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Neuroendocrine tumors head neck

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https://www.readbyqxmd.com/read/28299533/clival-paragangliomas-a-report-of-two-cases-involving-the-midline-skull-base-and-review-of-the-literature
#1
Jacob Ruzevick, Eun Kyung Koh, Luis F Gonzalez-Cuyar, Patrick J Cimino, Kristen Moe, Lorena A Wright, Richard Failor, Manuel Ferreira
Head and neck paragangliomas are rare neuroendocrine tumors that arise from paraganglion cells of the parasympathetic nervous system. Paragangliomas arising from the midline skull base have only rarely been reported. Surgery is the mainstay of treatment and adjuvant radiation is often recommended. These tumors can rarely secrete metanephrines and normetanephrines which can complicate operative management. Here we present two cases of clival paragangliomas with unique clinical presentations and review the previous literature on skull base paragangliomas...
March 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28297754/-clinicopathologic-characteristics-of-head-and-neck-carcinoma-showing-thymus-like-element
#2
X J Cui, C Y Zhang, P Su, B Lyu, Y B Ren, X S Fan, X F Zhang, Y Wang, Y H Song, Z Y Liu
Objective: To investigate clinicopathological features of carcinoma showing thymus-like elements (CASTLE) in the head and neck regions. Methods: Clinicopathological data of 7 patients with CASTLE in the head and neck regions were retrospectively reviewed.Immunohistochemical staining and in situ hybridization for EBER were performed. BRAF(V600E) mutation was examined by ARMS method in 6 cases. Results: There were 5 females and 2 males with age between 49 and 78 years (average of 65.6 years). All tumors were solitary nodular lesions with an infiltrative border, including 6 intrathyroid tumors and 1 extrathyroid tumor in the laryngeal pharynx...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28247231/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-what-is-new-in-the-2017-who-blue-book-for-tumours-of-the-hypopharynx-larynx-trachea-and-parapharyngeal-space
#3
Nina Gale, Mario Poljak, Nina Zidar
Chapter 3 "Tumours of the hypopharynx, larynx, trachea, and parapharyngeal space" of the World Health Organization (WHO) Blue Book 2017 "Classification of Head and Neck Tumours" shows a shortened list of entities, especially due to reducing the number of benign and malignant soft tissue tumours, malignant melanoma and some others, which are transferred to more frequently affected regions of the head and neck. The basic concept of the new edition is to assimilate all advances concerning the discussed tumours in a shorter framework, appropriate for daily work...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28247224/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-paragangliomas
#4
Michelle D Williams, Arthur S Tischler
Updated editions of The World Health Organization Classification of Tumours Pathology & Genetics for both Head and Neck Tumours and Tumours of Endocrine Organs took place in 2016 based on consensus conferences. These editions present unification of concepts in paragangliomas and highlight expanding knowledge of their etiology. There is a major emphasis in the new bluebooks on familial/syndromic paragangliomas, representing ~40% of all head and neck paragangliomas. Ancillary use of immunohistochemical evaluation, specifically of SDHB, allows the pathologist to screen for a large subset of these potentially hereditary cases...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28231563/hypoxia-pathway-mutations-in-pheochromocytomas-and-paragangliomas
#5
Diana Amorim-Pires, Joana Peixoto, Jorge Lima
Pheochromocytomas (PCC) and sympathetic paragangliomas (PGL) are rare neuroendocrine tumors, which derive from chromaffin cells occurring in the adrenal medulla and extra-adrenal sympathetic paraganglia. PCC and PGL are often benign, catecholamine-producing tumors, responsible for a myriad of symptoms that may be potentially hazardous to the patient. In contrast, nonsecreting parasympathetic PGL, derived from chief cells, develop mainly in the head and neck region. Although PCC/PGL are more commonly sporadic tumors, germline mutations are present in up to 40% of the patients, ranking these tumors among those with the highest degree of heritability...
