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Francis Price ocular

Anne-Sophie Benischke, Shivakumar Vasanth, Takashi Miyai, Kishore Reddy Katikireddy, Tomas White, Yuming Chen, Adna Halilovic, Marianne Price, Francis Price, Paloma B Liton, Ula V Jurkunas
Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regenerative potential. The large numbers of mitochondria in HCEnCs are critical for pump and barrier function required for corneal hydration and transparency. Fuchs Endothelial Corneal Dystrophy (FECD) is a highly prevalent late-onset oxidative stress disorder characterized by progressive loss of HCEnCs. We previously reported increased mitochondrial fragmentation and reduced ATP and mtDNA copy number in FECD. Herein, carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-induced mitochondrial depolarization decreased mitochondrial mass and Mfn2 levels, which were rescued with mitophagy blocker, bafilomycin, in FECD...
July 27, 2017: Scientific Reports
M Elizabeth Fini, Stephen G Schwartz, Xiaoyi Gao, Shinwu Jeong, Nitin Patel, Tatsuo Itakura, Marianne O Price, Francis W Price, Rohit Varma, W Daniel Stamer
Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma (SIG). Glucocorticoids initiate signaling cascades ultimately affecting expression of hundreds of genes; this provides the potential for a highly personalized pharmacological response. Studies attempting to define genetic risk factors were undertaken early in the history of glucocorticoid use, however scientific tools available at that time were limited and progress stalled...
January 2017: Progress in Retinal and Eye Research
Kishore Reddy Katikireddy, Thore Schmedt, Marianne O Price, Francis W Price, Ula V Jurkunas
Human corneal endothelial cells are derived from neural crest and because of postmitotic arrest lack competence to repair cell loss from trauma, aging, and degenerative disorders such as Fuchs endothelial corneal dystrophy (FECD). Herein, we identified a rapidly proliferating subpopulation of cells from the corneal endothelium of adult normal and FECD donors that exhibited features of neural crest-derived progenitor (NCDP) cells by showing absence of senescence with passaging, propensity to form spheres, and increased colony forming efficacy compared with the primary cells...
October 2016: American Journal of Pathology
Francis W Price, Matthew T Feng, Marianne O Price
In less than 10 years, the proportion of endothelial keratoplasty (EK) procedures has increased from less than 5% of the corneal grafts in the United States to over half. EK has made corneal grafts safer and provides better and more predictable visual results than standard full-thickness penetrating keratoplasty. Descemet membrane endothelial keratoplasty in particular has dramatically reduced the risk of rejection, allowing reduction in topical corticosteroid use, resulting in a lower incidence of steroid-induced intraocular pressure elevation...
October 2015: Cornea
Rachel H Epstein, Nick Mamalis, Francis W Price, Marianne O Price
UNLABELLED: A 68-year-old woman with bilateral keratoconus presented with persistent visual acuity deficits following cataract extraction with a neodymium:YAG capsulotomy in the right eye 2 years earlier. Penetrating keratoplasty (PKP) had been performed for keratoconus in the right eye without complications until steroid drops were discontinued after 10 years because of persistent elevated intraocular pressure. The right eye experienced immunologic rejection and failure of 3 PKPs, 1 Descemet-stripping endothelial keratoplasty (DSEK), and a trabeculectomy with an eventual anatomically successful DSEK before the patient died at 95 years of age...
February 2015: Journal of Cataract and Refractive Surgery
Francis W Price, Marianne O Price
Endothelial keratoplasty has evolved into a popular alternative to penetrating keratoplasty (PK) for the treatment of endothelial dysfunction. Although the earliest iterations were challenging and were not widely adopted, the iteration known as Descemet stripping endothelial keratoplasty (DSEK) has gained widespread acceptance. DSEK combines a simplified technique for stripping dysfunctional endothelium from the host cornea and microkeratome dissection of the donor tissue, a step now commonly completed in advance by eye bank technicians...
November 2013: Cornea
Lawrence R Tenkman, Marianne O Price, Francis W Price
PURPOSE: To describe the sudden clinical manifestations of keratoconus in a 51-year-old woman. METHODS: The patient had stable annual refractions for several years with 0.50 diopters (D) astigmatism in each eye and later developed 2.00 and 6.00 D of astigmatism in the right and left eyes, respectively. RESULTS: Topography and tomography showed definite keratoconus in the left eye and possible keratoconus in the right eye. The patient had no known family history of keratoconus and no known connective tissue disease other than fibromyalgia...
