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interheart study

Philip Joseph, Salim Yusuf, Shun Fu Lee, Quazi Ibrahim, Koon Teo, Sumathy Rangarajan, Rajeev Gupta, Annika Rosengren, Scott A Lear, Alvaro Avezum, Patricio Lopez-Jaramillo, Sadi Gulec, Afzalhussein Yusufali, Jephat Chifamba, Fernando Lanas, Rajesh Kumar, Noushin Mohammadifard, Viswanathan Mohan, Prem Mony, Annamarie Kruger, Xu Liu, Baoxia Guo, Wenqi Zhao, Youzhu Yang, Rajamohanan Pillai, Rafael Diaz, Ambigga Krishnapillai, Romaina Iqbal, Rita Yusuf, Andrzej Szuba, Sonia S Anand
OBJECTIVE: To evaluate the performance of the non-laboratory INTERHEART risk score (NL-IHRS) to predict incident cardiovascular disease (CVD) across seven major geographic regions of the world. The secondary objective was to evaluate the performance of the fasting cholesterol-based IHRS (FC-IHRS). METHODS: Using measures of discrimination and calibration, we tested the performance of the NL-IHRS (n=100 475) and FC-IHRS (n=107 863) for predicting incident CVD in a community-based, prospective study across seven geographic regions: South Asia, China, Southeast Asia, Middle East, Europe/North America, South America and Africa...
October 24, 2017: Heart: Official Journal of the British Cardiac Society
Ruohua Yan, Wei Li, Lu Yin, Yang Wang, Jian Bo
BACKGROUND: Most cardiovascular diseases occur in low- and middle-income regions of the world, but the socioeconomic distribution within China remains unclear. Our study aims to investigate whether the prevalence of cardiovascular diseases differs among high-, middle-, and low-income regions of China and to explore the reasons for the disparities. METHODS AND RESULTS: We enrolled 46 285 individuals from 115 urban and rural communities in 12 provinces across China between 2005 and 2009...
February 6, 2017: Journal of the American Heart Association
Yan-Yi Cheung, Bee-Choo Tai, Germaine Loo, See-Meng Khoo, Karen Yin-Phoon Cheong, Ferran Barbe, Chi-Hang Lee
There is increasing awareness that health screening may prevent some acute coronary events. Yet, obstructive sleep apnea (OSA) is seldom screened for and its relation with coronary risk markers is not well established. Consecutive adults (n = 696) enrolled in a cardiovascular health screening program were approached to determine the feasibility of incorporating OSA screening. Screening included questionnaires and a home-based sleep study. High-sensitivity C-reactive protein was the primary coronary risk marker, and other laboratory- and exercise treadmill-based markers were also reported...
April 1, 2017: American Journal of Cardiology
I Noor Hassim, M R Norazman, M Diana, Y Khairul Hazdi, I Rosnah
INTRODUCTION: Cardiovascular disease (CVD) caused significant burden to Malaysia as it accounted for 36% of total deaths. This study aims to evaluate the burden of cardiovascular risk factors among Malaysian adult and assess the difference between urban and rural population in the selected communities. METHODS: This study is part of the ongoing Prospective Urban Rural Epidemiology (PURE) database, whereby the baseline data were collected since June 2008. CVD risk was measured using INTERHEART risk score which comprised of eleven risk factors i...
December 2016: Medical Journal of Malaysia
Xueli Jiang, Lu Yin, Yang Wang, Wei Li, Yuqing Zhang
OBJECTIVE: We aimed to study whether there was a blood pressure range that was positively associated with stroke or coronary heart disease compared with other levels in the so-called normotensives with or without diabetes mellitus and intermediate or high risk-factor burden. DESIGN AND METHOD: We enrolled 42959 persons aged 35-70 years old between 2005 and 2009 from 70 rural and 45 urban communities in China, and assessed their cardiovascular risk-factor burden using the validated INTERHEART Risk Score...
September 2016: Journal of Hypertension
Andrew Smyth, Martin O'Donnell, Pablo Lamelas, Koon Teo, Sumathy Rangarajan, Salim Yusuf
BACKGROUND: Physical exertion, anger, and emotional upset are reported to trigger acute myocardial infarction (AMI). In the INTERHEART study, we explored the triggering association of acute physical activity and anger or emotional upset with AMI to quantify the importance of these potential triggers in a large, international population. METHODS: INTERHEART was a case-control study of first AMI in 52 countries. In this analysis, we included only cases of AMI and used a case-crossover approach to estimate odds ratios for AMI occurring within 1 hour of triggers...
