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https://www.readbyqxmd.com/read/26562408/association-between-graft-storage-time-and-donor-age-with-endothelial-cell-density-and-graft-adherence-after-descemet-membrane-endothelial-keratoplasty
#1
Marina Rodríguez-Calvo de Mora, Esther A Groeneveld-van Beek, Laurence E Frank, Jacqueline van der Wees, Silke Oellerich, Marieke Bruinsma, Gerrit R J Melles
IMPORTANCE: After retrospectively evaluating the clinical outcome of 500 consecutive cases after Descemet membrane endothelial keratoplasty (DMEK), we extended the analysis in this study by assessing the effect of donor-related parameters on endothelial cell density (ECD) decline and detachment rate in this group. OBSERVATIONS: This retrospective case series included 500 cases who had undergone DMEK from October 2007 to September 2012 at the Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, the Netherlands...
January 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26355238/endothelial-survival-after-descemet-membrane-endothelial-keratoplasty-effect-of-surgical-indication-and-graft-adherence-status
#2
Lamis Baydoun, Lisanne Ham, Vincent Borderie, Isabel Dapena, Jingzhen Hou, Laurence E Frank, Silke Oellerich, Gerrit R J Melles
IMPORTANCE: This study evaluates the longevity of Descemet membrane endothelial keratoplasty (DMEK) grafts in terms of endothelial survival and endothelial failure. OBJECTIVE: To determine endothelial survival and its association with the indication for surgery and/or partial graft detachment in DMEK. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cross-sectional study of data collected from August 8, 2006, until June 17, 2015, at a tertiary referral center...
November 2015: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26350990/a-case-of-severe-corneal-flattening-after-descemet-stripping-endothelial-keratoplasty
#3
Ester Fernández-López, Alina Miron, Svetlana Pogorelova, Oganes Oganesyan, Lamis Baydoun, Gerrit R J Melles
PURPOSE: To report a case of extreme corneal flattening after initially uneventful Descemet stripping endothelial keratoplasty (DSEK). METHODS: A 76-year-old man underwent uneventful DSEK for pseudophakic bullous keratopathy (PBK) in his left eye. Postoperative evaluations were performed using anterior segment optical coherence tomography and biomicroscopy. RESULTS: The DSEK graft showed full adherence to the host stroma. Two weeks after surgery, the transplanted cornea developed pronounced flattening of the central corneal curvature accompanied by graft folds and remained unchanged until the most recent follow-up 20 weeks after surgery...
January 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/26260281/the-association-of-refractive-error-with-glaucoma-in-a-multiethnic-population
#4
Ling Shen, Ronald B Melles, Ravikanth Metlapally, Lisa Barcellos, Catherine Schaefer, Neil Risch, Lisa J Herrinton, Christine Wildsoet, Eric Jorgenson
PURPOSE: To evaluate the association between refractive error and the prevalence of glaucoma by race or ethnicity. DESIGN: Cross-sectional study. PARTICIPANTS: Kaiser Permanente Northern California Health Plan members with refractive error measured at 35 years of age or older between 2008 and 2014 and with no history of cataract surgery, refractive surgery, or a corneal disorder. METHODS: We identified 34 040 members with glaucoma or ocular hypertension (OHTN; cases) and 403 398 members without glaucoma (controls)...
January 2016: Ophthalmology
https://www.readbyqxmd.com/read/25457380/deep-anterior-lamellar-keratoplasty-for-keratectasia-after-laser-in-situ-keratomileusis
#5
Ramin Salouti, Mohammad H Nowroozzadeh, Payam Makateb, Mohammad Zamani, Maryam Ghoreyshi, Gerrit R J Melles
PURPOSE: To assess the efficacy of deep anterior lamellar keratoplasty (DALK) for treating post-LASIK keratectasia. SETTING: Poostchi Eye Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. DESIGN: Retrospective interventional cases series. METHODS: The same surgeon performed all DALK procedures using the Melles manual technique. The preoperative and postoperative corrected distance visual acuity (CDVA), spherical equivalent (SE) refraction, keratometry (K) readings, and endothelial cell profiles were compared...
