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https://www.readbyqxmd.com/read/27828835/prospective-evaluation-of-fractional-co2-laser-treatment-of-mature-burn-scars
#1
Sigrid Blome-Eberwein, Christina Gogal, Michael J Weiss, Deborah Boorse, Patrick Pagella
The authors conducted a prospective study of fractional CO2 laser treatment of mature burn scars, comparing objective and subjective scar measurements evaluating at least one treatment and one control scar on the same patient pre- and post treatments. After institutional review board approval, burn survivors with mature blatant burn scars were invited to enter the study. A series of three fractional CO2 laser treatments was performed in an office setting, using topical anesthetic cream, at 40 to 90 mJ, 100 to 150 spots per cm...
November 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27718006/graft-dislocation-and-graft-failure-following-descemet-membrane-endothelial-keratoplasty-dmek-using-precut-tissue-a-retrospective-cohort-study
#2
Sonja Heinzelmann, Daniel Böhringer, Philipp Eberwein, Thomas Reinhard, Philip Maier
PURPOSE: Although the functional results following DMEK are better than after DSAEK, DSAEK still seems to be the standard procedure, as surgeons fear losing grafts during DMEK graft preparation. Therefore, eye banks offer precut DMEK grafts for direct use by the surgeon. Here, we analysed the functional results and complication rates for a precut technique compared to fresh preparations. METHODS: We retrospectively compared 453 standard to 11 precut (1-2 days before surgery) DMEK cases...
October 8, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27543645/evaluation-of-pharmacy-driven-dexmedetomidine-stewardship-and-appropriate-use-guidelines-in-a-community-hospital-setting
#3
M Alexandra Schickli, Kip A Eberwein, Marintha R Short, Patrick D Ratliff
BACKGROUND: Dexmedetomidine is a widely utilized agent in the intensive care unit (ICU) because it does not suppress respiratory drive and may be associated with less delirium than midazolam or propofol. Cost of dexmedetomidine therapy and debate as to the proper duration of use has brought its use to the forefront of discussion. OBJECTIVE: To validate the efficacy and cost savings associated with pharmacy-driven dexmedetomidine appropriate use guidelines and stewardship in mechanically ventilated patients...
August 18, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27461013/-surgical-removal-of-salzmann-s-nodules-using-intraoperative-mitomycin%C3%A2-c
#4
D Böhringer, D Widmer, P Eberwein, P Maier, T Reinhard
Salzmann's nodules comprise a heterogeneous group of greyish superficial corneal opacities. A substantial percentage is most likely caused by dystrophies. This could explain the recurrences after surgical removal. The Eye Center of the University Hospital Freiburg has been using mitomycin C intraoperatively during surgical removal of Salzmann's nodules since 2007 to prevent recurrences. We recently performed an uncontrolled prospective trial to evaluate this approach and also reviewed the literature. Worldwide, a total of 38 eyes have been treated with mitomycin C during surgery for Salzmann's nodules...
September 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27187915/the-costs-of-stunting-in-south-asia-and-the-benefits-of-public-investments-in-nutrition
#5
Meera Shekar, Julia Dayton Eberwein, Jakub Kakietek
South Asia is home to the largest number of stunted children worldwide: 65 million or 37% of all South Asian children under 5 were stunted in 2014. The costs to society as a result of stunting during childhood are high and include increased mortality, increased morbidity (in childhood and later as adults), decreased cognitive ability, poor educational outcomes, lost earnings and losses to national economic productivity. Conversely, investing in nutrition provides many benefits for poverty reduction and economic growth...
May 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27150121/long-term-follow-up-of-astigmatic-keratotomy-for-corneal-astigmatism-after-penetrating-keratoplasty
#6
Daniel Böhringer, Nina Dineva, Philip Maier, Florian Birnbaum, Thomas Kirschkamp, Thomas Reinhard, Philipp Eberwein
PURPOSE: To report the long-term stability of paired arcuate corneal keratotomies (AKs) in patients with high regular postpenetrating keratoplasty astigmatism. METHODS: Retrospective chart review of best-corrected visual acuity, refraction and keratometric values of 41 eyes with AK between 2003 and 2012. RESULTS: Magnitude of median target induced astigmatism vector was 9.2 dioptres (Dpt). We reached a median magnitude of surgically induced astigmatism vector of 9...