October 11, 2016: Circulation
Allan D Sniderman, Shofiqul Islam, Matthew McQueen, Michael Pencina, Curt D Furberg, George Thanassoulis, Salim Yusuf
BACKGROUND: Higher concentrations of the apolipoprotein B (apoB) lipoproteins increase the risk of cardiovascular disease. However, whether the risk associated with apoB lipoproteins varies with age has not been well examined. METHODS AND RESULTS: We determined the associations for total cholesterol, low-density lipoprotein (LDL)-cholesterol (LDL-C), non-high-density lipoprotein-cholesterol (non-HDL-C), apoB, apolipoprotein A-I (apoA-I), and HDL-cholesterol (HDL-C) with myocardial infarction at different ages in 11 760 controls and 8998 myocardial infarction cases of the INTERHEART Study...
October 13, 2016: Journal of the American Heart Association
Philip G Joseph, Guillaume Pare, Senay Asma, James C Engert, Salim Yusuf, Sonia S Anand
BACKGROUND: Myocardial infarction (MI) risk varies by ethnicity, although the influence of genetic factors remains unclear. Using a genetic risk score (GRS), we examined the association between 25 coronary artery disease (CAD)-related single nucleotide polymorphisms and MI across 6 ethnic groups. METHODS: We studied 8556 participants in the INTERHEART case-control study from 6 ethnic groups: Europeans, South Asians, Southeast Asians, Arabs, Latin Americans, and Africans...
December 2016: Canadian Journal of Cardiology
Xueli Jiang, Lu Yin, Yang Wang, Wei Li, Yuqing Zhang
OBJECTIVE: We aimed to study whether there was a blood pressure range that was positively associated with stroke or coronary heart disease compared with other levels in the so-called normotensives with or without diabetes mellitus and intermediate or high risk-factor burden. DESIGN AND METHOD: We enrolled 42959 persons aged 35-70 years old between 2005 and 2009 from 70 rural and 45 urban communities in China, and assessed their cardiovascular risk-factor burden using the validated INTERHEART Risk Score...
September 2016: Journal of Hypertension
Aishwarya L Vidyasagaran, Kamran Siddiqi, Mona Kanaan
OBJECTIVE: The purpose of this study was to assess the risk of ischaemic heart disease (IHD) and stroke (non-fatal and fatal) among adult ever-users of smokeless tobacco (ST). DESIGN: The study design involved a systematic review and meta-analysis of observational studies. METHODS: Data sources for the review included key electronic databases and reference lists. Studies were included based on design (cohort or case-control), exposure (exclusive use of ST or adjusted for smoking), and outcome (non-fatal and fatal IHD and stroke)...
June 2, 2016: European Journal of Preventive Cardiology
I Gouni-Berthold, H K Berthold
Cardiovascular disease (CVD) is a leading cause of death for both women and men. Common traditional risk factors for CVD, such as hypercholesterolemia, hypertension and smoking have a high prevalence in women and in some cases a greater health impact compared with men. Nevertheless, risk factors are treated less often and less aggressively in women than in men, partly due to decreased awareness on the part of public health opinion makers, patients and physicians. About seventy five percent of all coronary heart disease deaths among women could be avoided if CVD risk factors like hypercholesterolemia, hypertension and smoking are adequately treated...
2015: Current Medicinal Chemistry
Kamran Siddiqi, Sarwat Shah, Syed Muslim Abbas, Aishwarya Vidyasagaran, Mohammed Jawad, Omara Dogar, Aziz Sheikh
BACKGROUND: Smokeless tobacco is consumed in most countries in the world. In view of its widespread use and increasing awareness of the associated risks, there is a need for a detailed assessment of its impact on health. We present the first global estimates of the burden of disease due to consumption of smokeless tobacco by adults. METHODS: The burden attributable to smokeless tobacco use in adults was estimated as a proportion of the disability-adjusted life-years (DALYs) lost and deaths reported in the 2010 Global Burden of Disease study...
2015: BMC Medicine
Shuchi Anand, Roopa Shivashankar, Mohammed K Ali, Dimple Kondal, B Binukumar, Maria E Montez-Rath, Vamadevan S Ajay, R Pradeepa, M Deepa, Ruby Gupta, Viswanathan Mohan, K M Venkat Narayan, Nikhil Tandon, Glenn M Chertow, Dorairaj Prabhakaran
India is experiencing an alarming rise in the burden of noncommunicable diseases, but data on the incidence of chronic kidney disease (CKD) are sparse. Using the Center for Cardiometabolic Risk Reduction in South Asia surveillance study (a population-based survey of Delhi and Chennai, India) we estimated overall, and age-, sex-, city-, and diabetes-specific prevalence of CKD, and defined the distribution of the study population by the Kidney Disease Improving Global Outcomes (KDIGO) classification scheme. The likelihood of cardiovascular events in participants with and without CKD was estimated by the Framingham and Interheart Modifiable Risk Scores...
