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https://www.readbyqxmd.com/read/28821147/uv-crosslinkable-and-thermo-responsive-chitosan-hybrid-hydrogel-for-nir-triggered-localized-on-demand-drug-delivery
#1
Lei Wang, Baoqiang Li, Feng Xu, Zheheng Xu, Daqing Wei, Yujie Feng, Yaming Wang, Dechang Jia, Yu Zhou
Innovative drug delivery technologies based on smart hydrogels for localized on-demand drug delivery had aroused great interest. To acquire smart UV-crosslinkable chitosan hydrogel for NIR-triggered localized on-demanded drug release, a novel UV-crosslinkable and thermo-responsive chitosan was first designed and synthesized by grafting with poly N-isopropylacrylamide, acetylation of methacryloyl groups and embedding with photothermal carbon. The UV-crosslinkable unit (methacryloyl groups) endowed chitosan with gelation via UV irradiation...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821121/reductive-mineralization-of-cellulose-with-vanadium-iron-and-tungsten-chlorides-and-access-to-mxoy-metal-oxides-and-mxoy-c-metal-oxide-carbon-composites
#2
Aurélien Henry, Peter Hesemann, Johan G Alauzun, Bruno Boury
MxOy and MxOy/C composites (M=V, Fe and W) were obtained by mineralization of cellulose with several metal chlorides. Cellulose was used both as a templating agent and as an oxygen and a carbon source. Soluble chloride molecules (VOCl3 and WCl6) and a poorly soluble ionic chloride compound (FeCl3) were chosen as metal oxide precursors. In a first time, primary metal oxide/cellulose composites were obtained via a thermal treatment by reacting urea impregnated filter paper with the corresponding metal chlorides in an autoclave at 150°C after 3days...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821101/cholesteric-film-of-cu-ii-doped-cellulose-nanocrystals-for-colorimetric-sensing-of-ammonia-gas
#3
Shidong Dai, Nana Prempeh, Dagang Liu, Yimin Fan, Mingyue Gu, Yu Chang
With the increasing demand of environmental monitoring for toxic and odorous ammonia gas it is desired to develop specific green, cost-effective and in situ passive colorimetric alternatives to current complex instrumentations. In this work, we designed an ammonia gas sensor based on cholesteric liquid crystal films of copper(II)-doped cellulose nanocrystals (CNCCu(II)) whose structure, optical and sensing properties were investigated. The hybrid films using the low doping Cu(II) as a color-tuning agent inherited the chiral nematic signature and optical activity of CNCs, suggesting a strong chelation between copper ions and negatively charged CNCs...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821040/characteristics-of-a-free-standing-film-from-banana-pseudostem-nanocellulose-generated-from-tempo-mediated-oxidation
#4
R H Fitri Faradilla, George Lee, Ji-Youn Arns, Justine Roberts, Penny Martens, Martina H Stenzel, Jayashree Arcot
Demand for bioplastic, especially for food packaging, increases as the consumers become more aware of the destructive effect of non-biodegradable plastics. Nanocellulose from banana pseudo-stem has great potential to be formed as a bioplastic. This study aimed to characterize the free-standing film produced from banana pseudo-stem nanocellulose that was prepared by TEMPO-mediated oxidation. The film was found containing calcium oxalate crystals, which most likely influenced the film transparency and possibly affected the contact angle and tensile strength...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821009/evaluating-the-impact-of-connectivity-continuity-and-topography-of-sidewalk-network-on-pedestrian-safety
#5
Ahmed Osama, Tarek Sayed
With the increasing demand for sustainability, walking is being encouraged as one of the main active modes of transportation. However, pedestrians are vulnerable to severe injuries when involved in crashes which can discourage road users from walking. Therefore, studying factors that affect the safety of pedestrians is important. This paper investigates the relationship between pedestrian-motorist crashes and various sidewalk network indicators in the city of Vancouver. The goal is to assess the impact of network connectivity, directness, and topography on pedestrian safety using macro-level collision prediction models...
