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https://www.readbyqxmd.com/read/28102941/synthesis-of-primaquine-glyco-conjugates-as-potential-tissue-schizontocidal-antimalarial-agents
#1
Chandra S Azad, Mridula Saxena, Arif J Siddiqui, Jyoti Bhardwaj, Sunil K Puri, Guru P Dutta, Nity Anand, Anil K Saxena
Primaquine (PQ) is the only drug used to prevent relapse of malaria due to P. vivax and P. ovale, by eradicating the dormant liver form of the parasite (hypnozoites). The side effects associated with PQ limits is uses in treatment of malaria. To overcome the premature oxidative deamination and to increase the life span of drug in the biological system the novel glyco-conjugates of PQ were synthesized by coupling of primaquine with hexoses in phosphate buffer. The saccharide part of the hybrid molecules thought to be direct the drug to the liver, where hypnozoites resides...
January 19, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28095566/prospective-evaluation-of-the-safety-and-efficacy-of-a-1060-nm-large-spot-size-vacuum-assisted-hair-removal-diode-laser-system-in-asian-pacific-fitzpatrick-s-skin-types-iv-v-patients
#2
Sushil T Tahiliani, Harsh S Tahiliani
Laser-based photoepilation of dark skin types demands a delicate combination of appropriate light wavelengths and spot size to achieve optimal epidermal-to-follicular energy absorption ratios. This prospective study assessed the axillary, arm, thigh, and back hair clearing ef cacy of the LightSheer In nity 1060 nm diode laser in 10 Fitzpatrick skin type IV-V patients. Each area was treated up to ve times, at 4-6-week intervals, after which immediate skin responses and adverse events were recorded. Hair count, color and coarseness were assessed before each treatment session, as well as 1, 3, and 6 months following the last session...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28091427/evaluation-of-surface-characteristics-of-rotary-nickel-titanium-instruments-produced-by-different-manufacturing-methods
#3
U Inan, M Gurel
BACKGROUND: Instrument fracture is a serious concern in endodontic practice. OBJECTIVE: The aim of this study was to investigate the surface quality of new and used rotary nickel-titanium (NiTi) instruments manufactured by the traditional grinding process and twisting methods. MATERIALS AND METHODS: Total 16 instruments of two rotary NiTi systems were used in this study. Eight Twisted Files (TF) (SybronEndo, Orange, CA, USA) and 8 Mtwo (VDW, Munich, Germany) instruments were evaluated...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28079747/how-reliable-is-microscopy-and-culture-for-the-diagnosis-of-gonorrhea-an-11-year-experience-from-india
#4
Aradhana Bhargava, Manju Bala, Vikram Singh, Naveen Chandra Joshi, Monika Kakran, Poonam Puri, Niti Khunger, Venkatesh Ramesh, Ashok Kumar Saxena
Positivity of microscopy and culture was greater (P < 0.0001) in men with urethral discharge syndrome (65.8%) than in women with vaginal/cervical discharge (0.5%), indicating that basic diagnostic tests may not be cost-effective for diagnosis of vaginal/cervical discharge syndrome. Microscopy when compared with culture showed sensitivity, specificity, positive predictive value and negative predictive value of 95.4%, 77.6%, 84.6%, and 95.3%, in men, whereas in women, it was 77.8%, 99.9%, 92.1%, and 99.9%, respectively...
February 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28068971/a-comparison-of-the-shaping-ability-of-three-nickel-titanium-rotary-instruments-a-micro-computed-tomography-study-via-a-contrast-radiopaque-technique-in-vitro
#5
Zhao Wei, Zhi Cui, Ping Yan, Han Jiang
BACKGROUND: Micro-CT (μCT) studies that combine simulated canals with meglucamine diatrizoate to evaluate the shaping ability of nickel-titanium (NiTi) rotary instruments are lacking in the literature. The purpose of this study was to evaluate the shaping ability of three new different nickel-titanium rotary instruments in simulated root canals using μCT. METHODS: Thirty simulated root canals with a curvature of 60° were randomly allocated into the following 3 groups (n = 10): Group 1, ProTaper Universal (PTU) rotary system; Group 2, Reciproc single-file system; and Group 3, K3XF rotary system...
