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https://www.readbyqxmd.com/read/28212313/chemoprevention-of-rat-mammary-carcinogenesis-by-apiaceae-spices
#1
Farrukh Aqil, Jeyaprakash Jeyabalan, Radha Munagala, Srivani Ravoori, Manicka V Vadhanam, David J Schultz, Ramesh C Gupta
Scientific evidence suggests that many herbs and spices have medicinal properties that alleviate symptoms or prevent disease. In this study, we examined the chemopreventive effects of the Apiaceae spices, anise, caraway, and celery seeds against 17β-estrogen (E2)-mediated mammary tumorigenesis in an ACI (August-Copenhagen Irish) rat model. Female ACI rats were given either control diet (AIN 93M) or diet supplemented with 7.5% (w/w) of anise, caraway, or celery seed powder. Two weeks later, one half of the animals in each group received subcutaneous silastic implants of E2...
February 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28210221/pharmacogenomic-characterization-and-isobologram-analysis-of-the-combination-of-ascorbic-acid-and-curcumin-two-main-metabolites-of-curcuma-longa-in-cancer-cells
#2
Edna Ooko, Onat Kadioglu, Henry J Greten, Thomas Efferth
Curcuma longa has long been used in China and India as anti-inflammatory agent to treat a wide variety of conditions and also as a spice for varied curry preparations. The chemoprofile of the Curcuma species exhibits the presence of varied phytochemicals with curcumin being present in all three species but AA only being shown in C. longa. This study explored the effect of a curcumin/AA combination on human cancer cell lines. The curcumin/AA combination was assessed by isobologram analysis using the Loewe additivity drug interaction model...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28199150/development-and-validation-of-a-cultural-method-for-the-detection-and-isolation-of-salmonella-in-cloves
#3
Guodong Zhang, Laila Ali, Vikas Gill, Aparna Tatavarthy, Xiaohong Deng, Lijun Hu, Eric W Brown, Thomas S Hammack
Detection of Salmonella in some spices, such as cloves, remains a challenge due to their inherent antimicrobial properties. The purpose of this study was to develop an effective detection method for Salmonella from spices using cloves as a model. Two clove varieties, Ceylon and Madagascar, were used in the study. Cloves were inoculated with Salmonella enterica subsp. enterica serotypes Montevideo, Typhimurium, or Weltevreden at about 1, 3, or 6 log CFU/25 g. Two test portion sizes, 10 and 25 g, were compared...
February 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28194454/in-vitro-genotoxicity-of-carcinogenic-asarone-isomers
#4
S Haupenthal, K Berg, M Gründken, S Vallicotti, M Hemgesberg, K Sak, D Schrenk, M Esselen
The present study focused on genotoxic properties of the carcinogenic phenylpropanoids α-asarone and β-asarone, which are found in several herbs and spices, such as Acorus calamus or Acorus gramineus. Cytotoxic and genotoxic effects were determined in human liver carinoma HepG2 cells, in hamster lung fibroblast V79 cells and in human cytochrome P450 1A2 and human sulfotransferase 1C2 transfected V79 cells (tV79). The Alamar blue assay was used to measure cytotoxicity of both isomers prior to the identification of DNA damaging properties by single cell gel electrophoresis (comet assay)...
February 14, 2017: Food & Function
https://www.readbyqxmd.com/read/28191705/microbial-diversity-of-different-modified-atmosphere-packed-pot-stewed-duck-wings-products-during-8%C3%A2-c-storage
#5
K Ye, M Liu, J Liu, J Jiang, C Guo
: The objective of this study was to investigate the effect of spices and packaging films on the bacterial dynamics of pot-stewed duck wings (PSDW) during storage at 8°C. The results showed that spices added at a 1 : 1 ratio (weight ratio of pungent spices and fragrant spices) could delay the lag period of bacterial growth and extend the shelf-life of PSDW. Denaturing Gel Gradient Electrophoresis (DGGE) analysis indicated that the predominant bacteria in PSDW at the end of storage were Weisella hellenica, Weisella diestrammenae, Staphylococcus equorum and Streptococcus parauberis, and spices added at a 1 : 1 ratio showed better inhibition for bacteria at the end of storage, except for W...
