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Pyoderma gangenosum

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https://www.readbyqxmd.com/read/29182760/expression-patterns-of-tnf%C3%AE-madcam1-and-stat3-in-intestinal-and-skin-manifestations-of-inflammatory-bowel-disease
#1
Stephan R Vavricka, Jose A Galván, Heather Dawson, Alex Soltermann, Luc Biedermann, Michael Scharl, Alain M Schoepfer, Gerhard Rogler, Mareike B Prinz Vavricka, Luigi Terracciano, Alexander Navarini, Inti Zlobec, Alessandro Lugli, Thomas Greuter
Background: Pathogenesis of cutaneous extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) remains elusive. Efficacy of anti-TNF agents suggests TNF-dependent mechanisms. The role of other biologics such as anti-integrins or JAK-inhibitors is not yet clear. Methods: We performed immunohistochemistry for TNFα, NFκB, STAT1/STAT3, MAdCAM1, CD20/68, caspase 3/9, IFNγ, Hsp-27/70 on 240 intestinal (55 controls, 185 IBD) and 64 skin biopsies (11 controls, 18 Erythema nodosum (EN), 13 Pyoderma gangenosum (PG), 22 psoriasis)...
November 22, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/10917019/-a-case-of-aseptic-osteomyelitis-with-heel-ulcer-improved-by-steroid-application
#2
M Idogawa, H Takahashi, T Soma, M Mihara, T Mizukoshi, R Murakami, T Sugaya, Y Makiguchi, K Imai
A 43-year-old male patient was admitted to our hospital because of left heel pain and fever. He had had swelling of the left ankle joint and pain 4 years prior to this, and 4 years later, he was admitted to another hospital when left heel ulcer and fever developed. The ulcer was diagnosed and treated as a diabetic ulcer because of hyperglycemia. In spite of good control of blood sugar, the ulcer became enlarged and the pain deteriorated, so he was transferred to orthopedics. Antibiotics produced no response, and culture from a specimen of the ulcer was negative...
June 2000: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
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