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Satomi Igawa, Mari Kishibe, Masako Minami-Hori, Masaru Honma, Hisashi Tsujimura, Junko Ishikawa, Tsutomu Fujimura, Masamoto Murakami, Akemi Ishida-Yamamoto
Atopic dermatitis (AD) is a common inflammatory skin disorder. Chronic AD lesions present hyperkeratosis, indicating a disturbed desquamation process. Kallikrein-related peptidase (KLK) 7 is a serine protease involved in the proteolysis of extracellular corneodesmosome (CD) components, including desmocollin1 and corneodesmosin (Cdsn), which leads to desquamation. KLK7 is secreted by lamellar granules, and upregulated in AD lesional skin. However, despite increased KLK7 protein levels, immunostaining and electron microscopy indicated numerous CDs remaining in the uppermost layer of the stratum corneum (SC) from AD lesions...
October 18, 2016: Journal of Investigative Dermatology
Elena de Planell-Mas, Blanca Martínez-Garriga, Antonio Jesús Zalacain, Teresa Vinuesa, Miguel Viñas
INTRODUCTION: Plantar warts are caused by human papillomaviruses (HPVs) and have been associated with several HPV genotypes. However, there are few studies focused exclusively on plantar warts. In this work, we aim to identify the HPV genotypes of plantar warts and explore their relation to demographic and clinical characteristics of patients. MATERIAL AND METHODS: A total of 72 patients diagnosed with plantar warts were recruited at the Laser unit at Podiatric Hospital, University of Barcelona, Spain...
October 13, 2016: Journal of Medical Virology
Ana Cebollero, Teresa Puértolas, Isabel Pajares, Lourdes Calera, Antonio Antón
A retrospective observational study was conducted on patients diagnosed with serine/threonine-protein kinase B-Raf (BRAF)-mutated metastatic melanoma, who underwent first-line therapy with BRAF and mitogen-activated protein kinase kinase (MEK) inhibitors (vemurafenib, dabrafenib or a combination of dabrafenib and trametinib) at the Miguel Servet University Hospital (Zaragoza, Spain) between November, 2011 and August, 2015. The aim of this study was to analyse the toxicity produced by BRAF and MEK inhibitors...
October 2016: Molecular and Clinical Oncology
Ilaria Tocco-Tussardi, Nathalie Mobargha, Franco Bassetto, Vincenzo Vindigni
INTRODUCTION: Nevoid hyperkeratosis of the nipple and/or areola (NHNA) is a benign lesion with a female predominance and an aesthetically disturbing appearance. Spontaneous remission is not reported and medical treatments proposed so far have shown variable results. PRESENTATION OF CASE: We describe a rare case of an extensive variant of NHNA covering almost the entire breasts' surface. At present, only three other reports are present in the literature. Medical treatment proved not completely effective and the patient was also affected by a significant breast asymmetry-hypertrophy...
September 22, 2016: International Journal of Surgery Case Reports
Hannah Pischon, Moritz Radbruch, Anja Ostrowski, Pierre Volz, Christian Gerecke, Michael Unbehauen, Stefan Hönzke, Sarah Hedtrich, Joachim W Fluhr, Rainer Haag, Burkhard Kleuser, Ulrike Alexiev, Achim D Gruber, Lars Mundhenk
Inflammatory disorders of the skin pose particular therapeutic challenges due to complex structural and functional alterations of the skin barrier. Penetration of several anti-inflammatory drugs is particularly problematic in psoriasis, a common dermatitis condition with epidermal hyperplasia and hyperkeratosis. Here, we tested in vivo dermal penetration and biological effects of dendritic core-multishell-nanocarriers (CMS) in a murine skin model of psoriasis and compared it to healthy skin. In both groups, CMS exclusively localized to the stratum corneum of the epidermis with only very sporadic uptake by Langerhans cells...
October 1, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
J Ruiz-Rivero, M Campos Domíngez, V Parra Blanco, R Suárez-Fernández
No abstract text is available yet for this article.