February 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28162264/nonfunctioning-small-incidental-pancreatic-neuroendocrine-tumors-results-of-a-nonoperative-approach-cohort
#6
Catalina Uribe Galeano, Joan Fabregat Prous, Juli Busquets Barenys, Nuria Pelaez Serra, Lluís Secanella Medayo, Emilio Ramos Rubio, Sandra Ruiz Osuna, Carlos Villabona Artero
OBJECTIVE: The availability of new imaging techniques has conditioned an increase in the incidental diagnosis of small nonfunctioning pancreatic neuroendocrine tumors (PNET-NF). The best treatment is controversial, some authors advise a conservative approach in selected cases. Our aim is to analyze the evolution of incidental, small size PNET-NF, treated with clinical follow-up without surgery. METHODS: We performed a retrospective analysis of a prospective database of patients diagnosed incidentally with PNET-NF since November 2007 to September 2015...
February 2, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28028970/diagnostic-and-therapeutic-difficulties-in-carotid-body-paragangliomas-based-on-clinical-experience-and-a-review-of-the-literature
#7
Karolina Dorobisz, Tadeusz Dorobisz, Hanna Temporale, Tomasz Zatoński, Marzena Kubacka, Mariusz Chabowski, Andrzej Dorobisz, Tomasz Kręcicki, Dariusz Janczak
BACKGROUND: Paragangliomas are rare neuroendocrine tumors, representing 0.03% of all tumors. Half of them develop in the head and neck, and among these 50% are sporadic cervical tumors. OBJECTIVES: The aim of the study was to carry out an epidemiological and clinical analysis of paraganglioma patients diagnosed and treated at the authors' clinics between 1985 and 2014. MATERIAL AND METHODS: The medical data of 47 patients were analyzed. All the patients were qualified for surgery...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27938993/meta-analysis-of-701-published-cases-of-sinonasal-neuroendocrine-carcinoma-the-importance-of-differentiation-grade-in-determining-treatment-strategy
#8
REVIEW
Tom P van der Laan, René Iepsma, Max J H Witjes, Bernard F A M van der Laan, Boudewijn E C Plaat, Gyorgy B Halmos
The aim of this meta-analysis was to provide treatment guidelines for sinonasal neuroendocrine carcinoma (SNC) by combining all available data in the literature. A literature search for all studies concerning SNC was performed against the MEDLINE and EMBASE databases. Available clinical data was normalized, pooled, and statistically analyzed. A total of 701 cases of SNC were available for analysis, comprising 127 well or moderately differentiated sinonasal neuroendocrine carcinomas (SNEC), 459 sinonasal undifferentiated carcinoma (SNUC) and 115 sinonasal small cell carcinoma (SmCC)...
December 2016: Oral Oncology
https://www.readbyqxmd.com/read/27759689/complete-spontaneous-regression-of-merkel-cell-carcinoma-after-biopsy-a-case-report-and-review-of-the-literature
#9
REVIEW
Parnian Ahmadi Moghaddam, Kristine M Cornejo, Lloyd Hutchinson, Keith Tomaszewicz, Karen Dresser, April Deng, Patrick OʼDonnell
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine tumor that typically occurs on the head and neck of the elderly and follows an aggressive clinical course. Merkel cell polyomavirus (MCPyV) has been identified in up to 80% of cases and has been shown to participate in MCC tumorigenesis. Complete spontaneous regression of MCC has been rarely reported in the literature. We describe a case of a 79-year-old man that presented with a rapidly growing, 3-cm mass on the left jaw. An incisional biopsy revealed MCC...
