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https://www.readbyqxmd.com/read/29759046/classification-of-preterm-birth-with-placental-correlates
#1
Karen M Chisholm, Mary E Norton, Anna A Penn, Amy Heerema-McKenney
Premature birth lacks a widely accepted classification that unites features of the clinical presentation with placental pathology. To further explore associations between the clinical categories of preterm birth and placental histology, 109 infants with gestational age <34 weeks and birth weight <2000 g were selected and, based on electronic records, were classified into preterm birth categories of preterm labor, prelabor premature rupture of membranes, preeclampsia, indicated preterm birth for maternal factors (other than preeclampsia), indicated preterm birth for fetal factors, and the clinical diagnosis of abruption...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29754448/periodontal-infection-with-porphyromonas-gingivalis-induces-preterm-birth-and-lower-birth-weight-in-rats
#2
Shanshan Liang, Hongyu Ren, Haiying Guo, Wenyan Xing, Chang Liu, Yaoting Ji, Han Jiang, Ping Zhang, Minquan Du
Preterm birth (PTB), accompanied by low birth weight (LBW) or not, is a syndrome with tremendous risk factors and long-term health consequences for children. In recent decades, overwhelming studies have shown that periodontitis contributes to prematurity and LBW. This study was conducted to determine the link between maternal periodontitis and the pathogenesis of PTB and/or LBW through a rat infection model induced by Porphyromonas gingivalis, an important periodontopathic bacterium. The murine model was established by surgically ligating the left mandibular 1st molars and inoculating with P...
May 13, 2018: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29743041/plasma-inflammatory-and-immune-proteins-as-predictors-of-intra-amniotic-infection-and-spontaneous-preterm-delivery-in-women-with-preterm-labor-a-retrospective-study
#3
Hyunsoo Park, Kyo Hoon Park, Yu Mi Kim, Song Yi Kook, Se Jeong Jeon, Ha-Na Yoo
BACKGROUND: We investigated whether various inflammatory and immune proteins in plasma predict intra-amniotic infection and imminent preterm delivery in women with preterm labor and compared their predictive ability with that of amniotic fluid (AF) interleukin (IL)-6 and serum C-reactive protein (CRP). METHODS: This retrospective cohort study included 173 consecutive women with preterm labor who underwent amniocentesis for diagnosis of infection and/or inflammation in the AF...
May 9, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29724209/microbial-keratitis-induced-endophthalmitis-incidence-symptoms-therapy-visual-prognosis-and-outcomes
#4
Daniel Zapp, Daria Loos, Nikolaus Feucht, Ramin Khoramnia, Tamer Tandogan, Lukas Reznicek, Christian Mayer
BACKGROUND: To evaluate symptoms, therapies and outcomes in rare microbial keratitis-induced endophthalmitis. METHODS: Retrospective study with 11 patients treated between 2009 and 2014. Clinical findings, corneal diseases, history of steroids and trauma, use of contact lenses, number and type of surgical interventions, determination of causative organisms and visual acuity (VA) were evaluated. RESULTS: The incidence of transformation from microbial keratitis to an endophthalmitis was 0...
May 3, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29719651/combined-tenonplasty-and-scleral-graft-for-refractory-pseudomonas-scleritis-following-pterygium-removal-with-mitomycin-c-application
#5
Heidar Siatiri, Nima Mirzaee-Rad, Shruti Aggarwal, Ahmad Kheirkhah
Purpose: To report a surgical approach combining scleral patch graft and tenonplasty for successful management of refractory Pseudomonas scleritis following pterygium removal with mitomycin C application. Case Report: A 75-year-old diabetic woman with a history of prior pterygium excision and mitomycin C application developed infectious necrotizing scleritis caused by Pseudomonas aeruginosa . Owing to progression of scleritis despite medical management, the patient underwent surgery...
