keyword
MENU ▼
Read by QxMD icon Read
search

Nos1ap

keyword
https://www.readbyqxmd.com/read/27696408/widespread-brain-transcriptome-alterations-underlie-the-neuroprotective-actions-of-dietary-saffron
#1
Nicholas V Skladnev, Varshika Ganeshan, Ji Yeon Kim, Thomas J Burton, John Mitrofanis, Jonathan Stone, Daniel M Johnstone
Dietary saffron has shown promise as a neuroprotective intervention in clinical trials of retinal degeneration and dementia and in animal models of multiple CNS disorders, including Parkinson's disease. This therapeutic potential makes it important to define the relationship between dose and protection and the mechanisms involved. To explore these two issues, mice were pre-conditioned by providing an aqueous extract of saffron (0.01% w/v) as their drinking water for 2, 5 or 10 days before administration of the parkinsonian neurotoxin MPTP (50 mg/kg)...
October 1, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27460199/the-role-of-known-variants-of-kcnq1-kcnh2-kcne1-scn5a-and-nos1ap-in-water-related-deaths
#2
Iliana Tzimas, Jana-Christin Zingraf, Thomas Bajanowski, Micaela Poetsch
Drowning is one of the most frequent causes of accidental deaths worldwide, and still it remains a diagnosis of exclusion. Moreover, sudden cardiac deaths (SCD) or, if no actual cardiac alterations can be found, sudden unexplained deaths (SUD) represent a major group within mortality statistics as well. This leads to the assumption that there might be a general underlying cause for at least some cases of drowning, SCD, or SUD, for example, genetic aberrations in arrhythmia-associated genes. In the present study, blood samples of 171 corpses found in water (drowning, death after almost drowning, and unclear deaths) were analyzed in 19 known variants of the genes KCNQ1, KCNH2, KCNE1, SCN5A, and NOS1AP by minisequencing...
November 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27237129/research-progress-in-nos1ap-in-neurological-and-psychiatric-diseases
#3
REVIEW
Jie Wang, Lei Jin, Yufu Zhu, Xiuping Zhou, Rutong Yu, Shangfeng Gao
Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP, previously named CAPON) was firstly identified in rat brain in 1998. Structurally, NOS1AP consists of a phosphotyrosine-binding (PTB) domain at its N-terminal and a PDZ (PSD-95/discs-large/ZO-1) ligand motif at its C-terminal. The PTB domain of NOS1AP mediates the interactions with Dexras1, scribble, and synapsins. The PDZ ligand motif of NOS1AP binds to the PDZ domain of NOS1, the enzyme responsible for nitric oxide synthesis in the nervous system. NOS1AP is implicated in Dexras1 activation, neuronal nitric oxide production, Hippo pathway signaling, and dendritic development through the association with these important partners...
July 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27170476/oxidative-stress-induced-ventricular-arrhythmia-and-impairment-of-cardiac-function-in-nos1ap-deleted-mice
#4
Koji Sugiyama, Tetsuo Sasano, Junko Kurokawa, Kentaro Takahashi, Tadashi Okamura, Norihiro Kato, Mitsuaki Isobe, Tetsushi Furukawa
Genome-wide association study has identified that the genetic variations at NOS1AP (neuronal nitric oxide synthase-1 adaptor protein) were associated with QT interval and sudden cardiac death (SCD). However, the mechanism linking a genetic variant of NOS1AP and SCD is poorly understood. We used Nos1ap knockout mice (Nos1ap(-/-)) to determine the involvement of Nos1ap in SCD, paying special attention to oxidative stress.At baseline, a surface electrocardiogram (ECG) and ultrasound echocardiography (UCG) showed no difference between Nos1ap(-/-) and wild-type (WT) mice...
May 25, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27080431/sex-dichotomous-effects-of-nos1ap-promoter-dna-methylation-on-intracranial-aneurysm-and-brain-arteriovenous-malformation
#5
Zhepei Wang, Jikuang Zhao, Jie Sun, Sheng Nie, Keqing Li, Feng Gao, Tiefeng Zhang, Shiwei Duan, Yazhen Di, Yi Huang, Xiang Gao
The goal of this study was to investigate the contribution of NOS1AP-promoter DNA methylation to the risk of intracranial aneurysm (IA) and brain arteriovenous malformation (BAVM) in a Han Chinese population. A total of 48 patients with IAs, 22 patients with BAVMs, and 26 control individuals were enrolled in the study. DNA methylation was tested using bisulfite pyrosequencing technology. We detected significantly higher DNA methylation levels in BAVM patients than in IA patients based on the multiple testing correction (CpG4-5 methylation: 5...
