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Quantiferon in childrens

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https://www.readbyqxmd.com/read/28225337/multiple-cytokines-for-the-detection-of-mycobacterium-tuberculosis-infection-in-children-with-tuberculosis
#1
N Nausch, C Lundtoft, G Schulz, H Henckel, E Mayatepek, B Fleischer, F M Marx, M Jacobsen
SETTING: Interferon-gamma (IFN-γ) release assays (IGRAs) play an important role in the diagnosis of Mycobacterium tuberculosis infection. However, in children with tuberculosis (TB), some studies have shown increased frequencies of false-negative or indeterminate IGRA results. OBJECTIVE: To analyse the spectrum of different cytokines to improve the diagnostic accuracy of IGRAs in latent tuberculous infection (LTBI) and active TB. DESIGN: We performed multiplex cytokine expression analysis of QuantiFERON® Gold In-Tube supernatants in children with active TB (n = 21) and disease-free contacts with (n = 15) and without LTBI (n = 12), to determine the sensitivity and specificity of the modified tests...
March 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28215501/serial-quantiferon-testing-and-tuberculosis-disease-risk-among-young-children-an-observational-cohort-study
#2
Jason R Andrews, Elisa Nemes, Michele Tameris, Bernard S Landry, Hassan Mahomed, J Bruce McClain, Helen A Fletcher, Willem A Hanekom, Robin Wood, Helen McShane, Thomas J Scriba, Mark Hatherill
BACKGROUND: The value of quantitative interferon-γ release assay results for predicting progression from Mycobacterium tuberculosis infection to active disease is unknown. We aimed to investigate the relation between QuantiFERON-TB Gold In-Tube (QFT) conversion interferon-γ values and risk of subsequent active tuberculosis disease and of QFT reversion. METHODS: We analysed data from a reported vaccine efficacy trial of the tuberculosis vaccine MVA85A in South Africa...
February 16, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28043594/incidence-of-tuberculosis-among-children-living-in-contact-with-smear-positive-tuberculosis-advantages-and-limits-of-the-quantiferon-tb-gold-in-tube-test
#3
Djohar Hannoun, Fadila Boulahbal
OBJECTIVE/BACKGROUND: Children living in contact with smear-positive pulmonary tuberculosis (TB) patients are highly exposed to TB infection. Our objective was to estimate the incidence of TB in children living in contact with a Smear Positive (M+) pulmonary tuberculosis (PTM+) index case during 2years following exposure. METHODS: This was a descriptive, cohort, prospective, multicenter study of children aged from 6months to 15years in contact with a PTM+ case. The recruitment of children has been based on the diagnosed PTM+ index case and taken in charge by the Services of Control of Tuberculosis and Respiratory Diseases located in Algiers during 2014...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28000584/utility-of-the-quantiferon%C3%A2-tb-gold-in-tube-assay-for-the-diagnosis-of-tuberculosis-in-moroccan-children
#4
S El Azbaoui, A Sabri, S Ouraini, A Hassani, A Asermouh, A Agadr, R Abilkassem, N Dini, M Kmari, A Akhaddar, Z Laktati, S Aieche, N El Hafidi, F Ben Brahim, A A Bousfiha, F Ailal, C Deswarte, E Schurr, L Amar, J Bustamante, S Boisson-Dupuis, J L Casanova, L Abel, J El Baghdadi
SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Guérin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT...
December 1, 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27931340/utility-of-the-quantiferon-tb-gold-in-tube-assay-for-the-diagnosis-of-tuberculosis-in-moroccan-children
#5
S El Azbaoui, A Sabri, S Ouraini, A Hassani, A Asermouh, A Agadr, R Abilkassem, N Dini, M Kmari, A Akhaddar, Z Laktati, S Aieche, N El Hafidi, F Ben Brahim, A A Bousfiha, F Ailal, C Deswarte, E Schurr, L Amar, J Bustamante, S Boisson-Dupuis, J L Casanova, L Abel, J El Baghdadi
SETTING: The utility of interferon-gamma release assays (IGRAs), such as the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in diagnosing active tuberculosis (TB) in children is unclear and depends on the epidemiological setting. OBJECTIVE: To evaluate the performance of QFT-GIT for TB diagnosis in children living in Morocco, an intermediate TB incidence country with high bacille Calmette-Gurin vaccination coverage. DESIGN: We prospectively recruited 109 Moroccan children hospitalised for clinically suspected TB, all of whom were tested using QFT-GIT...