April 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29709964/bacterial-culture-negative-subclinical-intra-amniotic-infection-can-be-detected-by-bacterial-16s-ribosomal-dna-amplifying-polymerase-chain-reaction
#6
Sachi Morimoto, Hirokazu Usui, Tatsuya Kobayashi, Eiji Katou, Shunji Goto, Hirokazu Tanaka, Makio Shozu
Comprehensive analysis of bacterial DNA enhanced our understanding of the maternal microbiome and its disturbance in preterm birth, although clinical utility of these techniques remains to be determined. We examined whether broad-range polymerase technique is useful for detection of culture-negative intra-amniotic infection (IAI). Pregnant women who underwent amniocentesis for the management of preterm birth with or without the premature rupture of membranes. Bacterial 16S ribosomal DNA in the amniotic fluid was detected by polymerase chain reaction (PCR) using primers for a sequence shared by Ureaplasma, Mycoplasma, and other bacteria...
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29709096/17ohp-c-in-patients-with-spontaneous-preterm-labor-and-intact-membranes-is-there-an-effect-according-to-the-presence-of-intra-amniotic-inflammation
#7
Satoshi Yoneda, Noriko Yoneda, Arihiro Shiozaki, Osamu Yoshino, Tomohiro Ueno, Hideki Niimi, Isao Kitajima, Kentaro Tamura, Yukako Kawasaki, Masami Makimoto, Taketoshi Yoshida, Shigeru Saito
PROBLEM: It is not known whether 17-alpha-hydroxyprogesterone caproate (17OHP-C) is effective for preventing preterm delivery with an episode of preterm labor (PTL) with or without intra-amniotic inflammation/infection. METHODS OF STUDY: This was a retrospective cohort study. One hundred and seven PTL patients were selected and divided into a 17OHP-C group (use of 17OHP-C: n = 53) and a no-treatment group (no use of 17OHP-C: n = 54). Moreover, the patients were divided into three subgroups (subgroup A: without intra-amniotic inflammation, B: with mild intra-amniotic inflammation, and C: with severe intra-amniotic inflammation) according to their level of amniotic interleukin (IL)-8, and perinatal prognosis was analyzed...
April 30, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29701378/amniotic-membrane-in-the-treatment-of-varicose-ulcers-a-center-experience
#8
J Rocha-Neves, André Ferreria, Joel Sousa, Marina Dias-Neto, Luis Gamas, Isabel Vilaça, José Teixeira
INTRODUCTION: Amniotic membrane (AM) is an option as a cover in varicose leg ulcers, promoting epithelization. Anti-inflammatory and analgesic proprieties are described, as well as high levels of growth factors and angiogenesis. The costs are inferior to surgical plasty. The aim of this work is to describe the results of AM in the treatment of varicous leg ulcers in a group of patients refractory to the best medical treatment. METHODS: A pilot prospective trial was conducted...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29699432/vaginal-antiseptics-reduce-the-risk-of-perinatal-infection-with-group-b-streptococci
#9
Jesús Joaquín Hijona, Antonio Luis Carballo, María Soledad Sánchez, Nataliya Dyachkova, Juan Francisco Expósito, José Luis Alcázar
OBJECTIVE: To evaluate the efficacy and safety of dequalinium chloride (DQC; 10 mg vaginal tablets), administered shortly prior to delivery in women with group B streptococcus (GBS) infection. METHODS: This observational, longitudinal, and prospective study involved 201 pregnant women at term, potentially carriers of GBS bacteria, scheduled for induction with oxytocin and with no premature rupture of amniotic membranes. RESULTS: A total of 163 women (81...