May 16, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26962151/twenty-eight-genetic-loci-associated-with-st-t-wave-amplitudes-of-the-electrocardiogram
#6
Niek Verweij, Irene Mateo Leach, Aaron Isaacs, Dan E Arking, Joshua C Bis, Tune H Pers, Marten E van den Berg, Leo-Pekka Lyytikäinen, Phil Barnett, Xinchen Wang, Elsayed Z Soliman, Cornelia M van Duijn, Mika Kähönen, Dirk J van Veldhuisen, Jan A Kors, Olli T Raitakari, Claudia T Silva, Terho Lehtimäki, Hans L Hillege, Joel N Hirschhorn, Laurie A Boyer, Wiek H van Gilst, Alvaro Alonso, Nona Sotoodehnia, Mark Eijgelsheim, Rudolf A de Boer, Paul I W de Bakker, Lude Franke, Pim van der Harst
The ST segment and adjacent T wave amplitudes (ST-T wave) of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed the first GWA meta-analysis of ST-T wave amplitudes in up to 37,977 individuals identifying 71 robust genotype-phenotype associations clustered within 28 independent loci. Fifty-four genes were prioritized as candidates underlying the phenotypes, including genes with established roles in the cardiac repolarization phase (SCN5A/SCN10A, KCND3, KCNB1, NOS1AP and HEY2) and others with as yet undefined cardiac function...
March 8, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/26946266/dexras1-a-unique-ras-gtpase-interacts-with-nmda-receptor-activity-and-provides-a-novel-dissociation-between-anxiety-working-memory-and-sensory-gating
#7
G C Carlson, R E Lin, Y Chen, B R Brookshire, R S White, I Lucki, S J Siegel, S F Kim
Dexras1 is a novel GTPase that acts at a confluence of signaling mechanisms associated with psychiatric and neurological disease including NMDA receptors, NOS1AP and nNOS. Recent work has shown that Dexras1 mediates iron trafficking and NMDA-dependent neurodegeneration but a role for Dexras1 in normal brain function or psychiatric disease has not been studied. To test for such a role, mice with germline knockout (KO) of Dexras1 were assayed for behavioral abnormalities as well as changes in NMDA receptor subunit protein expression...
May 13, 2016: Neuroscience
https://www.readbyqxmd.com/read/26869880/overexpression-of-isoforms-of-nitric-oxide-synthase-1-adaptor-protein-encoded-by-a-risk-gene-for-schizophrenia-alters-actin-dynamics-and-synaptic-function
#8
Kristina Hernandez, Przemyslaw Swiatkowski, Mihir V Patel, Chen Liang, Natasha R Dudzinski, Linda M Brzustowicz, Bonnie L Firestein
Proper communication between neurons depends upon appropriate patterning of dendrites and correct distribution and structure of spines. Schizophrenia is a neuropsychiatric disorder characterized by alterations in dendrite branching and spine density. Nitric oxide synthase 1 adaptor protein (NOS1AP), a risk gene for schizophrenia, encodes proteins that are upregulated in the dorsolateral prefrontal cortex (DLPFC) of individuals with schizophrenia. To elucidate the effects of NOS1AP overexpression observed in individuals with schizophrenia, we investigated changes in actin dynamics and spine development when a long (NOS1AP-L) or short (NOS1AP-S) isoform of NOS1AP is overexpressed...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/26861996/interaction-of-nos1ap-with-the-nos-i-pdz-domain-implications-for-schizophrenia-related-alterations-in-dendritic-morphology
#9
Esin Candemir, Leonie Kollert, Lena Weißflog, Maria Geis, Antje Müller, Antonia M Post, Aet O'Leary, Jaanus Harro, Andreas Reif, Florian Freudenberg
Schizophrenia involves morphological brain changes, including changes in synaptic plasticity and altered dendritic development. Amongst the most promising candidate molecules for schizophrenia are neuronal nitric oxide (NO) synthase (NOS-I, also known as nNOS) and its adapter protein NOS1AP (previously named CAPON). However, the precise molecular mechanisms by which NOS-I and NOS1AP affect disease pathology remain to be resolved. Interestingly, overexpression of NOS1AP affects dendritic morphology, possibly through increased association with the NOS-I PDZ domain...
April 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26810132/genetic-markers-predicting-sulphonylurea-treatment-outcomes-in-type-2-diabetes-patients-current-evidence-and-challenges-for-clinical-implementation
#10
REVIEW
N K Loganadan, H Z Huri, S R Vethakkan, Z Hussein
The clinical response to sulphonylurea, an oral antidiabetic agent often used in combination with metformin to control blood glucose in type 2 diabetes (T2DM) patients, has been widely associated with a number of gene polymorphisms, particularly those involved in insulin release. We have reviewed the genetic markers of CYP2C9, ABCC8, KCNJ11, TCF7L2 (transcription factor 7-like 2), IRS-1 (insulin receptor substrate-1), CDKAL1, CDKN2A/2B, KCNQ1 and NOS1AP (nitric oxide synthase 1 adaptor protein) genes that predict treatment outcomes of sulphonylurea therapy...