May 6, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/26764879/comparison-of-long-term-outcomes-of-femtosecond-laser-assisted-keratoplasty-with-conventional-keratoplasty
#7
Moritz C Daniel, Daniel Böhringer, Philip Maier, Philipp Eberwein, Florian Birnbaum, Thomas Reinhard
PURPOSE: Astigmatism is a significant problem in penetrating keratoplasty. Lower astigmatism and better visual outcomes had been expected from laser-assisted penetrating keratoplasty, that is, from the top-hat, mushroom, or zig-zag cutting profiles. We report the long-term outcomes of 141 femtosecond laser-assisted penetrating keratoplasties retrospectively. We compare these outcomes with those of penetrating keratoplasty using the guided trephine system (GTS). METHODS: In all, 141 femtosecond laser-assisted penetrating keratoplasties had been performed in 119 patients...
March 2016: Cornea
https://www.readbyqxmd.com/read/26556236/unusually-high-soil-nitrogen-oxide-emissions-influence-air-quality-in-a-high-temperature-agricultural-region
#8
P Y Oikawa, C Ge, J Wang, J R Eberwein, L L Liang, L A Allsman, D A Grantz, G D Jenerette
Fertilized soils have large potential for production of soil nitrogen oxide (NOx=NO+NO2), however these emissions are difficult to predict in high-temperature environments. Understanding these emissions may improve air quality modelling as NOx contributes to formation of tropospheric ozone (O3), a powerful air pollutant. Here we identify the environmental and management factors that regulate soil NOx emissions in a high-temperature agricultural region of California. We also investigate whether soil NOx emissions are capable of influencing regional air quality...
2015: Nature Communications
https://www.readbyqxmd.com/read/26079101/modulation-of-focal-adhesion-constituents-and-their-down-stream-events-by-egf-on-the-cross-talk-of-integrins-and-growth-factor-receptors
#9
Philipp Eberwein, Dougal Laird, Simon Schulz, Thomas Reinhard, Thorsten Steinberg, Pascal Tomakidi
Within the concept of integrin growth factor receptor (GFR) cross-talk, little is known about the effects of GFRs on focal adhesions (FAs). Therefore, we tested the hypothesis whether EGF can modulate constituents of FAs and subsequent down-stream events. To this end, EGF-treated keratinocytes were subjected to combined fluorescence imaging and western blotting, to quantify expression and/or activation of molecules, involved in integrin GFR cross-talk, and receptor proximal and distal signaling events. Generally, EGF response revealed an amplified redistribution or activation of molecules under study, which will be explained in detail from the plasma membrane to the cell interior...
October 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/25997048/simultaneous-transplantation-of-limbal-stem-cells-may-reduce-recurrences-of-granular-dystrophy-after-corneal-transplantation-2-long-term-case-reports
#10
Stefan J Lang, Philipp Eberwein, Helga Reinshagen, Thomas Reinhard, Rainer Sundmacher
To present 2 cases with long-term relapse-free intervals only after limbo-keratoplasty but not after conventional penetrating keratoplasty in granular dystrophy.Retrospective review of the patient charts and photographs taken during long-term follow-up of 2 cases with granular dystrophy, in which 1 eye received penetrating keratoplasty and the fellow eye received penetrating limbo-keratoplasty.In the first patient, 1 eye showed extensive recurrence of granular deposits 17 years after penetrating keratoplasty was performed while in the second eye two-thirds of the corneal transplant adjacent to the transplanted limbal area remained clear 12 years after the limbo-corneal transplant...
