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JOURNAL ARTICLE
Paula Rodríguez-Molino, Araceli González Sánchez, Antoni Noguera-Julián, Aleix Soler-García, Patricia Martínez Paz, Ana Méndez-Echevarría, Fernando Baquero-Artigao, Miguel González Muñoz, María Jesús Ruíz-Serrano, Manuel Monsonís, Rocío Sánchez León, Jesús Saavedra-Lozano, Begoña Santiago-García, Talía Sainz
We analyzed 136 children with tuberculosis disease or infection and a positive QuantiFERON-TB (QFT) assay, followed-up for a median of 21 months (0.4-11years). QFT reversed in 16.9% of cases, with significant decreases in TB1 (-1.72 vs . -0.03 IU/ml, p=0.001) and TB2 (-1.65 vs . -0.43 IU/ml, p=0.005) levels compared to non-reverters. We found a higher QFT reversion rate among children under 5 years (25.0% vs 11.9%, p=0.042), and those with TST induration <15mm (29% vs 13.3%, p=0.055). Our data reveal that, although QFT test remained positive in the majority of children, reversion occurred in 16% of cases in a progressive and stable pattern...
2024: Frontiers in Immunology
#2
JOURNAL ARTICLE
Paula Rodríguez-Molino, Marc Tebruegge, Antoni Noguera-Julian, Olaf Neth, Katy Fidler, Folke Brinkmann, Talia Sainz, Inga Ivaskeviciene, Nicole Ritz, Maria Joao Brito, Tiago Milheiro Silva, Vira Chechenieva, Maryna Serdiuk, Laura Lancella, Cristina Russo, Aleix Soler-García, Maria Luisa Navarro, Renate Krueger, Cornelia Feiterna-Sperling, Anna Starshinova, Antonina Hiteva, Anna Hoffmann, Paulius Kalibatas, Andrea Lo Vecchio, Sara Maria Scarano, Matilde Bustillo, Daniel Blázquez Gamero, María Espiau, Danilo Buonsenso, Lola Falcón, Louise Turnbull, Elena Colino, Santiago Rueda, Charlotte Buxbaum, Begoña Carazo, Cristina Alvarez, Marta Dapena, Anabel Piqueras, Svetlana Velizarova, Iveta Ozere, Florian Götzinger, Marta Pareja, Maria Isabel Garrote Llanos, Beatriz Soto, Sonia Rodríguez Martín, Jose Javier Korta, Beatriz Pérez-Gorricho, Mercedes Herranz, Ángel Hernández-Bartolomé, Mariana Díaz-Almirón, Malte Kohns Vasconcelos, Laura Ferreras-Antolín, Begoña Santiago-García
BACKGROUND: In high-resource settings the survival of immunocompromised (IC) children has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools and outcome of IC children with TB in Europe. METHODS: Multicentre, matched case-control study within the Paediatric Tuberculosis Network European Trials Group (ptbnet), capturing TB cases <18 years diagnosed 2000-2020...
April 3, 2024: Clinical Infectious Diseases
#3
JOURNAL ARTICLE
Tomas M Perez-Porcuna, Antoni Noguera-Julian, Maria Teresa Riera-Bosch, Esperança Macià-Rieradevall, José Santos-Santiago, Maria Àngels Rifà Pujol, Maria Eril, Lídia Aulet-Molist, Emma Padilla-Esteba, Maria Teresa Tórtola, Jordi Gómez I Prat, Anna Vilamala Bastarras, Josep Sebastià Rebull-Fatsini, Andrea Papaleo, Neus Rius-Gordillo, Alessandra Q Gonçalves, Àngels Naranjo-Orihuela, Marta Urgelles, Mónica G García-Lerín, Gemma Jimenez-Lladser, Beatriz Lorenzo-Pino, Mónica Adriana Giuliano-Cuello, Maria Teresa Pascual-Sánchez, Mónica Marco-García, Rosa Abellana, Maria Espiau, Maria Nieves Altet-Gómez, Angels Orcau-Palau, Joan A Caylà, Antoni Soriano-Arandes
BACKGROUND: Most paediatric tuberculosis (TB) cases in low-TB-incidence countries involve children born to migrant families. This may be partially explained by trips to their countries of origin for visiting friends and relatives (VFR). We aimed to estimate the risk of latent TB infection (LTBI) and TB in children VFR. METHODS: We conducted a prospective multicentric observational study in Catalonia (Spain) from 06/2017 to 12/2019. We enrolled children aged < 15 years with a negative tuberculin skin test (TST) at baseline and at least one parent from a high-TB-incidence country, and who had travelled to their parent's birth country for ≥21 days...