December 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27783642/prevalence-and-diagnosis-of-latent-tuberculosis-infection-in-young-children-in-the-absence-of-a-gold-standard
#6
Tomas Maria Perez-Porcuna, Hélio Doyle Pereira-da-Silva, Carlos Ascaso, Adriana Malheiro, Samira Bührer, Flor Martinez-Espinosa, Rosa Abellana
INTRODUCTION: For adequate disease control the World Health Organization has proposed the diagnosis and treatment of latent tuberculous infection (LTBI) in groups of risk of developing the disease such as children. There is no gold standard (GS) test for the diagnosis of LTBI. The objective of this study was to estimate the prevalence of LTBI in young children in contact with a household case of tuberculosis (TB-HCC) and determine the accuracy and precision of the Tuberculin Skin Test (TST) and QuantiFERON-TB Gold in-tube (QFT) used in the absence of a GS...
2016: PloS One
https://www.readbyqxmd.com/read/27749653/quantiferon-tb-gold-in-tube-improves-tuberculosis-diagnosis-in-children
#7
Roberta Petrucci, Giulia Lombardi, Ilaria Corsini, Maria Letizia Bacchi Reggiani, Francesca Visciotti, Filippo Bernardi, Maria Paola Landini, Salvatore Cazzato, Paola Dal Monte
BACKGROUND: The diagnostic accuracy of Quantiferon-TB Gold In-Tube (QFT-IT) is uncertain in the pediatric population, while tuberculin skin test (TST) is still conventionally used despite its limitations. The aim of this study was to compare the performance of QFT-IT with TST in a large cohort of children screened for tuberculosis (TB) infection because of contact tracing, suspected TB, arrival from endemic country or immunosuppressive therapy. METHODS: A retrospective analysis was conducted on 517 children 0-14 years of age evaluated at the pediatric unit of the S...
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27730117/potential-role-for-interferon-%C3%AE-release-assays-in-tuberculosis-screening-in-a-remote-canadian-community-a-case-series
#8
Wilson Kwong, Thomas Krahn, Ann Cleland, Janet Gordon, Wendy Wobeser
BACKGROUND: Current Canadian guidelines suggest that neonatal Bacille Calmette-Guérin (BCG) vaccination does not result in false-positive tuberculosis (TB) skin tests, despite a growing body of evidence that interferon-γ release assays may be a more specific alternative in identifying latent tuberculosis infections in vaccinated populations. We set out to evaluate the relationship between TB skin tests and interferon-γ release assays in patients who previously received neonatal BCG vaccine...
July 2016: CMAJ Open
https://www.readbyqxmd.com/read/27220068/accurate-diagnosis-of-latent-tuberculosis-in-children-people-who-are-immunocompromised-or-at-risk-from-immunosuppression-and-recent-arrivals-from-countries-with-a-high-incidence-of-tuberculosis-systematic-review-and-economic-evaluation
#9
Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Farah Seedat, Tara Gurung, Karoline Freeman, Sian Taylor-Phillips, Clare Walker, Jason Madan, Ngianga-Bakwin Kandala, Aileen Clarke, Paul Sutcliffe
BACKGROUND: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) [(Zopf 1883) Lehmann and Neumann 1896], is a major cause of morbidity and mortality. Nearly one-third of the world's population is infected with MTB; TB has an annual incidence of 9 million new cases and each year causes 2 million deaths worldwide. OBJECTIVES: To investigate the clinical effectiveness and cost-effectiveness of screening tests [interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs)] in latent tuberculosis infection (LTBI) diagnosis to support National Institute for Health and Care Excellence (NICE) guideline development for three population groups: children, immunocompromised people and those who have recently arrived in the UK from high-incidence countries...
May 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27199468/interferon-gamma-release-assays-and-pediatric-public-health-tuberculosis-screening-the-san-francisco-program-experience-2005-to-2008
#10
Jennifer A Grinsdale, Shamim Islam, Olivia Chang Tran, Christine S Ho, L Masae Kawamura, Julie M Higashi
BACKGROUND: Interferon-gamma release assay utilization in pediatric tuberculosis (TB) screening is limited by a paucity of longitudinal experience, particularly in low-TB burden populations. METHODS: We conducted a retrospective review of QuantiFERON (QFT)-TB Gold results in San Francisco children from 2005 to 2008. Concordance with the tuberculin skin test (TST) was analyzed for a subset of children. Progression to active disease was determined through San Francisco and California TB registry matches...
