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https://www.readbyqxmd.com/read/29882233/periocular-co-2-laser-resurfacing-severe-ocular-complications-from-multiple-unintentional-laser-impacts-on-the-protective-metal-eye-shields
#1
Martin J C van Gemert, Paul R Bloemen, Wei-Yong Wang, Cees W M van der Geld, Rudy M M A Nuijts, Hayri Hortoglu, Albert Wolkerstorfer, Daniel M de Bruin, Ton G van Leeuwen, H A Martino Neumann, Martine J Jager
BACKGROUND AND OBJECTIVES: A 36-year-old woman underwent CO2 laser resurfacing for periocular rhytides using protective stainless steel Cox II ocular shields. Immediately after the treatment, corneal lesions were seen in both eyes. The left eye subsequent developed corneal ulceration and scarring, a deformed iris, cataract, and lower eye lashes showing signs of acute burns. The right cornea had a small inferior mid-peripheral superficial lesion and concomitant lower mid-peripheral burned eye lashes...
June 8, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29699800/dosimetric-effects-of-bolus-and-lens-shielding-in-treating-ocular-lymphomas-with-low-energy-electrons
#2
Lori Young, Landon S Wootton, Alan M Kalet, Olga Gopan, Fei Yang, Samuel Day, Michael Banitt, Jay J Liao
Radiation therapy is an effective treatment for primary orbital lymphomas. Lens shielding with electrons can reduce the risk of high-grade cataracts in patients undergoing treatment for superficial tumors. This work evaluates the dosimetric effects of a suspended eye shield, placement of bolus, and varying electron energies. Film (GafChromic EBT3) dosimetry and relative output factors were measured for 6, 8, and 10 MeV electron energies. A customized 5-cm diameter circle electron orbital cutout was constructed for a 6 × 6-cm applicator with a suspended lens shield (8-mm diameter Cerrobend cylinder, 2...
April 23, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29689030/checkpoint-inhibitor-immune-therapy-systemic-indications-and-ophthalmic-side-effects
#3
Lauren A Dalvin, Carol L Shields, Marlana Orloff, Takami Sato, Jerry A Shields
PURPOSE: To review immune checkpoint inhibitor indications and ophthalmic side effects. METHODS: A literature review was performed using a PubMed search for publications between 1990 and 2017. RESULTS: Immune checkpoint inhibitors are designed to treat system malignancies by targeting one of three ligands, leading to T-cell activation for attack against malignant cells. These ligands (and targeted drug) include cytotoxic T-lymphocyte antigen-4 (CTLA-4, ipilimumab), programmed death protein 1 (PD-1, pembrolizumab, nivolumab), and programmed death ligand-1 (PD-L1, atezolizumab, avelumab, durvalumab)...
June 2018: Retina
https://www.readbyqxmd.com/read/29610174/recalcitrant-atopic-keratoconjunctivitis-in-children-a-case-report-and-literature-review
#4
Jing Li, Xiaohui Luo, Hongmin Ke, Lingyi Liang
Atopic keratoconjunctivitis (AKC) is the most severe type of allergic conjunctivitis and may eventually lead to blindness. Although AKC is reported to be more prevalent in adults, we report a child with AKC whose clinical characteristics were not inconsistent with those typically seen in adult patients with AKC, and who was refractory to traditional topical anti-inflammatory and immunosuppressant therapies. An 11-year-old boy presented with a 3-month history of ocular redness and itching and decreased vision for a week in both eyes...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29552271/ocular-injury-in-cosmetic-laser-treatments-of-the-face
#5
REVIEW
Amy Huang, Arianna Phillips, Tony Adar, Andrea Hui
BACKGROUND: The eye is a vulnerable and commonly injured organ in cosmetic laser procedures of the face. Treatment of the eyelids and periorbital areas increases this risk, especially when ocular protection devices are not used or are removed during the procedure. A study has shown that injury from laser epilation of the periocular areas is one of the most common causes of litigation in cutaneous laser surgery. OBJECTIVE: The goal of this review is to determine the causes of ocular injury in cosmetic laser procedures and derive lessons on critical safety elements to prevent future injury...
February 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29443798/clinical-features-imaging-and-natural-history-of-myelinated-retinal-nerve-fiber-layer
#6
Raksha Rao, Elif B Turkoglu, Emil A T Say, Carol L Shields
PURPOSE: To evaluate the natural history of myelinated retinal nerve fiber layer (MRNFL) through clinical features and enhanced depth imaging optical coherence tomography. METHODS: This is a retrospective, noncomparative, case series of patients who underwent thorough clinical examination to document associated ocular and systemic features. Enhanced depth imaging optical coherence tomography was performed when MRNFL was located posteriorly and accessible to imaging...
