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ocular response analyzer

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https://www.readbyqxmd.com/read/28782513/the-effect-of-age-on-the-response-of-retinal-capillary-filling-to-changes-in-intraocular-pressure-measured-by-optical-coherence-tomography-angiography
#1
Xiaoyun Jiang, Elaine Johnson, William Cepurna, Diana Lozano, Shaojie Men, Ruikang K Wang, John Morrison
PURPOSE: To compare the effect of elevated intraocular pressure (IOP) on retinal capillary filling in elderly vs adult rats using optical coherence tomography angiography (OCTA). METHODS: The IOP of elderly (24-month-old, N=12) and adult (6-8month-old, N=10) Brown Norway rats was elevated in 10mmHg increments from 10 to 100mmHg. At each IOP level, 3D OCT data were captured using an optical microangiography (OMAG) scanning protocol and then post-processed to obtain both structural and vascular images...
August 3, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28763557/c2orf71-mutations-as-a-frequent-cause-of-autosomal-recessive-retinitis-pigmentosa-clinical-analysis-and-presentation-of-8-novel-mutations
#2
MULTICENTER STUDY
Christina Gerth-Kahlert, Amit Tiwari, James V M Hanson, Vaishnavi Batmanabane, Elias Traboulsi, Mark E Pennesi, Abdullah A Al-Qahtani, Byron L Lam, John Heckenlively, Sandrine A Zweifel, Ajoy Vincent, Fabienne Fierz, Daniel Barthelmes, Kari Branham, Naheed Khan, Angela Bahr, Luzy Baehr, István Magyar, Samuel Koller, Silvia Azzarello-Burri, Dunja Niedrist, Elise Heon, Wolfgang Berger
Purpose: To define the phenotype of C2orf71 associated retinopathy and to present novel mutations in this gene. Methods: A retrospective multicenter study of patients with retinopathy and identified C2orf71 mutations was performed. Ocular function (visual acuity, visual fields, electroretinogram [ERG] responses); retinal morphology (fundus, optical coherence tomography); and underlying mutations were analyzed. Results: Thirteen patients from 11 families, who were aged 7 to 63 years (mean: 32...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28761329/comparison-of-different-intraocular-pressure-measurement-techniques-in-normal-eyes-and-post-small-incision-lenticule-extraction
#3
Mohamed Hosny, Fayrouz Aboalazayem, Hoda El Shiwy, Mohsen Salem
PURPOSE: The purpose of the study was to determine the accuracy of intraocular pressure (IOP) measurement after small incision lenticule extraction (SMILE) using Goldmann applanation tonometry (GAT) and ocular response analyzer (ORA). METHODS: This is a prospective clinical study that was conducted on 30 eyes in the interval between February 2016 and September 2016. The age of the patients ranged between 19 and 40 years. The patients underwent SMILE surgery using the femto laser...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28756375/anterior-posterior-and-biomechanical-parameters-of-cornea-during-pregnancy-in-healthy-eyes-a-cohort-study
#4
Mohammad Naderan, Ali Jahanrad
BACKGROUND: To investigate the effect of pregnancy on anterior, posterior and biomechanical corneal parameters of healthy eyes. METHOD: In this prospective cohort study, 70 pregnant participants with clinically healthy eyes underwent corneal topographic imaging evaluation by Pentacam and biomechanical assessment by Ocular Response Analyzer (ORA) before pregnancy, at the third trimester of pregnancy (34th week of pregnancy) and 12 months after delivery. The same number of age-matched non-pregnant females was evaluated at the corresponding appointments as the control group...