April 26, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29692884/use-of-amniotic-membrane-in-the-treatment-of-patients-with-bronj-two-case-reports
#10
Mirko Ragazzo, Diletta Trojan, Lisa Spagnol, Adolfo Paolin, Luca Guarda Nardini
The use of bisphosphonates has led to a new disease, bisphosphonate-related osteonecrosis of the jaw (BRONJ). There is currently no effective treatment for this disease; the surgical approach is controversial. The widespread use of human amniotic membrane (HAM) in surgery and the results obtained have highlighted its many potential properties, including antimicrobial, anti-inflammatory, antifibrotic and antiapoptotic, as well as its capacity for encouraging epithelialisation and cell differentiation. These properties are believed to encourage the recovery of patients with BRONJ, facilitating the wound healing process after surgical debridement of the bone...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29691387/fetal-demise-and-failed-antibody-therapy-during-zika-virus-infection-of-pregnant-macaques
#11
Diogo M Magnani, Thomas F Rogers, Nicholas J Maness, Nathan D Grubaugh, Nathan Beutler, Varian K Bailey, Lucas Gonzalez-Nieto, Martin J Gutman, Núria Pedreño-Lopez, Jaclyn M Kwal, Michael J Ricciardi, Tereance A Myers, Justin G Julander, Rudolf P Bohm, Margaret H Gilbert, Faith Schiro, Pyone P Aye, Robert V Blair, Mauricio A Martins, Kathrine P Falkenstein, Amitinder Kaur, Christine L Curry, Esper G Kallas, Ronald C Desrosiers, Pascal J Goldschmidt-Clermont, Stephen S Whitehead, Kristian G Andersen, Myrna C Bonaldo, Andrew A Lackner, Antonito T Panganiban, Dennis R Burton, David I Watkins
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29686267/amniotic-fluid-c-reactive-protein-as-a-predictor-of-infection-in-caesarean-section-a-feasibility-study
#12
Zbigniew Marchocki, Angela Vinturache, Kevin Collins, Paddy O' Reilly, Keelin O'Donoghue
This study evaluated the feasibility of maternal C-reactive protein (CRP) in amniotic fluid (AF) as a predictor of post-partum infection in women who undergo emergency or elective caesarean section (CS). AF bacterial culture and levels of hs-CRP in maternal serum and AF were evaluated in Day 0 and three days thereafter (Day 3) in 79 women undergoing CS. Univariate analyses assessed the clinical and demographic characteristics, whereas the ROC curves assessed the feasibility of hs-CRP as marker of inflammation in women who undergo CS...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29685081/longitudinal-trajectory-of-vulvovaginal-candidiasis-trichomoniasis-and-bacterial-vaginosis-during-pregnancy-as-well-as-the-impact-on-pregnancy-outcome-a-preliminary-study
#13
Cheng-Yang Hu, Feng-Li Li, Xiao-Guo Hua, Wen-Jiang, Xiu-Jun Zhang
OBJECTIVES: The aims of this study were to describe the course of vulvovaginal candidiasis (VVC), trichomoniasis, and bacterial vaginosis (BV) in pregnancy and to explore the association between these longitudinal changes and pregnancy outcomes. METHODS: A total of 793 pregnant women were enrolled at the first trimester of pregnancy and were followed prospectively twice at the second and third trimester. VVC, trichomoniasis, and BV were evaluated at each trimester of pregnancy...
April 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29673373/chorioamnionitis-neuroinflammation-and-injury-timing-is-key-in-the-preterm-ovine-fetus
#14
Ruth Gussenhoven, Rob J J Westerlaken, Daan R M G Ophelders, Alan H Jobe, Matthew W Kemp, Suhas G Kallapur, Luc J Zimmermann, Per T Sangild, Stanislava Pankratova, Pierre Gressens, Boris W Kramer, Bobbi Fleiss, Tim G A M Wolfs
BACKGROUND: Antenatal infection (i.e., chorioamnionitis) is an important risk factor for adverse neurodevelopmental outcomes after preterm birth. Destructive and developmental disturbances of the white matter are hallmarks of preterm brain injury. Understanding the temporal effects of antenatal infection in relation to the onset of neurological injury is crucial for the development of neurotherapeutics for preterm infants. However, these dynamics remain unstudied. METHODS: Time-mated ewes were intra-amniotically injected with lipopolysaccharide at 5, 12, or 24 h or 2, 4, 8, or 15 days before preterm delivery at 125 days gestational age (term ~ 150 days)...
April 19, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29668332/neurological-complications-of-zika-virus-infection
#15
Francisco Javier Carod-Artal
Zika virus (ZIKV) disease is a vector-borne infectious disease transmitted by Aedes mosquitoes. Recently, ZIKV has caused outbreaks in most American countries. Areas covered: Publications about neurological complications of ZIKV infection retrieved from pubmed searchers were reviewed, and reference lists and relevant articles from review articles were also examined. Vertical/intrauterine transmission leads to congenital infection and causes microcephaly and congenital ZIKV syndrome. ZIKV preferentially infects human neural progenitor cells and triggers cell apoptosis...