June 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/27171581/quantiferon-tb-test-in-children-with-miliary-tuberculosis
#11
Erika Silvestro, Irene Raffaldi, Silvia Virano, Carlo Scolfaro
No abstract text is available yet for this article.
June 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27086575/infliximab-is-the-new-kid-on-the-block-in-kawasaki-disease-a-single-centre-study-over-8-years-from-north-india
#12
Surjit Singh, Dhrubajyoti Sharma, Deepti Suri, Anju Gupta, Amit Rawat, Manoj Kumar Rohit
This was a single-centre study to evaluate the usefulness of tumour necrosis factor-α (TNF-α) blocker, infliximab (IFX), for treatment of Kawasaki disease (KD) in children in Northern Indian. The study was carried out in the Paediatric Allergy-Immunology Unit, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. The study period was January 2007 to March 2015. Review of records of 23 children with KD who had received IFX was carried out. Median age at presentation was 2 years (range 2 months to 12 years)...
May 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26993789/performance-of-interferon-%C3%AE-release-assays-in-the-diagnosis-of-confirmed-active-tuberculosis-in-immunocompetent-children-a-new-systematic-review-and-meta-analysis
#13
Patrizia Laurenti, Matteo Raponi, Chiara de Waure, Marta Marino, Walter Ricciardi, Gianfranco Damiani
BACKGROUND: Tuberculosis (TB) is a global public health problem, causing morbidity and mortality in adults and children. The most reliable diagnostic tools currently available are the in vivo Tuberculin Skin Test (TST) and the ex vivo Interferon-γ release assays (IGRAs). Several clinical, radiological, and bacteriological features make the detection of active (overt disease) TB in children difficult. Although recently developed immunological assays such as QuantiFERON-TB Gold In-Tube (QFT-IT) and T-SPOT®...
March 18, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26933841/the-effect-of-deworming-on-tests-of-tuberculosis-infection-in-children-with-recent-tuberculosis-exposure-a-randomized-controlled-trial
#14
Marieke M Van der Zalm, Nelda van Soelen, Anna M Mandalakas, Marc Jacobsen, Anne K Detjen, Florian M Marx, Harleen M S Grewal, Mark F Cotton, Gerhard Walzl, Anneke C Hesseling
BACKGROUND: Helminth infestations are associated with T-helper cell type 2 (Th2) immune responses, leading to suppression of Th1 responses required to control Mycobacterium tuberculosis infection. We hypothesized that deworming after documented M. tuberculosis exposure might improve Th1 immune responses. METHODS: This was a randomized controlled trial comparing the effect of early versus delayed (after 3 months) deworming on tuberculin skin testing (TST) and Quantiferon-Gold-in-tube responses among children from a setting with a known high burden of M...
June 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26635208/tuberculosis-in-pediatric-patients-treated-with-anti-tnf%C3%AE-drugs-a-cohort-study
#15
Joan Calzada-Hernández, Jordi Anton-López, Rosa Bou-Torrent, Estíbaliz Iglesias-Jiménez, Sílvia Ricart-Campos, Javier Martín de Carpi, Vicenç Torrente-Segarra, Judith Sánchez-Manubens, Clara Giménez-Roca, Librada Rozas-Quesada, Maria Teresa Juncosa-Morros, Clàudia Fortuny, Antoni Noguera-Julian
BACKGROUND: Adult patients receiving anti-TNFα drugs are at increased risk of tuberculosis (TB), but studies in pediatric populations are limited, and the best strategy for latent tuberculosis infection (LTBI) screening in this population remains controversial. We describe the prevalence of LTBI prior to anti-TNFα therapy and the long-term follow-up after biological treatment initiation in a cohort of children and adolescents. METHODS: Cohort observational study in children and adolescents receiving anti-TNFα agents in a tertiary-care pediatric hospital...
