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Quantiferon in childrens

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https://www.readbyqxmd.com/read/29875345/spondylodiscitis-in-paediatric-patients-the-importance-of-early-diagnosis-and-prolonged-therapy
#1
Sonia Bianchini, Andrea Esposito, Nicola Principi, Susanna Esposito
Background: Spondylodiscitis (SD), the concurrent infection of a vertebral disc and the adjacent vertebral bodies, is a very severe disease that can lead to death or cause spinal deformities, segmental instabilities, and chronic pain, which significantly reduces the quality of life for affected patients. Early diagnosis and treatment are essential in order to reduce the risk of negative outcomes. The two cases of SD that are described in this paper might be useful for informing paediatric approaches to children with SD...
June 7, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29866596/interferon-gamma-release-assay-based-screening-for-pediatric-latent-tuberculosis-infection-in-an-urban-primary-care-network
#2
James Gaensbauer, Bryn Gonzales, Robert Belknap, Michael L Wilson, Mary E O'Connor
OBJECTIVE: To assess outcomes from a QuantiFERON-tuberculosis (TB) Gold (QFT)-based screening for pediatric latent TB infection (LTBI) in the Denver Health Community Health System (CHS), an urban primary-care network in the US. STUDY DESIGN: We retrospectively analyzed all QFTs (n = 6685) performed on children aged 2-18 years between January 5, 2011, and August 18, 2014. Risk factors for positive testing in the CHS population were identified by logistic regression, and further assessed using a case-control comparison...
June 1, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29731933/latent-tuberculosis-infection-diagnosis-and-treatment
#3
Biljana Ilievska-Poposka, Marija Metodieva, Maja Zakoska, Cveta Vragoterova, Dejan Trajkov
INTRODUCTION: Latent tuberculosis infection (LTBI) is defined as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis (TB). Diagnosis and treatment for LTBI are important for TB, especially in high-risk populations. Tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used to diagnose LTBI. AIM: The study aims to present the first results with IGRA test compared with TST in the screening of LTBI and the treatment results in the cases with LTBI in Macedonia...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29562270/low-indeterminate-rates-associated-with-use-of-the-quantiferon-tb-gold-in-tube-test-in-children-with-inflammatory-bowel-disease-on-long-term-infliximab
#4
Eugene Vortia, Victor E Uko, Belinda Yen-Lieberman, Jill Frawley, Sarah E Worley, Lara Danziger-Isakov, Barbara Kaplan, Lori Mahajan
Background: Tumor necrosis factor alpha (TNF-α) inhibitors are linked with increased risk of reactivation of active tuberculosis. The QuantiFERON-TB Gold In-Tube test is approved for screening latent tuberculosis infection in children and adults. There are limited data on the test performance in children on long-term treatment with TNF-α inhibitors. The objective of this study was to assess the proportion of indeterminate results for the QuantiFERON-TB Gold In-Tube in children with inflammatory bowel disease (IBD) on long-term infliximab treatment and to evaluate the range of interferon-γ responses to mitogen...
March 19, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29493468/evaluation-of-the-quantiferon%C3%A2-tb-gold-in-tube-assay-and-tuberculin-skin-test-for-the-diagnosis-of-latent-tuberculosis-infection-in-an-iranian-referral-hospital
#5
Babak Pourakbari, Korosh Yousefi, Shima Mahmoudi, Reihaneh Hosseinpour Sadeghi, Setareh Mamishi
Mycobacterium tuberculosis remains as a vital threat to global health and its diagnosis is still complicated. Since there is no gold standard for the diagnosis of latent tuberculosis infection (LTBI), its diagnosis routinely relies on measurement of host immune responses to M. tuberculosis antigens using the tuberculin skin test (TST) and Interferon-Ƴ release assays (IGRAs). The aim of this study was to evaluate LTBI among hospitalized children and their patents/guardians as general populations in Children Medical Center, an Iranian referral hospital...
