keyword
MENU ▼
Read by QxMD icon Read
search

Component separation

keyword
https://www.readbyqxmd.com/read/28098823/integrative-mirna-gene-expression-analysis-enables-refinement-of-associated-biology-and-prediction-of-response-to-cetuximab-in-head-and-neck-squamous-cell-cancer
#1
Loris De Cecco, Marco Giannoccaro, Edoardo Marchesi, Paolo Bossi, Federica Favales, Laura D Locati, Lisa Licitra, Silvana Pilotti, Silvana Canevari
This paper documents the process by which we, through gene and miRNA expression profiling of the same samples of head and neck squamous cell carcinomas (HNSCC) and an integrative miRNA-mRNA expression analysis, were able to identify candidate biomarkers of progression-free survival (PFS) in patients treated with cetuximab-based approaches. Through sparse partial least square-discriminant analysis (sPLS-DA) and supervised analysis, 36 miRNAs were identified in two components that clearly separated long- and short-PFS patients...
January 14, 2017: Genes
https://www.readbyqxmd.com/read/28098756/detection-of-the-vascular-endothelial-growth-factor-with-a-novel-bioluminescence-resonance-energy-transfer-pair-using-a-two-component-system
#2
Tobias Wimmer, Eva Schroeter, Birgit Lorenz, Knut Stieger
In this paper we describe a two-component BRET (bioluminescence resonance energy transfer)-based method to detect vascular endothelial growth factor (VEGF) molecules in unknown samples as the basis for subsequent in vivo use. A luminescent VEGF binding molecule, which binds in the receptor binding motif of VEGF, is used as the energy donor, transferred to a fluorophore-coupled VEGF binding molecule (acceptor), which binds to the neuropilin binding motif of VEGF, thus enabling energy transfer from the donor to the acceptor molecule...
January 13, 2017: Sensors
https://www.readbyqxmd.com/read/28098500/exploring-black-college-females-perceptions-regarding-hiv-prevention-message-content
#3
Rasheeta Chandler-Coley, Henry Ross, Oluwatobi Ozoya, Celia Lescano, Timothy Flannigan
Media messages can facilitate the delivery of accurate information related to HIV and sexually transmitted infection. This study's purpose was to examine preexisting media campaigns from the iMPPACS study to assess age-, gender-, and culturally appropriate components identified by African American females who attend historically Black colleges/universities. In 3 separate focus group sessions, 31 Black female college students (M age = 20) viewed 4 vignettes and heard 3 audio-only clips, then ranked and commented on them based on perceived satisfaction with HIV prevention content and appropriateness of delivery...
January 18, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28098023/key-parameters-for-behaviour-related-to-source-separation-of-household-organic-waste-a-case-study-in-hanoi-vietnam
#4
Kosuke Kawai, Luong Thi Mai Huong
Proper management of food waste, a major component of municipal solid waste (MSW), is needed, especially in developing Asian countries where most MSW is disposed of in landfill sites without any pretreatment. Source separation can contribute to solving problems derived from the disposal of food waste. An organic waste source separation and collection programme has been operated in model areas in Hanoi, Vietnam, since 2007. This study proposed three key parameters (participation rate, proper separation rate and proper discharge rate) for behaviour related to source separation of household organic waste, and monitored the progress of the programme based on the physical composition of household waste sampled from 558 households in model programme areas of Hanoi...
January 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28097282/casimir-effect-between-pinned-particles-in-two-dimensional-jammed-systems
#5
Juan-José Liétor-Santos, Justin C Burton
The Casimir effect arises when long-ranged fluctuations are geometrically confined between two surfaces, leading to a macroscopic force. Traditionally, these forces have been observed in quantum systems and near critical points in classical systems. Here we show the existence of Casimir-like forces between two pinned particles immersed in two-dimensional systems near the jamming transition. We observe two components to the total force: a short-ranged, depletion force and a long-ranged, repulsive Casimir-like force...
