mays-l
#11
Katrin Töpner, Guilherme J M Rosa, Daniel Gianola, Chris-Carolin Schön
Relationships among traits were investigated on the genomic and residual levels using novel methodology. This included inference on these relationships via Bayesian networks and an assessment of the networks with structural equation models. The methodology employed three steps. First, a Bayesian multiple-trait Gaussian model was fitted to the data to decompose phenotypic values into their genomic and residual components. Second, genomic and residual network structures among traits were learned from estimates of these two components...
June 21, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28637417/effect-of-heteropterys-aphrodisiaca-on-anxiety-and-male-exposure-of-female-mice-with-advanced-age
#12
Daniela Miranda Farias, Maria Silvia Ostetto, Rozimeri Colleti, Thais Barbosa, Jorge Aparecido Barros, Sergio Machado, Eric Murillo-Rodríguez, Susana E Moreno, André Barciela Veras
BACKGROUND: Effect of Heteropterys aphrodisiac (dog-node) on anxiety and function Of adult female wistar mice. The Project is an experiment with the use of Of H. aphrodisiac root extract, in order to observe the frequency of Sexual exposure of females exposed to the extract, quantify the effect of the extract on the Concentration of total testosterone and observe the anxiety levels of the animals Exposed. Results will be measured with the laboratory testosterone test and LCE and CA tests...
June 21, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28636933/drosophila-neuropeptide-f-signaling-independently-regulates-feeding-and-sleep-wake-behavior
#13
Brian Y Chung, Jennifer Ro, Sabine A Hutter, Kylie M Miller, Lakshmi S Guduguntla, Shu Kondo, Scott D Pletcher
Proper regulation of sleep-wake behavior and feeding is essential for organismal health and survival. While previous studies have isolated discrete neural loci and substrates important for either sleep or feeding, how the brain is organized to coordinate both processes with respect to one another remains poorly understood. Here, we provide evidence that the Drosophila Neuropeptide F (NPF) network forms a critical component of both adult sleep and feeding regulation. Activation of NPF signaling in the brain promotes wakefulness and adult feeding, likely through its cognate receptor NPFR...
June 20, 2017: Cell Reports
https://www.readbyqxmd.com/read/28636604/liquid-droplet-formation-by-hp1%C3%AE-suggests-a-role-for-phase-separation-in-heterochromatin
#14
Adam G Larson, Daniel Elnatan, Madeline M Keenen, Michael J Trnka, Jonathan B Johnston, Alma L Burlingame, David A Agard, Sy Redding, Geeta J Narlikar
Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands. Here we identify a new property of the human HP1α protein: the ability to form phase-separated droplets. While unmodified HP1α is soluble, either phosphorylation of its N-terminal extension or DNA binding promotes the formation of phase-separated droplets. Phosphorylation-driven phase separation can be promoted or reversed by specific HP1α ligands...
June 21, 2017: Nature
https://www.readbyqxmd.com/read/28636597/phase-separation-drives-heterochromatin-domain-formation
#15
Amy R Strom, Alexander V Emelyanov, Mustafa Mir, Dmitry V Fyodorov, Xavier Darzacq, Gary H Karpen
Constitutive heterochromatin is an important component of eukaryotic genomes that has essential roles in nuclear architecture, DNA repair and genome stability, and silencing of transposon and gene expression. Heterochromatin is highly enriched for repetitive sequences, and is defined epigenetically by methylation of histone H3 at lysine 9 and recruitment of its binding partner heterochromatin protein 1 (HP1). A prevalent view of heterochromatic silencing is that these and associated factors lead to chromatin compaction, resulting in steric exclusion of regulatory proteins such as RNA polymerase from the underlying DNA...
