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ocular response analyzer

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https://www.readbyqxmd.com/read/29677354/retinoic-acid-maintains-function-of-neural-crest-derived-ocular-and-craniofacial-structures-in-adult-zebrafish
#1
Bahaar Chawla, William Swain, Antionette L Williams, Brenda L Bohnsack
Purpose: Retinoic acid (RA) is required for embryonic formation of the anterior segment of the eye and craniofacial structures. The present study further investigated the role of RA in maintaining the function of these neural crest-derived structures in adult zebrafish. Methods: Morphology and histology were analyzed by using live imaging, methylacrylate sections, and TUNEL assay. Functional analysis of vision and aqueous humor outflow were assayed with real-time imaging...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29675776/pluripotent-stem-cells-for-retinal-tissue-engineering-current-status-and-future-prospects
#2
REVIEW
Ratnesh Singh, Oscar Cuzzani, François Binette, Hal Sternberg, Michael D West, Igor O Nasonkin
The retina is a very fine and layered neural tissue, which vitally depends on the preservation of cells, structure, connectivity and vasculature to maintain vision. There is an urgent need to find technical and biological solutions to major challenges associated with functional replacement of retinal cells. The major unmet challenges include generating sufficient numbers of specific cell types, achieving functional integration of transplanted cells, especially photoreceptors, and surgical delivery of retinal cells or tissue without triggering immune responses, inflammation and/or remodeling...
April 19, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29643950/higher-intraocular-pressure-levels-associated-with-lower-hysteresis-in-type-2-diabetes
#3
Sinan Bekmez, Tolga Kocaturk
Aim: To investigate the differences of corneal biomechanic characteristics using Ocular Response Analyzer (ORA, Reichert; USA) on type 2 diabetics and healthy subjects. Methods: One hundred eyes of 100 subjects (between the ages of 17-91) who applied to Adnan Menderes University's Ophthalmology Clinic between January-March 2015 were included in this study, 50 diabetics (Group 1) and 50 healthy controls (Group 2). The eyes included in the study were randomly chosen...
2018: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29619111/intratympanic-gentamicin-for-intractable-m%C3%A3-ni%C3%A3-re-s-disease-a-review-and-analysis-of-audiovestibular-impact
#4
Sertaç Yetişer
Introduction  Intratympanic gentamicin regulates the symptoms in most patients with incapacitating Ménière's disease. The treatment protocols have changed over the years from medical labyrinthectomy to preservation of vestibular function. Objectives  This study aims to review the audiovestibular response related to the effect of the drug in controlling vertigo. Data Synthesis  Articles were identified by means of a search in the PubMed database using the key words Meniere and intratympanic or transtympanic gentamicin ...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29611480/systematic-development-and-optimization-of-in-situ-gelling-system-for-moxifloxacin-ocular-nanosuspension-using-high-pressure-homogenization-with-improved-encapsulation-efficiency
#5
Lalit Kumar Khurana, Romi Singh, Harinder Singh, Manju Sharma
BACKGROUND: The objective of this study was to apply Quality by Design (QbD) principles on process parameter optimization for development of hybrid delivery system (combination of (SLNs) and In-situ gelling system) for hydrophilic drug Moxifloxacin Hydrochloride (MOX) to achieve its controlled delivery, which otherwise may not be possible through single type of technology. METHODS: Risk assessment studies were carried out to identify probable risks influencing CQAs on the product...
April 2, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29606853/the-role-of-corneal-hysteresis-during-the-evaluation-of-patients-with-possible-normal-tension-glaucoma
#6
Ming Chen, Laura Kueny, Arthur L Schwartz
Purpose: There are multiple reports of the role of corneal hysteresis (CH) as an independent risk factor for the diagnosis and risk of progression of normal-tension glaucoma (NTG). Our study measured CH with the Ocular Response Analyzer (ORA) in patients with intraocular pressure (IOP) <21 mmHg to investigate if a low CH would identify NTG in this Asian-based practice. Methods: This was a prospective cross-sectional study of patients who underwent routine eye examination during 2016 in a private practice in Honolulu, Hawaii, where most patients are Asian...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29588569/in-vivo-assessment-of-changes-in-corneal-hysteresis-and-lamina-cribrosa-position-during-acute-intraocular-pressure-elevation-in-eyes-with-markedly-asymmetrical-glaucoma
#7
Corrado Gizzi, Mauro Cellini, Emilio C Campos
Purpose: To investigate the biomechanical response of the cornea, lamina cribrosa (LC), and prelaminar tissue (PT) to an acute intraocular pressure (IOP) increase in patients with markedly asymmetrical glaucoma and in healthy controls. Patients and methods: A total of 24 eyes of 12 patients with markedly asymmetrical primary open-angle glaucoma (POAG) and 12 eyes of 12 healthy patients were examined with spectral-domain optical coherence tomography (SD-OCT) and ocular response analyzer (ORA) at baseline and during acute IOP elevation by means of an ophthalmodynamometer...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29578513/puncture-induced-iris-neovascularization-as-a-mouse-model-of-rubeosis-iridis
#8
Filippo Locri, Monica Aronsson, Ophélie Beaujean, Anders Kvanta, Helder André
We describe a model of puncture-induced iris neovascularization as a general model for noninvasive evaluation of angiogenesis. The model is also relevant for targeting neovascular glaucoma, a sight-threatening complication of diabetic retinopathy. This method is based on the induction of iris vascular response by a series of self-sealing uveal punctures on BALB/c mice and takes advantage of the postpartum maturation of mouse ocular vasculature. Mouse pups undergo uveal punctures from postnatal day 12.5, when the pups naturally open their eyes, until postnatal day 24...