January 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28097277/combining-the-spin-separated-exact-two-component-relativistic-hamiltonian-with-the-equation-of-motion-coupled-cluster-method-for-the-treatment-of-spin-orbit-splittings-of-light-and-heavy-elements
#6
Zhanli Cao, Zhendong Li, Fan Wang, Wenjian Liu
The spin-separated exact two-component (X2C) relativistic Hamiltonian [sf-X2C+so-DKHn, J. Chem. Phys., 2012, 137, 154114] is combined with the equation-of-motion coupled-cluster method with singles and doubles (EOM-CCSD) for the treatment of spin-orbit splittings of open-shell molecular systems. Scalar relativistic effects are treated to infinite order from the outset via the spin-free part of the X2C Hamiltonian (sf-X2C), whereas the spin-orbit couplings (SOC) are handled at the CC level via the first-order Douglas-Kroll-Hess (DKH) type of spin-orbit operator (so-DKH1)...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28097048/effects-of-grazing-intensity-and-the-use-of-veterinary-medical-products-on-dung-beetle-biodiversity-in-the-sub-mountainous-landscape-of-central-italy
#7
Mattia Tonelli, José R Verdú, Mario E Zunino
Grazing extensification and intensification are among the main problems affecting European grasslands. We analyze the impact of grazing intensity (low and moderate) and the use of veterinary medical products (VMPs) on the dung beetle community in the province of Pesaro-Urbino (Italy). Grazing intensity is a key factor in explaining the diversity of dung beetles. In the case of the alpha diversity component, sites with a low level of grazing activity-related in a previous step to the subsequent abandonment of traditional farming-is characterized by a loss of species richness (q = 0) and a reduction in alpha diversity at the levels q = 1 and q = 2...
2017: PeerJ
https://www.readbyqxmd.com/read/28097047/quantifying-the-on-and-off-contributions-to-the-flash-erg-with-the-discrete-wavelet-transform
#8
Mathieu Gauvin, Maja Sustar, John M Little, Jelka Brecelj, Jean-Marc Lina, Pierre Lachapelle
PURPOSE: Discrete wavelet transform (DWT) analyses suggest that the 20- and 40-Hz components of the short-flash photopic electroretinogram (ERG) are closely related to the ON and OFF pathways, respectively. With the DWT, we examined how the ERG ON and OFF components are modulated by the stimulus intensity and/or duration. METHODS: Discrete wavelet transform descriptors (20, 40 Hz and 40:20-Hz ratio) were extracted from ERGs evoked to 25 combinations of flash durations (150-5 ms) and strengths (0...
January 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28096216/basal-filopodia-and-vascular-mechanical-stress-organize-fibronectin-into-pillars-bridging-the-mesoderm-endoderm-gap
#9
Yuki Sato, Kei Nagatoshi, Ayumi Hamano, Yuko Imamura, David Huss, Seiichi Uchida, Rusty Lansford
Cells may exchange information with other cells and tissues by exerting forces on the extracellular matrix (ECM). Fibronectin (FN) is an important ECM component that forms fibrils through cell contacts and creates directionally biased geometry. Here, we demonstrate that FN is deposited as pillars between widely separated germ layers, namely the somitic mesoderm and the endoderm, in quail embryos. Alongside the FN pillars, long filopodia protrude from the basal surfaces of somite epithelial cells. Loss-of-function of Ena/VASP, α5β1-integrins or talin in the somitic cells abolished the FN pillars, indicating that FN pillar formation is dependent on the basal filopodia through these molecules...
