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https://www.readbyqxmd.com/read/28723106/proteins-breaking-bad-a-free-energy-perspective
#1
Jessica Valle-Orero, Rafael Tapia-Rojo, Edward C Eckels, Jaime Andres Rivas-Pardo, Ionel Popa, Julio M Fernandez
Protein ageing may manifest as a mechanical disease that compromises tissue elasticity. As proved recently, while proteins respond to changes in force with an instantaneous elastic recoil followed by a folding contraction, aged proteins break bad, becoming unstructured polymers. Here, we explain this phenomenon in the context of a free energy model, predicting the changes in the folding landscape of proteins upon oxidative ageing. Our findings validate that protein folding under force is constituted by two separable components, polymer properties and hydrophobic collapse, and demonstrate that the latter becomes irreversibly blocked by oxidative damage...
July 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28722757/discrimination-of-polygoni-multiflori-radix-and-cynanchi-auriculati-radix-using-ultra-high-performance-liquid-chromatography-fingerprints-and-chemical-pattern-recognition
#2
Lili Sun, Meng Wang, Yali Liu, Huijie Zhang, Yanan Liu, Xiaoliang Ren, Yanru Deng
In this work, a strategy was proposed to discriminate Polygoni Multiflori Radix (PMR) and its adulteration (Cynanchi Auriculati Radix, CAR). The ultra-high performance liquid chromatography (UHPLC) fingerprints were established to analyze samples containing PMR, CAR and mixtures simultaneously. Multivariate classification methods were applied to analyze the obtained UHPLC fingerprints, including principal component analysis (PCA), partial least square discriminant analysis (PLS-DA), soft independent modeling of class analogy (SIMCA), support vector machine discriminant analysis (SVMDA), and counter-propagation artificial neural network (CP-ANN)...
July 19, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28722486/neurotoxic-effects-of-subchronic-intratracheal-mn-nanoparticle-exposure-alone-and-in-combination-with-other-welding-fume-metals-in-rats
#3
Zsuzsanna Máté, Edina Horváth, András Papp, Krisztina Kovács, Etelka Tombácz, Dániel Nesztor, Tamás Szabó, Andrea Szabó, Edit Paulik
Manganese (Mn) is a toxic heavy metal exposing workers in various occupational settings and causing, among others, nervous system damage. Metal fumes of welding, a typical source of Mn exposure, contain a complex mixture of metal oxides partly in nanoparticle form. As toxic effects of complex substances cannot be sufficiently understood by examining its components separately, general toxicity and functional neurotoxicity of a main pathogenic welding fume metal, Mn, was examined alone and combined with iron (Fe) and chromium (Cr), also frequently found in fumes...
July 19, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28722398/fractionation-and-concentration-of-high-salinity-textile-wastewater-using-an-ultra-permeable-sulfonated-thin-film-composite
#4
Meng Li, Yujian Yao, Wen Zhang, Junfeng Zheng, Xuan Zhang, Lianjun Wang
A sulfonated thin-film composite (TFC) nanofiltration membrane was fabricated using 2,2'-benzidinedisulfonic acid (BDSA) and trimesoyl chloride (TMC) on a polyether sulfone substrate by conventional interfacial polymerization. Due to a nascent barrier layer with a loose architecture, the obtained TFC-BDSA-0.2 membrane showed an ultra-high pure water permeability of 48.1 ± 2.1 L-1 m-2 h-1 bar-1, and a considerably low NaCl retention ability of <1.8% over a concentration range of 10-100 g L-1. The membrane, which possesses a negatively charged surface, displayed an excellent rejection of over 99% towards Congo red (CR), and allowed the fast fractionation of high-salinity textile wastewater...