March 8, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29564407/corneal-hysteresis-and-corneal-resistance-factor-in-pellucid-marginal-degeneration
#9
Mohamad Reza Sedaghat, Hadi Ostadi-Moghadam, Mahmoud Jabbarvand, Farshad Askarizadeh, Hamed Momeni-Moghaddam, Foroozan Narooie-Noori
Purpose: To evaluate and compare corneal hysteresis (CH) and corneal resistance factor (CRF) in pellucid marginal degeneration (PMD), keratoconus (KCN), and normal eyes using the Ocular Response Analyzer (ORA). Methods: In this retrospective study, corneal biomechanical parameters were measured in patients with PMD ( n  = 102) and KCN ( n  = 202) and normal subjects ( n  = 208) using the ORA. Data, including full patient history as well as the results of refraction, slit-lamp biomicroscopy, Pentacam HR (Oculus), and ORA (Reichert; Buffalo, New York, USA), were collected from medical records...
March 2018: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/29558197/asymmetry-between-left-and-right-eyes-in-keratoconus-patients-increases-with-the-severity-of-the-worse-eye
#10
T Eppig, C Spira-Eppig, S Goebels, B Seitz, M El-Husseiny, M Lenhart, K Papavasileiou, N Szentmáry, A Langenbucher
PURPOSE: To evaluate whether the inter-eye asymmetry of keratoconus (KC) patients is different from a healthy control group and to investigate how asymmetry changes with increasing severity of the disease. METHODS: In this retrospective study, we included both eyes of 350 patients with KC (age 35 ± 13 years) and 68 candidates planned for refractive surgery (control group, age 37 ± 11 years). Inclusion criteria for the KC group were keratoconus in at least one eye with Pentacam Topographical Keratoconus Classification (TKC) of at least 0...
March 20, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29557828/the-influence-of-corneal-biomechanical-properties-on-intraocular-pressure-measurements-using-a-rebound-self-tonometer
#11
Lyndsay Brown, William Foulsham, Savva Pronin, Andrew J Tatham
PURPOSE: To examine the effect of corneal biomechanical properties on intraocular pressure (IOP) measurements obtained using a rebound self-tonometer (Icare HOME) compared to Goldmann applanation tonometry (GAT). METHODS: An observational study of 100 patients with glaucoma or ocular hypertension. All had a comprehensive ophthalmic examination and standard automated perimetry. IOP was assessed by GAT, Icare HOME and Ocular Response Analyzer (ORA), which was also used to assess corneal hysteresis (CH) and corneal resistance factor (CRF)...
March 19, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29535566/functional-analysis-and-immunochemical-analyses-of-ca-2-homeostasis-related-proteins-expression-of-glaucoma-induced-retinal-degeneration-in-rats
#12
Ji-Yeon Lee, Su-Ja Oh
The retinal degeneration resulting from elevated intraocular pressure was evaluated through functional and morphological analyses, for better understanding of the pathophysiology of glaucoma. Ocular hypertension was induced via unilateral episcleral venous cauterization in rats. Experimental time was set at 1 and 3 days, and 1, 2, 4, and 8 weeks post-operation. Retinal function was analyzed using electroretinography. For morphological analysis, retinal tissues were processed for immunochemistry by using antibodies against the calcium-sensing receptor and calcium-binding proteins...
February 2018: Experimental Neurobiology
https://www.readbyqxmd.com/read/29534581/electrochemotherapy-with-bleomycin-and-cisplatin-enhances-cytotoxicity-in-primary-and-metastatic-uveal-melanoma-cell-lines-in-vitro
#13
M Fiorentzis, H Kalirai, P Katopodis, B Seitz, A Viestenz, S E Coupland
Electrochemotherapy (ECT) enhances responsiveness to cytotoxic drugs in numerous cell lines in vitro. Clinically ECT is widely applied for skin tumor ablation and has shown efficacy in treating non-resectable colorectal liver metastases. There is limited experience of ECT for ocular tumor therapy. We investigated the cytotoxic effect of bleomycin and cisplatin in combination with electroporation on chemoresistant human uveal melanoma (UM) cell lines in vitro. Four UM cell lines (Mel 270, 92-1, OMM-1, OMM-2...
2018: Neoplasma
https://www.readbyqxmd.com/read/29518571/functional-correlate-and-delineated-connectivity-pattern-of-human-motion-aftereffect-responses-substantiate-a-subjacent-visual-vestibular-interaction
#14
Ria Maxine Rühl, Thomas Bauermann, Marianne Dieterich, Peter Zu Eulenburg
The visual motion aftereffect (MAE) is the most prominent aftereffect in the visual system. Regarding its function, Psychophysical studies suggest its function to be a form of sensory error correction, possibly also triggered by incongruent visual-vestibular stimulation. Several observational imaging experiments have deducted an essential role for region MT+ in the perception of a visual MAE but not provided conclusive evidence. Potential confounders with the MAE such as ocular motor performance, attention, and vection sensations have also never been controlled for...
March 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29516062/qualitative-analysis-of-the-dix-hallpike-maneuver-in-multi-canal-bppv-using-a-biomechanical-model-introduction-of-an-expanded-dix-hallpike-maneuver-for-enhanced-diagnosis-of-multi-canal-bppv
#15
Henri Traboulsi, Michael Teixido
Introduction/Objective: Multiple canal BPPV can be a diagnostic challenge to the clinician. This is due in part to the complex anatomy of the labyrinth but also to complex and often simultaneous ocular responses that result from stimulation of multiple canals during traditional diagnostic testing. Our objective was to analyze the Dix-Hallpike maneuver used in the diagnosis of BPPV to look for patterns of simultaneous canal response and to develop a diagnostic maneuver that will allow separation of canal responses in multiple canal BPPV...
September 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29514380/-evaluation-of-changes-in-corneal-biomechanics-in-patients-with-systemic-sclerosis
#16
Nicole Zimmermann, Svea Brandt, Jeanette Brünner, Carl Erb
INTRODUCTION: Our study compares the biomechanical properties of the cornea in patients with long-term pre-existing (for at least 10 years) systemic sclerosis (SSc) with those of healthy suspects. MATERIAL/METHODS: The examination was performed in 14 systemic SSc patients and 38 healthy volunteers. Non-invasive assessment of corneal biomechanical parameters, including central corneal thickness (CCT), corneal hysteresis (CH) and corneal resistance factor (CRF), was performed in one randomised study eye in accordance with a standardised protocol...
March 7, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29500424/systemic-inflammation-induced-by-lipopolysaccharide-aggravates-inherited-retinal-dystrophy
#17
Agustina Noailles, Victoria Maneu, Laura Campello, Pedro Lax, Nicolás Cuenca
Retinal neurodegenerative diseases involve a scenario of inflammation and cell death that leads to morphological alterations and visual impairment. Non-ocular inflammatory processes could affect neurodegenerative retinal disorders and their progression, at least in part by activating microglial cells and releasing pro-inflammatory cytokines. Our purpose was to study the consequences of a systemic inflammatory process in the progression of retinal degeneration in P23H rats, a retinitis pigmentosa (RP) model...
March 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29492541/volumetric-ophthalmic-ultrasound-for-inflight-monitoring-of-visual-impairment-and-intracranial-pressure
#18
Aaron Dentinger, Michael MacDonald, Douglas Ebert, Kathleen Garcia, Ashot Sargsyan
OBJECTIVE:  The objective is enhanced ophthalmic ultrasound imaging to monitor ocular structure and intracranial dynamics changes related to visual impairment and intracranial pressure (ICP) induced by microgravity. The goals are to improve the ease of use and reduce operator variability by automatically rendering improved views of the anatomy and deriving new metrics of the morphology and dynamics. MATERIALS AND METHODS:  A prototype three-dimensional (3-D) probe was integrated onto a portable ultrasound scanner...
2018: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/29483893/mathematical-methods-for-measuring-the-visually-enhanced-vestibulo-ocular-reflex-and-preliminary-results-from-healthy-subjects-and-patient-groups
#19
Jorge Rey-Martinez, Angel Batuecas-Caletrio, Eusebi Matiño, Gabriel Trinidad-Ruiz, Xabier Altuna, Nicolas Perez-Fernandez
Background: Visually enhanced vestibulo-ocular reflex (VVOR) is a well-known bedside clinical test to evaluate visuo-vestibular interaction, with clinical applications in patients with neurological and vestibular dysfunctions. Owing to recently developed diagnostic technologies, the possibility to perform an easy and objective measurement of the VVOR has increased, but there is a lack of computational methods designed to obtain an objective VVOR measurement. Objectives: To develop a method for the assessment of the VVOR to obtain a gain value that compares head and eye velocities and to test this method in patients and healthy subjects...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29460822/optimum-number-of-sweeps-in-clinical-ovemp-recording-how-many-sweeps-are-necessary
#20
Arthur Mallinson, Anouk Kuijpers, Neil Longridge
OBJECTIVE: Ocular vestibular-evoked myogenic potentials (OVEMPs) in our hands provide us with reproducible and consistent results; however, it has been shown that the OVEMP amplitude decreases with increased stimulus duration. The exact number of stimuli for OVEMP recording is not consistent among the published papers describing this test. We aimed to determine the number of stimuli needed to produce a satisfactory OVEMP response and the consequences of a more prolonged stimulation to the OVEMP response...
February 20, 2018: Journal of International Advanced Otology
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