December 2014: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/25439596/clinical-outcome-of-500-consecutive-cases-undergoing-descemet-s-membrane-endothelial-keratoplasty
#6
Marina Rodríguez-Calvo-de-Mora, Ruth Quilendrino, Lisanne Ham, Vasilios S Liarakos, Korine van Dijk, Lamis Baydoun, Isabel Dapena, Silke Oellerich, Gerrit R J Melles
PURPOSE: To evaluate the clinical outcome of 500 consecutive cases after Descemet's membrane endothelial keratoplasty (DMEK) and the effect of technique standardization. DESIGN: Prospective, interventional case series at a tertiary referral center. PARTICIPANTS: A total of 500 eyes of 393 patients who underwent DMEK for Fuchs' endothelial corneal dystrophy, bullous keratopathy, or previous corneal transplant failure. METHODS: Best-corrected visual acuity (BCVA), endothelial cell density (ECD), pachymetry, and intraoperative and postoperative complications were evaluated before and 1, 3, and 6 months after DMEK...
March 2015: Ophthalmology
https://www.readbyqxmd.com/read/25055208/the-impact-of-central-corneal-thickness-on-the-risk-for-glaucoma-in-a-large-multiethnic-population
#7
Sophia Y Wang, Ronald Melles, Shan C Lin
PURPOSE: To investigate the relationship between central corneal thickness (CCT) and demographics, and determine whether CCT may be a substantial mediator of the relationships between glaucoma and its demographic risk factors. METHODS: This cross-sectional study included patients in the Kaiser Permanente Northern California health plan from January 1, 2007 to December 31, 2011 who were 40 years and older and had a documented CCT measurement (N=81,082). Those with any cornea-related diagnoses or a history of corneal refractive surgery were excluded...
December 2014: Journal of Glaucoma
https://www.readbyqxmd.com/read/24725378/a-simple-ex-vivo-model-for-teaching-descemet-membrane-endothelial-keratoplasty
#8
Konstantinos Droutsas, Michael Petrak, Gerrit R J Melles, Chryssanthi Koutsandrea, Ilias Georgalas, Walter Sekundo
PURPOSE: To describe a simple ex vivo porcine model for teaching Descemet Membrane Endothelial Keratoplasty (DMEK). METHODS: Twenty freshly enucleated porcine eyes were used to create a pseudo-graft from the porcine lens capsule and implant it into an intact porcine globe using the standardized 'no-touch' technique of the Netherlands Institute for Innovative Ocular Surgery (NIIOS). RESULTS: The DMEK pseudo-graft could be inserted, centred, unfolded and appositioned in all cases...
August 2014: Acta Ophthalmologica
https://www.readbyqxmd.com/read/24557359/midstromal-isolated-bowman-layer-graft-for-reduction-of-advanced-keratoconus-a-technique-to-postpone-penetrating-or-deep-anterior-lamellar-keratoplasty
#9
Korine van Dijk, Jack Parker, C Maya Tong, Lisanne Ham, Jessica T Lie, Esther A Groeneveld-van Beek, Gerrit R J Melles
Midstromal implant of an isolated Bowman layer graft is a new approach to reduce ectasia in eyes with advanced keratoconus. The procedure should postpone penetrating or deep anterior lamellar keratoplasty. Ten eyes of 9 patients with progressive, advanced keratoconus and contact lens intolerance underwent the procedure with no intraoperative adverse events. Throughout the study period, we observed no complications related to stromal dissection and/or the Bowman layer graft. Maximum corneal power decreased from a mean (SD) of 74...
April 1, 2014: JAMA Ophthalmology
https://www.readbyqxmd.com/read/23876866/potential-causes-of-incomplete-visual-rehabilitation-at-6-months-postoperative-after-descemet-membrane-endothelial-keratoplasty
#10
Isabel Dapena, Ru-Yin Yeh, Lamis Baydoun, Javier Cabrerizo, Korine van Dijk, Lisanne Ham, Gerrit R J Melles
PURPOSE: To determine the various causes of unexpected incomplete visual rehabilitation at 6 months postoperative after Descemet membrane endothelial keratoplasty (DMEK). DESIGN: Retrospective study of prospectively collected data at a tertiary referral center. METHODS: From a larger group of 400 consecutive DMEK surgeries, the last 200 consecutive eyes were reviewed for visual discomfort despite a best-corrected visual acuity (BCVA) of ≥20/25 (≥0...