March 4, 2024: Journal of Travel Medicine
#4
JOURNAL ARTICLE
Paulo Cesar Pereira Dos Santos, Nicole Louise Messina, Roberto Dias de Oliveira, Patricia Vieira da Silva, Marco Antonio Moreira Puga, Margareth Dalcolmo, Glauce Dos Santos, Marcus Vinícius Guimarães de Lacerda, Bruno Araújo Jardim, Fernando Fonseca de Almeida E Val, Nigel Curtis, Jason R Andrews, Julio Croda
BACKGROUND: The effectiveness of BCG vaccine for adult pulmonary tuberculosis remains uncertain. In this study, we aimed to evaluate the effect of vaccination with BCG-Denmark to prevent initial and sustained interferon-γ release assay conversion in Brazilian health-care workers. METHODS: This substudy is a nested randomised controlled trial embedded within the BRACE trial (NCT04327206). Specifically, this substudy enrolled Brazilian health-care workers (aged ≥18 years) from three sites in Brazil (Manaus, Campo Grande, and Rio de Janeiro) irrespective of previously receiving BCG vaccination...
February 26, 2024: Lancet Infectious Diseases
#5
JOURNAL ARTICLE
Agnieszka Strzelak, Anna Komorowska-Piotrowska, Agnieszka Borowa, Maria Krasińska, Wojciech Feleszko, Marek Kulus
PURPOSE: To determine the utility of interferon-gamma-inducible protein 10 (IP-10) for identifying active tuberculosis (TB) and TB infection (TBI) in children in BCG-vaccinated populations, establish its diagnostic performance characteristics, and evaluate changes in IP-10 level during anti-TB chemotherapy. METHODS: Concentrations of IP-10 and IFN-γ were measured in QuantiFERON-TB Gold (QFT) supernatants in children with suspected TB or due to recent TB contact...
January 13, 2024: Diagnostics
#6
JOURNAL ARTICLE
Dilara Bulut Gökten, Fatma Yümün Kavak, Rıdvan Mercan
The incidence of tuberculosis in developed countries has decreased over the years due to the use of effective tuberculosis drugs and improvements in socio-economic conditions. However, with the ease of global transport and increased travel to countries with high tuberculosis prevalence, the reduction in extrapulmonary tuberculosis cases has been less significant compared with the overall decrease in tuberculosis cases. Extrapulmonary tuberculosis can manifest in a variety of ways. Tuberculous dactylitis, a rare form of tuberculous osteomyelitis, was first described by Rankin in 1886...
January 16, 2024: Modern rheumatology case reports
#7
JOURNAL ARTICLE
Thomas Volkman, Visai Muruganandah, Hamish Graham, Shidan Tosif, Simon Stokes, Sarath Ranganathan
BACKGROUND: Previous meta-analysis regarding the performance of QuantiFERON Gold-In-Tube in children have yielded contrasting results. Emerging data in children younger than 5 years of age necessitates a new analysis. METHODS: Systematic searches were conducted of MedLINE, EMBASE and Cochrane databases between 1998-2023. Pooled estimates of sensitivities and specificities of QFT-GIT compared to tuberculin skin test (TST) were calculated. The Kappa (k) coefficient was calculated for each study to determine the degree of congruence between TST and QFT-GIT results...
2024: PloS One
#8
JOURNAL ARTICLE
Ryosuke Hirabayashi, Haruo Nakayama, Misuzu Yahaba, Hirotomo Yamanashi, Takeshi Kawasaki
INTRODUCTION: The accurate diagnosis of tuberculosis (TB) in children is essential for its effective management and control. Reliable diagnostic tools that are currently available for identifying TB infection include the in vivo tuberculosis skin test (TST) and ex vivo interferon-gamma release assays (IGRAs). This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of IGRAs in children. METHODS: Of the 768 screened studies, 47 met the eligibility criteria...
December 15, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#9
JOURNAL ARTICLE
Huiwen Zheng, Jing Xiao, Feina Li, Hao Chen, Deze Li, Yonghong Wang, Yajie Guo, Yuying Chen, Chen Shen
BACKGROUND: Interferon-gamma release assay (IGRA) is the main tool for the diagnosis of latent tuberculosis (TB) infection (LTBI). However, the indeterminate results were more frequent in children, and the underlying reasons were largely speculative. We aimed to compare QuantiFERON-TB Gold In-Tube (QFT-GIT) with X.DOT-TB (XDOT) for diagnosing LTBI, and to identify the risk factors associated with indeterminate results in children. METHODS: A retrospective study for children<18 years old, at risk for LTBI or progression to TB disease, received either QFT-GIT or X...
