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ocular response analyzer cornea

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https://www.readbyqxmd.com/read/29082447/impact-of-herpetic-stromal-immune-keratitis-in-corneal-biomechanics-and-innervation
#1
Manuel Ángel Marcos-Fernández, Sara Sánchez Tabernero, Jose María Herreras, David José Galarreta
PURPOSE: To study corneal innervation in eyes with history of herpetic keratitis and its correlation with corneal sensitivity and biomechanical properties. METHODS: A total of 56 eyes were included, of which 16 had a history of unilateral immune stromal herpetic keratitis, 16 were their contralateral eyes, and 20 were healthy controls. Structural analysis of corneal nerve plexus was performed by confocal microscopy. Biomechanical properties were measured with the Ocular Response Analyzer...
October 29, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29032108/pregnancy-induced-changes-in-corneal-biomechanics-and-topography-are-thyroid-hormone-related
#2
David Tabibian, Begoña M de Tejada, Zisis Gatzioufas, Sabine Kling, Vanessa S Meiss, Marc-Olivier Boldi, Véronique Othenin-Girard, Antonina Chilin, Julien Lambiel, Florence Hoogewoud, Farhad Hafezi
PURPOSE: To identify biomechanical and topographic changes of the cornea during pregnancy and the postpartum period and its association to hormonal changes. DESIGN: Prospective single-center observational cohort study. METHODS: Participants were 24 pregnant women (48 eyes), monitored throughout pregnancy and after delivery. Biomechanical and topographic corneal properties were measured using the Ocular Response Analyzer (ORA) and a Scheimpflug imaging system (Pentacam HR) each trimester and 1 month after delivery...
October 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28932334/corneal-biomechanics-in-ectatic-diseases-refractive-surgery-implications
#3
Renato Ambrósio, Fernando Faria Correia, Bernardo Lopes, Marcella Q Salomão, Allan Luz, Daniel G Dawson, Ahmed Elsheikh, Riccardo Vinciguerra, Paolo Vinciguerra, Cynthia J Roberts
BACKGROUND: Ectasia development occurs due to a chronic corneal biomechanical decompensation or weakness, resulting in stromal thinning and corneal protrusion. This leads to corneal steepening, increase in astigmatism, and irregularity. In corneal refractive surgery, the detection of mild forms of ectasia pre-operatively is essential to avoid post-operative progressive ectasia, which also depends on the impact of the procedure on the cornea. METHOD: The advent of 3D tomography is proven as a significant advancement to further characterize corneal shape beyond front surface topography, which is still relevant...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28903153/colony-stimulating-factor-1-receptor-expressing-cells-infiltrating-the-cornea-control-corneal-nerve-degeneration-in-response-to-hsv-1-infection
#4
Ana J Chucair-Elliott, Hem R Gurung, Meghan M Carr, Daniel J J Carr
Purpose: Herpes simplex virus type-1 (HSV-1) is a leading cause of neurotrophic keratitis, characterized by decreased or absent corneal sensation due to damage to the sensory corneal innervation. We previously reported the elicited immune response to infection contributes to the mechanism of corneal nerve regression/damage during acute HSV-1 infection. Our aim is to further establish the involvement of infiltrated macrophages in the mechanism of nerve loss upon infection. Methods: Macrophage Fas-Induced Apoptosis (MAFIA) transgenic C57BL/6 mice were systemically treated with AP20187 dimerizer or vehicle (VEH), and their corneas, lymph nodes, and blood were assessed for CD45+CD11b+GFP+ cell depletion by flow cytometry (FC)...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28756375/anterior-posterior-and-biomechanical-parameters-of-cornea-during-pregnancy-in-healthy-eyes-a-cohort-study
#5
Mohammad Naderan, Ali Jahanrad
BACKGROUND: To investigate the effect of pregnancy on anterior, posterior and biomechanical corneal parameters of healthy eyes. METHOD: In this prospective cohort study, 70 pregnant participants with clinically healthy eyes underwent corneal topographic imaging evaluation by Pentacam and biomechanical assessment by Ocular Response Analyzer (ORA) before pregnancy, at the third trimester of pregnancy (34th week of pregnancy) and 12 months after delivery. The same number of age-matched non-pregnant females was evaluated at the corresponding appointments as the control group...
