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Brucellosis in childrens

Keziban Aslı Bala, Murat Doğan, Sultan Kaba, Sinan Akbayram, Oktay Aslan, Selami Kocaman, Gülsüm İclal Bayhan, Lokman Üstyol, Nihat Demir
BACKGROUND Our study aimed to demonstrate the frequency of the syndrome of inappropriate ADH secretion (SIADH) and associated factors during the course of brucellosis in children and adolescents. MATERIAL AND METHODS The study included children and adolescents aged 0-18 years old diagnosed with brucellosis between 2012 and 2014. The data were collected from patient charts. The diagnosis of brucellosis was made based on titrations >1:160 in standard Wright tube agglutination tests and/or positive culture tests...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Shahzad Ali, Shamim Akhter, Heinrich Neubauer, André Scherag, Miriam Kesselmeier, Falk Melzer, Iahtasham Khan, Hosny El-Adawy, Asima Azam, Saima Qadeer, Qurban Ali
BACKGROUND: Brucella species occasionally cause spontaneous human abortion. Brucella can be transmitted commonly through the ingestion of raw milk or milk products. The objective of this study was to determine the sero-prevalence of and to identify potential risk factors for brucellosis in pregnant women from Rawalpindi, Pakistan. METHODS: We conducted a cross-sectional study at the Gynecology Outdoor Patient department of the Benazir Bhutto Hospital, Rawalpindi, Pakistan from March to June 2013...
2016: BMC Infectious Diseases
K Venugopal Menon, Tamer Malak Moawad Sorour
BACKGROUND: The prevalence and characteristics of spontaneous spondylodiscitis in the Middle East is unknown. There seems to be an emerging dominance of pyogenic infections over Tuberculosis and Brucellosis. METHODS: Retrospective observational study based on electronic case records of 4 years from a tertiary reference facility in Oman. Case records, microbiology reports, blood reports, imaging studies, histopathology and surgical reports of all spinal infection cases were studied...
August 2, 2016: World Neurosurgery
Kamuran Karaman, Sinan Akbayram, Sultan Kaba, Serap Karaman, Mesut Garipardiç, Ilyas Aydin, Ahmet Fayik Öner
This retrospective study included seven paediatric cases aged from 4 to 14 (10.2±3.4) years with pathologically proved haemophagocytic lymphohistiocytosis from a single institution during 2009 and 2013. Over this time period, 496 patients with brucellosis were diagnosed. None of the patients (3 boys and 4 girls) had a history of any haematologic disorder. All patients had an anamnesis for recently consumed unpasteurised homemade dairy products or had a contact history with sheep and/or cows. The diagnosis of brucellosis was confirmed by standard tube agglutination test in all patients; titres were 1: 1280 in seven patients...
June 1, 2016: Le Infezioni in Medicina
Kamuran Karaman, Sinan Akbayram, Gülsüm I Bayhan, Murat Dogan, Mehmet Parlak, Hatice T Akbayram, Hadi Geylan, Mesut Garipardic, Ahmet F Oner
The aim of the present study was to present the hematologic findings of 622 cases diagnosed with acute brucellosis. Medical records of children with brucellosis, admitted to Yuzuncu Yil University Hospital over a 6-year period, were analyzed retrospectively. Three hundred ninety-seven (63.8%) patients were male and 225 (36.2%) were female. The mean age was 11 years (range, 1 to 16 y). The mean hematologic values were as follows: hemoglobin 9.4 (3.4 to 17) g/dL, hematocrite 28% (12% to 50%), leukopenia 2.8 (1...
August 2016: Journal of Pediatric Hematology/oncology
C Bréhin, S Ray, R Honorat, M-F Prère, A Bicart-See, I Claudet, E Grouteau
Brucellosis is an overlooked infection of widespread geographic distribution. This disease is rarely evoked when assessing unexplained pediatric fever, and only 20-30 cases (children and adults) are confirmed per year. Risk factors for contracting brucellosis are exposure to bodily fluids and consumption of unpasteurized dairy products from infected animals. Most cases of brucellosis are associated with traveling to or importing contaminated goods from endemic areas. Here, we report a case of brucellosis in a 16-month-old patient hospitalized for an acute febrile illness in a French general pediatric ward...
July 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Orli Megged, Bibiana Chazan, Atef Ganem, Abeer Ayoub, Anna Yanovskay, Waheeb Sakran, Dan Miron, Ahuva Dror-Cohen, Yoram Kennes, Svetlana Berdenstein, Daniel Glikman
Two parallel outbreaks of Brucella melitensis infection occurred in 2014 in two geographical areas in Israel. In two medical centers in northern Israel and one medical center in Jerusalem, 102 patients (58 children, 47 adults) were diagnosed with brucellosis. Most patients (N = 76, 72%) were Muslim Arabs, 28 (27%) were Druze, and one was Jewish. The source of infection was often traced to cheese from the Palestinian Authority. Biovar-1 was evident in 98% in northern Israel but only in 42% in Jerusalem. Most common manifestations were fever (82%) and osteoarticular symptoms (49%)...
