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https://www.readbyqxmd.com/read/29672771/effects-of-subclinical-footpad-dermatitis-and-emotional-arousal-on-surface-foot-temperature-recorded-with-infrared-thermography-in-turkey-toms-meleagris-gallopavo
#1
R O Moe, J Bohlin, A Flø, G Vasdal, H Erlandsen, E Guneriussen, E C Sjökvist, S M Stubsjøen
Footpad dermatitis is a condition that causes lesions on the plantar surface of the footpads in growing turkeys. Potential inflammatory processes and pain associated with increasing severity of footpad dermatitis raise animal welfare concerns. This study investigated whether the temperature of the plantar surface of the foot (the footpads and the entire plantar foot including interdigital membranes) assessed with infrared thermography reflects severity of mild footpad dermatitis as assessed with a Visual Analogue Scale in 80 turkey toms at 10 weeks of age...
April 17, 2018: Poultry Science
https://www.readbyqxmd.com/read/29658796/lichen-sclerosus-of-the-oral-mucosa-clinical-and-histopathological-findings-review-of-the-literature-and-a-case-report
#2
Anna-Maija Matela, Jaana Hagström, Hellevi Ruokonen
OBJECTIVES: Lichen sclerosus (LS) is a rare, chronic mucocutaneous disease that most frequently affects the female genital area. Oral manifestations are seldom detected; only 36 well-documented and histopathologically verified oral LS cases have been published. MATERIALS AND METHODS: Here we describe one patient affected by oral (LS) and review of the literature 1957-2017. RESULTS: Findings in our review suggest a female to male ratio of 1...
April 16, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29629648/cutaneous-squamous-cell-carcinoma-associated-with-zalophus-californianus-papillomavirus-1-in-a-california-sea-lion
#3
Jennifer A Luff, Rachel E Burns, Michelle Mader, Kara D Priest, Allison D Tuttle
Papillomaviruses (PVs) are found in many species and infect epithelial cells at both mucosal and cutaneous sites. PVs are generally species-specific and cause benign epithelial proliferations, often forming papillomas or plaques. Rarely, these infections can persist, allowing progression to in situ and invasive cancers. We describe herein a case of multiple cutaneous pigmented plaques from a California sea lion ( Zalophus californianus) that progressed to in situ and invasive squamous cell carcinoma (SCC). The lesions were characterized by epithelial hyperplasia, hyperkeratosis, and hypergranulosis that bordered more dysplastic areas, and, at one site, bordered an invasive SCC...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29618363/alitretinoin-reduces-erythema-in-inherited-ichthyosis
#4
Giuliana Onnis, Christine Chiaverini, Geoffroy Hickman, Isabelle Dreyfus, Judith Fischer, Emmanuelle Bourrat, Juliette Mazereeuw-Hautier
BACKGROUND: Acitretin is the main retinoid used to treat severe inherited ichthyosis. Alternatives may be considered if it results ineffective or there are side-effects, or for women of childbearing age. Our objective is evaluation of the effects and tolerance of alitretinoin. An observational retrospective multicentric study was designed to analyse patients with inherited ichthyosis treated by alitretinoin. RESULTS: A total of 13 patients were included, 11 of whom were receiving acitretin at inclusion...
April 4, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29617836/met-receptor-tyrosine-kinase-and-chemoprevention-of-oral-cancer
#5
Pierre Saintigny, William N William, Jean-Philippe Foy, Vassiliki Papadimitrakopoulou, Wenhua Lang, Li Zhang, You Hong Fan, Lei Feng, Edward S Kim, Adel K El-Naggar, J Jack Lee, Li Mao, Waun Ki Hong, Mark W Lingen, Scott M Lippman
Background: We have previously shown that gene expression profiles of oral leukoplakia (OL) may improve the prediction of oral cancer (OC) risk. To identify new targets for prevention, we performed a systematic survey of transcripts associated with an increased risk of oral cancer and overexpressed in OC vs normal mucosa (NM). Methods: We used gene expression profiles of 86 patients with OL and available outcomes from a chemoprevention trial of OC and NM. MET expression was evaluated using immunohistochemistry in 120 OL patients, and its association with OC development was tested in multivariable analysis...
