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https://www.readbyqxmd.com/read/28726607/acute-febrile-illness-and-complications-due-to-murine-typhus-texas-usa1-2
#1
Zeeshan Afzal, Sunand Kallumadanda, Feng Wang, Vagish Hemmige, Daniel Musher
Murine typhus occurs relatively commonly in southern Texas, as well as in California. We reviewed records of 90 adults and children in whom murine typhus was diagnosed during a 3-year period in 2 hospitals in southern Texas, USA. Most patients lacked notable comorbidities; all were immunocompetent. Initial signs and symptoms included fever (99%), malaise (82%), headache (77%), fatigue (70%), myalgias (68%), and rash (39%). Complications, often severe, in 28% of patients included bronchiolitis, pneumonia, meningitis, septic shock, cholecystitis, pancreatitis, myositis, and rhabdomyolysis; the last 3 are previously unreported in murine typhus...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28711388/impact-of-13-valent-pneumococcal-conjugate-vaccine-on-pneumococcal-meningitis-in-children
#2
Jesus Ruiz-Contreras, Juan Picazo, Juan Casado-Flores, Fernando Baquero-Artigao, Teresa Hernández-Sampelayo, Enrique Otheo, Cristina Méndez, María Del Amo, César Balseiro
OBJECTIVES: To evaluate the impact of 13-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children. METHODS: Children younger than 15years of age attending 27 hospitals in the Region of Madrid with confirmed pneumococcal meningitis were identified in a prospective surveillance study, from 2007 to 2015. Clinical data, neurological sequelae, pneumococcal vaccination status, serotyping and antibiotic susceptibility were recorded. RESULTS: One hundred and four cases of pneumococcal meningitis were identified, 63 during the period of routine 7-valent pneumococcal conjugate vaccine immunisation (May 2007-April 2010) and 41 during the period of 13-valent pneumococcal conjugate vaccine immunisation (May 2010-April 2015)...
July 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28710409/machine-learning-algorithms-for-risk-prediction-of-severe-hand-foot-mouth-disease-in-children
#3
Bin Zhang, Xiang Wan, Fu-Sheng Ouyang, Yu-Hao Dong, De-Hui Luo, Jing Liu, Long Liang, Wen-Bo Chen, Xiao-Ning Luo, Xiao-Kai Mo, Lu Zhang, Wen-Hui Huang, Shu-Fang Pei, Bao-Liang Guo, Chang-Hong Liang, Zhou-Yang Lian, Shui-Xing Zhang
The identification of indicators for severe HFMD is critical for early prevention and control of the disease. With this goal in mind, 185 severe and 345 mild HFMD cases were assessed. Patient demographics, clinical features, MRI findings, and laboratory test results were collected. Gradient boosting tree (GBT) was then used to determine the relative importance (RI) and interaction effects of the variables. Results indicated that elevated white blood cell (WBC) count > 15 × 10(9)/L (RI: 4(9).47, p < 0...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705671/antibiotic-resistance-in-west-africa-a-systematic-review-and-meta-analysis
#4
REVIEW
Kerlly J Bernabé, Céline Langendorf, Nathan Ford, Jean-Baptiste Ronat, Richard A Murphy
BACKGROUND: Growing data suggest that antibiotic-resistant bacterial infections are common in low and middle-income countries. This review summarizes the microbiology of key bacterial syndromes encountered in West Africa and estimates the prevalence of antimicrobial resistance (AMR) that could compromise first-line empirical treatment. METHODS: We systematically searched for studies reporting on the epidemiology of infection and AMR in West Africa. Within each syndrome, the pooled proportion and 95% confidence intervals were calculated for each pathogen-antibiotic pair, using random effects models...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705180/etiology-and-prognosis-of-acute-viral-encephalitis-and-meningitis-in-chinese-children-a-multicentre-prospective-study
#5
Junhong Ai, Zhengde Xie, Gang Liu, Zongbo Chen, Yong Yang, Yuning Li, Jing Chen, Guo Zheng, Kunling Shen
BACKGROUND: In China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children. METHODS: This was a multicentre prospective study. Two hundred and sixty one viral encephalitis patients and 285 viral meningitis patients were enrolled. The mean age of viral encephalitis and meningitis were 5...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28702307/childhood-pneumonia-and-meningitis-in-the-eastern-highlands-province-papua-new-guinea-in-the-era-of-conjugate-vaccines-study-methods-and-challenges
#6
Christopher C Blyth, Rebecca Ford, Joycelyn Sapura, Tonny Kumani, Geraldine Masiria, John Kave, Lapule Yuasi, Andrew Greenhill, Ilomo Hwaihwanje, Amanda Lang, Deborah Lehmann, William Pomat
BACKGROUND: Pneumonia and meningitis are common causes of severe childhood illness in Papua New Guinea (PNG). The etiology of both clinical conditions in PNG has not been recently assessed. Changes in lifestyle, provision and access to healthcare, antimicrobial utilization and resistance, and the national childhood vaccination schedule necessitate reassessment. METHODS: A prospective case-control study was undertaken, enrolling children <5 years of age to determine the contemporary etiology of clinically defined moderate or severe pneumonia or suspected meningitis...