December 13, 2023: BMC Infectious Diseases
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JOURNAL ARTICLE
Davaasambuu Ganmaa, Polyna Khudyakov, Uyanga Buyanjargal, Enkhtsetseg Tserenkhuu, Sumiya Erdenenbaatar, Chuluun-Erdene Achtai, Narankhuu Yansanjav, Baigal Delgererekh, Munkhzaya Ankhbat, Enkhjargal Tsendjav, Batbayar Ochirbat, Badamtsetseg Jargalsaikhan, Davaasambuu Enkhmaa, Adrian R Martineau
BACKGROUND: Vitamin D supplementation has been shown to increase total hip areal bone mineral density in healthy children and adolescents. We aimed to investigate whether supplementing schoolchildren living in Mongolia with weekly vitamin D3 for 3 years affected fracture risk. METHODS: We did a multicentre, double-blind, randomised, placebo-controlled trial across 18 public schools in Ulaanbaatar, Mongolia. Schoolchildren were eligible if they were aged 6-13 years at screening, had a negative QuantiFERON-TB Gold In-tube assay (QFT) result, were not hypersensitive to vitamin D or immunocompromised, did not use vitamin D supplements, did not have clinical signs of rickets, and had no intention of leaving Ulaanbaatar within 3 years...
December 1, 2023: Lancet Diabetes & Endocrinology
#11
JOURNAL ARTICLE
Edna S Majaliwa, Kandi Muze, Evance Godfrey, Kenneth Byashalira, Blandina T Mmbaga, Kaushik Ramaiya, Sayoki G Mfinanga
BACKGROUND: Data for latent tuberculosis in patients with type 1 Diabetes in Africa is limited. We assessed the prevalence of latent tuberculosis in youth and children with type 1 Diabetes in Dar es Salaam -Tanzania. METHODS: Our cross-sectional study recruited children and youth with T1DM by stage of puberty, glycaemic control, and age at diagnosis from January to December 2021 in Dar es Salaam. Participants were screened for the presence of latent Tuberculosis using the QuantiFERON test...
October 30, 2023: BMC Infectious Diseases
#12
JOURNAL ARTICLE
Aleix Soler-Garcia, Anna Gamell, Manuel Monsonís, José Javier Korta-Murua, María Espiau, Elena Rincón-López, Paula Rodríguez-Molino, Tomàs Pérez-Porcuna, Matilde Bustillo-Alonso, Begoña Santiago, Marc Tebruegge, Antoni Noguera-Julian
We studied 295 children (tuberculosis disease, n = 159; latent tuberculosis infection, n = 136) with positive QuantiFERON-TB Gold-Plus assay results. No significant differences between first and second antigen tube interferon-gamma responses were detected, irrespective of patient and disease characteristics at diagnosis. Of patients with a repeat assay after treatment completion (n = 65), only 16.9% converted to negative results.
August 1, 2023: Pediatric Infectious Disease Journal
#13
Hanae Aouraghe, Soumia Benchekroun, Chafiq Mahraoui, Naima ElHafidi
Multifocal tuberculosis (TB) accounts for up to one-third of all cases of TB and children are at higher risk for extrapulmonary TB than adults. Spinal TB is the regular form of skeletal TB. Spondylodiscitis TB represents 47%-94% of spinal TB. Cervical localization is rare but remains dangerous because of diagnostic difficulties and severe complications. We report a case of a 10-year-old Moroccan girl, bacille Calmette-Guerin vaccinated, with no medical history or trauma, parents and siblings are healthy and no contact with TB...
2023: International Journal of Mycobacteriology
#14
JOURNAL ARTICLE
Hao Chen, Huiwen Zheng, Lang Cui, Jing Xiao, Feina Li, Yonghong Wang, Yajie Guo, Yuying Chen, Yue Yuan, Chen Shen
OBJECTIVE: We aimed to compare QuantiFERON-TB Gold In-Tube (QFT-GIT) and X.DOT-TB for screening latent tuberculosis infection (LTBI) in kawasaki patients, and to identify the risk factors associated with indeterminate IGRA results. METHODS: We conducted a retrospective study on children with KD, who were screened for mycobacterium tuberculosis (Mtb) infection by either ELISA-based QFT-GIT or ELISPOT-based X.DOT-TB tests, admitted in Department of Cardiology, Beijing Children's Hospital from July 2019 to April 2022...
2023: Frontiers in Pediatrics
#15
Guozhong Zhou, Qingyi Luo, Shiqi Luo, Hongbo Chen, Shunli Cai, Xin Guo, Jian He, Yuan Xia, Hanse Li, Yingchen Zhou, Yazhou Zhang, Chao Song
OBJECTIVES: We aimed to evaluate the indeterminate rate of interferon gamma release assays (IGRAs) in the detection of latent tuberculosis infection (LTBI). METHODS: On 15 November 2022, we searched the PubMed® (National Library of Medicine, Bethesda, MD, USA), Embase® (Elsevier, Amsterdam, the Netherlands), and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two investigators independently extracted the study data and assessed their quality using a modified quality assessment of diagnostic accuracy studies (i...