March 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29611610/prevalence-of-skin-diseases-amongst-moroccan-fishermen
#6
Omar Laraqui, Nadia Manar, Salwa Laraqui, Tarik Ghailan, Frédéric Deschamps, Reda Hammouda, Chakib El Houssine Laraqui
BACKGROUND: The main objective was to evaluate the prevalence of skin diseases amongst fishermen, to specify the different clinical forms, associations and most frequent localisations, and to identify potential aetiological factors. The secondary objectives were to assess the knowledge, attitudes and practices of seafarers regarding occupational dermatoses to conduct information, awareness and education campaigns on risk factors and behaviours and to propose adapted prevention. MATERIALS AND METHODS: This cross-sectional survey involved 1102 artisanal fishermen who attended the annual legal medical consultation at the occupational health service...
2018: International Maritime Health
https://www.readbyqxmd.com/read/29604103/recalcitrant-psoriasiform-dermatosis-of-the-face-is-it-related-to-pityriasis-rubra-pilaris
#7
Emily Yiping Gan, See Ket Ng, Chee Leok Goh, Siong See Joyce Lee
BACKGROUND: There are patients with recalcitrant psoriasiform plaques that do not fit into conventional categories of facial dermatoses. Our study aims to describe the clinico-pathological characteristics of several patients with a unique presentation of persistent psoriasiform facial rashes. METHODS: This retrospective cross-sectional study analyzed clinical and histological data of known cases of recalcitrant psoriasiform dermatosis of the face diagnosed at National Skin Centre, Singapore, over 10 years...
March 31, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29599670/dermoscopic-assessment-of-skin-toxicities-in-patients-with-melanoma-during-treatment-with-vemurafenib
#8
Marcin Rajczykowski, Grazyna Kaminska-Winciorek, Elzbieta Nowara, Marzenna Samborska-Plewicka, Sebastian Giebel
Introduction: The use of vemurafenib in melanoma has improved the survival of patients; however, it is associated with skin toxicities. Aim: To assess skin toxicities by dermoscopy in patients treated with vemurafenib. Material and methods: Eight patients with BRAF V600 mutation positive metastatic melanoma were examined dermoscopically during vemurafenib treatment. All skin lesions occurring during therapy were assessed clinically and dermoscopically using a hand-held dermoscope with polarised and non-polarised light...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29594144/an-unexpected-case-of-scurvy-in-a-peritoneal-dialysis-patient
#9
Raymonda El Khoury, Mitchell Warren, Saba Ali, James L Pirkle
This case describes an obese adult male peritoneal dialysis patient who presented with a pruritic follicular rash. Nutrient deficiency was not suspected initially in this case because there was no history of protein-calorie malnutrition, but the patient reported a diet devoid of fruits and vegetables and had not been taking his dialysis vitamin as prescribed. Skin biopsy showed follicular hyperkeratosis with fragmented hair shafts and corkscrew hairs consistent with scurvy. After supplementation with ascorbic acid 500 mg twice daily for 2 weeks, the rash resolved completely...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29587599/pathological-and-clinical-pathological-changes-induced-by-four-week-repeated-dose-oral-administration-of-the-wood-preservative-chromated-copper-arsenate-in-wistar-rats
#10
Naofumi Takahashi, Toshinori Yoshida, Sayuri Kojima, Satoru Yamaguchi, Ryoichi Ohtsuka, Makio Takeda, Tadashi Kosaka, Takanori Harada
Chromated copper arsenate (CCA) is used as a wood preservative worldwide. Exposure to it may adversely affect human health. Some events have increased human exposure to CCA, including the Great East Japan Earthquake, which generated a large amount of lumber debris from CCA-treated woods. We elucidated the toxicity due to daily exposure to CCA over a 4-week period at doses of 0, 8, 40, and 80 mg/kg/day in Wistar Hannover rats. Chromium (Cr) and arsenic (As), but not copper, were detected in the plasma samples of rats treated with various doses of CCA...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29587357/importance-of-footwear-for-preventing-xerosis-and-hyperkeratosis-in-older-people-with-psychiatric-disorders-living-in-an-institution
#11
Ana María Pérez-Pico, Félix Marcos-Tejedor, María José Iglesias-Sánchez, Raquel Mayordomo Acevedo
Few studies have focused on the relation between the use and characteristics of footwear and the presence of foot lesions in people with psychiatric disorders. This work analyzes the influence of different footwear habits on the presence of deformities and ungueal and dermal pathologies of the foot of institutionalized people with psychiatric disorders compared to people without these disorders. A transversal and observational study was conducted on 107 participants, divided into two groups who have used different types of shoes throughout their lives...