August 15, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28820966/reactive-oxygen-species-responsive-polymeric-nanoparticles-for-alleviating-sepsis-induced-acute-liver-injury-in-mice
#6
Gan Chen, Hongzhang Deng, Xiang Song, Mingzi Lu, Lian Zhao, Sha Xia, Guoxing You, Jingxiang Zhao, Yulong Zhang, Anjie Dong, Hong Zhou
Sepsis-associated acute liver injury contributes to the pathogenesis of multiple organ dysfunction syndrome and is associated with increased mortality. Currently, no specific therapeutics for sepsis-associated liver injury are available. With excess levels of reactive oxygen species (ROS) being implicated as key players in sepsis-induced liver injury, we hypothesize that ROS-responsive nanoparticles (NPs) formed via the self-assembly of diblock copolymers of poly(ethylene glycol) (PEG) and poly(propylene sulfide) (PPS) may function as an effective drug delivery system for alleviating sepsis-induced liver injury by preferentially releasing drug molecules at the disease site...
August 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28820938/multi-scale-simulation-of-receptor-drug-association-kinetics-application-to-neuramidase-inhibitors
#7
Fabian Zeller, Manuel P Luitz, Rainer Bomblies, Martin Zacharias
A detailed understanding of the drug-receptor association process is of fundamental importance for drug design. Due to the long timescales of typical binding kinetics, the atomistic simulation of the ligand traveling from bulk solution into the binding site is still computationally challenging. In this work, we apply a multi-scale approach of combined molecular dynamics (MD) and Brownian dynamics (BD) simulations to investigate association pathway ensembles for the two prominent H1N1 neuraminidase inhibitors oseltamivir and zanamivir...
August 18, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28820936/elucidating-substrate-promiscuity-within-the-fabi-enzyme-family
#8
Gabriel S Freund, Terrence E O'Brien, Logan Vinson, Dylan Alexander Carlin, Andrew Yao, Wai Shun Mak, Ilias Tagkopoulos, Marc T Facciotti, Dean J Tantillo, Justin B Siegel
The rapidly growing appreciation of enzymes' catalytic and substrate promiscuity may lead to their expanded use in the fields of chemical synthesis and industrial biotechnology. Here we explore the substrate promiscuity of enoyl-acyl carrier protein reductases (commonly known as FabI), and how that promiscuity is a function of inherent reactivity and the geometric demands of the enzyme's active site. We demonstrate that these enzymes catalyze the reduction of a wide range of substrates, particularly α,β-unsaturated aldehydes...
August 18, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28820896/a-strategy-for-scaling-up-access-to-comprehensive-care-in-adults-with-chagas-disease-in-endemic-countries-the-bolivian-chagas-platform
#9
Maria-Jesus Pinazo, Jimy Pinto, Lourdes Ortiz, Jareth Sánchez, Wilson García, Ruth Saravia, Mirko-R Cortez, Silvia Moriana, Enric Grau, Daniel Lozano, Joaquim Gascon, Faustino Torrico
BACKGROUND: Bolivia has the highest prevalence of Chagas disease (CD) in the world (6.1%), with more than 607,186 people with Trypanosoma cruzi infection, most of them adults. In Bolivia CD has been declared a national priority. In 2009, the Chagas National Program (ChNP) had neither a protocol nor a clear directive for diagnosis and treatment of adults. Although programs had been implemented for congenital transmission and for acute cases, adults remained uncovered. Moreover, health professionals were not aware of treatment recommendations aimed at this population, and research on CD was limited; it was difficult to increase awareness of the disease, understand the challenges it presented, and adapt strategies to cope with it...