October 2013: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/23635857/descemet-membrane-endothelial-keratoplasty-learning-curve-of-a-single-surgeon
#11
Konstantinos Droutsas, Eleftherios Giallouros, Gerrit R J Melles, Klio Chatzistefanou, Walter Sekundo
PURPOSE: To evaluate the learning curve of standardized "no-touch" Descemet membrane endothelial keratoplasty (DMEK) of a single surgeon in a clinic without an in-house eye bank facility. METHODS: For 25 eyes of 22 patients, Descemet graft preparation and DMEK surgery were performed according to the protocols of the Netherlands Institute for Innovative Ocular Surgery with minor modifications. Best spectacle-corrected visual acuity, subjective refraction, Scheimpflug tomography, and endothelial cell density of the donor tissue were documented before and at 1, 3, and 6 months after the surgery; intraoperative and postoperative complications were recorded...
August 2013: Cornea
https://www.readbyqxmd.com/read/23187168/large-diameter-descemet-membrane-endothelial-keratoplasty-in-buphthalmic-eyes
#12
Ruth Quilendrino, Ru-Yin Yeh, Isabel Dapena, Lisanne Ham, Martin Dirisamer, Jaco van Niekerk, Gerrit R J Melles
PURPOSE: To report the outcomes of Descemet membrane endothelial keratoplasty (DMEK) using a large diameter graft in the management of endothelial decompensation in buphthalmic eyes. METHODS: Four eyes of 4 adults (1 man, 3 women) with bullous keratopathy and buphthalmos secondary to congenital glaucoma were treated with DMEK using posterior lamellar grafts with diameters ranging from 10 to 12 mm. The mean age was 31 (±9) years (range, 20-38 years). Mean follow-up time was 13...
May 2013: Cornea
https://www.readbyqxmd.com/read/23149125/predictive-value-of-optical-coherence-tomography-in-graft-attachment-after-descemet-s-membrane-endothelial-keratoplasty
#13
Ru-Yin Yeh, Ruth Quilendrino, Fayyaz U Musa, Vasilios S Liarakos, Isabel Dapena, Gerrit R J Melles
PURPOSE: To evaluate the predictive value of early anterior segment optical coherence tomography (AS-OCT) on graft adherence or detachment after Descemet's membrane endothelial keratoplasty (DMEK). DESIGN: Retrospective study of prospectively collected data at a tertiary referral center. PARTICIPANTS: A total of 87 eyes of 87 patients of a consecutive series of 142 DMEK surgeries. METHODS: Anterior segment OCT was performed within the first hour after DMEK and at 1 week, 1 month, 3 months, and 6 months, and for each time interval detachments were classified as "none," ≤ 1/3 detachment, >1/3 detachment of the total graft surface area, or "complete" detachment...
February 2013: Ophthalmology
https://www.readbyqxmd.com/read/23108011/near-complete-visual-recovery-and-refractive-stability-in-modern-corneal-transplantation-descemet-membrane-endothelial-keratoplasty-dmek
#14
RANDOMIZED CONTROLLED TRIAL
Korine van Dijk, Lisanne Ham, Win Hou W Tse, Vasilios S Liarakos, Ruth Quilendrino, Ru-Yin Yeh, Gerrit R J Melles
OBJECTIVE: To report the 6 months results of a large prospective study on Descemet membrane endothelial keratoplasty (DMEK) for management of corneal endothelial disorders. METHODS: DMEK was performed in 300 consecutive eyes with Fuchs endothelial dystrophy, bullous keratopathy or previous corneal transplant failure. Best spectacle corrected visual acuity (BSCVA), refractive outcome and endothelial cell density (ECD) were evaluated before and at 1, 3, and 6 months after surgery...
February 2013: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/22520310/outcomes-of-descemet-membrane-endothelial-keratoplasty-in-phakic-eyes
#15
Jack Parker, Martin Dirisamer, Miguel Naveiras, Win Hou W Tse, Korine van Dijk, Laurence E Frank, Lisanne Ham, Gerrit R J Melles
PURPOSE: To determine the clinical outcomes of isolated Descemet membrane transplantation (ie, Descemet membrane endothelial keratoplasty [DMEK]) in phakic eyes. SETTING: Tertiary referral center. DESIGN: Cohort study. METHODS: Phakic eyes from a larger group of consecutive eyes that had DMEK for Fuchs endothelial dystrophy were examined. The examination included corrected distance visual acuity (CDVA), subjective and objective refractions, endothelial cell density (ECD), and intraoperative and postoperative complications at 1, 3, and 6 months...