February 28, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29462104/high-incidence-of-tuberculosis-infection-in-hiv-exposed-children-exiting-an-isoniazid-preventive-therapy-trial
#6
Lisa M Cranmer, Heather R Draper, Anna M Mandalakas, Soyeon Kim, George McSherry, Emma Krezinski, Joan Coetzee, Charles Mitchell, Sharon Nachman, Mercia van der Linde, Mark F Cotton, Anneke C Hesseling
Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON®-TB Gold (QFT) among HIV-exposed children in South Africa at enrolment and one year follow-up. The incidence of TB infection was high for HIV+ (11 cases/100 child-years) and HIV-exposed uninfected (HEU) children (15 cases/100 child-years). QFT may identify HIV-exposed children at risk for TB disease progression.
February 16, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29442397/tuberculin-skin-test-versus-interferon-gamma-release-assay-in-refugee-children-a-retrospective-cohort-study
#7
Chris Elliot, Ben Marais, Phoebe Williams, Paul Joshua, Sherri Towle, Graham Hart, Karen Zwi
AIM: The aim of this study was to assist clinicians evaluating refugee children for latent tuberculosis infection (LTBI) by comparing paired tuberculin skin test (TST) and Quantiferon Gold In-Tube (QGIT) test results with clinical management decisions and follow-up data in a large cohort of newly arrived refugee children. METHODS: This was a retrospective analysis of all refugee children (<15 years of age) evaluated for LTBI with both TST and interferon-γ release assay between 2007 and 2010 in the Illawarra-Shoalhaven region of New South Wales, Australia...
February 14, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29364534/italian-multicentre-study-found-infectious-and-vaccine-preventable-diseases-in-children-adopted-from-africa-and-recommends-prompt-medical-screening
#8
Elena Chiappini, Mauro Zaffaroni, Martina Bianconi, Giuseppina Veneruso, Nicolino Grasso, Silvia Garazzino, Rosangela Arancio, Piero Valentini, Anna Ficcadenti, Maria Rosalia Da Riol, Simona La Placa, Luisa Galli, Maurizio de Martino, Gianni Bona
AIM: This study evaluated the prevalence of infectious diseases and immunisation status of children adopted from Africa. METHODS: We studied 762 African children referred to 11 Italian paediatric centres in 2009-2015. Clinical and laboratory data were retrospectively collected and analysed. RESULTS: The median age of the children (60.3% males) was 3 years and 6 months, 52.6% came from Ethiopia and 50.1% had at least one infectious disease...
January 24, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29182688/interferon-gamma-release-assay-for-the-diagnosis-of-latent-tuberculosis-infection-a-latent-class-analysis
#9
Tan N Doan, Damon P Eisen, Morgan T Rose, Andrew Slack, Grace Stearnes, Emma S McBryde
BACKGROUND: Accurate diagnosis and subsequent treatment of latent tuberculosis infection (LTBI) is essential for TB elimination. However, the absence of a gold standard test for diagnosing LTBI makes assessment of the true prevalence of LTBI and the accuracy of diagnostic tests challenging. Bayesian latent class models can be used to make inferences about disease prevalence and the sensitivity and specificity of diagnostic tests using data on the concordance between tests. We performed the largest meta-analysis to date aiming to evaluate the performance of tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) for LTBI diagnosis in various patient populations using Bayesian latent class modelling...
2017: PloS One
https://www.readbyqxmd.com/read/29142046/quantitative-analysis-of-gamma-interferon-release-assay-response-in-children-with-latent-and-active-tuberculosis
#10
Giulia Lombardi, Roberta Petrucci, Ilaria Corsini, Maria Letizia Bacchi Reggiani, Francesca Visciotti, Filippo Bernardi, Maria Paola Landini, Salvatore Cazzato, Paola Dal Monte
The use of interferon gamma (IFN-γ) release assays (IGRAs) for the diagnosis of tuberculosis (TB) infection in children is still under debate because of concerns about the immature immune response in children. The aim of this study was to investigate quantitative values of the QuantiFERON-TB Gold In-Tube (QFT-IT) test, a commercially available IGRA, in a large cohort of children screened for TB infection. A retrospective analysis was conducted on samples from 517 children aged 0 to 14 years old at the Pediatric Unit of S...
