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https://www.readbyqxmd.com/read/28983648/optimising-yield-and-resource-utilisation-of-summer-maize-under-the-conditions-of-increasing-density-and-reducing-nitrogen-fertilization
#1
Shanshan Wei, Xiangyu Wang, Qicen Zhu, Dong Jiang, Shuting Dong
The inefficient use of resources always poses risks of maize (Zea mays L.) yield reduction in China. We performed this research to monitor the effects of increasing plant density and reducing nitrogen (N) rate on radiation-use efficiency (RUE), N efficiency traits, grain yield (GY) and their inter-relationships. Besides, whether GY and resource-use efficiency can both be maximized was examined. Hence, a 2-year field experiment was conducted using a widely grown variety "Denghai 618" in Shandong, China. Treatments contained two different plant densities [67,500 (D1) and 97,500 (D2) plant ha(-1)] and three N levels [0 (N-2), 180 (N-1), 360 (Nck) kg ha(-1)], set D1Nck as control...
October 5, 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/28979184/spin90-modulates-long-term-depression-and-behavioral-flexibility-in-the-hippocampus
#2
Dae Hwan Kim, Minkyung Kang, Chong-Hyun Kim, Yun Hyun Huh, In Ha Cho, Hyun-Hee Ryu, Kyung Hwun Chung, Chul-Seung Park, Sangmyung Rhee, Yong-Seok Lee, Woo Keun Song
The importance of actin-binding proteins (ABPs) in the regulation of synapse morphology and plasticity has been well established. SH3 protein interacting with Nck, 90 kDa (SPIN90), an Nck-interacting protein highly expressed in synapses, is essential for actin remodeling and dendritic spine morphology. Synaptic targeting of SPIN90 to spine heads or dendritic shafts depends on its phosphorylation state, leading to blockage of cofilin-mediated actin depolymerization and spine shrinkage. However, the physiological role of SPIN90 in long-term plasticity, learning and memory are largely unknown...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28954862/nck-deficiency-is-associated-with-delayed-breast-carcinoma-progression-and-reduced-metastasis
#3
David C Morris, Julia L Popp, Leung K Tang, Holly C Gibbs, Emily Schmitt, Sankar P Chaki, Briana C Bywaters, Alvin T Yeh, Weston W Porter, Robert C Burghardt, Rola Barhoumi, Gonzalo M Rivera
Although it is known that Nck regulates cell adhesion and migration by bridging tyrosine phosphorylation with cytoskeletal remodeling, the role of Nck in tumorigenesis and metastasis has remained undetermined. Here, we report that Nck is required for the growth and vascularization of primary tumors and lung metastases in a breast cancer xenograft model as well as extravasation following injection of carcinoma cells into the tail vein. We provide evidence that Nck directs the polarization of cell-matrix interactions for efficient migration in three-dimensional microenvironments...
September 27, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28874467/an-evolutionarily-conserved-pathway-essential-for-orsay-virus-infection-of-caenorhabditis-elegans
#4
Hongbing Jiang, Kevin Chen, Luis E Sandoval, Christian Leung, David Wang
Many fundamental biological discoveries have been made in Caenorhabditis elegans The discovery of Orsay virus has enabled studies of host-virus interactions in this model organism. To identify host factors critical for Orsay virus infection, we designed a forward genetic screen that utilizes a virally induced green fluorescent protein (GFP) reporter. Following chemical mutagenesis, two Viro (virus induced reporter off) mutants that failed to express GFP were mapped to sid-3, a nonreceptor tyrosine kinase, and B0280...
September 5, 2017: MBio
https://www.readbyqxmd.com/read/28771705/selected-signalling-proteins-recruited-to-the-t-cell-receptor-cd3-complex
#5
REVIEW
Jatuporn Ngoenkam, Wolfgang Schamel, Sutatip Pongcharoen
The T cell receptor (TCR)-CD3 complex, expressed on T cells, determines the outcome of a T cell response. It consists of the TCRαβ heterodimer and the non-covalently associated signalling dimers of CD3εγ, CD3εδ and CD3ζζ. TCRαβ binds specifically to a cognate peptide antigen bound to a major histocompatibility complex (MHC) molecule, whereas the CD3 subunits transmit the signal into the cytosol to activate signalling events. Recruitment of proteins to specialized localizations is one mechanism to regulate activation and termination of signalling...