July 29, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28745654/-analysis-of-corneal-biomechanical-changes-after-femtosecond-laser-assisted-laser-in-situ-keratomileusis-in-children-with-hyperopic-anisometropia
#5
I L Kulikova, O V Shlenskaya, N V Chapurin
AIM: to analyze corneal hysteresis (CH) and corneal resistance factor (RF) readings obtained with the Reichert Ocular Response Analyzer (ORA) before and after hyperopic femtolaser-assisted laser in situ keratomileusis (FS-LASIK) in children with anisometropia as well as to establish factors that may cause changes in these parameters. MATERIAL AND METHODS: CH and RF were evaluated before and 1.5 years after FS-LASIK performed on amblyopic eyes of 28 patients aged 6-14 years...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28706439/genome-wide-retinal-transcriptome-analysis-of-endotoxin-induced-uveitis-in-mice-with-next-generation-sequencing
#6
Yiguo Qiu, Peng Yu, Ru Lin, Xinyu Fu, Bingtao Hao, Bo Lei
PURPOSE: Endotoxin-induced uveitis (EIU) is a well-established mouse model for studying human acute inflammatory uveitis. The purpose of this study is to investigate the genome-wide retinal transcriptome profile of EIU. METHODS: The anterior segment of the mice was examined with a slit-lamp, and clinical scores were evaluated simultaneously. The histological changes in the posterior segment of the eyes were evaluated with hematoxylin and eosin (H&E) staining. A high throughput RNA sequencing (RNA-seq) strategy using the Illumina Hiseq 2500 platform was applied to characterize the retinal transcriptome profile from lipopolysaccharide (LPS)-treated and untreated mice...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28669846/meibomian-glands-meibum-and-meibogenesis
#7
REVIEW
Igor A Butovich
Meibum is a lipid-rich secretion that is produced by fully differentiated meibocytes in the holocrine Meibomian glands (MG) of humans and most mammals. The secretion is a part of a defense mechanism that protects the ocular surface from hazardous environmental factors, and from desiccation. Meibomian lipids that have been identified in meibum are very diverse and unique in nature. The lipid composition of meibum is different from virtually any other lipid pool found in the human body. In fact, meibum is quite different from sebum, which is the closest secretion that is produced by anatomically, physiologically, and biochemically related sebaceous glands...
June 29, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28664236/alterations-in-biomechanical-properties-of-the-cornea-among-patients-with-polycystic-kidney-disease
#8
Kubra Serefoglu Cabuk, Bennur Esen, Kursat Atalay, Ahmet Kirgiz, Rukiye Aydin
PURPOSE: The aim of this study was to evaluate the corneal biomechanical features in polycystic kidney disease (PKD) patients and compare them with the healthy individuals. METHODS: Totally 81 patients with a mean age of 48.46 ± 14.51 years and 60 control cases with a mean age of 44.68 ± 12.69 years were included in the study. All of the subjects underwent a complete ophthalmological examination, including visual acuity testing, biomicroscopic anterior and posterior segment examinations...
June 29, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#9
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28634727/safety-and-efficacy-of-chemosaturation-in-patients-with-primary-and-secondary-liver-tumors
#10
Martha M Kirstein, Steffen Marquardt, Nils Jedicke, Silke Marhenke, Wolfgang Koppert, Michael P Manns, Frank Wacker, Arndt Vogel
BACKGROUND: Chemosaturation with percutaneous hepatic perfusion (CS-PHP; hepatic CHEMOSAT(®) delivery system; Delcath Systems Inc, USA) is a novel medical device, which delivers high doses of melphalan directly to the liver in patients with primary and secondary liver tumors while limiting systemic toxicity through hemofiltration of the hepatic venous blood. The aim of this study was to analyze the safety and efficacy of the second-generation CS-PHP after 54 treatments at Hannover Medical School, Germany...
