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https://www.readbyqxmd.com/read/27882109/excisional-keratectomy-combined-with-focal-cryotherapy-and-amniotic-membrane-inlay-for-recalcitrant-filamentary-fungal-keratitis-a-retrospective-comparative-clinical-data-analysis
#1
Yingxin Chen, Minghong Gao, Joshua K Duncan, Di Ran, Denise J Roe, Michael W Belin, Mingwu Wang
The aim of the present study was to investigate the efficacy of a novel surgical intervention, excisional keratectomy combined with focal cryotherapy and amniotic membrane inlay (EKCAI), for the treatment of recalcitrant filamentary fungal keratitis. A retrospective analysis was performed of patients who underwent excisional keratectomy combined with conjunctival flap inlay (EKCFI), EKCAI or therapeutic penetrating keratoplasty (TPK) from January 2006 to January 2011. Recalcitrance was determined as being unresponsive to standard medical antifungal therapy for at ≥1 week...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27400080/enhanced-combined-tomography-and-biomechanics-data-for-distinguishing-forme-fruste-keratoconus
#2
Allan Luz, Bernardo Lopes, Katie M Hallahan, Bruno Valbon, Isaac Ramos, Fernando Faria-Correia, Paulo Schor, William J Dupps, Renato Ambrósio
PURPOSE: To evaluate the performance of the Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Depew, NY) variables and Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany) tomographic parameters in differentiating forme fruste keratoconus (FFKC) from normal corneas, and to assess a combined biomechanical and tomographic parameter to improve outcomes. METHODS: Seventy-six eyes of 76 normal patients and 21 eyes of 21 patients with FFKC were included in the study...
July 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27079610/application-of-corneal-tomography-before-keratorefractive-procedure-for-laser-vision-correction
#3
Allan Luz, Bernardo Lopes, Marcela Salomão, Renato Ambrósio
Ectasia after refractive surgery represents a major concern among refractive surgeons. Corneal abnormalities and preexisting corneal ectasia are the most important risk factors. Corneal topography and central corneal thickness are the factors traditionally screening for in refractive surgery candidates. Study of the anterior surface by Placido topography allows for identification of keratoconus before biomicroscopy. However, this is insufficient for the evaluation of pre-operative refractive surgery. There are cases of ectasia after laser in situ keratomilusis (LASIK) without identifiable risk factors such that there is a need to go beyond the corneal surface...
May 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/26949542/high-mmp-9-expression-may-contribute-to-retroprosthetic-membrane-formation-after-kpro-implantation-in-rabbit-corneal-alkali-burn-model
#4
Minghong Gao, Wei Sang, Fuying Liu, Hai Yu, Runhai Zhou, Michael Wellington Belin, Peter Zloty, Yingxin Chen
Purpose. To evaluate aqueous humor MMP-9 levels in alkali-burned rabbit cornea following KPr implantation and their roles in RPMs formation. Methods. Left eyes of 36 rabbits received a deep corneal alkali wound. 12 corneas were implanted with KPro and the other 24 control corneas were either penetrating keratoplasty or left without keratoplasty. Aqueous humor MMP-9 and TIMP-1 levels were determined and RPMs were obtained for histopathological and ultrastructural examination. Results. Alkali exposure induced significant increase in aqueous humor MMP-9 level and the data were further enhanced by KPro implantation...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/26789119/keratoconus-the-abcd-grading-system
#5
M W Belin, J K Duncan
PURPOSE: To propose a new keratoconus classification/staging system that utilises current tomographic data and better reflects the anatomical and functional changes seen in keratoconus. METHOD: A previously published normative database was reanalysed to generate both anterior and posterior average radii of curvature (ARC and PRC) taken from a 3.0 mm optical zone centred on the thinnest point of the cornea. Mean and standard deviations were recorded and anterior data were compared to the existing Amsler-Krumeich (AK) Classification...
June 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/26619387/suggested-guidelines-for-reporting-keratoprosthesis-results-consensus-opinion-of-the-cornea-society-asia-cornea-society-eucornea-pancornea-and-the-kpro-study-group
#6
Michael W Belin, Jose L Güell, Günther Grabner
PURPOSE: To propose a series of standardized guidelines for reporting keratoprosthesis (KPRO) results. METHODS: At the most recent KPRO Study Group Meeting (Barcelona, 2015), representatives of the 4 multinational corneal societies (Cornea Society, Asia Cornea Society, EuCornea, and PanCornea) and the KPRO Study Group agreed to propose consistent terminology for reporting KPRO results, especially in describing the length of follow-up and in the description of the KPRO itself...
February 2016: Cornea
https://www.readbyqxmd.com/read/26107012/international-values-of-central-pachymetry-in-normal-subjects-by-rotating-scheimpflug-camera
#7
Matthew T Feng, Joan T Kim, Renato Ambrósio, Michael W Belin, Satinder P S Grewal, Wang Yan, Mohamed Shafik Shaheen, Charlotte A Jordan, Charles McGhee, Naoyuki Maeda, Tobias H Neuhann, H Burkhard Dick, Andreas Steinmueller
PURPOSE: In corneal refractive surgery, postoperative ectasia risk assessment routinely includes pachymetric analysis at the apex and thinnest point. We examined whether these data differ worldwide and constructed preliminary country-specific normative thresholds. DESIGN: This was a multicenter, cross-sectional study. METHODS: Using the Pentacam Eye Scanner (OCULUS GmbH, Wetzlar, Germany), we examined 1 randomly selected eye from each of 555 normal adults (8 countries, 6 continents), measuring the thinnest point location, central pachymetry (thinnest point, pupillary center, and apex), and the apex-thinnest point difference...