September 30, 2016: Actas Dermo-sifiliográficas
Ling-I Hsu, Yu-Wen Cheng, Chien-Jen Chen, Meei-Maan Wu, Kuang-Hung Hsu, Hung-Yi Chiou, Chih-Hung Lee
Long-term arsenic exposure results in atherosclerosis and cancers, along with aberrant immune responses. Animal-based and epidemiological studies indicate that arsenic exposure increases susceptibility to viral and bacterial infections. This study aimed to assess whether arsenic exposure is associated with the development of fungal infection, which is substantially attributed to as a cause of aberrant immunity. Based on two well-established cohorts from two basins in southwestern (SW; high arsenic area) and northeastern (NE; low arsenic area) Taiwan (n=297 and 2738, respectively), the arsenic exposure in well water was estimated using HPLC-ICP-MS...
September 29, 2016: Environment International
Martin Ulrich, Iris Zalaudek, J Welzel
Actinic keratosis, Bowen disease, and invasive squamous cell carcinoma represent different steps within the disease continuum of squamous neoplasia. Although these stages of squamous neoplasia share common findings, reflectance confocal microscopy may be applied for their differentiation and distinction from other benign or malignant lesions. Hyperkeratosis represents the most important limitation in the evaluation of squamous neoplasia as it may impair the analysis of deeper epidermal and dermal structures significantly...
October 2016: Dermatologic Clinics
Siham Zahi, Laila Mahir, Soumia Meftah, Fatima Lmidmani, Abdellatif El Fatimi
OBJECTIVE: Premature aging syndromes are very rare and most often hereditary. Initially purely descriptive entities, these syndromes are now much better understood genetically and pathophysiologically and can now be classified according to the mechanisms involved. They often manifest as a pigmented skin dry, atrophic and sclerotic. There is no treatment for these conditions apart from that of their complications (frequent ulceration). OBSERVATIONS: Forty-five years of patient follow-up in dermatology for premature aging syndrome, addressed in our service for podiatric care...
September 2016: Annals of Physical and Rehabilitation Medicine
Janet Douglass, Patricia Graves, Susan Gordon
BACKGROUND: Measurements of tissue compressibility and extracellular fluid (ECF) are used to monitor progression of lymphedema, a chronic swelling of the subcutaneous tissue. Later stages of lymphedema are characterized by fibrotic induration in the subcutis and hyperkeratosis of the skin. Several devices are available to measure these changes, but previous reliability and validity studies have been conducted primarily on adult women with unilateral arm lymphedema using contralateral limbs as controls...
September 27, 2016: Lymphatic Research and Biology
Brian L Cypher, Jaime L Rudd, Tory L Westall, Leslie W Woods, Nicole Stephenson, Janet E Foley, Donald Richardson, Deana L Clifford
The San Joaquin kit fox ( Vulpes macrotis mutica) is a federally endangered small carnivore whose distribution is limited to the San Joaquin Valley in central California. Population decline is due to profound habitat loss, and conservation of all remaining populations is critical. A robust urban population occurs in the city of Bakersfield. In spring of 2013, putative cases of mange were reported in this population. Mites from affected animals were confirmed to be Sarcoptes scabiei morphologically and by DNA sequencing...
September 26, 2016: Journal of Wildlife Diseases
M Harman, M Durdu, I İbiloğlu
The relationship between acrokeratosis verruciformis (AVH; also known as Hopf disease) and Darier disease (DD) has been debated for several decades. There is still substantial controversy over the characterization and association of AVH with DD. Certain histopathological features overlapping with those of DD have been demonstrated in patients with AVH. Although cytological findings have been described in DD, no study has identified the cytological changes in AVH. We report a case of AVH exhibiting a DD-like cytological manifestation...
October 2016: Clinical and Experimental Dermatology
Zyad M AIBarrak, Adel S Alqarni, Elna P Chalisserry, Sukumaran Anil
BACKGROUND: Papillon-Lefèvre syndrome is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and aggressively progressing periodontitis leading to premature loss of deciduous and permanent dentition. The etiopathogenesis of the syndrome is relatively obscure, and immunologic, genetic, or possible bacterial etiologies have been proposed. CASE PRESENTATION: A series of five cases of Papillon-Lefèvre syndrome among the siblings in a family is presented here: a 3-year-old Arab girl, a 4-year-old Arab boy, a 11-year-old Arab boy, a 12-year-old Arab boy, and a 14-year-old Arab boy...