February 13, 2018: Retina
https://www.readbyqxmd.com/read/29352994/topical-drug-delivery-devices-a-review
#7
REVIEW
Christian J F Bertens, Marlies Gijs, Frank J H M van den Biggelaar, Rudy M M A Nuijts
For the treatment and prevention of ocular diseases, most patients are treated with conventional drug delivery formulations such as eye drops or ointments. However, eye drops and ointments suffer from low patient compliance and low effective drug concentration at the target site. Therefore, new medical devices are being explored to improve drug delivery to the eye. Over the years, various delivery devices have been developed including resorbable devices, oval- and ring-shaped devices, rod-shaped devices, punctum plugs, contact lenses and corneal shields...
March 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29296555/irritant-contact-keratitis-caused-by-the-bodily-fluids-of-a-brown-marmorated-stink-bug
#8
Yi-Syun Shen, Chao-Chien Hu
PURPOSE: The brown marmorated stink bug is native to Asia (China, Taiwan, Japan, and the Korean peninsula). Its bodily fluids are toxic and irritating to the human skin and eyes. Human case reports are rare. Only one report of irritant contact dermatitis has been published. We report a case of irritant contact keratitis resulting from the chemical components of the bodily fluids of the bug. MATERIALS AND METHODS: A case report. RESULTS: A 74-year-old male presented to our emergency department with pain and redness in his right eye, which had been exposed to the bodily fluids of a brown marmorated stink bug...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29232335/endogenous-klebsiella-pneumoniae-endophthalmitis-in-northern-california
#9
Ryan A Shields, Stephen J Smith, Carolyn K Pan, Diana V Do
PURPOSE: To report the clinical features, treatment modalities, and visual outcomes in 12 eyes with endogenous Klebsiella pneumoniae endophthalmitis (EKPE). METHODS: The medical records of all patients diagnosed with EKPE at Stanford Hospital (Palo Alto, CA) and Santa Clara Valley County Hospital (Santa Clara, CA) from January 2000 to March 2017 were retrospectively reviewed. RESULTS: A total of 10 patients (12 eyes) were diagnosed with EKPE...
December 11, 2017: Retina
https://www.readbyqxmd.com/read/29190246/optical-coherence-tomography-angiography-findings-of-deep-capillary-plexus-microischemia-after-intravenous-chemotherapy-for-retinoblastoma
#10
Kareem Sioufi, Emil A T Say, Sandor C Ferenczy, Ann M Leahey, Carol L Shields
PURPOSE: To study changes in the foveal microvascular anatomy using optical coherence tomography angiography (OCTA) after intravenous chemotherapy (IVC) for retinoblastoma (RB). METHODS: A retrospective comparative case-control series included 10 age-matched normal eyes with no documented ocular pathology (control), 10 fellow eyes of patients with unilateral RB treated with IVC (RB fellow), and 10 eyes with extramacular RB in patients with bilateral RB treated with IVC (RB tumor)...
November 22, 2017: Retina
https://www.readbyqxmd.com/read/29098285/risk-of-extraocular-extension-in-eyes-with-retinoblastoma-receiving-intravitreous-chemotherapy
#11
Jasmine H Francis, David H Abramson, Xunda Ji, Carol L Shields, Luiz F Teixeira, Amy C Schefler, Nathalie Cassoux, Doris Hadjistilianou, Jesse L Berry, Shahar Frenkel, Francis L Munier
Importance: The risk of extraocular extension from injecting chemotherapy into eyes with retinoblastoma is minimally understood; however, understanding this risk is important because of the increasing use of intravitreous chemotherapy. Objective: To evaluate the risk of extraocular extension in eyes with retinoblastoma that have received intravitreous chemotherapy injections. Design, Setting, and Participants: This retrospective cohort study was performed in 655 patients at 10 retinoblastoma centers in North and South American, European, Israeli, and Chinese centers...
December 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28937525/choroidal-melanoma-in-phakomatosis-pigmentovascularis-with-klippel-trenaunay-syndrome
#12
Carol L Shields, Maura Di Nicola, Marco Pellegrini, Jerry A Shields
PURPOSE: To describe the relationship of choroidal melanoma with phakomatosis pigmentovascularis in patients with Klippel-Trenaunay syndrome. METHODS: Retrospective review of 5 patients. RESULTS: In all 5 cases, the patient was white and the cutaneous port-wine stain was congenital. The port-wine stain involved the chin (n = 1), jawline (n = 2), lower cheek (n = 1), thorax (n = 5), abdomen (n = 4), upper (n = 4), and lower (n = 3) limb(s)...
September 20, 2017: Retina
https://www.readbyqxmd.com/read/28932485/incontinentia-pigmenti-in-a-child-with-suspected-retinoblastoma
#13
Stephanie J Weiss, Archana Srinivasan, Michael A Klufas, Carol L Shields
BACKGROUND: Incontinentia pigmenti is a rare X-linked dominant syndrome caused by mutation in the NEMO/IKKgamma gene, and characterized by a spectrum of cutaneous, ocular, neurologic and dental abnormalities. In the eye, findings include retinal vascular non-perfusion, occasionally with traction retinal detachment, retinal fibrosis, and retinal pigment epithelium defects. These findings can resemble retinoblastoma, especially when vitreoretinal fibrosis produces leukocoria. CASE REPORT: A 2-month-old girl born full-term presented with leukocoria, suspicious for retinoblastoma...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28910426/optical-coherence-tomography-angiography-features-of-iris-racemose-hemangioma-in-4-cases
#14
Jason L Chien, Kareem Sioufi, Sandor Ferenczy, Emil Anthony T Say, Carol L Shields
Importance: Optical coherence tomography angiography (OCTA) allows visualization of iris racemose hemangioma course and its relation to the normal iris microvasculature. Objective: To describe OCTA features of iris racemose hemangioma. Design, Setting, and Participants: Descriptive, noncomparative case series at a tertiary referral center (Ocular Oncology Service of Wills Eye Hospital). Patients diagnosed with unilateral iris racemose hemangioma were included in the study...
