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Quantiferon in childrens

Roberta Petrucci, Giulia Lombardi, Ilaria Corsini, Maria Letizia Bacchi Reggiani, Francesca Visciotti, Filippo Bernardi, Maria Paola Landini, Salvatore Cazzato, Paola Dal Monte
BACKGROUND: The diagnostic accuracy of Quantiferon-TB Gold In-Tube (QFT-IT) is uncertain in the pediatric population, while tuberculin skin test (TST) is still conventionally used despite its limitations. The aim of this study was to compare the performance of QFT-IT with TST in a large cohort of children screened for TB infection because of contact tracing, suspected TB, arrival from endemic country or immunosuppressive therapy. METHODS: A retrospective analysis was conducted on 517 children 0-14 years of age evaluated at the pediatric unit of the S...
October 3, 2016: Pediatric Infectious Disease Journal
Wilson Kwong, Thomas Krahn, Ann Cleland, Janet Gordon, Wendy Wobeser
BACKGROUND: Current Canadian guidelines suggest that neonatal Bacille Calmette-Guérin (BCG) vaccination does not result in false-positive tuberculosis (TB) skin tests, despite a growing body of evidence that interferon-γ release assays may be a more specific alternative in identifying latent tuberculosis infections in vaccinated populations. We set out to evaluate the relationship between TB skin tests and interferon-γ release assays in patients who previously received neonatal BCG vaccine...
July 2016: CMAJ Open
Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Farah Seedat, Tara Gurung, Karoline Freeman, Sian Taylor-Phillips, Clare Walker, Jason Madan, Ngianga-Bakwin Kandala, Aileen Clarke, Paul Sutcliffe
BACKGROUND: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) [(Zopf 1883) Lehmann and Neumann 1896], is a major cause of morbidity and mortality. Nearly one-third of the world's population is infected with MTB; TB has an annual incidence of 9 million new cases and each year causes 2 million deaths worldwide. OBJECTIVES: To investigate the clinical effectiveness and cost-effectiveness of screening tests [interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs)] in latent tuberculosis infection (LTBI) diagnosis to support National Institute for Health and Care Excellence (NICE) guideline development for three population groups: children, immunocompromised people and those who have recently arrived in the UK from high-incidence countries...
May 2016: Health Technology Assessment: HTA
Jennifer A Grinsdale, Shamim Islam, Olivia Chang Tran, Christine S Ho, L Masae Kawamura, Julie M Higashi
BACKGROUND: Interferon-gamma release assay utilization in pediatric tuberculosis (TB) screening is limited by a paucity of longitudinal experience, particularly in low-TB burden populations. METHODS: We conducted a retrospective review of QuantiFERON (QFT)-TB Gold results in San Francisco children from 2005 to 2008. Concordance with the tuberculin skin test (TST) was analyzed for a subset of children. Progression to active disease was determined through San Francisco and California TB registry matches...
June 2016: Journal of the Pediatric Infectious Diseases Society
Erika Silvestro, Irene Raffaldi, Silvia Virano, Carlo Scolfaro
No abstract text is available yet for this article.
June 2016: Pediatric Infectious Disease Journal
Surjit Singh, Dhrubajyoti Sharma, Deepti Suri, Anju Gupta, Amit Rawat, Manoj Kumar Rohit
This was a single-centre study to evaluate the usefulness of tumour necrosis factor-α (TNF-α) blocker, infliximab (IFX), for treatment of Kawasaki disease (KD) in children in Northern Indian. The study was carried out in the Paediatric Allergy-Immunology Unit, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. The study period was January 2007 to March 2015. Review of records of 23 children with KD who had received IFX was carried out. Median age at presentation was 2 years (range 2 months to 12 years)...
May 2016: Clinical and Experimental Rheumatology
Patrizia Laurenti, Matteo Raponi, Chiara de Waure, Marta Marino, Walter Ricciardi, Gianfranco Damiani
BACKGROUND: Tuberculosis (TB) is a global public health problem, causing morbidity and mortality in adults and children. The most reliable diagnostic tools currently available are the in vivo Tuberculin Skin Test (TST) and the ex vivo Interferon-γ release assays (IGRAs). Several clinical, radiological, and bacteriological features make the detection of active (overt disease) TB in children difficult. Although recently developed immunological assays such as QuantiFERON-TB Gold In-Tube (QFT-IT) and T-SPOT®...
2016: BMC Infectious Diseases
Marieke M Van der Zalm, Nelda van Soelen, Anna M Mandalakas, Marc Jacobsen, Anne K Detjen, Florian M Marx, Harleen M S Grewal, Mark F Cotton, Gerhard Walzl, Anneke C Hesseling
BACKGROUND: Helminth infestations are associated with T-helper cell type 2 (Th2) immune responses, leading to suppression of Th1 responses required to control Mycobacterium tuberculosis infection. We hypothesized that deworming after documented M. tuberculosis exposure might improve Th1 immune responses. METHODS: This was a randomized controlled trial comparing the effect of early versus delayed (after 3 months) deworming on tuberculin skin testing (TST) and Quantiferon-Gold-in-tube responses among children from a setting with a known high burden of M...