2017: Pneumonia
https://www.readbyqxmd.com/read/28702151/human-enteroviruses-in-cerebrospinal-fluid-of-children-with-suspected-aseptic-meningitis-a-study-in-northern-iran
#7
Farzin Sadeghi, Masoumeh Talebi-Nesami, Rahim Barari-Savadkouhi, Ali Bijani, Elahe Ferdosi-Shahandashti, Yousef Yahyapour
BACKGROUND: Enterovirus (EV) infections are one of the most common causes of aseptic meningitis in pediatrics. To diagnose EV meningitis, virus isolation in cell cultures is often time consuming and lacks sensitivity to be of clinical relevance. This makes the virus culture results difficult to interpret. The rapid detection of EVs in cerebrospinal fluid (CSF) by molecular diagnostic techniques may improve the management of patients with aseptic meningitis. The purpose of the present study was to develop a more convenient and sensitive alternative technique to viral culture...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28697163/utility-of-lumbar-puncture-in-children-presenting-with-status-epilepticus
#8
Kenneth A Michelson, Todd W Lyons, Kara B Johnson, Lise E Nigrovic, Marvin B Harper, Amir A Kimia
OBJECTIVES: Because meningitis may trigger seizures, we sought to determine its frequency in children with first-time status epilepticus (SE). METHODS: We performed a retrospective cross-sectional study of children aged 1 month to 21 years who presented to a single pediatric emergency department between 1995 and 2012 with SE and who had a lumbar puncture (LP) performed as part of the diagnostic evaluation. We defined bacterial meningitis as a cerebrospinal fluid (CSF) culture positive for a bacterial pathogen or CSF pleocytosis (CSF white blood cells ≥10 cells/mm) with a blood culture positive for a bacterial pathogen...
July 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28690025/invasive-pneumococcal-disease-caused-by-ceftriaxone-resistant-streptococcus-pneumoniae-in-taiwan
#9
Hao-Yuan Lee, Tsu-Lan Wu, Lin-Hui Su, Hsin-Chieh Li, Rajendra Prasad Janapatla, Chyi-Liang Chen, Cheng-Hsun Chiu
BACKGROUND: Invasive pneumococcal disease (IPD) was associated with mortality, but the risk factors associated with mortality remains controversial. METHODS: A retrospective cohort study was designed. All patients with IPD from 2011 to 2013 admitted in a medical center were screened and collected for their clinical presentations and laboratory characteristics. RESULTS: Approximately half of the 134 IPD isolates derived from these patients belonged to three major serotypes (19A, 6A and 3), which are included in 13-valent pneumococcal conjugate vaccine (PCV13), but not in 7-valent pneumococcal conjugate vaccine (PCV7)...