July 6, 2016: American Journal of Tropical Medicine and Hygiene
Mojtaba Kamali Aghdam, Kambiz Davari, Kambiz Eftekhari
Severe thrombocytopenia with bleeding is rarely reported in children with brucellosis, and recurrent epistaxis is extremely rare. Brucellosis with hemorrhage should be differentiated from viral hemorrhagic fever, malignancy, and other blood disorders. Bone marrow aspiration (BMA) is mandatory to differentiate from other blood diseases. An 8-year-old boy was admitted with recurrent epistaxis, petechiae and purpura on face and extremities and bleeding from the gums. During the hospitalization, he was febrile and complained of muscle pain...
March 2016: Acta Medica Iranica
Soner S Kara, Duygu Kara, Ali Fettah
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease with high mortality. Many disorders can mimic CCHF. It is important to recognize the condition and to perform differential diagnosis in endemic countries. Twenty-one children aged 18 years or less with a preliminary diagnosis of CCHF were retrospectively evaluated. Real-time PCR and a confirmatory indirect immunofluorescence assay for negative results were performed. The diagnoses determined that 9 patients had (42.9%) CCHF; 7 patients had (33.3%) viral upper respiratory tract infections (URTI); 2 patients had (9...
September 2016: Journal of Infection and Public Health
K Sidamonidze, M Ramishvili, I Kalandadze, D Tsereteli, M P Nikolich
In 2009-2013, 851 cases of brucellosis were registered in Georgia. Most cases of brucellosis were found in eastern Georgia (91.3% of cases). Mainly men were infected with brucellosis (81.0%).The age group with the most frequent cases of brucellosis is 30-59 years (48.5%). Brucellosis is rarely found among children(0-4 years - 2.0%, 5-14 years - 8.0%). Brucellosis cases were linked to professional activity; mainly by farmers (33.0% of those infected) and shepherds (27.0%). Biotyping Brucella by microbiological methods alone has limitations, so molecular typing was implemented in this study to confirm species...
October 2015: Georgian Medical News
Arzu Karli, Gulnar Sensoy, Canan Albayrak, Ozlem Koken, Sevgi Cıraklı, Nursen Belet, Davut Albayrak
Presenting with severe thrombocytopenia and pancytopenia is rare in children with brucellosis, and at the beginning it can be misdiagnosed as a hematological or a viral hemorrhagic disease. The follow-ups of 52 patients diagnosed with brucellosis from January, 2008, to December, 2013, in our clinic have shown the following results. Eleven out of these 52 patients revealed the fact that they had pancytopenia at the admission phase. Anemia and leukopenia were defined as hemoglobin levels and leukocyte counts below the standard values in terms of ages, thrombocytopenia as thrombocyte counts below 150,000/mm(3), and severe thrombocytopenia as thrombocyte counts below 20,000/mm(3)...
September 2015: Vector Borne and Zoonotic Diseases
Dan Zhu, Yanling Zhang, Xuemei Zhong, Xin Ma, Huijuan Ning, Yang Yang
OBJECTIVE: To present six cases of Brucella infection in children, analyze the characteristics of the disease, diagnostic and therapeutic process. METHOD: The clinical manifestations, laboratory test results and diagnostic process of 6 confirmed cases of brucellosis seen between 2011-2012 were retrospectively analyzed and domestic and foreign literature was reviewed. RESULT: All the 6 children had a history of either exposure to, travelling to endemic area, or consuming infected lamb/beef...
June 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Sead Ahmetagić, Humera Porobić Jahić, Nada Koluder, Lejla Čalkić, Snježana Mehanić, Eldira Hadžić, Nevzeta Ibrahimpašić, Svjetlana Grgić, Mirela Zirić, Jelena Bajić, Denis Žepić
AIM: To analyse clinical, laboratory and epidemiological characteristics of brucellosis in children in Bosnia and Herzegovina. METHODS: The study included 246 children aged 0-18 years, who were hospitalized in Clinics and Departments for Infectious Diseases in Tuzla, Sarajevo, Banja Luka, Zenica and Bihać in the period 2000-2013, in whom the diagnosis of brucellosis was established based on anamnestic data, clinical features and positive results from blood culture and/or positive results from one of the serological tests...