November 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27610258/primary-neuroendocrine-tumor-of-the-parotid-gland-a-case-report-and-a-comprehensive-review-of-a-rare-entity
#10
Olga Martínez-Sáez, Javier Molina-Cerrillo, Carmen Moreno García Del Real, Rafael Barberá Durban, Juan J Díez, Teresa Alonso-Gordoa, Enrique Grande Pulido
Neuroendocrine tumors (NETs) comprise a heterogeneous group of malignancies from cells derived from the neural crest with neuroendocrine differentiation. Despite the differences in the site of origin, nomenclature, biological behavior, and functional status, NETs share certain ultrastructural and immunohistochemical features. NETs are relative rare tumors with an annual incidence of 5.76 new cases per 100.000 inhabitants and they usually appear in the gastrointestinal tract or in the pulmonary system. Head and neck NETs are uncommon with limited information regarding frequency, most of them showing small cell carcinoma features...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27529044/an-extremely-rare-case-of-advanced-metastatic-small-cell-neuroendocrine-carcinoma-of-sinonasal-tract
#11
Yu Yu Thar, Poras Patel, Tiangui Huang, Elizabeth Guevara
Small cell neuroendocrine carcinoma (SNEC) is a rare form of malignancy. It mainly presents as bronchogenic neoplasm, and the extrapulmonary form accounts for only 0.1% to 0.4% of all cancers. These extrapulmonary tumors have been described most frequently in the urinary bladder, prostate, esophagus, stomach, colon and rectum, gall bladder, head and neck, cervix, and skin. Primary SNEC of the sinonasal tract is extremely rare with only less than 100 cases reported in the literature. Because of extreme rarity and aggressiveness of the tumor, the management for this entity varies considerably mandating multimodality approach...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27433367/a-unique-case-of-an-aggressive-gangliocytic-paraganglioma-of-the-filum-terminale
#12
Omar S Akbik, Crina Floruta, Muhammad O Chohan, Karen S SantaCruz, Andrew P Carlson
Paragangliomas are rare neuroendocrine tumors that are mostly found in the head and neck. Even less common are gangliocytic variant paragangliomas of the spine for which there are only 7 other documented cases in the literature. We report a case of gangliocytic paraganglioma of the sacral spine in a 68-year-old man. The growth pattern is documented over three years, which to our knowledge has not previously been reported in the literature and is different from the natural history. Clinical, radiological, and pathological characteristics of the tumor are discussed in light of available reports of this rare tumor...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27429827/an-eustachian-tube-neuroendocrine-carcinoma-a-previously-undescribed-entity-and-review-of-the-literature
#13
Gavin J le Nobel, Vincent Y Lin, Vladimir Iakovlev, John M Lee
Primary sinonasal and middle ear neuroendocrine carcinomas are rare malignancies of the head and neck. Owing to the rarity of these tumors, the clinical behavior and optimal management of these tumors are not well defined. We present a case of an incidentally discovered sinonasal neuroendocrine carcinoma that was found to originate from the Eustachian tube, which has not previously been described in the literature. This patient was treated with primary surgical resection using a combination of transnasal and transaural approaches and achieved an incomplete resection...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27400194/cytopathologic-features-of-nut-midline-carcinoma-a-series-of-26-specimens-from-13-patients
#14
Justin A Bishop, Christopher A French, Syed Z Ali
BACKGROUND: NUT midline carcinoma (NMC) is an increasingly recognized neoplasm defined by rearrangements of the nuclear protein in testis (NUT) gene (also known as NUTM1). NMC is important to diagnose for prognostic and diagnostic reasons, but to date, only a small case series and rare case reports of the cytopathologic features of NMC have been published. METHODS: All NMC specimens (confirmed by molecular testing and/or NUT immunoreactivity) with cytopathologic material available were identified at 2 academic centers...
December 2016: Cancer
https://www.readbyqxmd.com/read/27392929/p16-overexpression-in-high-grade-neuroendocrine-carcinomas-of-the-head-and-neck-potential-diagnostic-pitfall-with-hpv-related-carcinomas
#15
Llucia Alos, Sofia Hakim, Ana-Belen Larque, Jorge de la Oliva, Leonardo Rodriguez-Carunchio, Miguel Caballero, Alfons Nadal, Carles Marti, Nuria Guimera, Maria-Teresa Fernandez-Figueras, Wim Quint, Jaume Ordi
High-grade neuroendocrine carcinomas (HGNECs) of the head and neck have the morphological appearance of undifferentiated carcinomas and could be histologically similar to human papillomavirus (HPV)-associated non-keratinizing squamous cell carcinomas of the head and neck. The aim of the study is to characterize histologically, immunohistochemically, and virologically these unusual neoplasms. Nineteen HGNECs of the head and neck (1 oropharyngeal, 5 sinonasal, 7 of the larynx, and 6 of the parotid gland) were reviewed and analyzed with a immunohistochemical panel, with special emphasis on cell cycle proteins...