May 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29663900/congenital-toxoplasmosis-in-tunisia-prenatal-and-neonatal-diagnosis-and-postnatal-follow-up-of-35-cases
#16
Boudaouara Yosr, Aoun Karim, Maatoug Rania, Souissi Olfa, Bouratbine Aïda, Ben Abdallah Rym
Congenital toxoplasmosis (CT) results from transplacental passage of Toxoplasma gondii to the fetus during acute maternal infection. Our study aims to report clinical and biological patterns of 35 cases of CT diagnosed at the department of the Parasitology of the Pasteur Institute of Tunis and to access the performance of prenatal and early postnatal diagnosis techniques. Serological screening of maternal infection was performed by Immunoglobulin (Ig) M and IgG detection and IgG avidity determination. Prenatal diagnosis was based on both Toxoplasma DNA detection in the amniotic fluid and monthly ultrasound examinations...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29661198/adverse-effects-of-maternal-enterovirus-infection-on-the-pregnancy-outcome-a-prospective-and-retrospective-pilot-study
#17
Z Khediri, C Vauloup-Fellous, A Benachi, J M Ayoubi, L Mandelbrot, O Picone
BACKGROUND: Enteroviruses account for about one billion infections worldwide each year, the majority remain asymptomatic. Data on enterovirus infections during pregnancy appear to be very rare. Several cases have been reported in the literature of fetal and neonatal complications attributed to these viruses, but prospective data on these infections during pregnancy are not available. OBJECTIVE: To estimate the prevalence of enterovirus infections in febrile syndromes in pregnant women, and in case of in utero fetal death (IUFD)...
April 16, 2018: Virology Journal
https://www.readbyqxmd.com/read/29660299/infection-induced-thrombin-production-a-potential-novel-mechanism-for-preterm-premature-rupture-of-membranes-pprom
#18
Liping Feng, Terrence K Allen, William P Marinello, Amy P Murtha
BACKGROUND: Preterm premature rupture of membranes (PPROM) is a leading contributor to maternal and neonatal morbidity and mortality. Epidemiologic and experimental studies have demonstrated that thrombin causes fetal membrane weakening and subsequently PPROM. Although blood is suspected as the likely source of thrombin in fetal membranes and amniotic fluid of patients with PPROM, this has not been proven. Ureaplasma Parvum (U. parvum) is emerging as a pathogen involved in prematurity, including PPROM, but until now, prothrombin production directly induced by bacteria in fetal membranes has not been described...
April 13, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29626984/the-proteome-of-fetal-fluids-in-mares-with-experimentally-induced-placentitis
#19
S C Loux, B A Ball
INTRODUCTION: Placental inflammation (placentitis) is one of the leading causes of late-term abortion in mares. Although prognosis is good assuming early diagnosis and treatment, diagnostics are limited. METHODS: To better characterize the disease and identify potential biomarkers, we analyzed the proteome of fetal fluids (amniotic and allantoic) in both control mares (n = 5) and mares with experimentally-induced placentitis (n = 5) using LTQ-Orbitrap mass-spectrometry...
April 2018: Placenta
https://www.readbyqxmd.com/read/29619446/isolation-and-identification-of-brucella-suis-in-pigs-as-zoonotic-disease-in-endemic-areas-of-east-java-indonesia
#20
Emy Koestanti S, Wiwik Misaco, Sri Chusniati, Lilik Maslachah
Background: Brucellosis in pigs at East Java Indonesia has not only cause great economic losses due to a decrease in productivity of livestock but also are zoonotic. Infection on free brucelosis pigs were initially begun with the infected pigs both male and female, or the use of superior male pigs together. The elimination of the disease either on a group or population is considered as the most effective way to prevent the spread of the disease in pigs. Prevention efforts mainly addressed to vaccination, sanitary maintenace and government policy...
2018: African Journal of Infectious Diseases
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