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Fariba Ghassemi

Siamak Sabour, Fariba Ghassemi
No abstract text is available yet for this article.
October 2016: Retina
Naseh Mohammadi, Fariba Ghassemi, Esfandiar Shojaei, Pardis Moradnejad
PURPOSE: To describe a case of bilateral presumed tuberculous choroiditis which resolved promptly with a short course of antituberculous therapy. CASE REPORT: A 44-year-old lady presented with bilateral visual loss of 8 months'duration. Considering the presence of pan-uveitis, severe macular edema, multifocal leakage on fluorescein angiography, positive tuberculin skin test, and after excluding other diseases, she underwent anti-tuberculous therapy (ATT) for disseminated choroiditis due to presumed ocular tuberculosis...
April 2016: Journal of Ophthalmic & Vision Research
Puran Fadakar, Abolfazl Akbari, Fariba Ghassemi, Gholam Reza Mobini, Masoumeh Mohebi, Manzar Bolhassani, Hoda Abed Khojasteh, Mansour Heidari
Retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. The objective of this study was to investigate the effects of SD-208, TGF-β-RI kinase inhibitor, on the expression of some miRNAs including a miR-17/92 cluster in retinoblastoma cells. Prior to initiate this work, the cell proliferation was studied by Methyl Thiazolyl Tetrazolium (MTT) and bromo-2'-deoxyuridine (BrdU) assays. Then, the expression patterns of four miRNAs (18a, 20a, 22, and 34a) were investigated in the treated SD-208 (0...
June 2016: Acta Medica Iranica
Ramak Roohipoor, Mohammad Riazi-Esfahani, Nazanin Ebrahimiadib, Reza Karkhaneh, Mohammad Zarei, Sara Besharat, Fariba Ghassemi, Mohammad Reza Ostovaneh
PURPOSE: To evaluate the feasibility of screening for retinopathy of prematurity (ROP) by assessing the pupillary response to mydriatics. METHODS: This observational case series included 134 eyes of 67 premature infants with birth weight less than 2,000 grams and gestational age less than 33 weeks. A composite eye drop composed of phenylephrine 1%, tetracaine and tropicamide 0.5% was applied 3 times within 5-minute intervals and pupil diameters were measured. The eyes were examined by experienced ROP specialists using an indirect ophthalmoscope...
October 2015: Journal of Ophthalmic & Vision Research
Ramak Roohipoor, Elaheh Sharifian, Fariba Ghassemi, Mohammad Riazi-Esfahani, Reza Karkhaneh, Masoud Aghsaei Fard, Mohammad Zarei, Bobeck S Modjtahedi, Sasan Moghimi
PURPOSE: To compare choroidal thickness (CT) and retinal thickness (RT) between eyes with proliferative diabetic retinopathy treated with panretinal photocoagulation (PRP) or PRP with intravitreal bevacizumab (PRP + IVB). METHODS: Thirty-three patients with proliferative diabetic retinopathy were randomized to have one eye treated with PRP and the other with PRP + IVB. Change in CT was compared with baseline using enhanced depth imaging-optical coherence tomography at baseline and Months 1, 3, 6, and 10 after treatment...
October 2016: Retina
Reza Karkhaneh, Alireza Khodabande, Mohammad Riazi-Eafahani, Ramak Roohipoor, Fariba Ghassemi, Marjan Imani, Afsar Dastjani Farahani, Nazanin Ebrahimi Adib, Hamidreza Torabi
PURPOSE: To assess the effect of intravitreal bevacizumab for Type 1 retinopathy of prematurity (ROP) in zone II ROP. METHODS: We conducted a randomized clinical trial. Preterm infants with a gestational age less than 34 weeks or birthweight less than 2000 g were examined at 4 weeks chronological age or 31 weeks postmenstrual age (whichever was later). Preterm infants with Zone-II/Stage 2 or 3 and plus disease were included. Eligible infants were randomized to receive either conventional indirect laser therapy or intravitreal bevacizumab injections (0...
September 2016: Acta Ophthalmologica
Fariba Ghassemi, Alireza Khodabande
This manuscript focuses on high-risk factors of metastatic disease in retinoblastoma and evaluation of the current treatments of retinoblastoma. Presence of histopathologic high-risk factors is associated with a higher risk of local recurrence and systemic metastasis. Currently, globe-sparing therapies, including systemic chemotherapy, intra-arterial chemoreduction, intravitreal chemotherapy, focal consolidation, and combination therapies, are being used and investigated actively. Major advances are being made in the diagnosis and management of retinoblastoma that will lead to improved morbidity and mortality rates in patients with retinoblastoma...