2016: Journal of Medical Case Reports
J Pollock, D Bedenice, S H Jennings, M G Papich
The study objective was to determine the pharmacokinetics and clinical effects of an extended-release 5% eprinomectin formulation (Longrange(®) ) following subcutaneous (s.c.) injection in healthy (n = 6) and mange-infected (n = 4) adult alpacas. High-performance liquid chromatography was used to analyze plasma samples obtained at regular intervals for 161 days following a single 5 mg/kg injection s.c. in healthy alpacas, and for 5 days following each dose (3 treatments, 2 months apart) in mange-affected animals...
September 18, 2016: Journal of Veterinary Pharmacology and Therapeutics
Jean-Philip Lacroix, Beatrice Wang
BACKGROUND: Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with vemurafenib, dabrafenib is a more recent BRAF inhibitor approved by the Food and Drug Administration in May 2013 for metastatic melanoma; fewer data are available in the current literature regarding cutaneous toxicity...
September 13, 2016: Journal of Cutaneous Medicine and Surgery
Fiona F Lee, Charles W Bradley, Christine L Cain, Stephen D White, Catherine A Outerbridge, Lisa A Murphy, Elizabeth A Mauldin
BACKGROUND: Although zinc responsive dermatosis is typically a disorder of Arctic breed dogs, this study identifies similar cutaneous lesions on the face and pressure points of Boston terrier dogs. HYPOTHESIS/OBJECTIVES: To document the clinical and histological features of localized parakeratotic hyperkeratosis of Boston terrier dogs, to determine if the lesions respond to zinc supplementation and to determine whether tissue zinc levels were decreased in affected versus unaffected dogs...
October 2016: Veterinary Dermatology
Maraya De Jesus Semblano Bittencourt, Carolina Moraes Dias, Thaiane Lima Lage, Amanda Magno Parijós, Letícia Brito Mesquita, Alessandra Haber Carvalho
Nail involvement in Langerhans cell histiocytosis is uncommon and is said to indicate a poor prognosis. We describe a 2-year-old boy with onycholysis, subungual hyperkeratosis, and hemorrhages on his fingernails. He also had hepatosplenomegaly and pulmonary involvement. The diagnosis of Langerhans cell histiocytosis was made by histopathologic examination of skin and liver.The role of nail involvement as an unfavorable prognostic sign is still unclear and this paper concludes that nail involvement in Langerhans cell histiocytosis is a possible sign of multisystemic involvement...
2016: Dermatology Online Journal
Beate Muehe, Andreas Epple, Alexander Enk, Holger A Haenssle
No abstract text is available yet for this article.
September 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Sanaz Helli, Hossein Damghani, Daryoush Mohajeri, Mehran Mesgari Abbasi, Rana Attaran, Maryam Zahed
STATEMENT OF THE PROBLEM: Oral cancer is among the ten most common cancers worldwide. It affects the life quality of patients in many ways. PURPOSE: The aim of this study was to compare the effects of two different systemic doses of Viola Odorata syrup on the prevention of 4-Nitroquinoline-1-oxide (4-NQO) induced tongue dysplasia in rats. MATERIALS AND METHOD: Forty-eight male Wistar rats were divided into four groups of A, B, C and D. Group A served as the control group...
September 2016: Journal of Dentistry
Ana Gameiro, Rita Cabral, Ana Moreno, Oscar Tellechea
Superficial epidermolytic ichthyosis (SEI) is an autosomal dominant disorder caused by a mutation in the keratin 2 gene and clinically characterized by mild hyperkeratosis, superficial blisters and shedding, referred to as the moulting phenomenon. We report a case of SEI in an 18-month-old girl presenting with marked hypertrichosis. Although not invariably present, we believe that hypertrichosis can be an important clue for diagnosis.
September 7, 2016: Pediatric Dermatology
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