June 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28626817/comparison-of-current-tonometry-techniques-in-measurement-of-intraocular-pressure
#11
Behrooz Kouchaki, Hassan Hashemi, Abbasali Yekta, Mehdi Khabazkhoob
PURPOSE: To compare four tonometry techniques: Goldmann applanation tonometer (GAT), Dynamic contour tonometer (DCT), Non-contact tonometer (NCT), and Ocular Response Analyzer (ORA) in the measurement of intraocular pressure (IOP) and the impact of some corneal biomechanical factors on their performance. METHODS: In this cross-sectional study, volunteers with normal ophthalmic examination and no history of eye surgery (except for uncomplicated cataract surgery) or trauma were selected...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28626602/association-between-corneal-biomechanical-properties-with-ocular-response-analyzer-and-also-corvisst-tonometry-and-glaucomatous-visual-field-severity
#12
Kazunori Hirasawa, Masato Matsuura, Hiroshi Murata, Shunsuke Nakakura, Yoshitaka Nakao, Yoshiaki Kiuchi, Ryo Asaoka
PURPOSE: To investigate the association between corneal biomechanical properties measured with the Ocular Response Analyzer (ORA) and also CorvisST (CST) tonometry, and glaucomatous visual field (VF) severity. METHODS: One hundred forty-six eyes of 91 patients with primary open-angle glaucoma who performed Humphrey Field Analyzer 30-2 or 24-2 SITA-Standard, ORA, and CST within 180 days were included in this multicentral, observational cross-sectional study. The association between ORA parameters (corneal hysteresis [CH] and corneal resistant factor [CRF]), CST parameters (A1 and A2 time, A1 and A2 length, A1 and A2 velocity, A1 and A2 deformation amplitude, highest deformation amplitude, highest concavity time, peak distance, and radius), and other basic parameters (age, intraocular pressure with Goldmann applanation tonometry, central corneal thickness, and axial length) against mean total deviation (mTD) were analyzed using a linear mixed-model and model selection with corrected Akaike Information Criterion (AICc)...
June 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28620707/treatment-of-patients-with-neurotrophic-keratitis-stages-2-and-3-with-plasma-rich-in-growth-factors-prgf-endoret-eye-drops
#13
Ronald Mauricio Sanchez-Avila, Jesus Merayo-Lloves, Ana Cristina Riestra, Luis Fernandez-Vega Cueto, Eduardo Anitua, Leire Begoña, Francisco Muruzabal, Gorka Orive
PURPOSE: To provide preliminary data about efficacy and safety of plasma rich in growth factors (PRGF) eye-drops in neurotrophic keratitis (NK) and to analyze the possible influence of certain variables on treatment outcomes. METHODS: This retrospective study included patients with stages 2-3 of NK treated with PRGF eye-drops. Primary endpoint was the resolution time of corneal ulcer defect. Outcome measures including percentage of ulcer closure at 4 weeks, Ocular Surface Disease Index (OSDI), Best-Corrected Visual Acuity (BCVA) and Visual Analogue Scale (VAS) were also evaluated before and after treatment with PRGF...
June 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28617729/demographic-characteristics-and-prescribing-patterns-of-scleral-lens-fitters-the-scope-study
#14
Cherie B Nau, Jennifer Harthan, Ellen Shorter, Joseph Barr, Amy Nau, Nicolette T Chimato, David O Hodge, Muriel M Schornack
OBJECTIVES: This study reports demographic characteristics of scleral lens providers and indications for scleral lens prescription as assessed by a worldwide online survey. METHODS: The Scleral Lenses in Current Ophthalmic Practice: an Evaluation (SCOPE) study group designed the online survey regarding current scleral lens prescription and management practices. The Mayo Clinic Survey Research Center administered the survey, which was open from January 15 to March 31, 2015...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28609333/feasibility-of-the-digital-retinography-system-camera-in-the-pediatric-emergency-department
#15
Yaron Ivan, Sriram Ramgopal, Margarita Cardenas-Villa, Daniel G Winger, Li Wang, Melissa A Vitale, Richard A Saladino
PURPOSE: Direct ophthalmoscopy may be difficult without pupillary dilation and patient cooperation. Nonmydriatic ocular fundus photography (NMOFP) has been shown to be easily and efficiently accomplished by medical providers and improve the detection of abnormalities in adult emergency department (ED) patients. Nonmydriatic ocular fundus photography for pediatric ED patients has not been studied. The purpose of this study was to assess the ease of use of the Digital Retinography System (DRS) camera for NMOFP in ED patients aged 5 to 12 years and the quality of retinal images obtained with the DRS...