2015: Clinical Ophthalmology
Fariba Ghassemi, Hadi Ghadimi, Mojgan Nikdel
PURPOSE: To report a case of primary acquired melanosis (PAM) successfully treated with combined topical mitomycin C and interferon-α2b. CASE REPORT: A 75-year-old man presented with an extensive unilateral pigmented lesion involving 360° of the bulbar conjunctiva, extending to the fornices and palpebral conjunctiva. Map biopsy confirmed PAM with local atypia. Treatment was initiated with mitomycin C 0.04% eye drops for two courses. Although the lesion markedly responded to the treatment, residual lesions justified further therapy...
January 2015: Journal of Ophthalmic & Vision Research
Fariba Ghassemi, Hossein Ghanaati, Reza Karkhaneh, Leila Boujabadi, Seied Zia Tabatabaie, Mohammad Taher Rajabi
BACKGROUND: The management of retinoblastoma remains a challenge to the multidisciplinary team, particularly as treatment affects not only visual outcomes, but also ocular retention and morbidity. Management of retinoblastoma has evolved over the past two decades. OBJECTIVES: To report the result of intra-ophthalmic artery chemotherapy (IAC) for the treatment of refractory and advanced retinoblastoma tumors. PATIENTS AND METHODS: All patients who had failed to respond adequately to previous treatments and six naive patients with advanced retinoblastoma, receiving IAC between 2009 and 2012, were included in this institutional interventional case series...
August 2014: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Mehdi Sharifzadeh, Fariba Ghassemi, Fahimeh Asadi Amoli, Elham Rahmanikhah, Seid Zia Tabatabaie
PURPOSE: To report a case of adult retinoblastoma with a wrong diagnosis of melanoma. CASE REPORT: Herein, we present an adult retinoblastoma case who was misdiagnosed as melanoma in fine-needle aspiration biopsy with intravitreal hemorrhage and later neovascular glaucoma after biopsy. The diagnosis of retinoblastoma was confirmed after enucleation. CONCLUSION: Retinoblastoma should be considered in the differential diagnosis of an intraocular mass in adults, especially when media haziness precludes adequate ophthalmoscopic visualization...
July 2014: Journal of Ophthalmic & Vision Research
Fariba Ghassemi, Carol L Shields, Cesare Pirondini, Ralph C Eagle, Jerry A Shields
PURPOSE: To report a case of retinoblastoma in a child with oculocutaneous albinism (OCA). METHODS: A 24-month-old girl with classic features of OCA developed leukocoria in the left eye. RESULTS: The patient was found to have an endophytic retinoblastoma and an exophytic retinoblastoma, with a total retinal detachment and neovascularization of the iris. Enucle-ation was performed, and histopathology confirmed massive retinoblastoma with optic nerve involvement to the posterior margin of the lamina cribrosa but no choroidal invasion...
2010: Retinal Cases & Brief Reports
Fariba Ghassemi, Hormoz Chams, Siamak Sabour, Reza Karkhaneh, Farzad Farzbod, Mehdi Khodaparast, Parvaneh Vosough
PURPOSE: To discuss the clinical characteristics, treatment and outcomes of germline and non-germline retinoblastoma tumors. METHODS: A retrospective study was performed on retinoblastoma cases from 1979 to 2007. General characteristics of the patients, treatment modalities, histopathological findings and survival were compared in germline versus non-germline cases. RESULTS: We analyzed 557 cases of retinoblastoma with mean age of 32.2±22...
April 2014: Journal of Ophthalmic & Vision Research
Hooshang Faghihi, Fariba Ghassemi, Khalil Ghasemi Falavarjani, Ghasem Saeedi Anari, Mona Safizadeh, Kourosh Shahraki
OBJECTIVE: To present a series of cases with spontaneous closure of traumatic macular hole. DESIGN: Case series. PARTICIPANTS: Six eyes of 6 patients with traumatic macular hole. METHODS: The characteristics of eyes with macular hole secondary to blunt trauma in which the macular hole closed spontaneously without surgical manipulation were reviewed. RESULTS: Patient age range was 13 to 55 years...