March 24, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29580550/correlation-between-clinical-histopathologic-and-ultrasound-findings-in-focal-acral-hyperkeratosis
#12
J Company-Quiroga, B Echeverría, J C Tardío, C Martínez-Morán
No abstract text is available yet for this article.
March 23, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29575629/three-novel-gjb2-connexin-26-variants-associated-with-autosomal-dominant-syndromic-and-nonsyndromic-hearing-loss
#13
Desiree DeMille, Colleen M Carlston, Oliver H Tam, Janice C Palumbos, Heather J Stalker, Rong Mao, Roberto T Zori, David H Viskochil, Albert H Park, John C Carey
Connexin 26 (Cx26), encoded by the GJB2 gene, is a key protein involved in the formation of gap junctions in epithelial organs including the inner ear and palmoplantar epidermis. Pathogenic variants in GJB2 are responsible for approximately 50% of inherited sensorineural deafness. The majority of these variants are associated with autosomal recessive inheritance; however, rare reports of dominantly co-segregating variants have been published. Since we began offering GJB2 testing in 2003, only about 2% of detected GJB2 variants from our laboratory have been classified as dominant...
April 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29575617/novel-rspo1-mutation-causing-46-xx-testicular-disorder-of-sex-development-with-palmoplantar-keratoderma-a-review-of-literature-and-expansion-of-clinical-phenotype
#14
Karthik Tallapaka, Vineeth Venugopal, Ashwin Dalal, Shagun Aggarwal
Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and sex reversal (MIM # 610644) is a clinically distinctive form of SRY-negative 46,XX disorder of sex development. It is a rare autosomal recessive disorder caused due to biallelic loss of function mutations in RSPO1 gene. RSPO1 acts by activating the canonical β-catenin pathway and is one of the most important genes controlling female gonadal differentiation. RSPO1-associated disorders of sex development have been described only in three instances in the past...
April 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29528025/natural-thermal-spa-water-versus-hyperthermic-tap-water-for-treatment-of-recalcitrant-hand-warts-in-organ-transplant-recipients-a-patient-blinded-comparative-preliminary-study
#15
A Tülin Güleç
OBJECTIVES: Cutaneous warts represent a major problem in organ transplant recipients because of their extensive involvement and persistent course. Current therapeutic modalities often fail to achieve a successful response in patients with warts. We experienced a case involving an organ transplant recipient with recalcitrant mosaic warts who presented with complete clearance of lesions in 3 days after thermal spa bathing. Here, we evaluated the efficacy of natural thermal water versus hyperthermic tap water for treatment of recalcitrant hand warts in organ transplant recipients...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29523849/p63-is-a-key-regulator-of-irhom2-signalling-in-the-keratinocyte-stress-response
#16
Paola Arcidiacono, Catherine M Webb, Matthew A Brooke, Huiqing Zhou, Paul J Delaney, Keat-Eng Ng, Diana C Blaydon, Andrew Tinker, David P Kelsell, Anissa Chikh
Hyperproliferative keratinocytes induced by trauma, hyperkeratosis and/or inflammation display molecular signatures similar to those of palmoplantar epidermis. Inherited gain-of-function mutations in RHBDF2 (encoding iRHOM2) are associated with a hyperproliferative palmoplantar keratoderma and squamous oesophageal cancer syndrome (termed TOC). In contrast, genetic ablation of rhbdf2 in mice leads to a thinning of the mammalian footpad, and reduces keratinocyte hyperproliferation and migration. Here, we report that iRHOM2 is a novel target gene of p63 and that both p63 and iRHOM2 differentially regulate cellular stress-associated signalling pathways in normal and hyperproliferative keratinocytes...