June 2012: Journal of Refractive Surgery
Frederico P Guerra, Arundhati Anshu, Marianne O Price, Arthur W Giebel, Francis W Price
PURPOSE: To report 1-year outcomes of Descemet's membrane endothelial keratoplasty (DMEK) performed at 2 centers. DESIGN: Prospective, consecutive, interventional series. PARTICIPANTS: Patients with Fuchs' endothelial dystrophy, pseudophakic bullous keratoplasty, or failed previous graft (n = 136 eyes). INTERVENTION: The diseased central 7 mm of Descemet's membrane (DM) was stripped from the recipient cornea and replaced with healthy DM and endothelium stripped from donor corneas through a 2...
December 2011: Ophthalmology
Randall Olson, Eric Donnenfeld, Frank A Bucci, Francis W Price, Michael Raizman, Kerry Solomon, Uday Devgan, William Trattler, Steven Dell, R Bruce Wallace, Michelle Callegan, Heather Brown, Peter J McDonnell, Taryn Conway, Rhett M Schiffman, David A Hollander
PURPOSE: The purpose of this study is to characterize the bacterial flora of the ocular and periocular surface in cataract surgery patients and to determine the prevalence of methicillin resistance among staphylococcal isolates obtained from health care workers (HCWs) and non-HCWs. METHODS: In this prospective, multicenter, case series study, eyelid and conjunctival cultures were obtained from the nonoperative eye of 399 consecutive cataract patients on the day of surgery prior to application of topical anesthetics, antibiotics, or antiseptics...
December 10, 2010: Clinical Ophthalmology
Carlindo Da Reitz Pereira, Frederico P Guerra, Francis W Price, Marianne O Price
BACKGROUND/AIMS: To determine whether the stromal rim that carries the bare endothelial graft in Descemet's membrane automated endothelial keratoplasty (DMAEK) has any effect on final visual outcome or visual quality. METHODS: Twenty-four DMAEK eyes and 22 Descemet's membrane endothelial keratoplasty (DMEK) eyes (with no stromal rim) were evaluated for corrected distance acuity, full-field Humphrey visual field (VF) 120-2 and pupil size. The inner and outer diameter of the DMAEK stromal ring was measured from slit lamp photos...
July 2011: British Journal of Ophthalmology
Matthew B McCauley, Marianne O Price, Kelly M Fairchild, David A Price, Francis W Price
PURPOSE: To evaluate vision and endothelial cell survival in an initial Descemet membrane automated endothelial keratoplasty (DMAEK) series. METHODS: This was a prospective nonrandomized study of an initial consecutive series of 40 DMAEK cases, performed with or without concomitant phacoemulsification and intraocular lens implantation. The graft was dissected with a microkeratome. A central 6- to 7-mm big bubble was created to separate endothelium from stroma, and the overlying stroma was excised...
March 2011: Cornea
Marianne O Price, Kelly M Fairchild, David A Price, Francis W Price
PURPOSE: To assess 5-year Descemet's stripping endothelial keratoplasty (DSEK) graft survival and endothelial cell loss in the surviving grafts. DESIGN: Retrospective, interventional case series. PARTICIPANTS: One hundred sixty-five eyes of 149 patients treated with primary DSEK. METHODS: Donor corneal-scleral rims were dissected manually or with a microkeratome and were cut with a trephine. The graft was folded endothelial side inward and was inserted with forceps through a 5-mm incision...
April 2011: Ophthalmology
Francis W Price, Marianne O Price, Frederico Guerra
PURPOSE: To report a case of apparent central corneal thinning diagnosed after treatment of Fuchs dystrophy by Descemet membrane endothelial keratoplasty (DMEK) and to discuss treatment options with laser refractive surgery. METHODS: A pseudophakic patient with Fuchs dystrophy underwent DMEK, with removal of dysfunctional recipient endothelium and replacement with bare endothelium and Descemet membrane from a donor cornea. Subsequently, a standard preoperative evaluation for LASIK, including refraction, topography, Pentacam (Oculus Optikgeräte GmbH), and slit-lamp examination was performed...