March 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28187327/staphylococcal-ecosystem-of-kitoza-a-traditional-malagasy-meat-product
#6
Angela Ratsimba, Sabine Leroy, Jean Paul Chacornac, Danielle Rakoto, Elodie Arnaud, Victor Jeannoda, Régine Talon
Kitoza is a traditional meat product from Madagascar manufactured with strips of pork or beef. The process includes a first step of salting and mixing with spices followed by sun-drying or smoking step. As salting and drying select coagulase-negative staphylococci (CNS), our aim was to identify the CNS species in kitoza with the objective in the future of developing indigenous starters. Microbial analyses revealed that the only pathogenic bacterium enumerated was Staphylococcus aureus, which was found in 54% of the samples...
February 2, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28166943/cold-adaptive-thermogenesis-following-consumption-of-certain-pungent-spice-principles-a-validation-study
#7
Chaitanya Pandit, K R Anilakumar
Identifying a means to activate or potentiate thermogenic mechanisms through ingestion of dietary compounds have important implications in cold endurance and survival. Although many reports discuss the thermogenic potential of spices, it is surprising that none of the studies verify whether consumption of spices can improve cold endurance. In this study, we have attempted to evaluate if ingestion of certain spices can activate heat-generating mechanisms in the body such that a fall in. core body temperature (CBT) can be delayed or prevented when faced with a cold challenge...
February 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28162792/synthetic-pot-not-your-grandfather-s-marijuana
#8
REVIEW
Benjamin M Ford, Sherrica Tai, William E Fantegrossi, Paul L Prather
In the early 2000s in Europe and shortly thereafter in the USA, it was reported that 'legal' forms of marijuana were being sold under the name K2 and/or Spice. Active ingredients in K2/Spice products were determined to be synthetic cannabinoids (SCBs), producing psychotropic actions via CB1 cannabinoid receptors, similar to those of Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the primary active constituent in marijuana. Often abused by adolescents and military personnel to elude detection in drug tests due to their lack of structural similarity to Δ(9)-THC, SCBs are falsely marketed as safe marijuana substitutes...
January 27, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/28152080/nox1-and-nox4-are-required-for-the-differentiation-of-mouse-f9-cells-into-extraembryonic-endoderm
#9
Benjamin J Dickson, Mohamed I Gatie, Danielle M Spice, Gregory M Kelly
Mouse F9 cells differentiate to primitive endoderm (PrE) when treated with retinoic acid (RA). Differentiation is accompanied by increased reactive oxygen species (ROS) levels, and while treating F9 cells with antioxidants attenuates differentiation, H2O2 treatment alone is sufficient to induce PrE. We identified the NADPH oxidase (NOX) complexes as candidates for the source of this endogenous ROS, and within this gene family, and over the course of differentiation, Nox1 and Nox 4 show the greatest upregulation induced by RA...
2017: PloS One
https://www.readbyqxmd.com/read/28143589/protective-effect-of-curcuma-longa-l-extract-on-ccl4-induced-acute-hepatic-stress
#10
Geum-Hwa Lee, Hwa-Young Lee, Min-Kyung Choi, Han-Wool Chung, Seung-Wook Kim, Han-Jung Chae
BACKGROUND: The Curcuma longa L. (CLL) rhizome has long been used to treat patients with hepatic dysfunction. CLL is a member of the ginger family of spices that are widely used in China, India, and Japan, and is a common spice, coloring, flavoring, and traditional medicine. This study was performed to evaluate the hepatoprotective activity of CLL extract and its active component curcumin in an acute carbon tetrachloride (CCl4)-induced liver stress model. METHODS: Acute hepatic stress was induced by a single intraperitoneal injection of CCl4 (0...