June 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/26597662/genetic-assessment-of-additional-endophenotypes-from-the-consortium-on-the-genetics-of-schizophrenia-family-study
#11
REVIEW
Tiffany A Greenwood, Laura C Lazzeroni, Monica E Calkins, Robert Freedman, Michael F Green, Raquel E Gur, Ruben C Gur, Gregory A Light, Keith H Nuechterlein, Ann Olincy, Allen D Radant, Larry J Seidman, Larry J Siever, Jeremy M Silverman, William S Stone, Catherine A Sugar, Neal R Swerdlow, Debby W Tsuang, Ming T Tsuang, Bruce I Turetsky, David L Braff
The Consortium on the Genetics of Schizophrenia Family Study (COGS-1) has previously reported our efforts to characterize the genetic architecture of 12 primary endophenotypes for schizophrenia. We now report the characterization of 13 additional measures derived from the same endophenotype test paradigms in the COGS-1 families. Nine of the measures were found to discriminate between schizophrenia patients and controls, were significantly heritable (31 to 62%), and were sufficiently independent of previously assessed endophenotypes, demonstrating utility as additional endophenotypes...
January 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/26384012/association-of-nos1ap-variants-and-depression-phenotypes-in-schizophrenia
#12
Sern-Yih Cheah, Bruce R Lawford, Ross McD Young, C Phillip Morris, Joanne Voisey
BACKGROUND: The nitric oxide synthase 1 adaptor protein gene (NOS1AP) has previously been recognised as a schizophrenia susceptibility gene due to its role in glutamate neurotransmission. The gene is believed to inhibit nitric oxide (NO) production activated by the N-methyl-d-aspartate (NMDA) receptor and reduced NO levels have been observed in schizophrenia patients. However, association studies investigating NOS1AP and schizophrenia have produced inconsistent results, most likely because schizophrenia is a clinically heterogeneous disorder...
December 1, 2015: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26332198/nos1ap-polymorphisms-modify-qtc-interval-duration-but-not-cardiac-arrest-risk-in-hypertrophic-cardiomyopathy
#13
Nikki Earle, Jodie Ingles, Richard D Bagnall, Belinda Gray, Jackie Crawford, Warren Smith, Andrew N Shelling, Donald R Love, Chris Semsarian, Jonathan R Skinner
INTRODUCTION: The accurate prediction of the risk of sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) remains elusive. Corrected QT interval (QTc) duration is a known risk factor in various cardiac conditions. Single nucleotide polymorphisms (SNPs) have been linked to QTc length, and to SCD. Here we investigated the role of 21 candidate SNPs in QTc duration and SCD events in patients with HCM. METHODS AND RESULTS: This HCM registry-based study included patients with an ECG, medical history, first SCD event data, and DNA available...
December 2015: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/26230511/genetic-analysis-of-arrhythmogenic-diseases-in-the-era-of-ngs-the-complexity-of-clinical-decision-making-in-brugada-syndrome
#14
Catarina Allegue, Mònica Coll, Jesus Mates, Oscar Campuzano, Anna Iglesias, Beatriz Sobrino, Maria Brion, Jorge Amigo, Angel Carracedo, Pedro Brugada, Josep Brugada, Ramon Brugada
BACKGROUND: The use of next-generation sequencing enables a rapid analysis of many genes associated with sudden cardiac death in diseases like Brugada Syndrome. Genetic variation is identified and associated with 30-35% of cases of Brugada Syndrome, with nearly 20-25% attributable to variants in SCN5A, meaning many cases remain undiagnosed genetically. To evaluate the role of genetic variants in arrhythmogenic diseases and the utility of next-generation sequencing, we applied this technology to resequence 28 main genes associated with arrhythmogenic disorders...
2015: PloS One
https://www.readbyqxmd.com/read/26197318/nos1ap-o-glcnac-modification-involved-in-neuron-apoptosis-induced-by-excitotoxicity
#15
Liang Zhu, Tao Tao, Dongmei Zhang, Xiaojuan Liu, Kaifu Ke, Aiguo Shen
O-Linked N-acetylglucosamine, or O-GlcNAc, is a dynamic post-translational modification that cycles on and off serine and threonine residues of nucleocytoplasmic and mitochondrial proteins. In addition to cancer and inflammation diseases, O-GlcNAc modification appears to play a critical role during cell apoptosis and stress response, although the precise mechanisms are still not very clear. Here we found that nitric oxide synthase adaptor (NOS1AP), which plays an important part in glutamate-induced neuronal apoptosis, carries the modification of O-GlcNAc...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26035054/increase-of-heart-rate-and-qtc-by-amitriptyline-but-not-by-venlafaxine-is-correlated-to-serum-concentration
#16
Stefan Unterecker, Bruno Pfuhlmann, Juliane Kopf, Sarah Kittel-Schneider, Andreas Reif, Jürgen Deckert
Electrocardiographic pathologies are a common problem during antidepressant treatment. The authors investigated the association of serum concentrations of antidepressants and heart rate, QT, and QTc. Polymorphisms of NOS1AP (nitric oxide synthase 1 adaptor protein) rs10494366 and rs12143842 as potential influence factors also were considered. In the amitriptyline sample (n = 59), significant Spearman ρ correlations were found between serum concentration and QTc (r = 0.333, P = 0.010), as well as heart rate (r = 0...
