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https://www.readbyqxmd.com/read/28091448/oro-dental-characteristics-of-three-siblings-with-papillon-lefevre-syndrome
#1
O E Gungor, H Karayilmaz, H Yalcin, M Hatipoğlu
Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder, showing oral and dermatological manifestations in the form of aggressive periodontitis, leading to the premature loss of both primary and permanent teeth at a very young age and palmar-plantar hyperkeratosis. It was first described by two French physicians, Papillon and Lefevre in 1924. Immunologic, genetic, or possible bacterial etiologies have been thought to account for etiopathogenesis of PLS. Severe gingival inflammation and periodontal destruction occurred after the eruption of primary teeth...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28067422/epidermal-psoriasiform-hyperplasia-an-unrecognized-sign-of-folliculitis-decalvans-a-histological-study-of-26-patients
#2
B Matard, B Cavelier-Balloy, P Reygagne
BACKGROUND: Follicular hyperkeratosis along with hyperplasia of the follicular and inter-follicular epithelia are major histopathological characteristics of Hidradenitis Suppurativa (HS). The presence of an occasional thickening of lesional skin in some Folliculitis Decalvans (FD) patients and histological similarities between FD and HS led us to look for epidermal hyperplasia and follicular hyperkeratosis in FD patients. PATIENTS AND METHOD: We performed a retrospective histological analysis of 26 patients with FD...
January 9, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28063594/-scabies-of-the-nail-unit-in-an-infant
#3
A Finon, G Desoubeaux, M Nadal, G Georgescou, R Baran, A Maruani
BACKGROUND: There are no guidelines regarding the management of scabies in infants and recurrence is common at this age. We report the case of an infant with subungual hyperkeratosis and ungual lesions subsequent to classic scabies. PATIENTS AND METHODS: A 7-month-girl, treated 6 weeks earlier with esdepallethrin for scabies, consulted for acquired lesions on 3 toe nails. These nails were thickened and displayed subungual hyperkeratosis. Physical examination of the skin, the finger nails and mucous membranes was otherwise normal...
January 4, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28053911/verruciform-xanthoma-in-the-hard-palate-a-case-report-and-literature-review
#4
Alexandre Simões Garcia, Otávio Pagin, Paulo Sérgio da Silva Santos, Denise Tostes Oliveira
Oral verruciform xanthoma (OVX) is an uncommon lesion that appears on the oral mucosa. The aim of this paper was to discuss the probable etiopathogenesis of OVX in the hard palate, reinforcing the importance of including this lesion in the differential diagnosis of verrucous lesions. A 43-year-old male smoker presented with a painless lesion with a verrucous surface and erythematous spots on the hard palate. Excisional biopsy revealed oral mucosa consisting of hyperkeratosis, acanthosis, and elongated rete pegs...
December 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28052370/acantholytic-dermatosis-of-the-vagina-the-diagnostic-challenge-of-acantholytic-disease-in-the-genital-region
#5
J Kentley, R Cerio, M Khorshid, K Gibbon
We report the case of a 24-year-old woman with an 8-month history of deep pelvic pain and postcoital bleeding. Examination revealed desquamation of the vaginal epithelium with tender fissured plaques in the vagina, initially thought to be vaginal intraepithelial neoplasia. Histology showed squamous mucosa with suprabasal acantholysis and hyperkeratosis, and no evidence of viral infection, dysplasia or malignancy. These findings were consistent with acantholytic dermatosis (AD), a rare lesion that resembles Hailey-Hailey and Darier disease histopathologically, but can be distinguished on a clinical basis...
January 4, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28036153/semi-quantifiable-angiogenesis-parameters-in-association-with-the-malignant-transformation-of-oral-leukoplakia
#6
D Thiem, S Schneider, Narayan T V, V V Kumar, J Brieger, B Frerich, P W Kämmerer
BACKGROUND: Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leukoplakia (OL). MATERIALS AND METHODS: 131 histological preparations (oral leukoplakia/hyperkeratosis without dysplasia (OL; n=49), oral leukoplakia/hyperkeratosis with mild dysplasia (OL-SIN1; n=33), with moderate dysplasia (OL-SIN2; n=13) and leukoplakia-derived oral squamous cell carcinoma (OL-OSCC; n=36)) were evaluated for microvessel density (MVD), vessel diameter as well as for vascular endothelial growth factor (VEGF-A) expression...
December 30, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28009316/-efficacy-of-combined-use-of-antioxidative-and-phototherapy-in-the-treatment-of-vitiligo
#7
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, Ts Tsiskarishvili, L Chitanava
Despite of numerous investigations, carried out practically in all countries of the world for the study of vitiligo and the search for its new effective therapies, pathogenic mechanisms of vitiligo are still poorly understood, and the proposed treatments are not perfect. One of the most accepted theories of the pathogenesis of vitiligo is an oxidative stress theory, according to which a series of biochemical anomalies cause oxidative stress, leading to accumulation of melanocytotoxic substances and inhibition of natural processes of detoxification with subsequent destruction of melanocytes in vitiligo focus...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/28004028/nevoid-hyperkeratosis-of-the-nipple-mimicking-a-pigmented-basal-cell-carcinoma
#8
Caterina Mazzella, Claudia Costa, Gabriella Fabbrocini, Giovanni Francesco Marangi, Daniela Russo, Francesco Merolla, Massimiliano Scalvenzi
No abstract text is available yet for this article.