June 26, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28688564/utility-of-intraoperative-and-postoperative-radiographs-in-pediatric-cochlear-implant-surgery
#10
Samantha Anne, Jose Miguel Juarez, Amber Shaffer, David Eleff, Dennis Kitsko, Sarah Sydlowski, Erika Woodson, David Chi
OBJECTIVE: Routine plain film radiographs are often obtained to confirm proper placement of electrode after pediatric cochlear implant surgery. Objective is to evaluate necessity of routine radiographs in pediatric cochlear implant cases. STUDY DESIGN: Retrospective review. SETTING: Two tertiary care academic centers. SUBJECTS AND METHODS: Review of all children that underwent cochlear implantation from January 2003 thru June 2015...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28674823/comparison-of-scrub-typhus-with-and-without-meningitis
#11
Winsley Rose, Urmi Ghosh, Anu Punnen, Rajiv Sarkar, John Jude Antony Prakash, Valsan Philip Verghese
OBJECTIVE: To compare the children admitted with scrub typhus with and without meningitis. METHODS: All children admitted with scrub typhus over a 62 mo period were reviewed. Statistical analysis was performed to compare those with and without meningitis for demographic, clinical, investigations and outcome parameters. RESULTS: Four hundred twenty seven children were admitted with scrub typhus and 63 (14.8%) had meningitis. The mean cerebrospinal fluid white blood cell (CSF WBC) count was 71 cells/cu...
July 4, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28668572/characteristics-of-pediatric-invasive-pneumococcal-diseases-and-the-pneumococcal-isolates-in-suzhou-china-before-introduction-of-pcv13
#12
Xiyan Zhang, Jianmei Tian, Wei Shan, Jian Xue, Yunzhen Tao, Qian Geng, Yunfang Ding, Genming Zhao, Tao Zhang
BACKGROUND: Data on characteristics of invasive pneumococcal diseases (IPD) is limited in China. We aimed to understand the clinical features and explore the molecular characteristics of the pneumococcal isolates in China. METHODS: Since 2010, we prospectively collected the pneumococcal isolates and the IPD patients' demographic and clinical information in Suzhou University Affiliated Children's Hospital (SCH). The antibiotic susceptibility, serotypes, genotypes of Streptococcus pneumoniae strains were identified by E-test, quellung reaction and/or multiplex PCR, and multi-locus sequence typing, respectively...
June 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28662145/prevalence-and-antibiotic-resistance-profiles-of-cerebrospinal-fluid-pathogens-in-children-with-acute-bacterial-meningitis-in-yunnan-province-china-2012-2015
#13
Hongchao Jiang, Min Su, Liyue Kui, Hailin Huang, Lijuan Qiu, Li Li, Jing Ma, Tingyi Du, Mao Fan, Qiangming Sun, Xiaomei Liu
Acute bacterial meningitis is still considered one of the most dangerous infectious diseases in children. To investigate the prevalence and antibiotic resistance profiles of cerebrospinal fluid (CSF) pathogens in children with acute bacterial meningitis in Southwest China, CSF samples from 179 meningitis patients (3 days to 12 years old) with positive culture results were collected from 2012 to 2015. Isolated pathogens were identified using the Vitek-32 system. Gram stain results were used to guide subcultures and susceptibility testing...
2017: PloS One
https://www.readbyqxmd.com/read/28661973/determinants-of-antibiotic-tailoring-in-pediatric-intensive-care-a-national-survey
#14
Patricia S Fontela, Caroline Quach, Mohammad E Karim, Douglas F Willson, Elaine Gilfoyle, James Dayre McNally, Milagros Gonzales, Jesse Papenburg, Steven Reynolds, Jacques Lacroix
OBJECTIVES: To describe the criteria that currently guide empiric antibiotic treatment in children admitted to Canadian PICUs. DESIGN: Cross-sectional survey. SETTING: Canadian PICUs. SUBJECTS: Pediatric intensivists and pediatric infectious diseases specialists. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We used focus groups and literature review to design the survey questions and its four clinical scenarios (sepsis, pneumonia, meningitis, and intra-abdominal infections)...