August 3, 2017: Immunology
https://www.readbyqxmd.com/read/28526413/tcr-crosslinking-promotes-crk-adaptor-protein-binding-to-tyrosine-phosphorylated-cd3%C3%AE-chain
#6
Guangyu Dong, Rachel Kalifa, Pulak Ranjan Nath, Sigal Gelkop, Noah Isakov
T cell antigen receptor (TCR) binding of a peptide antigen presented by antigen-presenting cells (APCs) in the context of surface MHC molecules initiates signaling events that regulate T cell activation, proliferation and differentiation. A key event in the activation process is the phosphorylation of the conserved tyrosine residues within the CD3 chain immunoreceptor tyrosine-based activation motifs (ITAMs), which operate as docking sites for SH2 domain-containing effector proteins. Phosphorylation of the CD3ζ ITAMs renders the CD3 chain capable of binding the ζ-chain associated protein 70 kDa (ZAP70), a protein tyrosine kinase that is essential for T cell activation...
July 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28467797/synergistic-inhibition-effect-of-tnik-inhibitor-ky-05009-and-receptor-tyrosine-kinase-inhibitor-dovitinib-on-il-6-induced-proliferation-and-wnt-signaling-pathway-in-human-multiple-myeloma-cells
#7
Yura Lee, Jung-Il Jung, Kyeong-Yong Park, Soon Ae Kim, Jiyeon Kim
Multiple myeloma is a fetal form of plasma cell malignancy characterized by abnormal clonal proliferation of plasma cells. Especially, the canonical Wnt signaling pathway mediated by β-catenin is activated in multiple myeloma cells, stimulating their proliferation. Here, we investigated the relationship between interleukin-6-induced proliferation of multiple myeloma cells and Traf2- and Nck-interacting kinase (TNIK) expression in Wnt signaling. Interleukin-6 increased the proliferation of multiple myeloma cells and TNIK mRNA and protein expression...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28341832/mir-2425-5p-targets-rad9a-and-myog-to-regulate-the-proliferation-and-differentiation-of-bovine-skeletal-muscle-derived-satellite-cells
#8
Hui Li Tong, Run Ying Jiang, Wei Wei Zhang, Yun Qin Yan
Our group previously identified miR-2425-5p, a unique bovine miRNA; however, its biological function and regulation in muscle-derived satellite cells (MDSCs) remain unclear. Herein, stem-loop RT-PCR results showed that miR-2425-5p increased during MDSCs proliferation, but decreased during differentiation. Cell proliferation was examined using EdU assays, cyclin B1 (CCNB1) and proliferating cell nuclear antigen (PCNA) western blot (WB) and flow cytometry analysis. These results showed that miR-2425-5p mimics (miR-2425-M) enhanced MDSCs proliferation, whereas, miR-2425-5p inhibitor (miR-2425-I) had opposite effect...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341353/the-nck-and-abi-adaptor-genes-in-catfish-and-their-involvement-in-esc-disease-response
#9
Tao Zhou, Ning Li, Shikai Liu, Yulin Jin, Qiang Fu, Sen Gao, Yang Liu, Zhanjiang Liu
Adaptor proteins non-catalytic region of tyrosine kinase (NCK) and Abelson interactor (ABI) are crucial for disease response. NCK1 was identified to be a candidate gene for enteric septicemia of catfish (ESC) disease resistance, and was speculated to play similar roles during ESC and enteropathogenic Escherichia coli (EPEC) pathogenicity. ABI1 was reported as a positional candidate gene for bacterial cold water disease (BCWD) resistance in rainbow trout. In this study, three NCK genes and six ABI genes were identified in the channel catfish (Ictalurus punctatus) genome and blue catfish (I...
March 22, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28238268/aryl-alkyl-lysines-membrane-active-fungicides-that-act-against-biofilms-of-candida-albicans
#10
Chandradhish Ghosh, Vikas Yadav, Waleed Younis, Haroon Mohammad, Youssef A Hegazy, Mohamed N Seleem, Kaustuv Sanyal, Jayanta Haldar
Mortality due to pathogenic fungi has been exacerbated by the rapid development of resistance to frontline antifungal drugs. Fungicidal compounds with novel mechanisms of action are urgently needed. Aryl-alkyl-lysines, which are membrane-active small molecules, were earlier shown to be broad-spectrum antibacterial agents with potency in vitro and in vivo. Herein, we report the antifungal properties of aryl-alkyl-lysines. After identifying the most active compound (NCK-10), we tested its activity against a panel of clinically relevant pathogenic fungi and examined NCK-10's effect against immature and mature biofilms of Candida albicans...