November 2016: JAAD Case Reports
https://www.readbyqxmd.com/read/27995657/protective-effects-of-aloe-sterols-against-uvb-induced-photoaging-in-hairless-mice
#9
Eriko Misawa, Miyuki Tanaka, Marie Saito, Kazumi Nabeshima, Ruiqing Yao, Kouji Yamauchi, Fumiaki Abe, Yuki Yamamoto, Fukumi Furukawa
BACKGROUND: Aloe vera is a traditional medical plant whose gel has been widely used in skin care. Previously, we have identified Aloe sterols from Aloe vera as active ingredients. The present study investigated the protective effects of Aloe sterols without polysaccharides, against ultraviolet B (UVB)-induced skin photoaging in mice using Aloe vera gel extract (AVGE) obtained by supercritical fluid extraction. METHODS: AVGE was supplemented in the diet (12 or 120 ppm) and HR-1 hairless mice were exposed to UVB irradiation for 7 weeks...
December 20, 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27974717/classification-of-tattoo-complications-in-a-hospital-material-of-493-adverse-events
#10
Jørgen Serup, Mitra Sepehri, Katrina Hutton Carlsen
BACKGROUND/AIMS: Tattooing is a global trend. Clinical knowledge of complications is based on case reports collected over a century. Larger cohorts reflecting complications associated with contemporary trends are lacking. METHODS: The study was a retrospective review of a consecutive cohort of patients with tattoo complications diagnosed in the "Tattoo Clinic" of Bispebjerg University Hospital in Copenhagen, Denmark, from 2008 to 2015, based on patient history and systematic clinical examination...
December 15, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27965375/recessive-progressive-symmetric-erythrokeratoderma-results-from-a-homozygous-loss-of-function-mutation-of-krt83-and-is-allelic-with-dominant-monilethrix
#11
Khadim Shah, Muhammad Ansar, Zaib-Un-Nisa Mughal, Falak Sher Khan, Wasim Ahmad, Tracey M Ferrara, Richard A Spritz
BACKGROUND: Progressive symmetric erythrokeratoderma (PSEK) is a rare skin disorder characterised by symmetrically distributed demarcated hyperkeratotic plaques, often with associated palmoplantar hyperkeratosis, with new plaques appearing over time. Most cases are inherited in an autosomal dominant manner, although a few cases exhibit apparent autosomal recessive inheritance. OBJECTIVE: To identify the gene underlying autosomal recessive PSEK in a large Pakistani kindred...
December 13, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27939553/anatomical-characteristics-of-teats-and-premilking-bacterial-counts-of-teat-skin-swabs-of-primiparous-cows-exposed-to-different-types-of-bedding
#12
J F Guarín, C Baumberger, P L Ruegg
Bacterial populations of teat skin are associated with risk of intramammary infection and may be influenced by anatomical characteristics of teats. The objective of this study was to evaluate associations of selected anatomical characteristics of teats with bacterial counts of teat skin of cows exposed to different types of bedding. Primarily primiparous Holstein cows (n = 128) were randomly allocated to 4 pens within a single barn. Each pen contained 1 type of bedding [new sand (NES), recycled sand (RS), deep-bedded manure solids (DBMS), and shallow-bedded manure solids over foam core mattresses (SBMS)]...
December 8, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27938808/palmoplantar-psoriasis
#13
Burhan Engin, Özge Aşkın, Yalçın Tüzün
Palmoplantar psoriasis refers to a localized psoriasis variant. The disease can be associated with many clinical forms, including predominantly pustular lesions to thick scaly, hyperkeratotic plaques, or an overlapping of both of them. Palmoplantar psoriasis accounts for 3-4% of all psoriasis cases in most studies. Although it is localized only on the palms and the soles, the fissures, the hardening of the tissue, and hyperkeratosis affect daily routine activities. Taking the body surface area as a measure of severity can sometimes be misleading...
January 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/27925662/clinical-and-pathological-features-of-hair-coat-abnormalities-in-curly-coated-retrievers-from-uk-and-sweden
#14
R Bond, K Varjonen, A Hendricks, Y M Chang, H Brooks Brownlie
OBJECTIVES: To gain information on hair loss amongst curly coated retrievers by questionnaire and to define the clinical and pathological features of hair coat abnormalities in affected dogs in the United Kingdom and Sweden. MATERIALS AND METHODS: Questionnaires were completed by members of the Curly Coated Retriever Clubs. Fourteen dogs (six in the United Kingdom, eight in Sweden) were clinically examined and skin/hair samples collected for microscopy and histopathology...