July 29, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28745654/-analysis-of-corneal-biomechanical-changes-after-femtosecond-laser-assisted-laser-in-situ-keratomileusis-in-children-with-hyperopic-anisometropia
#6
I L Kulikova, O V Shlenskaya, N V Chapurin
AIM: to analyze corneal hysteresis (CH) and corneal resistance factor (RF) readings obtained with the Reichert Ocular Response Analyzer (ORA) before and after hyperopic femtolaser-assisted laser in situ keratomileusis (FS-LASIK) in children with anisometropia as well as to establish factors that may cause changes in these parameters. MATERIAL AND METHODS: CH and RF were evaluated before and 1.5 years after FS-LASIK performed on amblyopic eyes of 28 patients aged 6-14 years...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28664236/alterations-in-biomechanical-properties-of-the-cornea-among-patients-with-polycystic-kidney-disease
#7
Kubra Serefoglu Cabuk, Bennur Esen, Kursat Atalay, Ahmet Kirgiz, Rukiye Aydin
PURPOSE: The aim of this study was to evaluate the corneal biomechanical features in polycystic kidney disease (PKD) patients and compare them with the healthy individuals. METHODS: Totally 81 patients with a mean age of 48.46 ± 14.51 years and 60 control cases with a mean age of 44.68 ± 12.69 years were included in the study. All of the subjects underwent a complete ophthalmological examination, including visual acuity testing, biomicroscopic anterior and posterior segment examinations...
June 29, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#8
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28626602/association-between-corneal-biomechanical-properties-with-ocular-response-analyzer-and-also-corvisst-tonometry-and-glaucomatous-visual-field-severity
#9
Kazunori Hirasawa, Masato Matsuura, Hiroshi Murata, Shunsuke Nakakura, Yoshitaka Nakao, Yoshiaki Kiuchi, Ryo Asaoka
PURPOSE: To investigate the association between corneal biomechanical properties measured with the Ocular Response Analyzer (ORA) and also CorvisST (CST) tonometry, and glaucomatous visual field (VF) severity. METHODS: One hundred forty-six eyes of 91 patients with primary open-angle glaucoma who performed Humphrey Field Analyzer 30-2 or 24-2 SITA-Standard, ORA, and CST within 180 days were included in this multicentral, observational cross-sectional study. The association between ORA parameters (corneal hysteresis [CH] and corneal resistant factor [CRF]), CST parameters (A1 and A2 time, A1 and A2 length, A1 and A2 velocity, A1 and A2 deformation amplitude, highest deformation amplitude, highest concavity time, peak distance, and radius), and other basic parameters (age, intraocular pressure with Goldmann applanation tonometry, central corneal thickness, and axial length) against mean total deviation (mTD) were analyzed using a linear mixed-model and model selection with corrected Akaike Information Criterion (AICc)...
June 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28461014/comparison-of-corneal-biomechanical-properties-between-indian-and-chinese-adults
#10
COMPARATIVE STUDY
Jacqueline Chua, Monisha E Nongpiur, Wanting Zhao, Yih Chung Tham, Preeti Gupta, Charumathi Sabanayagam, Tin Aung, Tien Yin Wong, Ching-Yu Cheng
PURPOSE: To investigate the difference in corneal hysteresis (CH) and corneal resistance factor (CRF) between Indian and Chinese populations. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Three hundred eighty-two Singaporean Indian persons and 764 Singaporean Chinese 50 years of age or older were included from the Singapore Indian Eye Study and Singapore Chinese Eye Study, respectively. METHODS: Participants underwent standardized systemic and ocular examinations and interviewer-administered questionnaires for risk factor assessment...
September 2017: Ophthalmology
https://www.readbyqxmd.com/read/28287858/the-effect-of-pterygium-and-pterygium-surgery-on-corneal-biomechanics
#11
Mustafa Koç, Fuat Yavrum, Mehmet Murat Uzel, Emre Aydemir, Kemal Özülken, Pelin Yılmazbaş
PURPOSE: To evaluate the effect of pterygium and pterygium surgery on corneal biomechanics by ocular response analyzer (ORA, Reichert, USA). METHODS: This study considered 68 eyes (from 34 patients with a mean age of 21.2±7.1 years) with unilateral nasal, primary pterygium (horizontal length <4 mm), and having undergone pterygium excision and conjunctival autografting. Pterygium length and area were measured from a photograph of the anterior segment using Image J program...