October 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28880986/association-of-disease-location-and-treatment-with-survival-in-diffuse-large-b-cell-lymphoma-of-the-eye-and-ocular-adnexal-region
#15
Aseef H Ahmed, C Stephen Foster, Carol L Shields
Importance: Primary diffuse large B-cell lymphoma (DLBCL) of the ocular region is rare, and the utility of surgery and radiation therapy remains unresolved. Objective: To explore the clinical characteristics and determine factors associated with overall survival in primary vitreoretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL. Design, Setting, and Participants: This retrospective analysis included 396 patients with ophthalmic DLBCL from January 1, 1973, through December 31, 2014, using the Surveillance, Epidemiology, and End Results database...
October 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28877146/eye-protection-survey-of-dermatologists-and-office-staff
#16
David A Pate, Jeremy T Kampp
BACKGROUND: Splash injuries to mucosal membranes during procedures have been well documented in dermatology and carry a potential risk of blood-borne virus transmission. The risk to the ocular mucosa can be minimized with proper eye protection. OBJECTIVE: To examine the prevalence of wearing eye protection during dermatologic procedures by physicians, trainees, and office staff in dermatology. METHODS: A Cross-sectional observational study of US dermatologists, residents, nurses, and medical assistants was performed regarding eye protection during dermatologic procedures...
January 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28875742/medicated-ocular-bandages-and-corneal-health-potential-excipients-and-active-pharmaceutical-ingredients
#17
Ghada Zidan, Ilva D Rupenthal, Carol Greene, Ali Seyfoddin
Corneal blindness can occur due to improper healing of the corneal tissues after induced injury or abrasion which can be accidental, pathogenic, or after corneal surgery. Abnormal regulation of the healing mechanisms can lead to corneal opacity. Reducing inflammation and promoting epithelial wound healing are crucial for scar-free corneal recovery without eyesight complications. Current approaches for corneal wound healing involve amniotic membrane (AM) bandages, bandage contact lenses (BCL), and collagen shields in conjunction with frequent administration of therapeutic eye drops...
March 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28854872/the-functional-head-of-the-cambrian-radiodontan-stem-group-euarthropoda-amplectobelua-symbrachiata
#18
Peiyun Cong, Allison C Daley, Gregory D Edgecombe, Xianguang Hou
BACKGROUND: Segmental composition and homologies of the head of stem-group Euarthropoda have been the foci of recent studies on arthropod origins. An emerging hypothesis suggests that upper-stem group euarthropods possessed a three-segmented head/brain, including an ocular segment (protocerebrum) followed by the deutocerebrum with associated antennae/raptorial limbs and the tritocerebrum, while in the lower stem, head structures of Radiodonta are wholly associated with the protocerebrum and its preceding part...
August 30, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28791065/invisible-shield-review-of-the-corneal-epithelium-as-a-barrier-to-uv-radiation-pathogens-and-other-environmental-stimuli
#19
REVIEW
Hasan Bashir, John T Seykora, Vivian Lee
The ocular surface is comprised of the cornea and conjunctiva, which are structures that not only protect the eye but also enable vision. The corneal epithelium is the most superficial layer of the cornea, and therefore first line of defense against external assaults. Damage to this highly specialized structure could lead to vision loss, making it an important structure to investigate and understand. Here, we conducted a search of the current literature on the mechanisms the corneal epithelium has adapted against three frequent insults: UV-radiation, pathogens, and environmental assaults...
July 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28541267/choroidal-melanoma-sector-melanocytosis-and-retinal-pigment-epithelial-microdetachments-in-birt-hogg-dub%C3%A3-syndrome
#20
Charlotte L Marous, Molly R Marous, R Joel Welch, Jerry A Shields, Carol L Shields
PURPOSE: Birt-Hogg-Dubé Syndrome (BHDS) is a rare autosomal dominant condition that can predispose patients to numerous cutaneous fibrofolliculomas and other cutaneous lesions, pulmonary cysts with spontaneous pneumothorax, and multifocal renal tumors and cancer. The genetic mutations responsible for BHDS are related to tumor suppression and the mammalian target of rapamycin (mTOR) pathway. Previous reports of the ocular findings in BHDS include eyelid fibrofolliculomas, "flecked chorioretinopathy," and one report of choroidal melanoma...
May 22, 2017: Retinal Cases & Brief Reports
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