July 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28722396/a-novel-ceramic-grafted-separator-with-highly-thermal-stability-for-safe-lithium-ion-batteries
#5
Xiaoyu Jiang, Xiaoming Zhu, Xinping Ai, Hanxi Yang, Yuliang Cao
Separator is a critical component of lithium-ion batteries (LIBs), which not only allows ionic transport while prevents electrical contact between electrodes, but also plays a key role for thermal safety performance of LIBs. However, commercial separators for LIBs are typically microporous polyolefin membranes that pose challenges for battery safety, due to shrinking and melting at elevated temperature. Here, we demonstrate a strategy to improve the thermal stability and electrolyte affinity of polyethylene (PE) separators...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28722037/magnetite-hollow-microspheres-with-a-broad-absorption-bandwidth-of-11-9-ghz-toward-promising-lightweight-electromagnetic-microwave-absorption
#6
Ivan Shanenkov, Alexander Sivkov, Alexander Ivashutenko, Viktor Zhuravlev, Qing Guo, Liping Li, Guangshe Li, GuoDong Wei, Wei Han
High-performance magnetite-based hollow spheres with the advantages of low density and low loading content are promising as an ideal lightweight electromagnetic (EM) wave absorption candidate. However, the effective preparation methods for these hollow spheres are still limited, and as a result, materials design and practical applications based on their size-dependent EM microwave attenuation properties are poorly accessible. In this study, high quality magnetite hollow spheres were successfully prepared by a simple, fast, one-step, and scalable plasma dynamic method with sole use of inexpensive precursors (oxygen and mild steel)...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28720940/recovery-of-protein-hydrolysate-and-chitosan-from-black-tiger-shrimp-penaeus-monodon-heads-approaching-a-zero-waste-process
#7
Pham Thi Dan Phuong, Nguyen Cong Minh, Hoang Ngoc Cuong, Nguyen Van Minh, Nguyen The Han, Nguyen Van Hoa, Ha Thi Hai Yen, Trang Si Trung
Shrimp heads are considered as a potential source for the recovery of many valuable components such as chitin, protein and carotenoids. In the present study, both protein hydrolysate and chitin/chitosan were recovered using combination of physical, biological and chemical treatments. Shrimp heads were separated from liquid phase by a facile and efficient physical pretreatment. The liquid fraction was then hydrolyzed using formic acid and vacuum concentrated to obtain an astaxanthin-rich protein hydrolysate...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720125/profiling-of-the-perturbed-metabolomic-state-of-mouse-spleen-during-acute-and-chronic-toxoplasmosis
#8
Xiao-Qing Chen, Chun-Xue Zhou, Hany M Elsheikha, Shuai He, Gui-Xue Hu, Xing-Quan Zhu
BACKGROUND: Toxoplasma gondii, a common opportunistic protozoan, is a leading cause of illness and mortality among immunosuppressed individuals and during congenital infections. Current therapeutic strategies for toxoplasmosis are not fully effective at curtailing disease progression in these cases. Given the parasite ability to influence host immunity and metabolism, understanding of the metabolic alterations in the host's immune organs during T. gondii infection may enhance the understanding of the molecular mechanisms that define the pathophysiology of T...
July 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28719814/enantiomeric-separation-of-seven-%C3%AE-agonists-by-nace-study-of-chiral-selectivity-with-diacetone-d-mannitol-boric-acid-complex
#9
Lili Lv, Lijuan Wang, Jun Li, Yajun Jiao, Shengnan Gao, Jiachang Wang, Hongyuan Yan
A rapid and effective nonaqueous capillary electrophoresis (NACE)-ultraviolet (UV) method was developed for the enantiomeric separation of seven β-agonists. Diacetone-d-mannitol-boric acid complex was used as a new chiral selector. It was in situ synthesized by the reaction of diacetone-d-mannitol and boric acid in methanol medium containing triethylamine. The effects of diacetone-d-mannitol, boric acid, and triethylamine concentrations on the enantioseparation were carefully investigated. Under the optimized conditions, baseline enantioseparation could be obtained for six of the tested β-agonists within 12min...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28718343/application-of-t-sne-to-human-genetic-data
#10
Wentian Li, Jane E Cerise, Yaning Yang, Henry Han
The t-distributed stochastic neighbor embedding t-SNE is a new dimension reduction and visualization technique for high-dimensional data. t-SNE is rarely applied to human genetic data, even though it is commonly used in other data-intensive biological fields, such as single-cell genomics. We explore the applicability of t-SNE to human genetic data and make these observations: (i) similar to previously used dimension reduction techniques such as principal component analysis (PCA), t-SNE is able to separate samples from different continents; (ii) unlike PCA, t-SNE is more robust with respect to the presence of outliers; (iii) t-SNE is able to display both continental and sub-continental patterns in a single plot...