August 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28820856/perceived-wellness-associated-with-practice-and-competition-in-ncaa-division-i-football-players
#10
Aaron D Wellman, Sam C Coad, Patrick J Flynn, Ty K Siam, Christopher P McLellan
The present study assessed the influence of movement demands resulting from weekly practice sessions and games, on perceived wellness measurements taken post-game (Sunday) and 48 hours pre-game (Thursday) throughout the in-season period in National Collegiate Athletic Association (NCAA) division I football players. Thirty players were monitored using GPS receivers (Catapult Innovations OptimEye S5, Melbourne, Australia) during 12 games and 24 in-season practices. Movement variables included low-intensity distance, medium-intensity distance, high-intensity distance, sprint distance, total distance, player load, and acceleration and deceleration distance...
August 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28820836/the-surgeon-s-fist-with-the-thumb-up-to-guide-the-design-and-inset-of-the-osteoseptocutaneous-fibula-flap-in-mandibular-reconstruction
#11
Nidal F Al Deek, Chung-Kan Tsao, Fu-Chan Wei
Successful reconstruction of the oromandibular defect with the osteoseptocutaneous fibula flap necessitates flawless design and inset, an experience-demanding endeavor. Laterality of the fibula flap has been thought to pose a certain challenge to the reconstruction. To address this concern and guide flap design and inset, the authors propsed using the surgeon's fist with the thumb up to replicate key anatomic land marks of the fibula flap: the peroneal vessels and proximal bone end, the posterior crural septum including the septal vessels, the skin, and the lateral surface of the fibula bone...
August 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28820675/on-the-role-of-situational-stressors-in-the-disruption-of-global-neural-network-stability-during-problem-solving
#12
Mengting Liu, Chad E Forbes, Rachel C Amey
When individuals are placed in stressful situations, they are likely to exhibit deficits in cognitive capacity over and above situational demands. Despite this, individuals may still persevere and ultimately succeed in these situations. Little is known, however, about neural network properties that instantiate success or failure in both neutral and stressful situations, particularly with respect to regions integral for problem-solving processes that are necessary for optimal performance on more complex tasks...
August 18, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28820674/restoration-of-fmri-decodability-does-not-imply-latent-working-memory-states
#13
Sebastian Schneegans, Paul M Bays
Recent imaging studies have challenged the prevailing view that working memory is mediated by sustained neural activity. Using machine learning methods to reconstruct memory content, these studies found that previously diminished representations can be restored by retrospective cueing or other forms of stimulation. These findings have been interpreted as evidence for an activity-silent working memory state that can be reactivated dependent on task demands. Here, we test the validity of this conclusion by formulating a neural process model of working memory based on sustained activity and using this model to emulate a spatial recall task with retro-cueing...
August 18, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28820621/-doctors-killed-my-baby-argumentative-patterns-in-medical-disputes-in-china
#14
Dawei Pan
The recent surge in medical disputes requires that more attention be paid to the voices of laypeople. This article explores the argumentative nature of the public discourse of the reported "malpractice mobs" that strive to convince members of the public (in the place of health or legal experts) that they have been victims of medical errors and injustice. This case-based qualitative empirical study uses a pragma-dialectical approach to suggest a prototypical pattern of such public appeals that contains a basic argumentative pattern and various types of extensions...
August 18, 2017: Health Communication
https://www.readbyqxmd.com/read/28820477/lora-mobile-to-base-station-channel-characterization-in-the-antarctic
#15
Johnny Gaelens, Patrick Van Torre, Jo Verhaevert, Hendrik Rogier
Antarctic conditions demand that wireless sensor nodes are operational all year round and that they provide a large communication range of several tens of kilometers. LoRa technology operating in sub-GHz frequency bands implements these wireless links with minimal power consumption. The employed chirp spread spectrum modulation provides a large link budget, combined with the excellent radio-wave propagation characteristics in these bands. In this paper, an experimental wireless link from a mobile vehicle which transmits sensor data to a base station is measured and analyzed in terms of signal-to-noise ratio and packet loss...
