Q Liu, Q Wu, Y Wang, Y Zheng, X Wang, X Peng, X Wang, X Wei, S Zhang, J Qiao, L Li, Y Yang
PURPOSE/OBJECTIVE(S): For locally advanced laryngeal cancer (LAL), the local recurrence rate remains 19-40% after radical surgery with postoperative radiotherapy alone or with concurrent chemoradiotherapy in patients with unfavorable prognostic factors. We evaluate local control and acute toxicity of intraoperative radiation therapy (IORT) as a tumor bed boost for locally advanced laryngeal cancer in this prospective phase 2 trial. MATERIALS/METHODS: This phase II clinical study in which a total of 63 LAL patients (T2N1-3/T3N0-3/T4N0-3) were selected and received IORT (T2: 8-10Gy, T3,4:12-15 Gy) as a tumor bed boost during radical surgery, then received external-beam radiation therapy (EBRT) at a total dose of 54-60Gy within 6 weeks after surgery, 5 times per week, 1...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics