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ocular response analyzer

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https://www.readbyqxmd.com/read/28081172/influence-of-corneal-opacity-on-intraocular-pressure-assessment-in-patients-with-lysosomal-storage-diseases
#1
Joanna Wasielica-Poslednik, Giuseppe Politino, Irene Schmidtmann, Katrin Lorenz, Katharina Bell, Norbert Pfeiffer, Susanne Pitz
AIMS: To investigate an influence of mucopolysaccharidosis (MPS)- and Morbus Fabry-associated corneal opacities on intraocular pressure (IOP) measurements and to evaluate the concordance of the different tonometry methods. METHODS: 25 MPS patients with or without corneal clouding, 25 Fabry patients with cornea verticillata ≥ grade 2 and 25 healthy age matched controls were prospectively included into this study. Outcome measures: Goldmann applanation tonometry (GAT); palpatory assessment of IOP; Goldmann-correlated intraocular pressure (IOPg), corneal-compensated intraocular pressure (IOPcc), corneal resistance factor (CRF) and corneal hysteresis (CH) assessed by Ocular Response Analyzer (ORA); central corneal thickness (CCT) and density assessed with Pentacam...
2017: PloS One
https://www.readbyqxmd.com/read/28078103/the-potential-of-spectral-domain-optical-coherence-tomography-imaging-based-retinal-biomarkers
#2
REVIEW
Prateep Phadikar, Sandeep Saxena, Surabhi Ruia, Timothy Y Y Lai, Carsten H Meyer, Dean Eliott
BACKGROUND: Biomarker", a merged word of "biological marker", refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28076565/effect-of-corneal-biomechanical-properties-on-surgically-induced-astigmatism-and-higher-order-aberrations-after-cataract-surgery
#3
Mustafa Koç, Çağrı İlhan, Yaran Koban, Kemal Özülken, İrfan Durukan, Pelin Yılmazbaş
Purpose: To investigate the relationship between biomechanical properties of the cornea and postoperative refractive changes in patients with low-level astigmatism after cataract surgery. Methods: This prospective study recruited patients undergoing cataract surgery involving 2.8-mm superior incisions. Biomechanical properties of the cornea were evaluated preoperatively using the Ocular Response Analyzer, and corneal profiles were evaluated using a Scheimpflug system (Pentacam HR)...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28068412/a-comparison-of-gene-expression-profiles-between-glucocorticoid-responder-and-non-responder-bovine-trabecular-meshwork-cells-using-rna-sequencing
#4
Jaclyn Y Bermudez, Hannah C Webber, Bartley Brown, Terry A Braun, Abbot F Clark, Weiming Mao
The most common ocular side effect of glucocorticoid (GC) therapy is GC-induced ocular hypertension (OHT) and GC-induced glaucoma (GIG). GC-induced OHT occurs in about 40% of the general population, while the other 60% are resistant. This study aims to determine the genes and pathways involved in differential GC responsiveness in the trabecular meshwork (TM). Using paired bovine eyes, one eye was perfusion-cultured with 100nM dexamethasone (DEX), while the fellow eye was used to establish a bovine TM (BTM) cell strain...
2017: PloS One
https://www.readbyqxmd.com/read/28068365/tonographic-effect-of-ocular-response-analyzer-in-comparison-to-goldmann-applanation-tonometry
#5
Martin Zimmermann, Susanne Pitz, Irene Schmidtmann, Norbert Pfeiffer, Joanna Wasielica-Poslednik
AIMS: The tonographic effect is a phenomenon of intraocular pressure (IOP) reduction following repeated tonometry. This study examines whether the tonographic effect occurs following IOP measurement performed with Ocular Response Analyzer (ORA). METHODS: Both eyes of 31 glaucoma patients and 35 healthy controls underwent nine IOP-measurements performed with GAT and ORA. The number of GAT and ORA measurements performed on each eye differed depending on the randomly allocated investigation scheme...
2017: PloS One
https://www.readbyqxmd.com/read/28017229/vestibular-evoked-myogenic-potentials-and-mri-in-early-multiple-sclerosis-validation-of-the-vemp-score
#6
Luka Crnošija, Magdalena Krbot Skorić, Tereza Gabelić, Ivan Adamec, Mario Habek
BACKGROUND: To validate the VEMP score as a measure of brainstem dysfunction in patients with the first symptom of multiple sclerosis (MS) (clinically isolated syndrome (CIS)) and to investigate the correlation between VEMP and brainstem MRI results. METHODS: 121 consecutive CIS patients were enrolled and brainstem functional system score (BSFS) was determined. Ocular VEMP (oVEMP) and cervical VEMP (cVEMP) were analyzed for latencies, conduction block and amplitude asymmetry ratio and the VEMP score was calculated...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28010157/evaluation-of-immune-response-in-challenged-chickens-vaccinated-with-newcastle-disease-vaccine-using-gums-from-cedrela-odorata-and-khaya-senegalensis-as-delivery-agents
#7
V O Oyebanji, B O Emikpe, Omolade A Oladele, M O Odeniyi, A Salami, O I Osowole, O B Kasali, O A Akinboade
Immune response of challenged chickens following previous vaccinations with Newcastle disease vaccine using gums from Cedrela odorata and Khaya senegalensis as delivery agent were evaluated. Two hundred and fifty-two (252) one-day old chickens were divided into vaccine-gum oral (GVOR), vaccine-gum ocular (GVOC), vaccine oral (VOR), vaccine ocular (VOC), gum oral (GOR), gum ocular (GOC), No-gum-no-vaccine/challenged (NGNV/C) & No-gum-no-vaccine/unchallenged (NGNV/U) groups. They were vaccinated at days 21 & 42 and challenged at day 84...
December 23, 2016: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28002108/corneal-biomechanical-properties-after-penetrating-keratoplasty-or-deep-anterior-lamellar-keratoplasty-using-the-ocular-response-analyzer-a-meta-analysis
#8
Min-Shan Jiang, Jing-Yuan Zhu, Xue Li, Nan-Nan Zhang, Xue-Dian Zhang
PURPOSE: To evaluate the corneal biomechanical properties of patients who have undergone penetrating keratoplasty (PK) or deep anterior lamellar keratoplasty (DALK) using the ocular response analyzer. METHODS: Stata 13.0 SE was used for this meta-analysis. Studies in the literature that focused on corneal hysteresis (CH) or corneal resistance factor (CRF) after PK or DALK were retrieved by searching PubMed, Embase, Ovid, and Cochrane databases. We present the results as weighted mean difference (WMD) with a corresponding 95% confidence interval (CI)...
December 20, 2016: Cornea
https://www.readbyqxmd.com/read/27990593/is-the-unaffected-eye-really-unaffected-color-doppler-ultrasound-findings-in-unilaterally-active-central-serous-chorioretinopathy
#9
Iclal Erdem Toslak, Muhammet Kazim Erol, Devrim Toslak, Bulent Cekic, Mehtap Barc Ergun, Jennifer E Lim-Dunham
PURPOSE: To evaluate ocular hemodynamic changes using color Doppler ultrasonography imaging (CDI) with an emphasis on unaffected eyes of patients with central serous chorioretinopathy (CSC). METHODS: Twenty-seven patients with active CSC and 25 controls were analyzed using spectral domain-optical coherence tomography (SD-OCT) and CDI for choroidal imaging and evaluation of retrobulbar vessels, respectively. RESULTS: Resistive index (RI), pulsatility index (PI), and peak systolic velocity (PSV) of the ophthalmic artery (OA) and PSV, end-diastolic velocity (EDV), and mean velocity (Vmean) of the central retinal artery (CRA) in the patient group were less than those in the control group...
December 18, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27977478/corneal-biomechanical-changes-after-trabeculectomy-and-the-impact-on-intraocular-pressure-measurement
#10
Karin R Pillunat, Eberhard Spoerl, Naim Terai, Lutz E Pillunat
PURPOSE: To evaluate corneal biomechanical changes induced by trabeculectomy and their impact on intraocular pressure (IOP) measurements. MATERIALS AND METHODS: In total, 35 eyes of 35 consecutive glaucoma patients undergoing first-time trabeculectomy with mitomycin C were enrolled in this prospective interventional case series. Goldmann applanation tonometry (GAT) IOP, central corneal thickness, axial length, and Ocular Response Analyzer measurements [Goldmann-correlated IOP (IOPg), corneal-compensated IOP (IOPcc), corneal hysteresis (CH), and corneal resistance factor (CRF)] were assessed before and 6 months after uncomplicated trabeculectomy...
December 13, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27956045/biomechanical-properties-of-early-keratoconus-suppressed-deformation-signal-wave
#11
Hassan Hashemi, Asghar Beiranvand, Abbasali Yekta, Amir Asharlous, Mehdi Khabazkhoob
PURPOSE: To examine the diagnostic validity of different corneal biomechanical parameters for the detection of early keratoconus METHODS: Sixty-one eyes with a diagnosis of early keratoconus and 61 topographically normal eyes were enrolled in the study. All participants underwent testing with the Ocular Response Analyzer (ORA), and 40 indices from each cornea were included in the analysis. RESULTS: The mean (standard deviation: SD) of keratometry and central corneal thickness in keratoconic corneas was 46...
December 9, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27930778/melanopsin-containing-or-non-melanopsin-containing-retinal-ganglion-cells-response-to-acute-ocular-hypertension-with-or-without-brain-derived-neurotrophic-factor-neuroprotection
#12
Giuseppe Rovere, Francisco M Nadal-Nicolás, Jiawei Wang, Jose M Bernal-Garro, Nuria García-Carrillo, Maria Paz Villegas-Pérez, Marta Agudo-Barriuso, Manuel Vidal-Sanz
Purpose: To analyze the responses of different retinal ganglion cell (RGC) types to acute ocular hypertension (AOH) and intravitreal administration of brain-derived neurotrophic factor (BDNF). Methods: In adult albino rats, the anterior chamber of the left eye was cannulated with a needle connected to a saline container elevated 1½ meters above the eye for 75 minutes. Rats received 12 hours before a 5 μl intravitreal injection containing 5 μg BDNF in 1% albumin PBS or vehicle and were analyzed 3, 7, 14, or 45 days later...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27930443/otolith-dysfunction-in-persons-with-both-diabetes-and-benign-paroxysmal-positional-vertigo
#13
Linda J DʼSilva, Hinrich Staecker, James Lin, Christy Maddux, John Ferraro, Hongying Dai, Patricia M Kluding
OBJECTIVE: Vestibular dysfunction is a well-recognized complication of type 2 diabetes (DM) that may contribute to increased fall risk. The prevalence of benign paroxysmal positional vertigo (BPPV) is higher in people with DM. The impact of DM on the otolith organs of the vestibular system in people with BPPV is unknown. The purpose of this study was to analyze otolith function using vestibular-evoked myogenic potential (VEMP) tests in people with DM and concurrent BPPV (BPPV + DM), and to examine the relationships between VEMP variables and diabetes-related variables...
December 7, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27893063/assessment-of-the-psychometric-properties-of-a-questionnaire-assessing-patient-reported-outcomes-with-laser-in-situ-keratomileusis-prowl
#14
Ron D Hays, Michelle E Tarver, Karen L Spritzer, Steve Reise, Gene Hilmantel, Elizabeth M Hofmeister, Keri Hammel, Jeanine May, Frederick Ferris, Malvina Eydelman
Importance: Patient-reported outcome (PRO) measures for laser in situ keratomileusis (LASIK) are needed. Objective: To develop PRO measures to assess satisfaction, eye-related symptoms, and their effect on functioning and well-being following LASIK based on patient and expert input. Design, Setting, and Participants: The Patient-Reported Outcomes With LASIK (PROWL) studies were prospective observational studies of patients undergoing LASIK surgery for myopia, hyperopia, or astigmatism...
January 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27873338/high-myopes-have-lower-normalised-corneal-tangent-moduli-less-stiff-corneas-than-low-myopes
#15
Ying Hon, Guo-Zhen Chen, Shu-Hao Lu, David C C Lam, Andrew K C Lam
PURPOSE: To compare corneal tangent moduli between low and high myopes. METHODS: Corneal hysteresis (CH) and corneal resistance factor (CRF) of 32 low and 32 high myopes were obtained using an Ocular Response Analyzer, followed by a corneal indentation device that measured corneal stiffness. Corneal topography, pachymetry, Goldmann applanation tonometry intraocular pressure (GAT-IOP), and corneal compensated intraocular pressure (IOPcc) were also obtained. Corneal tangent modulus was calculated on the basis of corneal stiffness, central corneal thickness and corneal radius...
January 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/27863469/changes-in-intraocular-pressure-values-measured-with-noncontact-tonometer-nct-ocular-response-analyzer-ora-and-corvis-scheimpflug-technology-tonometer-cst-in-the-early-phase-after-small-incision-lenticule-extraction-smile
#16
Yang Shen, Xiangjian Su, Xiu Liu, Huamao Miao, Xuejun Fang, Xingtao Zhou
BACKGROUND: Corneal biomechanical properties are always compromised after corneal refractive surgeries thus leading to underestimated intraocular pressure (IOP) that complicates the management of IOP. We investigated the changes in postoperative baseline of IOP values measured with noncontact tonometer (NCT), ocular response analyzer (ORA) and corvis scheimpflug technology (CST) in the early phase after small incision lenticule extraction (SMILE). METHODS: Twenty-two eyes (-6...
November 18, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27847644/relationship-among-corneal-biomechanics-anterior-segment-parameters-and-geometric-corneal-parameters
#17
Sadık Görkem Çevik, Sertaç Argun Kıvanç, Berna Akova-Budak, Mediha Tok-Çevik
Purpose. To investigate the relationship between corneal biomechanical parameters, anterior segment parameters, and geometric corneal parameters in a healthy Caucasian group. Methods. This retrospective study included the healthy eyes with best corrected visual acuity of at least 20/40 of 122 Caucasian subjects. The anterior segment parameters and geometric corneal parameters such as corneal volume, central corneal thickness, horizontal and vertical corneal radii, anterior and posterior steep, and flat keratometric values were measured with a Scheimpflug camera...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27830201/corneal-biomechanics-after-small-incision-lenticule-extraction-versus-q-value-guided-femtosecond-laser-assisted-in-situ-keratomileusis
#18
Jun Zhang, Li Zheng, Xia Zhao, Yang Xu, Shu Chen
PURPOSE: The aim of this study was to compare the changes in corneal biomechanical properties following small-incision lenticule extraction (SMILE) versus Q-value-guided femtosecond laser-assisted in situ keratomileusis (Q-FS-LASIK). METHODS: In this prospective comparative study, patients with a sphere plus cylinder measurement of less than -10.00 D and cylinder measurement of less than -5.00 D were included in the study. A total of 160 patients (160 eyes) with myopia and myopic astigmatism were divided into the two groups, with 80 patients (80 eyes) allocated to SMILE and 80 patients (80 eyes) allocated to Q-FS-LASIK...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27829990/analysis-of-the-effects-of-preservative-free-tafluprost-on-the-tear-proteome
#19
Sebastian Funke, Sabine Beck, Katrin Lorenz, Marion Kotterer, Dominik Wolters, Natarajan Perumal, Norbert Pfeiffer, Franz H Grus
The purpose of the present study was to assess the ocular surface health status in primary open angle glaucoma (POAG) patients switching from topical application of preserved latanoprost (LT) to preservative-free tafluprost (PFT) by tear proteomic monitoring. Tear fluid of POAG patients showing dry eye symptoms, using LT and switching to PFT as well as tear fluid of healthy controls has been examined. Tear proteome dynamics was monitored over 24 weeks in a first mass spectrometric explorative analysis in a small POAG patient cohort (N = 3)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27829784/irbp-deficiency-permits-precocious-ocular-development-and-myopia
#20
Shanu Markand, Natecia L Baskin, Ranjay Chakraborty, Erica Landis, Sara A Wetzstein, Kevin J Donaldson, Priyanka Priyadarshani, Shannon E Alderson, Curran S Sidhu, Jeffrey H Boatright, P Michael Iuvone, Machelle T Pardue, John M Nickerson
PURPOSE: Interphotoreceptor retinoid-binding protein (IRBP) is abundant in the subretinal space and binds retinoids and lipophilic molecules. The expression of IRBP begins precociously early in mouse eye development. IRBP-deficient (KO) mice show less cell death in the inner retinal layers of the retina before eyelid opening compared to wild-type C57BL/6J (WT) controls and eventually develop profound myopia. Thus, IRBP may play a role in eye development before visually-driven phenomena...
2016: Molecular Vision
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