September 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27073708/growth-rate-analysis-of-an-untreated-glomus-vagale-on-mri
#16
Jeffrey Tzu-Yu Wang, Allen Yu-Yu Wang, Sheila Cheng, Lavier Gomes, Melville Da Cruz
Paragangliomas are slow growing, hypervascular neuroendocrine tumors that develop in the extra-adrenal paraganglion tissues. Paraganglioma involving the vagus nerve ganglia is termed glomus vagale. The slow growth of head and neck paragangliomas especially in the absence of symptom may obviate the necessity for any active intervention, in which case, a "wait and scan" policy is implemented involving long-term clinical and radiologic follow-ups. We present a case of a 71-year-old female with an untreated left glomus vagale who underwent a conservative "wait and rescan" plan of management and the tumor was observed with 8 serial MRI scans over a period of 7...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/26971069/a-peculiar-primary-paraganglioma-of-the-distal-thumb
#17
Sarah T Lander, Erin Coppola, Wakenda Tyler, John C Elfar
A paraganglioma is a highly vascularized neuroendocrine tumor most commonly found within the adrenal gland as a pheochromocytoma. Extra-adrenal paragangliomas are frequently located in the head, neck, thorax, and abdomen. We report the first documented case of a primary paraganglioma found within the appendicular skeleton. Only 2 additional cases of paragangliomas in the extremities have been documented, one in the soft tissue of the forearm and other within the median nerve. Our patient underwent amputation of the distal phalanx, with no sign of recurrence at greater than 1 year of follow-up...
May 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/26906950/immunohistochemical-expression-of-keratins-6-7-8-14-16-18-19-and-mnf-116-pancytokeratin-in-primary-and-metastatic-melanoma-of-the-head-and-neck
#18
COMPARATIVE STUDY
Rima A Safadi, Dima H Bader, Niveen I Abdullah, Maher A Sughayer
OBJECTIVE: To investigate the immunohistochemical expression (IHCE) of selected keratins in primary cutaneous and mucosal melanoma (pM), and metastatic melanoma (metsM) of the head and neck and to compare their expression to a group of undifferentiated/poorly differentiated tumors of the same anatomic region. STUDY DESIGN: IHCE of K6, K7, K8, K14, K16, K18, and K19 were studied in 29 melanomas and 70 cases of non-melanoma tumors of the same anatomic region (neuroendocrine carcinoma, neuroblastoma, olfactory neuroblastoma, sinonasal undifferentiated carcinoma, undifferentiated nasopharyngeal carcinoma, anaplastic large cell lymphoma, poorly differentiated squamous cell carcinoma (PDSCC), and Ewing sarcoma)...
May 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/26886644/differences-and-similarities-in-the-clinicopathological-features-of-pancreatic-neuroendocrine-tumors-in-china-and-the-united-states-a-multicenter-study
#19
MULTICENTER STUDY
Li-Ming Zhu, Laura Tang, Xin-Wei Qiao, Edward Wolin, Nicholas N Nissen, Deepti Dhall, Jie Chen, Lin Shen, Yihebali Chi, Yao-Zong Yuan, Qi-Wen Ben, Bin Lv, Ya-Ru Zhou, Chun-Mei Bai, Jie Chen, Yu-Li Song, Tian-Tian Song, Chong-Mei Lu, Run Yu, Yuan-Jia Chen
The presentation, pathology, and prognosis of pancreatic neuroendocrine tumors (PNETs) in Asian patients have not been studied in large cohorts. We hypothesized that the clinicopathological features of PNETs of Chinese patients might be different from those of US patients. The objectives of this study were to address whether PNETs in Chinese patients exhibit unique clinicopathological features and natural history, and can be graded and staged using the WHO/ENETS criteria. This is a retrospective review of medical records of patients with PNETs in multiple academic medical centers in China (7) and the United States (2)...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26872616/results-of-a-prospective-multicenter-neuroendocrine-tumor-registry-reporting-on-clinicopathologic-characteristics-of-greek-patients
#20
George C Nikou, Kalliopi Pazaitou-Panayiotou, Dimitrios Dimitroulopoulos, Georgios Alexandrakis, Pavlos Papakostas, Michalis Vaslamatzis, Philippos Kaldrymidis, Vyron Markussis, Anna Koumarianou
BACKGROUND: The rare incidence of neuroendocrine neoplasms (NENs) has contributed to a paucity of large epidemiologic studies of patients with this condition. We investigated the occurrence and clinicopathologic features of NENs in Greece. METHODS: Between October 2010 and November 2012 we collected data on 246 newly diagnosed patients from a broad-based multi-institutional registry that comprises eight academic and hospital sites in Greece. The WHO 2010 pathologic classification and the 7th AJCC Staging system was applied in all cases...
February 12, 2016: BMC Endocrine Disorders
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