January 15, 2017: Development
https://www.readbyqxmd.com/read/28096167/chemical-fingerprint-of-dachaihu-granule-and-its-chemical-correlation-between-raw-herbs
#10
Chunqin Mao, Yaping Zhou, De Ji, Xuanzhong Tan, Yi Tao, Wenyi Zang, Tulin Lu
To develop a method to overall evaluate the quality of Dachaihu Granule (DCHG), high-performance liquid chromatography coupled with diode array detector was used to establish chemical fingerprint of DCHG. The correlation between the formula and its raw herbs was also evaluated. According to the retention time of standard components, chemical fingerprint of DCHG was developed and a total of 21 constituents were characterized. The separation was performed on a Kromasil C18 column (250 mm × 4.6 mm i.d. with 5...
January 17, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28094501/artificial-cells-synthetic-compartments-with-life-like-functionality-and-adaptivity
#11
Bastiaan C Buddingh', Jan C M van Hest
Cells are highly advanced microreactors that form the basis of all life. Their fascinating complexity has inspired scientists to create analogs from synthetic and natural components using a bottom-up approach. The ultimate goal here is to assemble a fully man-made cell that displays functionality and adaptivity as advanced as that found in nature, which will not only provide insight into the fundamental processes in natural cells but also pave the way for new applications of such artificial cells. In this Account, we highlight our recent work and that of others on the construction of artificial cells...
January 17, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28094324/early-life-adversity-accelerates-cellular-ageing-and-affects-adult-inflammation-experimental-evidence-from-the-european-starling
#12
Daniel Nettle, Clare Andrews, Sophie Reichert, Tom Bedford, Claire Kolenda, Craig Parker, Carmen Martin-Ruiz, Pat Monaghan, Melissa Bateson
Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter multiple components of early-life adversity simultaneously. We developed a novel hand-rearing paradigm in European starling nestlings (Sturnus vulgaris), in which we separately manipulated nutritional shortfall and begging effort for a period of 10 days. The experimental treatments accelerated erythrocyte telomere attrition and increased DNA damage measured in the juvenile period...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094096/component-columella-augmentation-in-cleft-nose-rhinoplasty-a-preliminary-study
#13
B Bohluli, P Varedi, M Sezavar, S Pakzad, S C Bagheri
The purpose of this study was to evaluate the outcome of a component columella augmentation technique in cleft nose rhinoplasty. This prospective study included rhinoplasty procedures in bilateral cleft nose patients treated by component columella augmentation technique. After surgery, all patients were followed up daily for the first week, and then at 1 month and 6 months postoperative. The following four parameters were assessed: nasal tip projection, infratip lobule length, infratip lobule-to-base distance, and columella-labial angle...
January 13, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28093328/cinnamaldehyde-induces-apoptosis-and-reverses-epithelial-mesenchymal-transition-through-inhibition-of-wnt-%C3%AE-catenin-pathway-in-non-small-cell-lung-cancer
#14
Cunen Wu, Yuwen Zhuang, Shan Jiang, Fang Tian, Yuhao Teng, Xu Chen, Peiqiu Zheng, Shenlin Liu, Jinyong Zhou, Jian Wu, Ruiping Wang, Xi Zou
Cinnamaldehyde, the main chemical component of the essential oil separated from the traditional herb Cinnamomum cassia, has been demonstrated to be an efficient cytotoxic agent against several human cancers. The present experiment showed that cinnamaldehyde dose-dependently depresses the proliferation of three types of NSCLC cells and induces cell apoptosis in vitro and in vivo. Moreover, cinnamaldehyde attenuated CoCl2-induced EMT and decreased matrix metalloprotease (MMP) family while the in vivo study showed the same trend...
January 13, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28091956/does-caffeine-influence-the-anticholinesterase-and-antioxidant-properties-of-donepezil-evidence-from-in-vitro-and-in-vivo-studies
#15
Ganiyu Oboh, Opeyemi Babatunde Ogunsuyi, Oluwaseyi Emmanuel Olonisola
Caffeine is adjudged world's most consumed pharmacologically active food component. With reports of the potential cognitive enhancing properties of caffeine, we sought to investigate if caffeine can influence the anticholinesterase and antioxidant properties of donepezil-a selective acetylcholinesterase (AChE) inhibitor used in the management of Alzheimer's disease (AD). In vitro, we investigated the effect of donepezil (DON), caffeine (CAF) and their various combinations on the activity of AChE in rat brain homogenate, as well as determined their antioxidant properties...