February 1, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28134988/the-essential-oil-from-the-fruits-of-the-brazilian-spice-xylopia-sericea-a-st-hil-presents-expressive-in-vitro-antibacterial-and-antioxidant-activity
#11
Renata de F Mendes, Nícolas de C C Pinto, Josiane M da Silva, Jucélia B da Silva, Raquel C Dos S Hermisdorf, Rodrigo L Fabri, Luciana M Chedier, Elita Scio
OBJECTIVES: The aims of this study were to investigate the chemical composition and the antioxidant activity and antibacterial activity of the essential oil of Xylopia sericea fruits (OXS). The fruits of this species are popularly used for medicinal purposes, and as a condiment in food preparation. METHODS: The chemical composition of OXS was analysed by GC/MS. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) scavenging, β-carotene/linoleic acid bleaching and phosphomolybdenum and thiobarbituric acid-reactive substance (TBARS) assays were used to evaluate the antioxidant activity...
January 30, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28129008/curcumin-and-turmeric-modulate-the-tumor-promoting-effects-of-iron-in-vitro
#12
Donald J Messner, Todd Robinson, Kris V Kowdley
Free or loosely chelated iron has tumor-promoting properties in vitro. Curcumin, a polyphenol derived from the food spice turmeric (Curcuma longa), is a potent antioxidant that binds iron. The primary aim of this study was to investigate whether curcuminoids prevent tumor-promoting effects of iron in T51B cells, a non-neoplastic rat liver epithelial cell line. Purified curcuminoids (curcumin) or a standardized turmeric extract similarly reduced oxidative stress and cytotoxicity associated with iron overload (IC50 values near 10 μM, P < 0...
January 27, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28124597/pimping-up-drugs-recovered-superannuated-and-under-exploited-drugs-an-introduction-to-the-basics-of-drug-reprofiling
#13
Suzanne Jane Dilly, George Stephen Morris
Drug development has moved along way forward from the days of with doctors peddling cauldrons of herbs and spices, however the process can still miss opportunities for full exploitation of a drug's potential. Drug reprofiling provides a chance for an established or a forgotten drug to move into a new area of therapy, whether related to the known effects or in a completely new area. In an era of environmental awareness and spiraling costs for traditional drug development, a strategy to squeeze every benefit out of drugs with known safety, tolerability and pharmacological parameters must be a strategically sound desire...
January 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28118079/sugar-and-spice-and-potassium-channel-modulation
#14
Irwin B Levitan
No abstract text is available yet for this article.
January 24, 2017: Channels
https://www.readbyqxmd.com/read/28115093/%C3%AE%C2%BA-carrageenan-an-effective-drug-carrier-to-deliver-curcumin-in-cancer-cells-and-to-induce-apoptosis
#15
Malairaj Sathuvan, Ramar Thangam, Mani Gajendiran, Raju Vivek, Sengottuvelan Balasubramanian, Subramani Nagaraj, Palani Gunasekaran, Balaraman Madhan, Ramasamy Rengasamy
The current study is to develop a natural drug carrier with seaweed derived polymers namely κ-Carrageenan (κ-Car) for drug delivery applications. κ-Car is a natural polysaccharide which derived from edible red seaweeds, they are easily available, non-toxic, cost effective, biodegradable and biocompatible nature. Curcumin (Cur) is a yellow-orange polyphenol existing in turmeric, which is predominantly used as spice and food coloring agent. The ultimate use of polymeric composites, especially those composed of natural polymers, has become a very interesting approach in recent drug delivery applications, due to their non-toxicity and biological origin...