April 14, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28208209/emergence-of-tnik-inhibitors-in-cancer-therapeutics
#11
REVIEW
Tesshi Yamada, Mari Masuda
The outcome of patients with metastatic colorectal cancer remains unsatisfactory. To improve patient prognosis, it will be necessary to identify new drug targets based on molecules that are essential for colorectal carcinogenesis, and to develop therapeutics that target such molecules. The great majority of colorectal cancers (>90%) have mutations in at least one Wnt signaling pathway gene. Aberrant activation of Wnt signaling is a major force driving colorectal carcinogenesis. Several therapeutics targeting Wnt pathway molecules, including porcupine, frizzled receptors and tankyrases, have been developed, but none of them have yet been incorporated into clinical practice...
May 2017: Cancer Science
https://www.readbyqxmd.com/read/28003549/first-in-class-inhibitor-of-the-t-cell-receptor-for-the-treatment-of-autoimmune-diseases
#12
Aldo Borroto, Diana Reyes-Garau, M Angeles Jiménez, Esther Carrasco, Beatriz Moreno, Sara Martínez-Pasamar, José R Cortés, Almudena Perona, David Abia, Soledad Blanco, Manuel Fuentes, Irene Arellano, Juan Lobo, Haleh Heidarieh, Javier Rueda, Pilar Esteve, Danay Cibrián, Ana Martinez-Riaño, Pilar Mendoza, Cristina Prieto, Enrique Calleja, Clara L Oeste, Alberto Orfao, Manuel Fresno, Francisco Sánchez-Madrid, Antonio Alcamí, Paola Bovolenta, Pilar Martín, Pablo Villoslada, Antonio Morreale, Angel Messeguer, Balbino Alarcon
Modulating T cell activation is critical for treating autoimmune diseases but requires avoiding concomitant opportunistic infections. Antigen binding to the T cell receptor (TCR) triggers the recruitment of the cytosolic adaptor protein Nck to a proline-rich sequence in the cytoplasmic tail of the TCR's CD3ε subunit. Through virtual screening and using combinatorial chemistry, we have generated an orally available, low-molecular weight inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 (median inhibitory concentration) ~1 nM...
December 21, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27927633/nck-associated-protein-1-modulated-by-mirna-214-determines-vascular-smooth-muscle-cell-migration-proliferation-and-neointima-hyperplasia
#13
Tayyab Adeel Afzal, Le Anh Luong, Dan Chen, Cheng Zhang, Feng Yang, Qishan Chen, Weiwei An, Edmund Wilkes, Kenta Yashiro, Pedro R Cutillas, Li Zhang, Qingzhong Xiao
BACKGROUND: MicroRNA miR-214 has been implicated in many biological cellular functions, but the impact of miR-214 and its target genes on vascular smooth muscle cell (VSMC) proliferation, migration, and neointima smooth muscle cell hyperplasia is unknown. METHODS AND RESULTS: Expression of miR-214 was closely regulated by different pathogenic stimuli in VSMCs through a transcriptional mechanism and decreased in response to vascular injury. Overexpression of miR-214 in serum-starved VSMCs significantly decreased VSMC proliferation and migration, whereas knockdown of miR-214 dramatically increased VSMC proliferation and migration...
December 7, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27801778/antiviral-screening-of-multiple-compounds-against-ebola-virus
#14
Stuart D Dowall, Kevin Bewley, Robert J Watson, Seshadri S Vasan, Chandradhish Ghosh, Mohini M Konai, Gro Gausdal, James B Lorens, Jason Long, Wendy Barclay, Isabel Garcia-Dorival, Julian Hiscox, Andrew Bosworth, Irene Taylor, Linda Easterbrook, James Pitman, Sian Summers, Jenny Chan-Pensley, Simon Funnell, Julia Vipond, Sue Charlton, Jayanta Haldar, Roger Hewson, Miles W Carroll
In light of the recent outbreak of Ebola virus (EBOV) disease in West Africa, there have been renewed efforts to search for effective antiviral countermeasures. A range of compounds currently available with broad antimicrobial activity have been tested for activity against EBOV. Using live EBOV, eighteen candidate compounds were screened for antiviral activity in vitro. The compounds were selected on a rational basis because their mechanisms of action suggested that they had the potential to disrupt EBOV entry, replication or exit from cells or because they had displayed some antiviral activity against EBOV in previous tests...