May 2012: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/21782088/refractive-change-and-stability-after-descemet-membrane-endothelial-keratoplasty-effect-of-corneal-dehydration-induced-hyperopic-shift-on-intraocular-lens-power-calculation
#16
Lisanne Ham, Isabel Dapena, Kyros Moutsouris, Chandra Balachandran, Laurence E Frank, Korine van Dijk, Gerrit R J Melles
PURPOSE: To determine the refractive change and stability of the transplanted cornea after Descemet membrane endothelial keratoplasty (DMEK) through a 3.0 mm clear corneal incision. SETTING: Tertiary referral center. DESIGN: Cohort study. METHODS: Subjective and objective refractive data from pseudophakic eyes were obtained before and 3 and 6 months after DMEK. RESULTS: The study comprised 50 eyes, 7 were phakic and 43 pseudophakic...
August 2011: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/19273786/visual-rehabilitation-rate-after-isolated-descemet-membrane-transplantation-descemet-membrane-endothelial-keratoplasty
#17
Lisanne Ham, Chandra Balachandran, Christianne A Verschoor, Jacqueline van der Wees, Gerrit R J Melles
OBJECTIVE: To evaluate visual rehabilitation after Descemet membrane endothelial keratoplasty (DMEK) in the management of corneal endothelial disorders. METHODS: In this prospective, nonrandomized, clinical study, DMEK was performed in a first group of 35 consecutive patients with either Fuchs endothelial dystrophy or bullous keratopathy. The Descemet membrane was stripped from the recipient posterior stroma with the anterior chamber completely filled with air. Using a 3...
March 2009: Archives of Ophthalmology
https://www.readbyqxmd.com/read/18721723/donor-tissue-preparation-for-descemet-membrane-endothelial-keratoplasty
#18
Jessica T Lie, Rénuka Birbal, Lisanne Ham, Jacqueline van der Wees, Gerrit R J Melles
PURPOSE: To evaluate a technique for preparing a donor Descemet membrane carrying autologous endothelium for transplantation in Descemet membrane endothelial keratoplasty (DMEK). SETTING: Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands. METHODS: A 9.5 mm diameter DM carrying autologous endothelium was stripped from 10 corneoscleral rims that had been organ cultured for 1 week. The endothelial cell density (ECD) was evaluated with light microscopy before and immediately after DM was stripped and during 4 additional weeks of organ culture...
September 2008: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/18520629/vestibulo-ocular-reflex-characteristics-in-patients-with-unilateral-m%C3%A3-ni%C3%A3-re-s-disease
#19
Raphaël Maire, Guy van Melle
OBJECTIVE: The pathophysiologic concept of Ménière's disease assumes that endolymphatic hydrops is the cause of the symptoms via increased pressure in the endolymphatic space and/or ionic disorder due to ruptured membrane. The goal of this study was to assess whether the vestibulo-ocular reflex (VOR) properties in patients with Ménière's disease were consistent with the classical theory. MATERIAL AND METHODS: We studied 34 patients (19 women, 15 men) presenting with unilateral Ménière's disease divided into 2 groups according to the duration of the disease: 18 were in the early stage (< 12 mo), and 16 were in the late stage (> or = 12 mo)...
August 2008: Otology & Neurotology
https://www.readbyqxmd.com/read/17881533/n-terminal-fatty-acylation-of-transducin-profoundly-influences-its-localization-and-the-kinetics-of-photoresponse-in-rods
#20
COMPARATIVE STUDY
Vasily Kerov, William W Rubin, Michael Natochin, Nathan A Melling, Marie E Burns, Nikolai O Artemyev
N-terminal acylation of the alpha-subunits of heterotrimeric G-proteins is believed to play a major role in regulating the cellular localization and signaling of G-proteins, but physiological evidence has been lacking. To examine the functional significance of N-acylation of a well understood G-protein alpha-subunit, transducin (G alpha(t)), we generated transgenic mice that expressed a mutant G alpha(t) lacking N-terminal acylation sequence (G alpha(t)G2A). Rods expressing G alpha(t)G2A showed a severe defect in transducin cellular localization...
September 19, 2007: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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