March 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28111973/efficacy-of-crocin-and-safranal-as-protective-agents-against-genotoxic-stress-induced-by-gamma-radiation-urethane-and-procarbazine-in-mice
#16
A Koul, S K Abraham
Crocin (CRO) and safranal (SAF) are bioactive constituents of saffron (dried stigma of Crocus sativus flower), an expensive spice with medicinal properties. Aqueous extract of saffron is known for its antigenotoxic effect against environmental genotoxins/carcinogens. However, there is need to identify saffron constituents responsible for this antigenotoxic effect. The aim of our investigation was to ascertain the role of CRO and SAF as inhibitors of in vivo genotoxic stress. For this purpose, Swiss albino mice were pretreated with CRO (50-mg/kg body weight (bw))/SAF (0...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28110126/effect-of-supplementation-with-linseed-or-a-blend-of-aromatic-spices-and-time-on-feed-on-fatty-acid-composition-meat-quality-and-consumer-liking-of-meat-from-lambs-fed-dehydrated-alfalfa-or-corn
#17
C E Realini, G Bianchi, O Bentancur, G Garibotto
Cross-bred lambs (n=72) were fed finishing diets using a factorial arrangement of treatments: BASAL DIET (alfalfa pellets or corn), SUPPLEMENT (none, linseed or aromatic spices), TIME ON FEED (41 or 83days). Carcass and meat quality traits, fatty acid composition, color stability and consumer liking were determined. Feeding alfalfa improved sensory ratings and fatty acid composition of lamb. However, corn or longer alfalfa feeding would be recommended if heavier and fatter carcasses are sought. Consumer liking and fatty acid composition of lamb were improved with addition of spices and linseed, respectively...
December 29, 2016: Meat Science
https://www.readbyqxmd.com/read/28107947/surface-enhanced-raman-spectroscopy-sers-as-a-method-for-the-toxicological-analysis-of-synthetic-cannabinoids
#18
Thaddeus Mostowtt, Bruce McCord
Synthetic cannabinoids (K2, spice) present problems in forensic investigations because standard presumptive methods, such as immunoassays, are insufficiently specific for the wide range of potential target compounds. This issue can lead to problems with low sensitivity and yield false negative results. A potential solution to this problem is surface enhanced Raman spectroscopy (SERS). In this study we demonstrate the analysis of a set of structurally similar synthetic cannabinoids using SERS. The procedure involves mixing the analyte with gold nanoparticles prepared in a solution containing alkali or alkaline earth salt solutions...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107417/is-variety-the-spice-of-life-an-experimental-investigation-into-the-effects-of-species-richness-on-self-reported-mental-well-being
#19
Lukas J Wolf, Sophus Zu Ermgassen, Andrew Balmford, Mathew White, Netta Weinstein
Losses in biodiversity and trends toward urbanisation have reduced people's contact with biodiverse nature, yet the consequences for mental well-being are not well understood. Here, we demonstrate that greater plant and animal species richness in isolation causes an improvement in mental well-being. To do so, the present research experimentally manipulated species richness and assessed widely-used indicators of mental well-being. Participants viewed short videos of either high or low tree (Study 1) or bird (Study 2) species richness and reported on positive (i...
2017: PloS One
https://www.readbyqxmd.com/read/28105786/development-of-a-reference-database-for-assessing-dietary-nitrate-in-vegetables
#20
Lauren C Blekkenhorst, Richard L Prince, Natalie C Ward, Kevin D Croft, Joshua R Lewis, Amanda Devine, Sujata Shinde, Richard J Woodman, Jonathan M Hodgson, Catherine P Bondonno
SCOPE: Nitrate from vegetables improves vascular health with short term intake. Whether this translates into improved long term health outcomes has yet to be investigated. To enable reliable analysis of nitrate intake from food records there is a strong need for a comprehensive nitrate content of vegetables database. METHODS AND RESULTS: A systematic literature search (1980-2016) was performed using Medline, Agricola and CAB abstracts databases. The nitrate content of vegetables database contains 4237 records from 255 publications with data on 178 vegetables and 22 herbs and spices...
January 19, 2017: Molecular Nutrition & Food Research
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