February 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29140946/comparison-of-the-quantiferon-tb-gold-in-tube-assay-with-tuberculin-skin-test-for-the-diagnosis-of-latent-tuberculosis-infection-among-hiv-infected-and-uninfected-children
#11
COMPARATIVE STUDY
Walter Dehority, Rolando M Viani, Maria Rosario G Araneta, Graciano Lopez, Stephen A Spector
BACKGROUND: Diagnosis of latent tuberculosis infection (LTBI) is facilitated by tuberculin skin testing (TST) or interferon-gamma release assays such as the QuantiFERON TB Gold In-Tube (QTF-GIT) assays. Limited data exist on the utility of interferon-gamma release assays in HIV-infected children, which may be falsely negative due to immunosuppression. METHODS: A cross-sectional study comparing TST to QTF-GIT for the diagnosis of suspected LTBI was performed in children in Tijuana, Mexico, and in San Diego, California...
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29136358/is-secretion-of-ifn-gamma-in-response-to-mycobacterium-tuberculosis-antigens-in-youngest-children-sufficient-to-play-a-role-in-tb-diagnostics
#12
Teresa Bielecka, Anna Komorowska-Piotrowska, Katarzyna Krenke, Wojciech Feleszko, Marek Kulus
OBJECTIVES: To assess whether children ≤5 years of age, produce sufficient amounts of interferon gamma (IFN-ɣ) in response to phytohaemagglutinin (mitogen), and Mycobacterium tuberculosis antigens (TB antigens) in the QuantiFERON-TB Gold in-Tube test (QFT-GIT), (Cellestis Ltd., Australia). WORKING HYPOTHESIS: Is TB-antigen-induced IFN-ɣ response in children ≤5 years sufficient to consider QFT-GIT a possible tool for TB diagnostics? Study design, patient-subject selection, and methods: We recruited children 0-17 years old suspected of TB infection to this cross-sectional study, in whom QFT-GIT and TST were performed...
February 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28877156/performance-of-the-quantiferon-tb-gold-assay-among-hiv-infected-children-with-active-tuberculosis-in-france
#13
Myriam Hormi, Valérie Guérin-El Khourouj, Virginie Pommelet, Mohamed Jeljeli, Béatrice Pédron, Jean-Sébastien Diana, Albert Faye, Ghislaine Sterkers
BACKGROUND: Data regarding the use of QuantiFERON to assist the diagnosis of active tuberculosis (TB) in HIV-infected children are limited, especially in countries with low incidence of TB/HIV coinfection. METHODS: QuantiFERON results were analyzed in 63 HIV-infected children who presented to our hospital in Paris, France. Seventeen HIV-uninfected children with active TB (4 culture-confirmed) were included for comparison. RESULTS: The 63 HIV-infected children (median age: 11 yr) had 113 QuantiFERON tests...
April 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28840843/interferon-gamma-release-assay-in-response-to-pe35-ppe68-proteins-a-promising-diagnostic-method-for-diagnosis-of-latent-tuberculosis
#14
Shima Mahmoudi, Babak Pourakbari, Setareh Mamishi
Tuberculosis control relies on the identification and preventive treatment of people who are latently infected with Mycobacterium tuberculosis (Mtb). PE/PPE proteins have been reported to elicit CD4 and/or CD8 responses either in the form of whole recombinant proteins or as individual peptides. Very few of the PE and PPE proteins have been previously tested for responses in patients with TB and healthy donors. This is the first study to evaluate the Interferon Gamma Release Assay (IGRA) after stimulation with PE35 and PPE68...
March 1, 2017: European Cytokine Network
https://www.readbyqxmd.com/read/28646434/performance-of-quantiferon%C3%A2-tb-gold-in-tube-assay-in-children-receiving-disease-modifying-anti-rheumatic-drugs
#15
Francesca Gabriele, Maria Trachana, Maria Simitsopoulou, Polixeni Pratsidou-Gertsi, Elias Iosifidis, Zoi Dorothea Pana, Emmanuel Roilides
BACKGROUND: To evaluate the performance of the Quantiferon(®)-TB Gold In-Tube (QFT-IT) interferon (IFN)-γ assay for the detection of latent tuberculosis infection (LTBI) in children receiving anti-rheumatic treatment in a tertiary referral hospital of Northern Greece. METHODS: A total of 79 consecutive children receiving anti-rheumatic treatment [of which 18 screened prior to antitumor necrosis factor (TNF)-α treatment] were tested using Mantoux tuberculin skin test (TST) and QFT-IT...