August 2015: Medicinski Glasnik
Sevil Bilir Goksugur, Mervan Bekdas, Safiye Gurel, Tekin Tas, Esma Gokcen Sarac, Fatih Demircioglul, Erol Kismet
Brucellosis is a zoonotic infection, which is still a major public health concern worldwide. Common clinical findings are usually nonspecific involving fever, arthralgia, myalgia, weakness and malaise. Since none of the symptoms of brucellosis is pathognomonic, it may have a similar course with various multisystemic diseases. In terms of focal involvement, sacroiliitis is the most common musculoskeletal manifestation in adult patients, while it is quite rare in pediatric patients. Blood culture is the gold standard in the diagnosis of brucellosis...
March 2015: Acta Clinica Croatica
Adalet Aypak, Cenk Aypak, Yasemin Bayram
BACKGROUND: Brucellosis produces a variety of non-specific hematological abnormalities. The aim of the present study was to evaluate the hematological findings in childhood brucellosis. METHODS: Medical records of children with brucellosis admitted to a tertiary hospital in a 1 year period, were analyzed retrospectively. RESULTS: Sixty-nine patients (mean age, 14.5 ± 3.3 years) were diagnosed with brucellosis. The most common hematological finding was thrombocytopenia (n = 11, 15...
December 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
Beatrice Chipwaza, Ginethon G Mhamphi, Steve D Ngatunga, Majige Selemani, Mbaraka Amuri, Joseph P Mugasa, Paul S Gwakisa
INTRODUCTION: Bacterial etiologies of non-malaria febrile illnesses have significantly become important due to high mortality and morbidity, particularly in children. Despite their importance, there are few reports on the epidemiology of these diseases in Tanzania, and the true burden of such illnesses remains unknown. This study aimed to identify the prevalence of leptospirosis, brucellosis, typhoid fever and urinary tract infections and their rate of co-infections with malaria. METHODS: A cross-sectional study was conducted at Kilosa district hospital in Tanzania for 6 months...
May 2015: PLoS Neglected Tropical Diseases
Kristine von Bargen, Aurélie Gagnaire, Vilma Arce-Gorvel, Béatrice de Bovis, Fannie Baudimont, Lionel Chasson, Mile Bosilkovski, Alexia Papadopoulos, Anna Martirosyan, Sandrine Henri, Jean-Louis Mège, Bernard Malissen, Jean-Pierre Gorvel
Cervical lymph nodes (CLN) are the first lymph nodes encountered by material taking the oral route. To study their role in orally acquired infections, we analyzed 307 patients of up to 14 years treated in the university clinic of Skopje, Macedonia, for brucellosis, a zoonotic bacterial disease frequently acquired by ingestion of contaminated dairy products. From these children, 36% had lymphadenopathy. Among orally infected children, lymphadenopathy with CLN being the only lymph nodes affected was significantly more frequent as compared to those infected by contact with animals (83% vs...
2014: PloS One
Serdar Gül, Ozgun Kiriş Satilmiş, Baris Ozturk, Mehmet Ilker Gökçe, Ferit Kuscu
Brucellosis is an important public-health problem in Turkey. Children may constitute 20 to 30% of all brucellosis cases in the world, especially in the endemic regions. Data on the seroprevalence of brucellosis in childhood are very limited. In this study, we aimed to evaluate the seroprevalence of brucellosis among a child population. One thousand one hundred and ten subjects were included in the study. Blood samples were collected and tested with Rose Bengal (RB) and standard tube agglutination test (SAT)...
December 2014: Journal of Health, Population, and Nutrition
Abdelhafid Gabli, Amir Agabou, Zahra Gabli
A 31-months study was conducted to elucidate the prevalence of brucellosis in nomadic pastoralists and their goats in two provinces of the eastern Algerian high plateaus. Five hundred eight human and 4955 animal sera were screened with the Rose Bengal plate test and the complement fixation test for confirmation. Uterine fluids from aborting goats were subjected to microbiological analyses to determine the biovars responsible for abortions. The overall seroprevalence was 0.98% among animals and 15.84% among herds...
August 2015: Tropical Animal Health and Production
Mile Bosilkovski, Alfonso J Rodriguez-Morales
Brucellosis is still endemic in many countries in the world, however, having a significantly higher incidence in developing countries. As consequence of travel, risk for children from non-endemic areas would be considerable when visiting developing countries. Then, the purpose of this review is to provide, after a bibliographical search, an update on the main aspects of this disease in the traveler children. For the general practitioner, but particularly for travel medicine practitioner and pediatricians, these clinicoepidemiological considerations should be taken in mind in the differential diagnosis when assessing children returning from travel to brucellosis endemic areas...
2014: Recent Patents on Anti-infective Drug Discovery
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