June 21, 2017: Nature
https://www.readbyqxmd.com/read/28633681/copewell-a-conceptual-framework-and-system-dynamics-model-for-predicting-community-functioning-and-resilience-after-disasters
#16
Jonathan M Links, Brian S Schwartz, Sen Lin, Norma Kanarek, Judith Mitrani-Reiser, Tara Kirk Sell, Crystal R Watson, Doug Ward, Cathy Slemp, Robert Burhans, Kimberly Gill, Tak Igusa, Xilei Zhao, Benigno Aguirre, Joseph Trainor, Joanne Nigg, Thomas Inglesby, Eric Carbone, James M Kendra
OBJECTIVE: Policy-makers and practitioners have a need to assess community resilience in disasters. Prior efforts conflated resilience with community functioning, combined resistance and recovery (the components of resilience), and relied on a static model for what is inherently a dynamic process. We sought to develop linked conceptual and computational models of community functioning and resilience after a disaster. METHODS: We developed a system dynamics computational model that predicts community functioning after a disaster...
June 21, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28633668/use-of-social-adaptability-index-to-explain-self-care-and-diabetes-outcomes
#17
Jennifer A Campbell, Rebekah J Walker, Brittany L Smalls, Leonard E Egede
BACKGROUND: To examine whether the social adaptability index (SAI) alone or components of the index provide a better explanatory model for self-care and diabetes outcomes. METHODS: Six hundred fifteen patients were recruited from two primary care settings. A series of multiple linear regression models were run to assess (1) associations between the SAI and diabetes self-care/outcomes, and (2) associations between individual SAI indicator variables and diabetes self-care/outcomes...
June 20, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28633306/multivariate-phylogenetic-comparative-methods-evaluations-comparisons-and-recommendations
#18
Dean C Adams, Michael L Collyer
Recent years have seen increased interest in phylogenetic comparative analyses of multivariate datasets, but to date the varied proposed approaches have not been extensively examined. Here we review the mathematical properties required of any multivariate method, and specifically evaluate existing multivariate phylogenetic comparative methods in this context. Phylogenetic comparative methods based on the full multivariate likelihood are robust to levels of covariation among trait dimensions and are insensitive to the orientation of the dataset, but display increasing model misspecification as the number of trait dimensions increases...
June 13, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28633071/structural-characterization-of-the-immunostimulatory-exopolysaccharide-produced-by-leuconostoc-mesenteroides-strain-ntm048
#19
Chiaki Matsuzaki, Chikahiro Takagaki, Yusuke Tomabechi, Lennart S Forsberg, Christian Heiss, Parastoo Azadi, Kenji Matsumoto, Toshihiko Katoh, Koji Hosomi, Jun Kunisawa, Kenji Yamamoto, Keiko Hisa
The exopolysaccharide (EPS) produced by probiotic Leuconostoc mesenteroides subsp. mesenteroides strain NTM048 has been reported to be an immunostimulant that enhances mucosal IgA production. In this study, we found that intranasal administration of mice with the EPS and an antigen (ovalbumin) resulted in secretion of antigen-specific IgA and IgG in the airway mucosa and the serum, suggesting that the EPS has the adjuvant activity for use with mucosal vaccination. Methylation analysis coupled to GC-MS, and 1D and 2D NMR spectroscopy revealed that 94% of the EPS consists of an α-(1 → 6) glucan containing 4% of 1→3-linked α-glucose branches...
June 15, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28632057/rotation-sequence-to-report-humerothoracic-kinematics-during-3d-motion-involving-large-horizontal-component-application-to-the-tennis-forehand-drive
#20
Thomas Creveaux, Violaine Sevrez, Raphaël Dumas, Laurence Chèze, Isabelle Rogowski
The aim of this study was to examine the respective aptitudes of three rotation sequences (YtXf'Yh'', ZtXf'Yh'', and XtZf'Yh'') to effectively describe the orientation of the humerus relative to the thorax during a movement involving a large horizontal abduction/adduction component: the tennis forehand drive. An optoelectronic system was used to record the movements of eight elite male players, each performing ten forehand drives. The occurrences of gimbal lock, phase angle discontinuity and incoherency in the time course of the three angles defining humerothoracic rotation were examined for each rotation sequence...
February 28, 2017: Sports Biomechanics
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