January 9, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28046367/su-f-t-505-a-novel-approach-for-sparing-critical-organs-at-risk-for-cancer-patients-undergoing-radiation-oncology-treatments
#6
H Lavvafi, M Pourriahi, H Elahinia, M Elahinia, E Parsai
PURPOSE: A major goal of an effective radiation treatment plan is to deliver the maximum dose to the tumor while minimizing radiation exposure to the surrounding normal structures. For example, due to the radiation exposure to neighboring critical structures during prostate cancer treatment, a significant increase in cancer risk was observed for the bladder (77%) and the rectum (105%) over the following decade. Consequently, an effective treatment plan necessitates limiting the exposure to such organs which can best be achieved by physically displacing the organ at-risk...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044198/meloxicam-medication-reduces-orthodontically-induced-dental-root-resorption-and-tooth-movement-velocity-a-combined-in-vivo-and-in-vitro-study-of-dental-periodontal-cells-and-tissue
#7
Christian Kirschneck, Matthias Meier, Kathrin Bauer, Peter Proff, Jochen Fanghänel
Non-steroidal anti-inflammatory drugs (NSAID) are used to alleviate pain sensations during orthodontic therapy but are also assumed to interfere with associated pseudo-inflammatory reactions. In particular, the effects of partially selective COX-2 inhibition over the constitutively expressed COX-1 (11:1) on periodontal cells and tissue, as induced by the NSAID meloxicam, remain unclear. We investigate possible adverse side-effects and potentially useful beneficial effects during orthodontic therapy and examine underlying cellular and tissue reactions...
January 3, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28008468/localizing-small-lung-lesions-in-video-assisted-thoracoscopic-surgery-via-radiofrequency-identification-marking
#8
Yojiro Yutaka, Toshihiko Sato, Jitian Zhang, Koichi Matsushita, Hiroyuki Aiba, Yusuke Muranishi, Yasuto Sakaguchi, Teruya Komatsu, Fumitsugu Kojima, Tatsuo Nakamura, Hiroshi Date
BACKGROUND: To facilitate accurate localization of small lung lesions in thoracoscopic surgery, we employed a micro-radiofrequency identification tag designed to be delivered through the 2-mm working channel of a flexible bronchoscope. This report presents the results of preclinical studies of our novel localizing technique in a canine model. METHODS: To evaluate functional placement, three types of tags [Group A, tag alone (n = 18); Group B, tag + resin anchor (n = 15); and Group C, tag + NiTi coil anchor (n = 15)] were bronchoscopically placed in subpleural areas and subsegmental bronchi via our new delivery device; tags were examined radiographically on days 0-7 and day 14...
December 23, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28004210/exuberant-mitral-annular-calcification
#9
Melissa A Lyle, David F Snipelisky, Niti R Aggarwal, Fletcher A Miller, Nandan S Anavekar
Mitral annular calcification (MAC) is a chronic, progressive process characterized by calcium deposition on the mitral valve annulus. There is no current grading system to relay the severity of MAC. The primary purpose of this study was to investigate the extreme end of the severity spectrum in order to describe "exuberant mitral annular calcification", and a retrospective chart review of all patients with exuberant mitral annulus calcification evaluated at Mayo Clinic Rochester between January 1996 and December 2014 was performed...
December 22, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28000644/comparative-analysis-of-cleaning-ability-of-three-nickel-titanium-rotary-systems-protaper-universal-k3-and-mtwo-an-in-vitro-scanning-electron-microscopic-study
#10
Ambar W Raut, Vijay Mantri, Aparna Palekar, Rupal Gadodia, Shubham Kala, Radha A Raut
BACKGROUND: Endodontic instruments including the nickel-titanium (NiTi) instruments produce debris and smear layer during instrumentation. The study was carried out to evaluate and compare the cleaning effectiveness of root canal preparation using three different rotary NiTi instrumentation systems - ProTaper Universal, K3 and Mtwo by means of scanning electron microscopy (SEM). METHODS: Thirty-six freshly extracted permanent mandibular molars were randomly divided into four groups: ProTaper Universal, K3, Mtwo system and control group...