August 18, 2017: Sensors
https://www.readbyqxmd.com/read/28820304/predictors-of-quality-of-life-and-survival-following-gamma-knife-surgery-for-lung-cancer-brain-metastases-a-prospective-study
#16
Sidsel Bragstad, Marianne Flatebø, Gerd Karin Natvig, Geir Egil Eide, Geir Olve Skeie, Maziar Behbahani, Paal-Henning Pedersen, Per Øyvind Enger, Bente Sandvei Skeie
OBJECTIVE Lung cancer (LC) patients who develop brain metastases (BMs) have a poor prognosis. Estimations of survival and risk of treatment-related deterioration in quality of life (QOL) are important when deciding on treatment. Although we know of several prognostic factors for LC patients with BMs, the role of QOL has not been established. Authors of this study set out to evaluate changes in QOL following Gamma Knife surgery (GKS) for BMs in LC patients and QOL as a prognostic factor for survival. METHODS Forty-four of 48 consecutive LC patients with BMs underwent GKS in the period from May 2010 to September 2011, and their QOL was prospectively assessed before and 1, 3, 6, 9, and 12 months after GKS by using the Functional Assessment of Cancer Therapy-Brain (FACT-BR) questionnaire...
August 18, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28820230/are-you-ready-crisis-leadership-in-a-hyper-vuca-environment
#17
Khaldoon H Alkhaldi, Meredith L Austin, Boris A Cura, Darrell Dantzler, Leslie Holland, David L Maples, Jamie C Quarrelles, Robert K Weinkle, Leonard J Marcus
The current hyper-volatile, -uncertain, -complex, and -ambiguous (VUCA) threat environment demands a more cohesive support structure for crisis leaders who may be faced with crises of increasing magnitude and frequency and, in some instances, multiple crisis events simultaneously. The project team investigates the perceptions of crisis leaders regarding establishing a crisis leader advisor position for crisis leaders to benefit from their experience while prosecuting crisis response activities. The team linked hyper-VUCA crises, crisis response frameworks, meta-leadership, crisis leader attributes, and advisor attributes...
March 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28820022/self-reported-school-demands-and-psychosomatic-problems-among-adolescents-changes-in-the-association-between-1988-and-2011
#18
Karina Nygren, Curt Hagquist
AIMS: The aim of the present study was to examine changes over time in the relationship between self-reported school demands and psychosomatic problems, also considering the impact of student influence and teacher support. METHODS: Data from a cross-sectional study (Young in Värmland) including eight data collections (1988-2011) among Swedish students aged 15-16 were used ( n = 20,115). Analyses with multinomial logistic regression and descriptive statistics were applied...
August 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28820017/directive-and-nondirective-social-support-in-the-workplace-is-this-social-support-distinction-important-for-subjective-health-complaints-job-satisfaction-and-perception-of-job-demands-and-job-control
#19
Tone Langjordet Johnsen, Hege Randi Eriksen, Aage Indahl, Torill Helene Tveito
AIMS: Social support is associated with well-being and positive health outcomes. However, positive outcomes of social support might be more dependent on the way support is provided than the amount of support received. A distinction can be made between directive social support, where the provider resumes responsibility, and nondirective social support, where the receiver has the control. This study examined the relationship between directive and nondirective social support, and subjective health complaints, job satisfaction and perception of job demands and job control...
August 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28819995/the-effect-of-different-fish-feed-compositions-on-%C3%AE-13-c-and-%C3%AE-15-n-signatures-of-sea-bass-and-its-potential-value-for-tracking-mariculture-derived-nutrients
#20
Henrik Kusche, Nicola Hillgruber, Yvonne Rößner, Ulfert Focken
Increasing demand for fish and seafood calls for an expansion of aquaculture production. At the same time, the status of the marine environment must not be jeopardised. Stable isotopes are potential markers for tracking feed-based nutrient flows from aquaculture into marine biota. Here, we demonstrate how four experimental diets (main protein components: fishmeal, soya protein concentrate, wheat gluten, and Jatropha kernel meal) and a commercial diet induce characteristic δ(13)C and δ(15)N signals in sea bass (Dicentrarchus labrax) during nine weeks of laboratory feeding under replicate conditions...
August 18, 2017: Isotopes in Environmental and Health Studies
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