October 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28512556/pediatric-tuberculosis-in-northern-sardinia
#16
Maria Grazia Clemente, Elena Dore, Lidia Abis, Paola Molicotti, Stefania Zanetti, Paolina Olmeo, Roberto Antonucci
BACKGROUND AND OBJECTIVES: Migration flux is an increasing phenomenon in Italy, and it raises several public health issues and concerns in pediatric infectious diseases. This study investigated the clinical characteristics and outcomes of a pediatric population at high-risk for tuberculosis (TB) and the potential role of immigration as a risk factor. DESIGN: We performed an observational retrospective study of children referred to the only Pediatric Infectious Diseases Unit for Northern Sardinia over a 6-year-period (2009-2014)...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28407146/high-rates-of-latent-tb-infection-in-contacts-and-the-wider-community-in-south-india
#17
Padmanesan Narasimhan, Chandini Raina MacIntyre, Dilip Mathai, James Wood
Background: We aimed to compare TB transmission rates between case and community households in Vellore, South India. Methods: 359 household contacts (HHC) and 363 community contacts (CC) were assessed with tuberculin skin test (TST) and QuantiFERON TB Gold In-Tube test (QFT) between August 2010 and September 2011. Concordance test and multivariate risk factor assessment were conducted using logistic regression adjusted for clustering. Results: Latent TB infection (LTBI) positivity was similar between the two groups using both tests, with only moderate concordance observed between QFT and TST...
February 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28328809/infectious-diseases-prevalence-vaccination-coverage-and-diagnostic-challenges-in-a-population-of-internationally-adopted-children-referred-to-a-tertiary-care-children-s-hospital-from-2009-to-2015
#18
Sara Sollai, Francesca Ghetti, Leila Bianchi, Maurizio de Martino, Luisa Galli, Elena Chiappini
Infectious diseases are common in internationally adopted children (IAC).With the objective to evaluate infectious diseases prevalence in a large cohort of IAC and to explore possible risk factors for tuberculosis (TB) and parasitic infections, clinical and laboratory data at first screening visit of all IAC (<18 years) consecutively referred to our Center in 2009 to 2015 were collected and analyzed.In total, 1612 children (median age: 5.40 years; interquartile range: 3.00-7.90) were enrolled, 123/1612 (7...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28299430/alternative-quantiferon-cytokines-for-diagnosis-of-children-with-active-tuberculosis-and-hiv-co-infection-in-ghana
#19
Christian Lundtoft, Anthony Afum-Adjei Awuah, Norman Nausch, Anthony Enimil, Ertan Mayatepek, Ellis Owusu-Dabo, Marc Jacobsen
IFN-γ release assays (IGRAs) often present false-negative or indeterminate results in children with tuberculosis. HIV co-infection may contribute to decreased sensitivity of IGRAs by impairing T-cell IFN-γ expression. Measurement of alternative cytokines in QuantiFERON® (QFT) supernatants can circumvent the IFN-γ-dependency and may improve QFT sensitivity. We aimed to identify additional cytokines from QFT supernatants for detection of Mycobacterium tuberculosis infection in children with tuberculosis and HIV co-infection from Ghana...
June 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28276801/tuberculosis-infection-and-disease-in-the-2015-cohort-of-unaccompanied-minors-seeking-asylum-in-northern-stockholm-sweden
#20
Rutger Bennet, Margareta Eriksson
BACKGROUND: Minors with a stated age <18 years unaccompanied by a responsible adult form an increasing part of refugees to Europe. They are older than other asylum-seeking children and many come from countries with a high tuberculosis (TB) incidence. During the 2015 refugee crisis, 35,369 of 162,877 refugees (22%) seeking asylum in Sweden were unaccompanied minors, which gave us the opportunity to study their burden of TB infection and disease. METHODS: Of the unaccompanied minors seeking asylum in Sweden during 2015, 2936 (8...
July 2017: Infectious Diseases
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