October 2016: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27994227/temperature-dependent-fracture-properties-of-shape-memory-alloys-novel-findings-and-a-comprehensive-model
#11
Carmine Maletta, Emanuele Sgambitterra, Fabrizio Niccoli
Temperature dependent fracture properties of NiTi-based Shape Memory Alloys (SMAs), within the pseudoelastic regime, were analyzed. In particular, the effective Stress Intensity Factor (SIF) was estimated, at different values of the testing temperature, by a fitting of the William's expansion series, based on Digital Image Correlation (DIC) measurements. It was found that temperature plays an important role on SIF and on critical fast fracture conditions. As a consequence, Linear Elastic Fracture Mechanics (LEFM) approaches are not suitable to predict fracture properties of SMAs, as they do not consider the effects of temperature...
December 2016: Scientific Reports
https://www.readbyqxmd.com/read/27987734/bioactivity-and-electrochemical-behavior-of-hydroxyapatite-silicon-multi-walled-carbon-nano-tubes-composite-coatings-synthesized-by-epd-on-niti-alloys-in-simulated-body-fluid
#12
V Khalili, J Khalil-Allafi, J Frenzel, G Eggeler
In order to improve the surface bioactivity of NiTi bone implant and corrosion resistance, hydroxyapatite coating with addition of 20wt% silicon, 1wt% multi walled carbon nano-tubes and both of them were deposited on a NiTi substrate using a cathodic electrophoretic method. The apatite formation ability was estimated using immersion test in the simulated body fluid for 10days. The SEM images of the surface of coatings after immersion in simulated body fluid show that the presence of silicon in the hydroxyapatite coatings accelerates in vitro growth of apatite layer on the coatings...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27986098/the-effects-of-torsional-preloading-on-the-torsional-resistance-of-nickel-titanium-instruments
#13
Seung-Hei Oh, Jung-Hong Ha, Sang Won Kwak, Shin Wook Ahn, WooCheol Lee, Hyeon-Cheol Kim
INTRODUCTION: This study evaluated the effect of torsional preloading on the torsional resistance of nickel-titanium (NiTi) endodontic instruments. METHODS: WaveOne Primary (Dentsply Maillefer, Ballaigues, Switzerland) and ProTaper Universal F2 (Dentsply Maillefer) files were used. The ultimate torsional strength until fracture was determined for each instrument. In the phase 1 experiment, the ProTaper and WaveOne files were loaded to have a maximum load from 2...
January 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/27942768/mechanical-properties-of-different-esthetic-and-conventional-orthodontic-wires-in-bending-tests-an-in-vitro-study
#14
Ahmad Alobeid, Cornelius Dirk, Susanne Reimann, Tarek El-Bialy, Andreas Jäger, Christoph Bourauel
AIMS: The goal of this study was to determine the mechanical properties of different esthetic and conventional orthodontic wires in three-point and four-point bending tests, and in a biomechanical test employing three bracket systems. METHODS: The behavior of round wires with a diameter of 0.46 mm (0.018″) were investigated: uncoated nickel titanium (NiTi) wires, surface modified NiTi wires; FLI(®) Orthonol Wire(®) and glass fiber reinforced plastic wires. The biomechanical bending test was performed using the following bracket types: metal brackets (Discovery(®), Dentaurum), ceramic brackets (Fascination(®), Dentaurum), and plastic brackets (Elegance(®), Dentaurum)...
December 9, 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
https://www.readbyqxmd.com/read/27929924/effect-of-different-agitation-techniques-on-the-penetration-of-irrigant-and-sealer-into-dentinal-tubules
#15
Yu Gu, Hiran Perinpanayagam, David J W Kum, Yeon-Jee Yoo, Jin-Sun Jeong, Sang-Min Lim, Seok-Woo Chang, Seung-Ho Baek, Qiang Zhu, Kee-Yeon Kum
OBJECTIVE: The aim of this study was to compare the effectiveness of five intracanal agitation techniques on the penetration of irrigant and sealer into dentinal tubules. BACKGROUND DATA: Intracanal agitation techniques could promote chemomechanical debridement and the sealing of root canals during endodontic treatment. However, there is limited evidence for the agitation effect of Nd:YAP laser. MATERIALS AND METHODS: Human maxillary premolars with single straight canals (N = 60) were prepared with ProTaper Next(®) NiTi rotary files (Dentsply Maillefer) up to X4 (ISO 40 size)...