June 12, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28582288/a-survey-of-ocular-prosthetics-rehabilitation-in-the-united-kingdom-part-2-anophthalmic-patients-satisfaction-and-acceptance
#16
Muhanad M Hatamleh, Ahmad A Alnazzawi, Mojgan Abbariki, Noor Alqudah, Anne E Cook
AIM: Ocular prostheses are integral for anophthalmic patients. Part 1 of this study reported that patients' aetiology, opinions, and attitudes significantly affected their prosthetic eyes experience. Part 2 investigates the patient satisfaction and acceptance in light of some of the aetiological demographics reported in Part 1. METHODOLOGY: One hundred sixty questionnaires were delivered to anophthalmic patients attending oculoplastic clinic. Etiological aspects presented in the questionnaire were disseminated in part 1...
June 2, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28567618/ganglion-cell-loss-in-early-glaucoma-as-assessed-by-photopic-negative-response-pattern-electroretinogram-and-spectral-domain-optical-coherence-tomography
#17
Barbara Cvenkel, Maja Sustar, Darko Perovšek
PURPOSE: To evaluate discrimination ability of pattern electroretinography (PERG) and photopic negative response (PhNR) between early glaucoma and healthy controls, and their relationship with structural measurements using spectral-domain optical coherence tomography (SD-OCT). METHODS: Cross-sectional study with 34 patients with ocular hypertension (n = 7), suspect glaucoma (n = 17), and early glaucoma (n = 10), plus 24 age-matched controls. The following parameters were analyzed: P50 and N95 amplitude of the PERG, PhNR amplitude and PhNR/b-wave ratio, peripapillary retinal and macular nerve fiber layer (NFL) thicknesses, and ganglion cell complex (GCC) thickness...
August 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28542454/controlled-delivery-of-tauroursodeoxycholic-acid-from-biodegradable-microspheres-slows-retinal-degeneration-and-vision-loss-in-p23h-rats
#18
Laura Fernández-Sánchez, Irene Bravo-Osuna, Pedro Lax, Alicia Arranz-Romera, Victoria Maneu, Sergio Esteban-Pérez, Isabel Pinilla, María Del Mar Puebla-González, Rocío Herrero-Vanrell, Nicolás Cuenca
Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the retina in a rat model of retinitis pigmentosa. PLGA microspheres (MSs) containing TUDCA were produced by the O/W emulsion-solvent evaporation technique...
2017: PloS One
https://www.readbyqxmd.com/read/28540493/investigation-of-corneal-biomechanics-at-moderate-to-high-refractive-errors
#19
Nehir İnceoğlu, Sinan Emre, Mahmut Oğuz Ulusoy
PURPOSE: Corneal hysteresis (CH) and corneal resistance factor (CRF) are corneal biomechanical parameters which were measured by ocular response analyzer (ORA). Aim of this study was to define the CH and CRF in high myopic and hyperopic patients and compare the results with emmetropic control group. METHODS: A total of 193 eyes of 100 healthy volunteers were included. Study groups were high myopic patients (n = 27) with spherical refractive errors (SRE) of greater than -5...
May 24, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28501948/corneal-tomography-and-biomechanics-in-primary-pterygium
#20
M Vanathi, Sahil Goel, Anita Ganger, Tushar Agarwal, T Dada, Sudarshan Khokhar
PURPOSE: To study the Scheimpflug's imaging and corneal biomechanics in primary pterygium. METHODS: A prospective observational study of 55 patients with unilateral primary nasal pterygium was done. The normal fellow eyes of patients with pterygium were taken as controls. Clinical parameters noted included visual acuity, values of corneal curvature by doing Scheimpflug imaging, wavefront aberrations in terms of higher and lower-order aberrations and corneal hysteresis (CH) as well as corneal resistance factor (CRF) values by using ocular response analyzer...
May 13, 2017: International Ophthalmology
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