2023: Frontiers in Immunology
#16
REVIEW
Domenico Umberto De Rose, Pier Giorgio Pace, Francesca Ceccherini-Silberstein, Andrea Dotta, Massimo Andreoni, Loredana Sarmati, Marco Iannetta
Adults and children exhibit a broad range of clinical outcomes from SARS-CoV-2 infection, with minimal to mild symptoms, especially in the pediatric age. However, some children present with a severe hyperinflammatory post-infectious complication named multisystem inflammatory syndrome in children (MIS-C), mainly affecting previously healthy subjects. Understanding these differences is still an ongoing challenge, that can lead to new therapeutic strategies and avoid unfavorable outcomes. In this review, we discuss the different roles of T lymphocyte subsets and interferon-γ (IFN-γ) in the immune responses of adults and children...
April 28, 2023: Journal of Personalized Medicine
#17
RANDOMIZED CONTROLLED TRIAL
Keren Middelkoop, Justine Stewart, Neil Walker, Carmen Delport, David A Jolliffe, Anna K Coussens, James Nuttall, Jonathan C Y Tang, William D Fraser, Christopher J Griffiths, Geeta Trilok Kumar, Suzanne Filteau, Richard L Hooper, Robert J Wilkinson, Linda-Gail Bekker, Adrian R Martineau
OBJECTIVES: To determine whether weekly oral supplementation with 10,000 IU vitamin D3 for 3 years reduces the risk of sensitization to M. tuberculosis in South African schoolchildren aged 6-11 years with negative QuantiFERON-tuberculosis (TB) Gold Plus (QFT-Plus) assay results at baseline. METHODS: We conducted a phase 3 randomized placebo-controlled trial in 1682 children attending 23 primary schools in Cape Town. The primary outcome was a positive end-trial QFT-Plus result, analyzed using a mixed effects logistic regression model with the school of attendance included as a random effect...
September 2023: International Journal of Infectious Diseases: IJID
#18
JOURNAL ARTICLE
Maria-Myrto Dourdouna, Elizabeth-Barbara Tatsi, Vasiliki Syriopoulou, Athanasios Michos
Cellular immunity after SARS-CoV-2 infection or immunization may be important for long-lasting protection against severe COVID-19 disease. We investigated cellular immune responses after SARS-CoV-2 infection and/or vaccination with an interferon-γ release assay (QuantiFERON, QFN), in parallel, with humoral immunity assessment. We recruited 41 participants: unvaccinated convalescent children and adults and vaccinated uninfected or vaccinated convalescent adults. All vaccinated adults had received three doses of the BNT162b2 COVID-19 vaccine at 6...
March 30, 2023: Diagnostic Microbiology and Infectious Disease
#19
JOURNAL ARTICLE
Danilo Buonsenso, Giovanni Delogu, Maria Del Carmen Pereyra Boza, Flavio De Maio, Ivana Palucci, Laura Martino, Davide Pata, Maurizio Sanguinetti, Piero Valentini, Michela Sali
Commercially available Interferon-γ release assays (IGRAs), including the last-generation QuantiFERON TB-Plus (QFT-Plus), are effective in aiding the diagnosis of tuberculosis (TB) infection but cannot distinguish latent TB subjects from active TB patients. The aim of this study was to prospectively evaluate the performance of an HBHA-based IGRA, combined with commercially available IGRAs, to assess their usefulness as a prognostic biomarkers and aid in the monitoring of TB treatment in children. Following clinical, microbiological, and radiological assessment, children younger than 18 years of age classified as either LTBI or active TB were tested at baseline and during treatment by the QuantiFERON TB-Plus (QFT) assay and an aliquot of whole-blood was stimulated with HBHA...
February 27, 2023: European Journal of Pediatrics
#20
JOURNAL ARTICLE
Danilo Buonsenso, James A Seddon, Susanna Esposito, Lucia Barcellini
This review summarizes studies evaluating the performance of the QuantiFERON-TB Gold Plus (QFT-Plus) interferon-gamma release assay (IGRA) test for Mycobacterium tuberculosis (Mtb) infection in children. Literature searching was conducted using PubMed, MEDLINE and Embase (January 2017 to December 2021) and the terms "children" or "pediatric" and "IGRAs" or "QuantiFERON-TB Gold Plus." Selected studies (N = 14; 4646 subjects) enrolled children with Mtb infection, tuberculosis (TB) disease or healthy children with household TB contacts...
February 15, 2023: Pediatric Infectious Disease Journal
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