June 23, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28717559/measuring-the-effect-of-a-western-diet-on-liver-tissue-architecture-by-flim-autofluorescence-and-harmonic-generation-microscopy
#11
Suman Ranjit, Alexander Dvornikov, Evgenia Dobrinskikh, Xiaoxin Wang, Yuhuan Luo, Moshe Levi, Enrico Gratton
The phasor approach to auto-fluorescence lifetime imaging was used to identify and characterize a long lifetime species (LLS) (~7.8 ns) in livers of mice fed with a Western diet. The size of the areas containing this LLS species depends on the type of diet and the size distribution shows Western diet has much larger LLS sizes. Combination of third harmonic generation images with FLIM identified the LLS species with fat droplets and the droplet size distribution was estimated. Second harmonic generation microscopy combined with phasor FLIM shows that there is an increase in fibrosis with a Western diet...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28716911/activation-and-synchronization-of-the-oscillatory-morphodynamics-in-multicellular-monolayer
#12
Shao-Zhen Lin, Bo Li, Ganhui Lan, Xi-Qiao Feng
Oscillatory morphodynamics provides necessary mechanical cues for many multicellular processes. Owing to their collective nature, these processes require robustly coordinated dynamics of individual cells, which are often separated too distantly to communicate with each other through biomaterial transportation. Although it is known that the mechanical balance generally plays a significant role in the systems' morphologies, it remains elusive whether and how the mechanical components may contribute to the systems' collective morphodynamics...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28716270/rapid-sideline-performance-meets-outpatient-clinic-results-from-a-multidisciplinary-concussion-center-registry
#13
G Kyle Harrold, Lisena Hasanaj, Nicholas Moehringer, Isis Zhang, Rachel Nolan, Liliana Serrano, Jenelle Raynowska, Janet C Rucker, Steven R Flanagan, Dennis Cardone, Steven L Galetta, Laura J Balcer
OBJECTIVE: This study investigated the utility of sideline concussion tests, including components of the Sports Concussion Assessment Tool, 3rd Edition (SCAT3) and the King-Devick (K-D), a vision-based test of rapid number naming, in an outpatient, multidisciplinary concussion center treating patients with both sports-related and non-sports related concussions. The ability of these tests to predict clinical outcomes based on the scores at the initial visit was evaluated. METHODS: Scores for components of the SCAT3 and the K-D were fit into regression models accounting for age, gender, and sport/non-sport etiology in order to predict clinical outcome measures including total number of visits to the concussion center, whether the patient reached a SCAT3 symptom severity score≤7, and the total types of referrals each patient received over their course...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28716164/collagen-matrix-as-an-inlay-in-endoscopic-skull-base-reconstruction
#14
G M Oakley, J M Christensen, M Winder, B P Jonker, A Davidson, T Steel, C Teo, R J Harvey
BACKGROUND: Multi-layer reconstruction has become standard in endoscopic skull base surgery. The inlay component used can vary among autografts, allografts, xenografts and synthetics, primarily based on surgeon preference. The short- and long-term outcomes of collagen matrix in skull base reconstruction are described. METHODS: A case series of patients who underwent endoscopic skull base reconstruction with collagen matrix inlay were assessed. Immediate peri-operative outcomes (cerebrospinal fluid leak, meningitis, ventriculitis, intracranial bleeding, epistaxis, seizures) and delayed complications (delayed healing, meningoencephalocele, prolapse of reconstruction, delayed cerebrospinal fluid leak, ascending meningitis) were examined...