June 28, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28661964/cerebrospinal-fluid-b-lymphocyte-chemoattractant-cxcl-13-in-the-diagnosis-of-acute-lyme-neuroborreliosis-in-children
#15
Bjørn Barstad, Dag Tveitnes, Sølvi Noraas, Ingvild Selvik Ask, Maryam Saeed, Franziskus Bosse, Grete Vigemyr, Ilka Huber, Knut Øymar
BACKGROUND: Current markers of Lyme neuroborreliosis (LNB) in children have insufficient sensitivity in the early stage of disease. The B-lymphocyte chemoattractant CXCL13 in the cerebrospinal fluid (CSF) may be useful in diagnosing LNB, but its specificity has not been evaluated in studies including children with clinically relevant differential diagnoses. The aim of this study was to elucidate the diagnostic value of CSF CXCL13 in children with symptoms suggestive of LNB. METHODS: Children with symptoms suggestive of LNB were included prospectively into predefined groups with a high or low likelihood of LNB based on CSF pleocytosis and the detection of Borrelia antibodies or other causative agents...
June 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28654563/neuroborreliosis-in-swedish-children-a-population-based-study-on-incidence-and-clinical-characteristics
#16
Liv Södermark, Vignir Sigurdsson, Wilhelmina Näs, Pernilla Wall, Birger Trollfors
BACKGROUND: Borrelia burgdorferi is a common cause of bacterial meningitis but there are very few studies on incidence in Europe. OBJECTIVE: To report the incidence and symptoms of neuroborreliosis in Swedish children. DESIGN: Medical records of children (<15 years) treated for neuroborreliosis 2002-2014 were studied retrospectively. The patients were identified in the computerized registers of discharge diagnoses at the Departments of Pediatrics and Infectious Diseases in Gothenburg, Borås, Trollhättan and Halmstad using ICD-10 diagnosis codes G51...
June 24, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28646959/is-chickenpox-so-bad-what-do-we-know-about-immunity-to-varicella-zoster-virus-and-what-does-it-tell-us-about-the-future
#17
Anne A Gershon
Varicella and zoster continue to cause significant morbidity and even mortality in children and adults. Complications include bacterial superinfection, central nervous system manifestations such as meningitis, encephalitis, and cerebellar ataxia, and pain syndromes especially post herpetic neuralgia. Many developed countries but not all, are now administering live attenuated varicella vaccine routinely, with a decrease in the incidence of disease, providing personal and herd immunity. There is some controversy, however, in some countries concerning whether a decrease in the circulation of wild type virus will result in loss of immunity to VZV in persons who have already had varicella...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28645592/enlarged-encephalo-duro-myo-synangiosis-treatment-for-moyamoya-disease-in-young-children
#18
Wenjun Shen, Bin Xu, Hao Li, Xiaofeng Gao, Yujun Liao, Wei Shi, Rui Zhao, Yi Zhang
OBJECTIVE: To retrospectively evaluate the mid-term therapeutic effect of enlarged encephalo-duro-myo-synangiosis (EDMS) for moyamoya disease (MMD) in young children. METHODS: Seventy-seven children diagnosed with MMD by digital subtraction angiography (DSA) or magnetic resonance angiography (MRA) were treated between January 2011 and December 2014 in our center. Their clinical features, imaging and operative reports were analyzed. RESULTS: Four patients presented with intracerebral hemorrhage while 73 presented with ischemic symptoms...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28640700/cns-tumors-in-neurofibromatosis
#19
Jian Campian, David H Gutmann
Neurofibromatosis (NF) encompasses a group of distinct genetic disorders in which affected children and adults are prone to the development of benign and malignant tumors of the nervous system. The purpose of this review is to discuss the spectrum of CNS tumors arising in individuals with NF type 1 (NF1) and NF type 2 (NF2), their pathogenic etiologies, and the rational treatment options for people with these neoplasms. This article is a review of preclinical and clinical data focused on the treatment of the most common CNS tumors encountered in children and adults with NF1 and NF2...
July 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28634356/an-outbreak-of-echovirus-18-encephalitis-meningitis-in-children-in-hebei-province-china-2015
#20
Xiangpeng Chen, Jingjie Li, Jiayun Guo, Wenbo Xu, Suzhen Sun, Zhengde Xie
No abstract text is available yet for this article.
June 21, 2017: Emerging Microbes & Infections
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