January 13, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28091606/long-term-efficient-organic-photovoltaics-based-on-quaternary-bulk-heterojunctions
#16
Minwoo Nam, Minjeong Cha, Hyun Hwi Lee, Kahyun Hur, Kyu-Tae Lee, Jaehong Yoo, Il Ki Han, S Joon Kwon, Doo-Hyun Ko
A major impediment to the commercialization of organic photovoltaics (OPVs) is attaining long-term morphological stability of the bulk heterojunction (BHJ) layer. To secure the stability while pursuing optimized performance, multi-component BHJ-based OPVs have been strategically explored. Here we demonstrate the use of quaternary BHJs (q-BHJs) composed of two conjugated polymer donors and two fullerene acceptors as a novel platform to produce high-efficiency and long-term durable OPVs. A q-BHJ OPV (q-OPV) with an experimentally optimized composition exhibits an enhanced efficiency and extended operational lifetime than does the binary reference OPV...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28090441/principal-component-analysis-t1%C3%AF-voxel-based-relaxometry-of-the-articular-cartilage-a-comparison-of-biochemical-patterns-in-osteoarthritis-and-anterior-cruciate-ligament-subjects
#17
Valentina Pedoia, Colin Russell, Allison Randolph, Xiaojuan Li, Sharmila Majumdar
BACKGROUND: Quantitative MR, including T1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction. However, limited studies have been performed aimed to assess the spatial location and patterns of T1ρ. In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR)...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28089399/a-mass-balance-model-to-estimate-the-rate-of-composting-methane-oxidation-and-anaerobic-digestion-in-soil-covers-and-shallow-waste-layers
#18
Reza Rafiee, Lizanne Obersky, Sihuang Xie, William P Clarke
Although CH4 oxidation in landfill soil covers is widely studied, the extent of composting and CH4 oxidation in underlying waste layers has been speculated but not measured. The objective of this study was to develop and validate a mass balance model to estimate the simultaneous rates of anaerobic digestion (rAD), CH4 oxidation (rOX) and composting (rCOM) in environments where O2 penetration is variable and zones of aerobic and anaerobic activity are intermingled. The modelled domain could include, as an example, a soil cover and the underlying shallow waste to a nominated depth...
January 12, 2017: Waste Management
https://www.readbyqxmd.com/read/28089397/challenges-for-critical-raw-material-recovery-from-weee-the-case-study-of-gallium
#19
Maximilian Ueberschaar, Sarah Julie Otto, Vera Susanne Rotter
Gallium and gallium compounds are more frequently used in future oriented technologies such as photovoltaics, light diodes and semiconductor technology. In the long term the supply risk is estimated to be critical. Germany is one of the major primary gallium producer, recycler of gallium from new scrap and GaAs wafer producer. Therefore, new concepts for a resource saving handling of gallium and appropriate recycling strategies have to be designed. This study focus on options for a possible recycling of gallium from waste electric and electronic equipment...
January 12, 2017: Waste Management
https://www.readbyqxmd.com/read/28089381/pet-ct-underlying-physics-instrumentation-and-advances
#20
I Torres Espallardo
Since it was first introduced, the main goal of PET/CT has been to provide both PET and CT images with high clinical quality and to present them to radiologists and specialists in nuclear medicine as a fused, perfectly aligned image. The use of fused PET and CT images quickly became routine in clinical practice, showing the great potential of these hybrid scanners. Thanks to this success, manufacturers have gone beyond considering CT as a mere attenuation corrector for PET, concentrating instead on design high performance PET and CT scanners with more interesting features...
January 12, 2017: Radiología
keyword
keyword
6896
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"