July 18, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28715632/all-graphene-oxide-flexible-solid-state-supercapacitors-with-enhanced-electrochemical-performance
#15
Chikako Ogata, Ruriko Kurogi, Keisuke Awaya, Kazuto Hatakeyama, Takaaki Taniguchi, Michio Koinuma, Yasumichi Matsumoto
The rapid development of flexible and wearable electronics has led to an increase in the demand for flexible supercapacitors with enhanced electrochemical performance. Graphene oxide (GO) and reduced GO (rGO) exhibit several key properties required for supercapacitor components. Although solid-state rGO/GO/rGO supercapacitors with unique structures are promising, their moderate capacitance is inadequate for practical applications. Herein, we report a flexible solid-state rGO/GO/rGO supercapacitor comprising H2SO4-intercalated GO electrolyte/separator and pseudo-capacitive rGO electrodes, which demonstrate excellent electrochemical performance...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28715198/structural-variations-in-hybrid-all-nanoparticle-gibbsite-nanoplatelet-cellulose-nanocrystal-multilayered-films
#16
Clélia Martin, Robert David Barker, Erik B Watkins, Frederic Dubreuil, Emily D Cranston, Laurent Heux, Bruno Jean
Cellulose nanocrystals (CNCs) are promising bio-sourced building blocks for the production of high performance materials. In the last ten years, CNCs have been used in conjunction with polymers for the design of multilayered thin films via the layer-by-layer assembly technique. Herein, polymer chains have been replaced with positively charged inorganic gibbsite nanoplatelets (GN) to form hybrid "nanoparticle-only" composite films. A combination of atomic force microscopy and neutron reflectivity experiments was exploited to investigate the growth and structure of the films...
July 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28714728/functional-neural-changes-following-behavioral-therapies-and-disulfiram-for-cocaine-dependence
#17
Elise E DeVito, Guangheng Dong, Hedy Kober, Jiansong Xu, Kathleen M Carroll, Marc N Potenza
A growing literature exists on neural correlates of treatment outcome. However, different types-or components of-treatment have distinct theorized mechanisms of action. And it is not yet known how changes in neural activity across treatment relate to engagement in different treatment components. Participants with cocaine use disorders in a randomized clinical trial received cognitive-behavioral therapy (CBT) plus, in a 2 × 2 design, contingency management (CM) or no CM, and disulfiram or placebo. Participants performed a functional MRI Stroop task, a measure of cognitive control, at the beginning of and after the 12-week treatment...
July 17, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28713252/effect-of-postural-control-demands-on-early-visual-evoked-potentials-during-a-subjective-visual-vertical-perception-task-in-adolescents-with-idiopathic-scoliosis
#18
Yi-Tzu Chang, Ling-Fu Meng, Chun-Ju Chang, Po-Liang Lai, Chi-Wen Lung, Jen-Suh Chern
Subjective visual vertical (SVV) judgment and standing stability were separately investigated among patients with adolescent idiopathic scoliosis (AIS). Although, one study has investigated the central mechanism of stability control in the AIS population, the relationships between SVV, decreased standing stability, and AIS have never been investigated. Through event-related potentials (ERPs), the present study examined the effect of postural control demands (PDs) on AIS central mechanisms related to SVV judgment and standing stability to elucidate the time-serial stability control process...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28713241/cold-temperature-encoding-by-cutaneous-trpa1-and-trpm8-carrying-fibers-in-the-mouse
#19
Zoltan Winter, Philipp Gruschwitz, Stephanie Eger, Filip Touska, Katharina Zimmermann
Previous research identified TRPM8 and TRPA1 cold transducers with separate functions, one being functional in the non-noxious range and the second one being a nociceptive transducer. TRPM8-deficient mice present overt deficits in the detection of environmental cool, but not a lack of cold avoidance and TRPA1-deficient mice show clear deficits in some cold nocifensive assays. The extent of TRPA1's contribution to cold sensing in vivo is still unclear, because mice lacking both TRPM8 and TRPA1 (DKO) were described with unchanged cold avoidance from TRPM8(-/-) based on a two-temperature-choice assay and by c-fos measurement...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28712734/combined-direct-and-indirect-traumatic-carotid-cavernous-fistula-ccf-case-report-and-review-of-the-literature
#20
Isaac Josh Abecassis, Ryan P Morton, Louis J Kim, Basavaraj V Ghodke, Michael R Levitt
BACKGROUND: Within the current Barrow classification system, there are no categorical descriptions or reports in the literature of cavernous carotid fistulas (CCFs) with both a direct component (type A) and separate indirect contribution (type B, C, or D). We report the first definitive case of a combined simultaneous traumatic direct and indirect CCF, and review the literature on the similar existing entity of traumatic indirect CCFs presenting delayed and subsequent to the treatment of traumatic, direct CCFs...
July 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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