March 13, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28192588/conventional-versus-inverted-side-cut-flaps-for-femtosecond-laser-assisted-lasik-laboratory-and-clinical-evaluation
#12
RANDOMIZED CONTROLLED TRIAL
Vishal Jhanji, Tommy C Y Chan, Wai Ying Li, Rayne R Lim, Marco C Y Yu, Kasin Law, Peng Yi, Yolanda W Y Yip, Yumeng Wang, Tsz Kin Ng, Shyam S Chaurasia, Rajiv R Mohan
PURPOSE: To study the differences in early corneal cellular events and biomechanical properties after femtosecond laser-assisted LASIK performed using conventional or inverted side-cut angles. METHODS: In the laboratory study, left eyes of 24 rabbits underwent LASIK flap creation with a 70° or 115° side-cut. The contralateral eyes served as controls. The corneas were harvested 24 hours postoperatively. In the clinical study, 2 eyes of each patient (n = 29) were randomized to corneal flap creation with 70° or 115° side-cut angles during LASIK...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28162196/-comparison-of-the-effects-of-different-side-cut-angles-on-corneal-biomechanical-properties-after-femtosecond-laser-assisted-laser-in-situ-keratomileusis
#13
COMPARATIVE STUDY
H Li, Y Wang, R Dou, L Wang, L L Xu, X J Li, J M Zhang
Objective: To evaluate the effects of side-cut angles on corneal biomechanical properties after femtosecond laser assisted-laser in situ keratomileusis (FS-LASIK). Methods: In this clinical control study, 97 right eyes of 97 patients with myopia and myopic astigmatism undergoing FS-LASIK surgery were included randomly. Two types of side-cut angles were designed for the flap, 90° in 48 eyes and 130° in 49 eyes. The values of corneal resistance factor (CRF), cornea hysteresis (CH) and 37 biomechanical waveform parameters were measured using the ocular response analyzer preoperatively and at 1 and 3 months postoperatively...
January 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28094315/the-usefulness-of-corvisst-tonometry-and-the-ocular-response-analyzer-to-assess-the-progression-of-glaucoma
#14
Masato Matsuura, Kazunori Hirasawa, Hiroshi Murata, Shunsuke Nakakura, Yoshiaki Kiuchi, Ryo Asaoka
Corneal Visualization Scheimpflug Technology (CST) and Ocular Response Analyzer (ORA) measurements were carried out in 105 eyes of 69 patients with primary open-angle glaucoma. All patients had axial length (AL), central corneal thickness (CCT), intraocular pressure (IOP) with Goldmann applanation tonometry (GAT) and eight visual fields (VF)s with the Humphrey Field Analyzer. VF progression was summarized using a time trend analysis of mean total deviation (mTD) and the association between mTD progression rate and a number of ocular parameters (including CST and ORA measurements) was assessed using mixed linear regression analysis...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081172/influence-of-corneal-opacity-on-intraocular-pressure-assessment-in-patients-with-lysosomal-storage-diseases
#15
Joanna Wasielica-Poslednik, Giuseppe Politino, Irene Schmidtmann, Katrin Lorenz, Katharina Bell, Norbert Pfeiffer, Susanne Pitz
AIMS: To investigate an influence of mucopolysaccharidosis (MPS)- and Morbus Fabry-associated corneal opacities on intraocular pressure (IOP) measurements and to evaluate the concordance of the different tonometry methods. METHODS: 25 MPS patients with or without corneal clouding, 25 Fabry patients with cornea verticillata ≥ grade 2 and 25 healthy age matched controls were prospectively included into this study. Outcome measures: Goldmann applanation tonometry (GAT); palpatory assessment of IOP; Goldmann-correlated intraocular pressure (IOPg), corneal-compensated intraocular pressure (IOPcc), corneal resistance factor (CRF) and corneal hysteresis (CH) assessed by Ocular Response Analyzer (ORA); central corneal thickness (CCT) and density assessed with Pentacam...