July 2015: Kidney International
S L M A Beeres
No abstract text is available yet for this article.
November 2004: Netherlands Heart Journal
Fernando Lanas, Pamela Serón, Alejandra Lanas
Cardiovascular diseases are the leading cause of death in Latin America, with ischemic heart disease as the principal cause in most countries. Risk factors for cardiovascular disease are highly prevalent in the region, but there are international variations in the pattern and level of risk factors. Overweight and obesity are increasing. In the 2012 Mexican National Survey, overweight or obesity was found in 64.9% of men and 73% of women, and they were strongly associated with sedentarism. The most characteristic dyslipidemia abnormality in the region is low high-density lipoprotein cholesterol, followed by elevated low-density lipoprotein cholesterol and increased levels of triglycerides...
December 2013: Global Heart
Richard Kones, Umme Rumana
This article presents core epidemiological studies that establish the basis for cardiovascular prevention strategies. The results of the classic INTERHEART and INTERSTROKE studies that delineated population-attributed risk for myocardial infarction and stroke are described. Differences in the levels or types of prevention-primordial, primary, and secondary-lead to the concept that risk occurs on a continuum throughout life with great variability, beginning in infancy. Any meaningful and sustained reduction in cardiovascular risk must begin in childhood, as habits formed early in life have an impact for decades...
August 2014: Hospital Practice (Minneapolis)
Darryl P Leong, Andrew Smyth, Koon K Teo, Martin McKee, Sumathy Rangarajan, Prem Pais, Lisheng Liu, Sonia S Anand, Salim Yusuf
BACKGROUND: Although moderate alcohol use is associated with protection against myocardial infarction (MI), it is not known whether this effect is generalizable to populations worldwide. It is also uncertain whether differences in the pattern of alcohol use (and in particular heavy episodic consumption) between different regions negate any beneficial effect. METHODS AND RESULTS: We included 12 195 cases of first MI and 15 583 age- and sex-matched controls from 52 countries...
July 29, 2014: Circulation
Dongfang Xie, Wei Li, Yang Wang, Hongqiu Gu, Koon Teo, Lisheng Liu, Salim Yusuf
BACKGROUND: Less sleep time and snoring have been associated with cardiovascular disease (CVD) risk in Western populations; however, few studies have evaluated the different aspects of sleep duration and snoring frequency in relation to CVD, and this association has not been examined in China. The present study aimed to address the relation between sleep duration, snoring frequency and risk of acute myocardial infarction (AMI) in China population. METHODS: We conducted a hospital-based case-control study...
2014: BMC Public Health
Guang Hao, Wei Li, Koon Teo, Xingyu Wang, Jingang Yang, Yang Wang, Lisheng Liu, Salim Yusuf
We assessed the association between tea consumption and acute myocardial infarction (AMI) using INTERHEART China data. Cases (n = 2909) and controls (n = 2947) were randomly selected and frequency matched by age and sex. Participants who drank tea ≥4 cups/d had a significantly higher risk of AMI than tea nondrinkers; odds ratio (OR) was 1.29 (95% confidence interval [CI]: 1.03-1.61) compared with tea nondrinkers. A similar trend was found in green tea drinkers; OR was 1.52 (95% CI: 1.13-2.05) in the participants who drank 3 cups/d and 1...
March 2015: Angiology
Swneke D Bailey, Changchun Xie, Guillaume Paré, Alexandre Montpetit, Viswanathan Mohan, Salim Yusuf, Hertzel Gerstein, James C Engert, Sonia S Anand
AIMS/HYPOTHESIS: Dyslipidaemia, a common feature of type 2 diabetes, is characterised by an increase in atherogenic particles, quantifiable through apolipoprotein B (ApoB) levels. Genetic studies of lipid levels have focused on Europeans; a study in South Asians could identify novel genes. METHODS: We tested 31,739 single nucleotide polymorphisms (SNPs) from ∼ 2,000 genes in 2,573 South Asians from the epidemiological arm of the Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication (DREAM) study (EpiDREAM) for association with ApoB and we tested two novel associations for replication in 1,181 South Asians from the INTERHEART case-control study...
April 2014: Diabetologia
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