August 2014: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Fariba Ghassemi, Fatemeh Bazvand, Seyedeh Simindokht Hosseini
PURPOSE: To report the diagnoses of lesions initially misdiagnosed as ocular melanoma. METHODS: This retrospective study included all new patients who were referred with a presumptive diagnosis of choroidal melanoma to the ocular oncology clinic at Farabi Eye Hospital from January 2009 to December 2012. Each patient underwent a full ocular examination and B-scan ultrasonography by an ocular oncologist. The final diagnosis was made based on a combination of clinical features, fluorescein angiography, indocyanine green angiography, optical coherence tomography, neuroimaging and biopsy when necessary...
January 2014: Journal of Ophthalmic & Vision Research
Mojtaba Abrishami, Fariba Ghassemi, Zakieh Vahedian
A 14-year-old boy presented with a 6-month history of small white masses in his right eye. Examination revealed a white floating fluffy lesion and 2 vegetative hornlike white lesions originating at the periphery of the iris. On ultrasound biomicroscopy, a normal echogenic mass was detected on the inferior iris root and angle, with no posterior chamber or cilliary body involvement. Histopathology following an excisional biopsy revealed keratinous material. There was no recurrence during 10 months of follow-up...
June 2014: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Fariba Ghassemi, Carol L Shields, Hadi Ghadimi, Alireza Khodabandeh, Ramak Roohipoor
IMPORTANCE: Demonstrating the usefulness and complications of multiagent intravitreal chemotherapy is necessary for successful treatment in patients with recalcitrant vitreous seeding of retinoblastoma. OBJECTIVE: To determine the efficacy and complications of combined intravitreal chemotherapy (melphalan hydrochloride and topotecan hydrochloride) for viable vitreous seeding from retinoblastoma. DESIGN, SETTING, AND PARTICIPANTS: This retrospective study was conducted in a hospital setting...
August 2014: JAMA Ophthalmology
Fariba Ghassemi, Marjan Akbari-Kamrani
PURPOSE: To report two cases of retinitis pigmentosa (RP) associated with vasoproliferative tumors (VPTs) and Coats-like fundus. CASE REPORTS: Two patients with RP presented with recent loss of vision due to combined VPTs and Coats-like retinal vascular alterations. One patient had two VPTs with adjacent capillary nonperfusion, telangiectasia and aneurysmal vascular changes in one eye. The other patient had prominent VPT with Coats-like retinal vascular alterations in both eyes...
July 2013: Journal of Ophthalmic & Vision Research
Fariba Ghassemi, Nazanin Ebrahimiadib, Ramak Roohipoor, Sasan Moghimi, Fateme Alipour
PURPOSE: To evaluate changes of retinal nerve fiber layer (RNFL) thickness after panretinal photocoagulation (PRP) in red versus green laser-treated eyes. PROCEDURE: This is a prospective, randomized, fellow-eye controlled clinical trial conducted on 60 eyes of 30 patients (mean age 52.3 ± 7.8 years; 57% male) with early- to high-risk proliferative diabetic retinopathy type II diabetes who received standard red or green laser treatment. Scanning laser polarimetry (GDx) was performed to evaluate RNFL thickness at baseline and at week 6...
2013: Ophthalmologica. Journal International D'ophtalmologie
Fariba Ghassemi, Fahimeh Asadi Amoli
The aim of this study is to evaluate the pathological findings of the eye after intravitreal melphalan for viable vitreous seeding from retinoblastoma. All enucleated eyes receiving an intravitreal injection of melphalan (10-50 μg in 0.05 cc) were evaluated for histological changes. Of 25 treated cases, 8 eyes needed enucleation because of phthisis, parent request, or new tumor development. One of the cases was excluded from the study because of a history of intra-arterial chemotherapy with melphalan. There was no case of needle-site scleral involvement by retinoblastoma cells...
June 2014: International Ophthalmology
Fariba Ghassemi, Hadi Ghadimi, Fahimeh Asadi Amoli, Mohammad Riazi Esfahani, Vida Tavakoli, Ghassemi Fariba
A 4-year-old boy presented with unilateral endophthalmitis and echography revealed an abscess in the vitreous cavity. A pars plana vitrectomy with intravitreal antibiotic injections was performed with a presumed diagnosis of endophthalmitis; however, the patient returned after 10 days with fibrin reaction in the anterior chamber, iris nodules and cataract. The vitreous sample from the vitrectomy showed Toxoplasma gondii parasite, so he was treated with intravitreal clindamycin and lensectomy. The postoperative fundus examination revealed multifocal white patches with calcified deposits and cytology proved the diagnosis of retinoblastoma...
February 2014: International Ophthalmology
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