August 2015: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/25972165/unexpected-heterodivalent-recruitment-of-nos1ap-to-nnos-reveals-multiple-sites-for-pharmacological-intervention-in-neuronal-disease-models
#17
Li-Li Li, Raquel M Melero-Fernandez de Mera, Jia Chen, Wei Ba, Nael Nadif Kasri, Mingjie Zhang, Michael J Courtney
The protein NOS1AP/CAPON mediates signaling from a protein complex of NMDA receptor, PSD95 and nNOS. The only stroke trial for neuroprotectants that showed benefit to patients targeted this ternary complex. NOS1AP/nNOS interaction regulates small GTPases, iron transport, p38MAPK-linked excitotoxicity, and anxiety. Moreover, the nos1ap gene is linked to disorders from schizophrenia, post-traumatic stress disorder, and autism to cardiovascular disorders and breast cancer. Understanding protein interactions required for NOS1AP function, therefore, has broad implications for numerous diseases...
May 13, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/25918243/nos1ap-functionally-associates-with-yap-to-regulate-hippo-signaling
#18
Leanne Clattenburg, Michael Wigerius, Jiansong Qi, Jan K Rainey, Jillian L Rourke, Shanmugam Muruganandan, Christopher J Sinal, James P Fawcett
Deregulation of cellular polarity proteins and their associated complexes leads to changes in cell migration and proliferation. The nitric oxide synthase 1 adaptor protein (NOS1AP) associates with the tumor suppressor protein Scribble to control cell migration and oncogenic transformation. However, how NOS1AP is linked to the cell signaling events that curb oncogenic progression has remained elusive. Here we identify several novel NOS1AP isoforms, NOS1APd, NOS1APe, and NOS1APf, with distinct cellular localizations...
July 2015: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/25819866/genetic-markers-of-repolarization-and-arrhythmic-events-after-acute-coronary-syndromes
#19
N J Earle, K K Poppe, A P Pilbrow, V A Cameron, R W Troughton, J R Skinner, D R Love, A N Shelling, G A Whalley, C J Ellis, A M Richards, R N Doughty
BACKGROUND: There is a genetic contribution to the risk of ventricular arrhythmias in survivors of acute coronary syndromes (ACS). We wished to explore the role of 33 candidate single nucleotide polymorphisms (SNPs) in prolonged repolarization and sudden death in patients surviving ACS. METHODS: A total of 2,139 patients (1680 white ethnicity) surviving an admission for ACS were enrolled in the prospective Coronary Disease Cohort Study. Extensive clinical, echocardiographic, and neurohormonal data were collected for 12 months, and clinical events were recorded for a median of 5 years...
April 2015: American Heart Journal
https://www.readbyqxmd.com/read/25737393/analysis-for-genetic-modifiers-of-disease-severity-in-patients-with-long-qt-syndrome-type-2
#20
Iris C R M Kolder, Michael W T Tanck, Pieter G Postema, Julien Barc, Moritz F Sinner, Sven Zumhagen, Anja Husemann, Birgit Stallmeyer, Tamara T Koopmann, Nynke Hofman, Arne Pfeufer, Peter Lichtner, Thomas Meitinger, Britt M Beckmann, Robert J Myerburg, Nanette H Bishopric, Dan M Roden, Stefan Kääb, Arthur A M Wilde, Jean-Jacques Schott, Eric Schulze-Bahr, Connie R Bezzina
BACKGROUND: Considerable interest exists in the identification of genetic modifiers of disease severity in the long-QT syndrome (LQTS) as their identification may contribute to refinement of risk stratification. METHODS AND RESULTS: We searched for single-nucleotide polymorphisms (SNPs) that modulate the corrected QT (QTc)-interval and the occurrence of cardiac events in 639 patients harboring different mutations in KCNH2. We analyzed 1201 SNPs in and around 18 candidate genes, and in another approach investigated 22 independent SNPs previously identified as modulators of QTc-interval in genome-wide association studies in the general population...
June 2015: Circulation. Cardiovascular Genetics
keyword
keyword
68908
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"