2017: PloS One
https://www.readbyqxmd.com/read/28076565/effect-of-corneal-biomechanical-properties-on-surgically-induced-astigmatism-and-higher-order-aberrations-after-cataract-surgery
#16
Mustafa Koç, Çağrı İlhan, Yaran Koban, Kemal Özülken, İrfan Durukan, Pelin Yılmazbaş
Purpose: To investigate the relationship between biomechanical properties of the cornea and postoperative refractive changes in patients with low-level astigmatism after cataract surgery. Methods: This prospective study recruited patients undergoing cataract surgery involving 2.8-mm superior incisions. Biomechanical properties of the cornea were evaluated preoperatively using the Ocular Response Analyzer, and corneal profiles were evaluated using a Scheimpflug system (Pentacam HR)...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27956045/biomechanical-properties-of-early-keratoconus-suppressed-deformation-signal-wave
#17
Hassan Hashemi, Asghar Beiranvand, Abbasali Yekta, Amir Asharlous, Mehdi Khabazkhoob
PURPOSE: To examine the diagnostic validity of different corneal biomechanical parameters for the detection of early keratoconus METHODS: Sixty-one eyes with a diagnosis of early keratoconus and 61 topographically normal eyes were enrolled in the study. All participants underwent testing with the Ocular Response Analyzer (ORA), and 40 indices from each cornea were included in the analysis. RESULTS: The mean (standard deviation: SD) of keratometry and central corneal thickness in keratoconic corneas was 46...
April 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27873338/high-myopes-have-lower-normalised-corneal-tangent-moduli-less-stiff-corneas-than-low-myopes
#18
Ying Hon, Guo-Zhen Chen, Shu-Hao Lu, David C C Lam, Andrew K C Lam
PURPOSE: To compare corneal tangent moduli between low and high myopes. METHODS: Corneal hysteresis (CH) and corneal resistance factor (CRF) of 32 low and 32 high myopes were obtained using an Ocular Response Analyzer, followed by a corneal indentation device that measured corneal stiffness. Corneal topography, pachymetry, Goldmann applanation tonometry intraocular pressure (GAT-IOP), and corneal compensated intraocular pressure (IOPcc) were also obtained. Corneal tangent modulus was calculated on the basis of corneal stiffness, central corneal thickness and corneal radius...
January 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/27803856/effect-of-femtosecond-and-microkeratome-flaps-creation-on-the-cornea-biomechanics-during-laser-in-situ-keratomileusis-one-year-follow-up
#19
Qian Sun, Zheng-Zheng Deng, Yue-Hua Zhou, Jing Zhang, Xiao-Yan Peng
AIM: To compare the corneal biomechanical outcomes at one year after laser in situ keratomileusis (LASIK) with the flaps created by Ziemer and Moria M2 microkeratome with 110 head and -20 blade. METHODS: Totally 100 eyes of 50 consecutive patients were enrolled in this prospective study and divided into two groups for corneal flaps created by ZiemerFemto LDV and Moria M2 microkeratome with 110 head and -20 blade. Corneal biomechanical properties including cornea resistance factor (CRF) and cornea hysteresis (CH) were measured before and 1, 3, 6, 12mo after surgery by ocular response analyzer...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27800259/comparison-of-changes-in-corneal-biomechanical-properties-after-photorefractive-keratectomy-and-small-incision-lenticule-extraction
#20
Yusuf Yıldırım, Onur Ölçücü, Abdurrahman Başcı, Alper Ağca, Engin Bilge Özgürhan, Cengiz Alagöz, Ali Demircan, Ahmet Demirok
OBJECTIVES: To compare the postoperative biomechanical properties of the cornea after photorefractive keratectomy (PRK) and small incision lenticule extraction (SMILE) in eyes with low and moderate myopia. MATERIALS AND METHODS: We retrospectively examined 42 eyes of 23 patients undergoing PRK and 42 eyes of 22 patients undergoing SMILE for the correction of low and moderate myopia. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured with an Ocular Response Analyzer before and 6 months after surgery...
April 2016: Turkish Journal of Ophthalmology
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