October 27, 2016: Viruses
https://www.readbyqxmd.com/read/27754058/os-15-06-sequential-activation-of-intrarenal-ace-ace2-as-the-progression-of-hypertensive-nephropathy-in-2-kidney-10clip-2k1c-goldblatt-rats
#15
Yang Gyun Kim, Sangho Lee, Ju Young Moon, Se Yeon Kim, Yu Ho Lee, Seok Jong Song, Kyung Whan Jeoung, Tae Won Lee, Chun Gyu Ihm
OBJECTIVE: Intrarenal renin-angiotensin system (RAS) had an important role to generate and maintain hypertension in 2-kidny 1-clip (2K1C) rats. This study purposed to assess how various intrarenal RAS components of 2K1C rats contributed to hypertension in different parts (cortex, medulla) of both sides (CK; clipped-kidney, NCK; non-clipped kidney) at different times (2 weeks; 2w and 5 weeks; 5w after clipping operation). DESIGN AND METHOD: We conducted to insert clip to left renal artery or sham operation to SD rats, then systolic blood pressure (SBP) was measured at one week interval...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27713059/bmp4-msx1-signaling-and-osr2-control-tooth-organogenesis-through-antagonistic-regulation-of-secreted-wnt-antagonists
#16
Shihai Jia, Hyuk-Jae Edward Kwon, Yu Lan, Jing Zhou, Han Liu, Rulang Jiang
Mutations in MSX1 cause craniofacial developmental defects, including tooth agenesis, in humans and mice. Previous studies suggest that Msx1 activates Bmp4 expression in the developing tooth mesenchyme to drive early tooth organogenesis. Whereas Msx1(-/-) mice exhibit developmental arrest of all tooth germs at the bud stage, mice with neural crest-specific inactivation of Bmp4 (Bmp4(ncko)(/ncko)), which lack Bmp4 expression in the developing tooth mesenchyme, showed developmental arrest of only mandibular molars...
December 1, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27650168/comprehensive-modeling-and-discovery-of-mebendazole-as-a-novel-traf2-and-nck-interacting-kinase-inhibitor
#17
Zhi Tan, Lu Chen, Shuxing Zhang
TRAF2- and NCK-interacting kinase (TNIK) represents one of the crucial targets for Wnt-activated colorectal cancer. In this study, we curated two datasets and conducted a comprehensive modeling study to explore novel TNIK inhibitors with desirable biopharmaceutical properties. With Dataset I, we derived Comparative Molecular Similarity Indices Analysis (CoMSIA) and variable-selection k-nearest neighbor models, from which 3D-molecular fields and 2D-descriptors critical for the TNIK inhibitor activity were revealed...
September 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27642978/os-15-06-sequential-activation-of-intrarenal-ace-ace2-as-the-progression-of-hypertensive-nephropathy-in-2-kidney-10clip-2k1c-goldblatt-rats
#18
Yang Gyun Kim, Sangho Lee, Ju Young Moon, Se Yeon Kim, Yu Ho Lee, Seok Jong Song, Kyung Whan Jeoung, Tae Won Lee, Chun Gyu Ihm
OBJECTIVE: Intrarenal renin-angiotensin system (RAS) had an important role to generate and maintain hypertension in 2-kidny 1-clip (2K1C) rats. This study purposed to assess how various intrarenal RAS components of 2K1C rats contributed to hypertension in different parts (cortex, medulla) of both sides (CK; clipped-kidney, NCK; non-clipped kidney) at different times (2 weeks; 2w and 5 weeks; 5w after clipping operation). DESIGN AND METHOD: We conducted to insert clip to left renal artery or sham operation to SD rats, then systolic blood pressure (SBP) was measured at one week interval...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27602130/hsa-mir-137-hsa-mir-520e-and-hsa-mir-590-3p-perform-crucial-roles-in-lynch-syndrome
#19
Changyu Zhou, Jiayu Li, Jiarui Li, Yingchun Wan, Tao Li, Piyong Ma, Yingjian Wang, Haiyan Sang
The aim of the present study was to identify the differentially expressed microRNAs (DEMs) between Lynch syndrome (LS) and the normal colonic (N-C) control samples, predict the target genes (TGs) and analyze the potential functions of the DEMs and TGs. The miRNA expression dataset GSE30454, which included data of 13 LS and 20 N-C tissue samples, was downloaded from the Gene Expression Omnibus. The classical t-test in Linear Models for Microarray Data package was used for DEM identification. TG prediction was performed using 5 databases...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27578512/relationship-between-cytogenetic-complexity-and-peritumoral-edema-in-high-grade-astrocytoma
#20
Kyung Ho Jeong, Young Jin Song, Jin Yeong Han, Ki Uk Kim
BACKGROUND: The purpose of the study is to reveal the association of cytogenetic compltyexi and peritumoral edema volume (PTEV) and its prognostic significance in high-grade astrocytoma patients by culturing patient tumor cells. METHODS: Twenty-seven high-grade astrocytoma patients were divided into three groups according to karyotype complexity: normal, non-complex karyotype (NCK), and complex karyotype (CK). Endothelial growth factor receptor (EGFR) amplification was detected by FISH, and its association with chromosome 7 abnormalities was analyzed...
November 2016: Annals of Laboratory Medicine
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