May 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25989036/-patient-centred-care-of-ocular-graft-vs-host-disease-in-germany
#11
REVIEW
P Eberwein, T Dietrich-Ntoukas, H Westekemper, C Cursiefen, P Steven
BACKGROUND: Ocular GvHD is a severe complication following allogenic blood stem cell transplantation leading to massive reduction in quality of life and ocular pathologies including corneal perforation. Interdisciplinary patient-centred care needs to be performed in specialized ophthalmic centers that provide all diagnostic and therapeutic options, however, only few clinics have the necessary infrastructure. In addition there is a lack of transparency and easily accessible information for the patients regarding ophthalmic care and specialized centres...
May 2015: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/25631459/correlation-of-electrical-and-structural-properties-of-single-as-grown-gaas-nanowires-on-si-111-substrates
#12
Genziana Bussone, Heiko Schäfer-Eberwein, Emmanouil Dimakis, Andreas Biermanns, Dina Carbone, Abbes Tahraoui, Lutz Geelhaar, Peter Haring Bolívar, Tobias U Schülli, Ullrich Pietsch
We present the results of the study of the correlation between the electrical and structural properties of individual GaAs nanowires measured in their as-grown geometry. The resistance and the effective charge carrier mobility were extracted for several nanowires, and subsequently, the same nano-objects were investigated using X-ray nanodiffraction. This revealed a number of perfectly stacked zincblende and twinned zincblende units separated by axial interfaces. Our results suggest a correlation between the electrical parameters and the number of intrinsic interfaces...
February 11, 2015: Nano Letters
https://www.readbyqxmd.com/read/25410061/concise-reviews-the-role-of-biomechanics-in-the-limbal-stem-cell-niche-new-insights-for-our-understanding-of-this-structure
#13
REVIEW
Philipp Eberwein, Thomas Reinhard
The limbal stem cell niche is a structure of the ocular surface that is characterized by high specification, organization, and clinical significance. Harboring the limbal epithelial stem cells, which are the progenitor cells of the corneal epithelium, it provides a niche environment that guarantees the self-renewal of the corneal epithelial stem cells throughout life. Growth factors, stromal niche cells, and specific extracellular matrix compositions provide this environment. In recent years, another important component has been added to this list: the biomechanical aspect of the niche...
March 2015: Stem Cells
https://www.readbyqxmd.com/read/25401738/are-entry-criteria-for-cataract-surgery-justified
#14
Daniel Böhringer, Werner Vach, Kai Hagenlocher, Philipp Eberwein, Philip Maier, Thomas Reinhard
PURPOSE: The German Ophthalmological Society (GOS) recently proposed surgical entry criteria, i.e. 300 cataract surgeries. We herein correlate the surgical hands-on experience with the risk of posterior capsule ruptures in order to assess whether this number is appropriate. METHODS: We identified all cataract operations that had been performed at the University Eye Hospital Freiburg since 1995. For each surgeon, we assigned a running number to his/her procedures in the order they had been performed...
2014: PloS One
https://www.readbyqxmd.com/read/25297703/diffusion-weighted-magnetic-resonance-imaging-for-the-diagnosis-of-patients-with-lumbar-nerve-root-entrapment-syndromes-results-from-a-pilot-study
#15
Maximilian Reinhold, Christian Ederer, Benjamin Henninger, Alexandra Eberwein, Christian Kremser
PURPOSE: Lumbar nerve root entrapment syndromes cause radicular signs and symptoms in the affected leg. The applicability of diffusion-weighted imaging (DWI) for the assessment of lower lumbar nerves (L4-S1) has been demonstrated. The purpose of this pilot study was to establish DWI reference data for the all lumbosacral nerve roots (L1-S1) in a healthy, asymptomatic study population and to determine its potential as a diagnostic tool for patients with lumbar radicular syndromes. METHODS: 20 asymptomatic healthy volunteers were included (average age 39 years (24-59 years; n = 10 female, n = 10 male)...