2015: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/26614186/pott-s-disease-in-moroccan-children-clinical-features-and-investigation-of-the-interleukin-12-interferon-%C3%AE-pathway
#16
S El Azbaoui, N Alaoui Mrani, A Sabri, Z Jouhadi, F Ailal, A A Bousfiha, J Najib, N El Hafidi, C Deswarte, E Schurr, J Bustamante, S Boisson-Dupuis, J-L Casanova, L Abel, J El Baghdadi
SETTING: Tuberculosis spondylodiscitis (TS), or Pott's disease, an extra-pulmonary form of tuberculosis (TB), is rare and difficult to diagnose in children. Some cases of severe TB in children were recently explained by inborn errors of immunity affecting the interleukin-12/interferon-gamma (IL-12/IFN-γ) axis. OBJECTIVE: To analyse clinical data on Moroccan children with TS, and to perform immunological and genetic explorations of the IL-12/IFN-γ axis. DESIGN: We studied nine children with TS diagnosed between 2012 and 2014...
December 2015: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/26439935/accuracy-of-quantiferon-tb-gold-test-for-tuberculosis-diagnosis-in-children
#17
Michela Sali, Danilo Buonsenso, Delia Goletti, Pamela D'Alfonso, Antonella Zumbo, Giovanni Fadda, Maurizio Sanguinetti, Giovanni Delogu, Piero Valentini
OBJECTIVES: To evaluate the accuracy of the QuantiFERON-TB Gold assay (QFT-IT) in children with suspected active or latent TB infection (LTBI). METHODS: A retrospective study was conducted on 621 children (0-14 years old) evaluated for TB infection or disease. Following clinical assessment, children were tested with the QFT-IT assay. RESULTS: Among the 140 active TB suspects, we identified 19 cases of active disease. The overall sensitivity for active TB was 87...
2015: PloS One
https://www.readbyqxmd.com/read/26407408/relating-tuberculosis-tb-contact-characteristics-to-quantiferon-tb-gold-and-tuberculin-skin-test-results-in-the-toronto-pediatric-tb-clinic
#18
Winsley Rose, Stanley E Read, Ari Bitnun, Elizabeth Rea, Derek Stephens, Wanatpreeya Pongsamart, Ian Kitai
BACKGROUND: Few data relate interferon-γ-release-assay results in children to source case sputum status, the best predictor of infectiousness of tuberculosis (TB) patients. We evaluated the QuantiFERON-Gold-in-tube assay (QFT) and tuberculin skin test (TST) in children with different types of TB exposure. METHODS: The TST and QFT were performed in referred TB-exposed children and adolescents who had not undergone prior TST screening (tested in parallel), and the QFT was performed in referred TST-positive individuals...
June 2015: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/26379347/quantiferon-tb-gold-and-tuberculin-skin-test-for-the-diagnosis-of-latent-tuberculosis-infection-in-children
#19
Hossein Masoumi Asl, Abdolvahab Alborzi, Bahman Pourabbas, Mehdi Kalani
BACKGROUND: Appropriate diagnosis and treatment of latent tuberculosis infection (LTBI) play the most important role in the control of tuberculosis. This study aimed to determine the prevalence of LTBI among healthy tuberculosis unexposed children vaccinated with BCG using the tuberculin skin test (TST) and QuantiFERON TB Gold In-Tube (QFT-GIT) and comparing the agreement between the two tests. METHODS: A cross-sectional study was carried out between October 2009 and March 2010 in 24 schools and 11 daycare centers...
September 2015: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/26362753/diagnostic-utility-of-quantiferon-tb-gold-in-tube-test-in-pediatric-tuberculosis-disease-in-taiwanese-children
#20
Kin-Sun Wong, Yen-Chun Huang, Han-Chung Hu, Yhu-Chering Huang, Chang-Hui Wen, Tzou-Yien Lin
PURPOSE: To compare the performance of a commercial interferon-gamma release assay, QuantiFERON TB Gold-in-Tube (QFG-IT) with the tuberculin skin test (TST) in Taiwanese children for the diagnosis of active tuberculosis (TB). METHODS: A retrospective chart analysis of pediatric patients (<18 years of age) who underwent QFG-IT tests and TST for the confirmation of active TB between January 2008 and June 2014. RESULTS: The sensitivity of QFG-IT was 100% [95% confidence interval (CI): 63...
August 28, 2015: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
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