April 2011: Journal of Refractive Surgery
Marianne O Price, Francis W Price
From its inception over a century ago, penetrating keratoplasty grew to become the most common and most successful form of solid tissue transplantation. Yet clinicians have long recognized the limitations of full-thickness corneal transplants, including prolonged visual rehabilitation, unpredictable refractive changes, susceptibility to ocular surface complications and vulnerability to traumatic wound rupture. Selective replacement of diseased or damaged posterior corneal layers was conceptualized and implemented a half century ago...
March 2010: Clinical & Experimental Ophthalmology
Matthew R Richardson, Marianne O Price, Francis W Price, Jennifer C Pardo, Juan C Grandin, Jinsam You, Mu Wang, Mervin C Yoder
Aqueous humor (AH) supports avascular tissues in the anterior segment of the eye, maintains intraocular pressure, and potentially influences the pathogenesis of ocular diseases. Nevertheless, the AH proteome is still poorly defined despite several previous efforts, which were hindered by interfering high abundance proteins, inadequate animal models, and limited proteomic technologies. To facilitate future investigations into AH function, the AH proteome was extensively characterized using an advanced proteomic approach...
December 11, 2009: Molecular Vision
Marianne O Price, Arthur W Giebel, Kelly M Fairchild, Francis W Price
PURPOSE: To describe Descemet's membrane endothelial keratoplasty (DMEK) techniques, perioperative challenges, management, and visual and refractive outcomes. DESIGN: Prospective, multicenter, consecutive case series. PARTICIPANTS: Sixty eyes of 56 patients with Fuchs' endothelial dystrophy, pseudophakic bullous keratopathy, or failed previous graft. INTERVENTION: Descemet's membrane (DM) and endothelium were stripped from donor corneas submerged in corneal storage solution in a corneal viewing chamber...
December 2009: Ophthalmology
Thasarat S Vajaranant, Marianne O Price, Francis W Price, Weihua Gao, Jacob T Wilensky, Deepak P Edward
PURPOSE: (1) To characterize the pattern of intraocular pressure (IOP) changes after Descemet's stripping endothelial keratoplasty (DSEK) in patients without preexisting glaucoma and in those with preexisting glaucoma, with and without prior glaucoma surgery. (2) To compare vision and IOP outcomes among the 3 groups. DESIGN: A retrospective chart review. PARTICIPANTS: A total of 805 DSEK cases performed in 641 patients by a single surgeon from December 2003 to August 2007 were available in the database...
September 2009: Ophthalmology
Vanessa Ngakeng, Matthew J Hauck, Marianne O Price, Francis W Price
PURPOSE: To describe clinical outcomes of patients who underwent implantation of the AlphaCor keratoprosthesis, without the second stage of the procedure, in which the central anterior layer of the corneal stromal pocket is excised to expose the keratoprosthesis optic to the exterior of the eye. METHODS: Outcomes of 6 consecutive cases of AlphaCor implantation without the second stage of the procedure were retrospectively reviewed. The cases were performed at 1 tertiary referral center between February 2005 and December 2006...
September 2008: Cornea
Marianne O Price, Kashif M Baig, Jacob W Brubaker, Francis W Price
PURPOSE: To determine whether eye bank predissected corneal grafts provide outcomes comparable to surgeon-dissected grafts for Descemet stripping automated endothelial keratoplasty (DSAEK). DESIGN: Randomized, prospective, double-masked clinical trial. METHODS: Twenty pairs of donor corneas were harvested. One cornea from each pair was randomized to be precut at an eye bank for next-day use. The surgeon dissected the fellow cornea intraoperatively using a comparable microkeratome and protocol...
July 2008: American Journal of Ophthalmology
Thasarat S Vajaranant, Marianne O Price, Francis W Price, Jacob T Wilensky, Deepak P Edward
PURPOSE: The effect of increased corneal thickness after Descemet stripping endothelial keratoplasty (DSEK) on intraocular pressure (IOP) measurement has not been previously studied. It is uncertain if this increase in corneal thickness would artificially elevate IOP reading by Goldmann tonometry [GAT] (Haag-Streit, Konig, Switzerland). Therefore the effect of DSEK-related thick cornea on IOP measurement was investigated using three different techniques. DESIGN: Prospective cross-sectional study...
May 2008: American Journal of Ophthalmology
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