February 2015: European Spine Journal
https://www.readbyqxmd.com/read/25138759/cystoid-macular-oedema-following-descemet-membrane-endothelial-keratoplasty
#16
Sonja Heinzelmann, Philip Maier, Daniel Böhringer, Silja Hüther, Philipp Eberwein, Thomas Reinhard
BACKGROUND: To determine the incidence and potential risk factors of cystoid macular oedema (CMO) following Descemet membrane endothelial keratoplasty (DMEK) with or without simultaneous cataract surgery. METHODS: In this study, 155 eyes of 88 patients suffering from Fuchs endothelial dystrophy (81%), bullous keratopathy (17.6%) or other corneal diseases (1.4%) underwent DMEK. 52% were pseudophacic (DMEK) and 48% received simultaneous cataract surgery (DMEK combined with cataract surgery (Triple-DMEK)) at the Eye Center at Albert Ludwigs University of Freiburg between May 2011 and June 2013...
January 2015: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/25007396/determination-of-the-ph-dependent-redox-potential-of-glucose-oxidase-by-spectroelectrochemistry
#17
Stephan Vogt, Marcel Schneider, Heiko Schäfer-Eberwein, Gilbert Nöll
The pH dependent redox potential of the oxidoreductase glucose oxidase (GOx) from Aspergillus niger, which is the most frequently applied enzyme in electrochemical glucose biosensors and biofuel cells, was measured between pH 4.5 and 8.5 using UV/vis spectroelectrochemistry. In the entire pH range under investigation, the flavin adenine dinucleotide cofactor of GOx changed directly from the oxidized quinone to the doubly reduced hydroquinone. No stable semiquinoid species could be detected if electrochemical equilibrium was reached...
August 5, 2014: Analytical Chemistry
https://www.readbyqxmd.com/read/24975741/heterojunction-hybrid-devices-from-vapor-phase-grown-mos2
#18
Chanyoung Yim, Maria O'Brien, Niall McEvoy, Sarah Riazimehr, Heiko Schäfer-Eberwein, Andreas Bablich, Ravinder Pawar, Giuseppe Iannaccone, Clive Downing, Gianluca Fiori, Max C Lemme, Georg S Duesberg
We investigate a vertically-stacked hybrid photodiode consisting of a thin n-type molybdenum disulfide (MoS2) layer transferred onto p-type silicon. The fabrication is scalable as the MoS2 is grown by a controlled and tunable vapor phase sulfurization process. The obtained large-scale p-n heterojunction diodes exhibit notable photoconductivity which can be tuned by modifying the thickness of the MoS2 layer. The diodes have a broad spectral response due to direct and indirect band transitions of the nanoscale MoS2...
2014: Scientific Reports
https://www.readbyqxmd.com/read/24675376/influence-of-donor-characteristics-on-descemet-membrane-endothelial-keratoplasty
#19
Sonja Heinzelmann, Silja Hüther, Daniel Böhringer, Philipp Eberwein, Thomas Reinhard, Philip Maier
PURPOSE: Penetrating keratoplasty is being replaced by posterior lamellar techniques like Descemet stripping automated endothelial keratoplasty or Descemet membrane endothelial keratoplasty (DMEK) for the surgical treatment of patients with endothelial insufficiency. Although DMEK leads to the best visual results, Descemet stripping automated endothelial keratoplasty is still the standard procedure for many surgeons because it is technically more standardized. Here, we investigated how donor characteristics may influence DMEK surgery...
June 2014: Cornea
https://www.readbyqxmd.com/read/24349336/short-term-azithromycin-treatment-promotes-cornea-allograft-survival-in-the-rat
#20
Katrin Wacker, Sophy Denker, Antonia Hildebrand, Philipp Eberwein, Thomas Reinhard, Johannes Schwartzkopff
BACKGROUND: Any inflammatory response following corneal transplantation may induce rejection and irreversible graft failure. The purpose of this study is to analyze the anti-inflammatory effect of azithromycin (AZM) following experimental keratoplasty in rats. METHODS: Corneal transplants were performed between Fisher-donor and Lewis-recipient rats. Recipients were postoperatively treated three times daily with AZM, miglyol, ofloxacin or dexamethasone eye drops...
2013: PloS One
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