December 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27920816/concomitant-extraspinal-hyperostosis-and-osteoporosis-in-a-patient-with-congenital-ichthyosis
#15
Niloufar Torkamani, Pramit Phal, Ravi Savarirayan, Peter Simm, George Varigos, John Wark
Ichthyosiform dermatosis is a term referred to a group of disorders that have as their basis a disorder of keratinization (1). These conditions which are present at birth result in a generalized dry, scaly skin without any inflammation. There are several types of ichthyosis based on their clinical presentation and mode of inheritance. The most common types are: ichthyosis vulgaris, X-linked recessive ichthyosis, epidermolytic hyperkeratosis (bullous), lamellar ichthyosis and non-bullous ichthyosiform erythroderma...
May 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/27876998/occurrence-of-knemidokoptes-mutans-and-laminosioptes-cysticola-in-backyard-poultry-in-india
#16
C Sreedevi, P Ramesh, P Mala Kondaiah, N Lakshmi Rani, M Abhishek
Birds reared in backyard poultry farming system are more prone to parasitic infestation resulting in economic losses to rural community. The present study reports occurrence of Knemidokoptes mutans and Laminosioptes cysticola mites in a male Aseel bird. Clinical signs observed in the affected bird include hyperkeratosis with whitish film layer on shank and hock region of legs. Focal areas of sloughing of skin with oozing of blood were also observed on the back and on the legs. Examination of skin scrapings from the affected sites revealed different developmental stages of Knemidokoptes mutans and Laminosioptes cysticola mites...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27865803/leukoplakia-a-diagnostic-and-management-algorithm
#17
REVIEW
Alessandro Villa, Sook Bin Woo
Oral white lesions are frequently encountered in daily practice. Most white lesions are benign (eg, reactive keratoses or keratoses from inflammatory conditions) and the diagnosis is usually evident from the clinical presentation and histopathology. Leukoplakia is a common condition characterized by an increased risk for malignant transformation. Histopathology of leukoplakia can disclose hyperkeratosis with dysplasia or carcinoma or hyperkeratosis or parakeratosis without dysplasia. Treatment depends on demographic, social, clinical, and histopathologic factors...
October 26, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27864007/six-generations-of-epidermolytic-palmoplantar-keratoderma-associated-with-a-krt9-r163w-mutation
#18
Peng Wang, Xiao-Jing Kang, Xiao-Hui Tang, Jian-Yong Liu, Wen-Zheng Li, Wei-Jia Wang, Sheng-Nan Liang, Yan-Yan Feng, Yuan Ding, Wen-Jing Chen
Epidermolytic palmoplantar keratoderma (EPPK) is a rare autosomal dominant skin disorder characterized by diffuse hyperkeratosis on the palms and soles. Whole-exome sequencing (WES) has become a powerful tool for the detection of rare causal variants of Mendelian disorders. However, no causal gene for EPPK in the Uygur population has been identified until now, and no treatment exists than can address the underlying pathology.WES analysis was undertaken on two individuals from a large Uygur EPPK pedigree whose disease locus mapped to 17q21...
November 2016: Cancer Genetics
https://www.readbyqxmd.com/read/27852057/novel-mutations-c-28g-t-p-ala10ser-and-c-189g-t-p-glu63asp-in-wdr62-associated-with-early-onset-acanthosis-and-hyperkeratosis-in-a-patient-with-autosomal-recessive-microcephaly-type-2
#19
Santasree Banerjee, Huishuang Chen, Hui Huang, Jing Wu, Zhiyun Yang, Weiping Deng, Dongna Chen, Jianlian Deng, Yan Su, Yang Li, Chao Wu, Ye Wang, Hao Zeng, Yiming Wang, Xunhua Li
Microcephaly (MCPH) is a developmental disorder characterized by reduced brain size and intellectual disability. A proportion of microcephaly is caused by defects in a single gene. Microcephaly 2 (MCPH2) is one of the most frequent subtypes of MCPH.WD repeat-containing protein 62 gene (WDR62) is the most frequently mutated gene in MCPH2 patients. Phenotypes involving dermatological changes in MCPH2 have not been reported. We have identified and investigated a 5-year-old Chinese girl with markedly reduced brain size (86% of normal size), intellectual disability and psychomotor developmental delay...
November 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27847737/treatment-of-nevoid-basal-cell-carcinoma-syndrome-a-case-report
#20
Dong-Uk Seo, Su-Gwan Kim, Ji-Su Oh, Jae-Seek You
Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is characterized by various embryological deformities and carcinoma formation. It is caused by PTCHI gene mutations and is autosomal dominantly inherited. Some of the main symptoms of NBCCS are multiple basal cell carcinomas, multiple keratocystic odontogenic tumors (KCOTs) of the mandible, hyperkeratosis of the palmar and plantar, skeletal deformity, calcification of the falx cerebri, and facial defomity. Recurrent KCOT is the main symptom of NBCCS and is present in approximately 90% of patients...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
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