June 2016: Pediatric Infectious Disease Journal
Joan Calzada-Hernández, Jordi Anton-López, Rosa Bou-Torrent, Estíbaliz Iglesias-Jiménez, Sílvia Ricart-Campos, Javier Martín de Carpi, Vicenç Torrente-Segarra, Judith Sánchez-Manubens, Clara Giménez-Roca, Librada Rozas-Quesada, Maria Teresa Juncosa-Morros, Clàudia Fortuny, Antoni Noguera-Julian
BACKGROUND: Adult patients receiving anti-TNFα drugs are at increased risk of tuberculosis (TB), but studies in pediatric populations are limited, and the best strategy for latent tuberculosis infection (LTBI) screening in this population remains controversial. We describe the prevalence of LTBI prior to anti-TNFα therapy and the long-term follow-up after biological treatment initiation in a cohort of children and adolescents. METHODS: Cohort observational study in children and adolescents receiving anti-TNFα agents in a tertiary-care pediatric hospital...
2015: Pediatric Rheumatology Online Journal
S El Azbaoui, N Alaoui Mrani, A Sabri, Z Jouhadi, F Ailal, A A Bousfiha, J Najib, N El Hafidi, C Deswarte, E Schurr, J Bustamante, S Boisson-Dupuis, J-L Casanova, L Abel, J El Baghdadi
SETTING: Tuberculosis spondylodiscitis (TS), or Pott's disease, an extra-pulmonary form of tuberculosis (TB), is rare and difficult to diagnose in children. Some cases of severe TB in children were recently explained by inborn errors of immunity affecting the interleukin-12/interferon-gamma (IL-12/IFN-γ) axis. OBJECTIVE: To analyse clinical data on Moroccan children with TS, and to perform immunological and genetic explorations of the IL-12/IFN-γ axis. DESIGN: We studied nine children with TS diagnosed between 2012 and 2014...
December 2015: International Journal of Tuberculosis and Lung Disease
Michela Sali, Danilo Buonsenso, Delia Goletti, Pamela D'Alfonso, Antonella Zumbo, Giovanni Fadda, Maurizio Sanguinetti, Giovanni Delogu, Piero Valentini
OBJECTIVES: To evaluate the accuracy of the QuantiFERON-TB Gold assay (QFT-IT) in children with suspected active or latent TB infection (LTBI). METHODS: A retrospective study was conducted on 621 children (0-14 years old) evaluated for TB infection or disease. Following clinical assessment, children were tested with the QFT-IT assay. RESULTS: Among the 140 active TB suspects, we identified 19 cases of active disease. The overall sensitivity for active TB was 87...
2015: PloS One
Winsley Rose, Stanley E Read, Ari Bitnun, Elizabeth Rea, Derek Stephens, Wanatpreeya Pongsamart, Ian Kitai
BACKGROUND: Few data relate interferon-γ-release-assay results in children to source case sputum status, the best predictor of infectiousness of tuberculosis (TB) patients. We evaluated the QuantiFERON-Gold-in-tube assay (QFT) and tuberculin skin test (TST) in children with different types of TB exposure. METHODS: The TST and QFT were performed in referred TB-exposed children and adolescents who had not undergone prior TST screening (tested in parallel), and the QFT was performed in referred TST-positive individuals...
June 2015: Journal of the Pediatric Infectious Diseases Society
Hossein Masoumi Asl, Abdolvahab Alborzi, Bahman Pourabbas, Mehdi Kalani
BACKGROUND: Appropriate diagnosis and treatment of latent tuberculosis infection (LTBI) play the most important role in the control of tuberculosis. This study aimed to determine the prevalence of LTBI among healthy tuberculosis unexposed children vaccinated with BCG using the tuberculin skin test (TST) and QuantiFERON TB Gold In-Tube (QFT-GIT) and comparing the agreement between the two tests. METHODS: A cross-sectional study was carried out between October 2009 and March 2010 in 24 schools and 11 daycare centers...
September 2015: Iranian Journal of Medical Sciences
Kin-Sun Wong, Yen-Chun Huang, Han-Chung Hu, Yhu-Chering Huang, Chang-Hui Wen, Tzou-Yien Lin
PURPOSE: To compare the performance of a commercial interferon-gamma release assay, QuantiFERON TB Gold-in-Tube (QFG-IT) with the tuberculin skin test (TST) in Taiwanese children for the diagnosis of active tuberculosis (TB). METHODS: A retrospective chart analysis of pediatric patients (<18 years of age) who underwent QFG-IT tests and TST for the confirmation of active TB between January 2008 and June 2014. RESULTS: The sensitivity of QFG-IT was 100% [95% confidence interval (CI): 63...