March 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29512192/the-clinical-phenotype-and-a-novel-col7a1-mutation-in-a-chinese-family-with-dystrophic-epidermolysis-bullosa-pruriginosa
#17
Yun-Zhu Mu, Zi-Cen Du, Zheng-Zhong Zhang, Hao Yang, Xing Chen, Yanbo Wang, Lin-Li Liu
Distrophic epidermolysis bullosa pruriginosa(DEB-Pr, OMIM#604129) is a rare subtype of epidermolysis bullosa dystrophica. It is characterized by recurrent vesicles and erosions on the extensor of the limbs at birth or shortly thereafter and pruriginosa papules and nodules accompanied with intense itching and nail dystrophy in adult stage1 . Histology reveals hyperkeratosis, mild acanthosis and a subepidermal blister formation2 . Electron microscopic studies showed alterations in the number and ultrastructure of anchoring fibrils in lesional, perilesional and non-lesional skin3 ...
March 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29491614/cutaneous-horn-a-mask-to-underlying-malignancy
#18
Rashmi Gs Phulari, Rajendrasinh Rathore, Trupti Pramod Talegaon, Arpan Shah
Cutaneous horns ( cornu cutaneum ) are uncommon lesions consisting of keratotic material resembling that of an animal horn. It is a conical- or cylindrical-shaped excessive hyperkeratosis of variable size ranging from few millimeters to several centimeters with a variable in size and shape, such as cylindrical, conical, pointed, transversely or longitudinally corrugated, or curved like a ram's horn. The lesions typically occur in sun-exposed areas, particularly the face, ear, nose, forearms and dorsum of hands...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29491192/crusted-nipple-and-areola-a-new-aetiology-of-secondary-hyperkeratosis-of-the-nipple-and-areola
#19
Dhaifallah A Alenizi
Hyperkeratosis of the nipple and areola is a rare condition first described by Tauber in 1923. Less than 100 cases have been reported in the literature. Hyperkeratosis of the nipple and areola presents as hyperkeratotic, hyperpigmented plaques on the nipple and areola. It is more common in females. An 18-year-old female patient presented with hyperkeratotic, plaque-like, hard crusts on both nipples and areolas. The examining physician could successfully remove this crust using his finger. The crust had accumulated as a result of the patient's reluctance to touch or clean the breast area due to psychological issues...
March 1, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29486632/bilateral-hyperkeratosis-of-the-nipples-and-areolae-with-linear-nevus-a-rare-case-report-and-review-of-the-literature
#20
Mei-Fang Wang, Li Wang, Lin-Feng Li
Hyperkeratosis of the nipple and areola is an uncommon dermatosis without well-defined etiology, which occurs mostly in young women and may only be a cosmetic problem. In 1938, Levy-Frankel classified this disease into three variants; type I involves hyperkeratosis with an epidermal nevus, and has rarely been reported. We report a case of a 23-year-old woman with long-term bilateral pigmentation and thickening of the nipples and areolae, accompanied with dark brown, flat lesions with a linear distribution on her left forearm...
February 28, 2018: Postgraduate Medicine
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