November 3, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27928563/sumanene-derivatives-functionalized-at-the-internal-carbon
#16
Niti Ngamsomprasert, Jing-Shuang Dang, Shuhei Higashibayashi, Yumi Yakiyama, Hidehiro Sakurai
The first sumanene derivatives functionalized at the convex face of the internal carbon were reported. The structure of racemic hydroxysumanenone was confirmed by X-ray crystal analysis. The obtained structure was composed of the single enantiomer.
December 8, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27903508/the-patient-perspective-on-absence-of-disease-activity-in-rheumatoid-arthritis-a-survey-to-identify-key-domains-of-patient-perceived-remission
#17
Lilian H D van Tuyl, Martina Sadlonova, Sarah Hewlett, Bev Davis, Caroline Flurey, Niti Goel, Laure Gossec, Cecilie Heegaard Brahe, Catherine L Hill, Wijnanda Hoogland, John Kirwan, Merete L Hetland, Dirkjan van Schaardenburg, Josef S Smolen, Tanja Stamm, Marieke Voshaar, George A Wells, Maarten Boers
BACKGROUND: Guidelines suggest treatment in rheumatoid arthritis (RA) to target remission, in close consultation with the patient. Our recent qualitative study of the patients' perspective on remission in RA identified 26 domains. The current study aimed to identify a short list of the most important aspects to inform future research. METHODS: Patients with RA from the Netherlands, the UK, Austria, Denmark, France and the USA completed a survey that contained all domains identified in our qualitative study...
November 30, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27891305/single-file-reciprocating-systems-a-systematic-review-and-meta-analysis-of-the-literature-comparison-of-reciproc-and-waveone
#18
REVIEW
Rana Alsilani, Fatima Jadu, Dania F Bogari, Ahmed M Jan, Turki Y Alhazzazi
The introduction of single-file nickel-titanium (NiTi) reciprocating systems has been a major breakthrough in the field of endodontics. Thus, the aim of this study was to compare the available reciprocating systems, Reciproc and WaveOne, using a meta-analysis with different parameters. A comprehensive electronic literature search for Reciproc and WaveOne using PubMed and Google scholar was initially conducted in September 2014 and updated in September 2016. Inclusion and exclusion criteria were then established...
September 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27877845/modulated-interaction-in-double-layer-shape-memory-based-micro-designed-actuators
#19
Corneliu Crăciunescu, Aurel Ercuta
The effect of superposed transitions in actuators with layered shape memory alloy (SMA) films undergoing martensitic phase transformation is analyzed in terms of a model developed for two layers of different composition, deposited at the same temperature on a substrate. A significant difference is observed in the actuation versus temperature relationship, depending on the thermal and elastic properties of the SMA layers and their martensitic transformation temperature. The prediction of the actuation is exemplified using a multilayer model and is verified for a cantilever actuator with NiTi and NiMnGa layers deposited on a Si substrate...
December 2015: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27862387/interfacial-engineering-of-hierarchically-porous-niti-hydrogels-nanocomposites-with-exceptional-antibiofouling-surfaces
#20
Dongmian Zang, Hui Yi, Zhandong Gu, Lie Chen, Dong Han, Xinglin Guo, Shutao Wang, Mingjie Liu, Lei Jiang
Seamlessly bridging the hard and the soft, a strategy to fabricate hierarchically porous NiTi/hydrogels nanocomposites is reported herein. The nanocomposite surface can hold high-content water while keeping its hierarchical nanoscale topography, thus showing exceptional antibiofouling performance. This strategy will lead to antibiofouling alloy (e.g., NiTi)/hydrogel nanocomposites for improved stents and other blood-contacting implants and medical devices.
November 10, 2016: Advanced Materials
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