August 28, 2015: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
Linda Petrone, Angela Cannas, Francesco Aloi, Martin Nsubuga, Joseph Sserumkuma, Ritah Angella Nazziwa, Levan Jugheli, Tedson Lukindo, Enrico Girardi, Klaus Reither, Delia Goletti
OBJECTIVES: Interferon-γ inducible protein 10 (IP-10), either in blood or in urine, has been proposed as a tuberculosis (TB) biomarker for adults. This study aims to evaluate the potential of IP-10 diagnostics in children from Uganda, a high TB-endemic country. METHODS: IP-10 was measured in the blood and urine concomitantly taken from children who were prospectively enrolled with suspected active TB, with or without HIV infection. Clinical/microbiological parameters and commercially available TB-immune assays (tuberculin skin test (TST) and QuantiFERON TB-Gold In-Tube (QFT-IT)) were concomitantly evaluated...
2015: BioMed Research International
Lei Bao, Tao Li, Ni Diao, Yaojie Shen, Lingyun Shao, Ying Zhang, Shuihua Lu, Wenhong Zhang
BACKGROUND: The QuantiFERON-TB Gold In-Tube (QFT-GIT) is a newly developed but widely used interferon-γ release assay for diagnosing tuberculosis (TB). However, research has not determined whether age or the use of an immune suppressive or anti-TB treatment influences this assay's ability to detect TB. We assessed the QFT-GIT diagnostic performance for active tuberculosis (ATB) in children and adults in an endemic country and explored the effects of glucocorticoids and anti-TB therapy on the diagnostic value of the QFT-GIT...
2015: PloS One
Kany Kany A Luabeya, Michele D Tameris, Hennie D Geldenhuys, Humphrey Mulenga, Amaryl Van Schalkwyk, Elizabeth J Hughes, Asma Toefey, Thomas J Scriba, Gregory Hussey, Hassan Mahomed, Helen McShane, Bernard Landry, Willem A Hanekom, Mark Hatherill
BACKGROUND: The risk of developing tuberculosis (TB) disease in HIV-uninfected children after isoniazid preventive therapy (IPT) for a positive QuantiFERON-TB Gold In-Tube test (QFT-GIT) is unknown. The aim of this study was to evaluate risk of TB disease after IPT in young HIV-uninfected children with a positive QFT-GIT result, or household TB contact. METHODS: HIV-uninfected South African infants aged 4-6 months were screened for enrolment in a TB vaccine trial...
November 2015: Pediatric Infectious Disease Journal
Humphrey Mulenga, Michele D Tameris, Kany Kany A Luabeya, Hennie Geldenhuys, Thomas J Scriba, Gregory D Hussey, Hassan Mahomed, Bernard S Landry, Willem A Hanekom, Helen McShane, Mark Hatherill
BACKGROUND: Childhood tuberculosis (TB) is usually Mycobacterium tuberculosis (MTB) culture negative. Furthermore, clinical presentation may be altered by active case finding, isoniazid prophylaxis and early treatment. We aimed to establish the value of presenting symptoms for intrathoracic TB case diagnosis among young children. METHODS: Healthy, HIV-uninfected, South African infants in an efficacy trial of a novel TB vaccine (MVA85A) were followed for 2 years for suspected TB...
November 2015: Pediatric Infectious Disease Journal
Ivan Pavić, Vera Katalinić-Janković, Jasna Čepin-Bogović, Arnes Rešić, Slavica Dodig
BACKGROUND: Interferon-γ release assays (IGRAs) offer the possibility of improved detection of latent tuberculosis infection (LTBI). OBJECTIVE: To analyze discordant tuberculin skin testing (TST) and IGRA results in ethnic Croatian children as old as 5 years for whom there is documented exposure to an adult with active tuberculosis (TB) and who have been vaccinated with Bacillus Calmette-Guérin. METHODS: In specimens from our cohort individuals, we tested the performances of the QuantiFERON-TB Gold In-Tube (QFT-GIT) test and TST and analyzed discordant results...
2015: Laboratory Medicine
Marc Tebruegge, Binita Dutta, Susan Donath, Nicole Ritz, Benjamin Forbes, Kattia Camacho-Badilla, Vanessa Clifford, Christel Zufferey, Roy Robins-Browne, Willem Hanekom, Stephen M Graham, Tom Connell, Nigel Curtis
RATIONALE: Current immunodiagnostic tests for tuberculosis (TB), including the tuberculin skin test and IFN-γ release assay (IGRA), have significant limitations, which include their inability to distinguish between latent TB infection (LTBI) and active TB, a distinction critical for clinical management. OBJECTIVES: To identify mycobacteria-specific cytokine biomarkers that characterize TB infection, determine their diagnostic performance characteristics, and establish whether these biomarkers can distinguish between LTBI and active TB...
August 15, 2015: American Journal of Respiratory and Critical Care Medicine
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