January 2012: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/25880872/experimental-study-on-cryotherapy-for-fungal-corneal-ulcer
#8
Yingxin Chen, Weijia Yang, Minghong Gao, Michael Wellington Belin, Hai Yu, Jing Yu
BACKGROUND: Fungal corneal ulcer is one of the major causes of visual impairment worldwide. Treatment of fungal corneal ulcer mainly depends on anti-fungal agents. In the current study, we developed an integrated combination therapy of cryotherapy and anti-fungal agents to facilitate effective treatment of fungal corneal ulcer. METHODS: Rabbit models of cornea infection were established using a combined method of intrastromal injection and keratoplasty. After treatment with cryotherapy and anti-fungal agents, scanning electron microscopy, transmission electron microscopy, and confocal microscopy were conducted to observe changes in microstructure in the rabbits...
2015: BMC Ophthalmology
https://www.readbyqxmd.com/read/25878897/comparative-analysis-of-anterior-segment-parameters-in-normal-and-keratoconus-eyes-generated-by-scheimpflug-tomography
#9
Faik Orucoglu, Ebru Toker
Purpose. To assess and compare the anterior and posterior corneal surface parameters, keratoconus indices, thickness profile data, and data from enhanced elevation maps of keratoconic and normal corneas with the Pentacam Scheimpflug corneal tomography and to determine the sensitivity and specificity of these parameters in discriminating keratoconus from normal eyes. Methods. The study included 656 keratoconus eyes and 515 healthy eyes with a mean age of 30.95 ± 9.25 and 32.90 ± 14.78 years, respectively. Forty parameters obtained from the Pentacam tomography were assessed by the receiver operating characteristic curve analysis for their efficiency...
2015: Journal of Ophthalmology
https://www.readbyqxmd.com/read/25768386/monitoring-corneal-densities-following-primary-pterygium-excision-with-adjuvant-topical-mitomycin-c-application-an-observational-study-of-corneal-scar-changes
#10
Ka Wai Kam, Michael W Belin, Alvin L Young
PURPOSE: Corneal densitometry is an inherent feature of the Pentacam device. We aim to assess the changes in corneal scar density with serial Scheimpflug images following primary pterygium excision with topical application of mitomycin-C. METHODS: We recruited patients who underwent primary, single-headed pterygium excision with topical adjuvant mitomycin-C. Scheimpflug images were taken at postoperative weeks 1, 4, and 12, and all patients received topical corticosteroid and antibiotic treatment for at least 4 weeks postoperatively...
May 2015: Cornea
https://www.readbyqxmd.com/read/25694823/efficacy-and-safety-of-corneal-transplantation-using-corneas-from-foreign-donors-versus-domestic-donors-a-prospective-randomized-controlled-trial
#11
Yingxin Chen, Congling Liao, Minghong Gao, Michael Wellington Belin, Mingwu Wang, Hai Yu, Jing Yu
Purpose. To assess the efficacy and safety of corneal transplantation using corneas from foreign donors. Methods. One hundred and eight patients needing therapeutic penetrating keratoplasty were randomly divided into 2 groups (54 cases/group): foreign group using foreign donor corneas and domestic group using domestic donor corneas. Clinical outcome and incidence of postoperative complications were compared between groups. Results. No significant difference with respect to the therapeutic outcome and postoperative Best Corrected Visual Acuity (BCVA) and neovascularization by final follow-up was observed between the two groups...
2015: Journal of Ophthalmology
https://www.readbyqxmd.com/read/25320954/tomographic-parameters-for-the-detection-of-keratoconus-suggestions-for-screening-and-treatment-parameters
#12
REVIEW
Michael W Belin, Ovette F Villavicencio, Renato R Ambrósio
Tomographic corneal evaluation has added significantly more information in the evaluation of the ectatic cornea. Additional information from the posterior cornea and a full corneal thickness map in addition to anterior corneal analysis has increased the ability to identify early and subtle corneal changes. Although these newer examination modalities have increased our sensitivity in refractive screening, problems still persist when attempting to assure treatment trials (such as collagen cross-linking) for early disease are performed to an appropriate patient population...
November 2014: Eye & Contact Lens
https://www.readbyqxmd.com/read/25017414/long-term-outcomes-of-boston-type-1-keratoprosthesis-implantation-a-retrospective-multicenter-cohort
#13
MULTICENTER STUDY
Divya Srikumaran, Beatriz Munoz, Anthony J Aldave, James V Aquavella, Sadeer B Hannush, Robert Schultze, Michael Belin, Esen Karamursel Akpek
PURPOSE: To study the long-term outcomes of Boston type 1 keratoprosthesis (KPro) surgery. DESIGN: Retrospective, multicenter case series. PARTICIPANTS: A total of 158 eyes of 150 patients underwent KPro implantation at 5 participating tertiary centers in the United States between January 2003 and December 2006. Of those, 139 eyes of 133 patients were included in the analyses. METHODS: The medical records of consecutive adult patients who received KPro surgery were reviewed...
November 2014: Ophthalmology
https://www.readbyqxmd.com/read/23925323/scheimpflug-imaging-for-keratoconus-and-ectatic-disease
#14
REVIEW
Michael W Belin, Renato Ambrósio
Scheimpflug cross-sectioning anterior segment imaging offers significant advantages over traditional placido based curvature analysis and ultrasound pachymetry. The accurate measurement of both the anterior and posterior corneal surfaces and the anterior and posterior lens allows for the creation of a three-dimensional reconstruction of the anterior segment. Changes on both the posterior cornea and/or corneal thickness map are earlier indicators of ectatic change than would otherwise be identifiable with only anterior curvature and ultrasonic pachymetry...
August 2013: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/23499061/retention-of-the-boston-keratoprosthesis-type-1-multicenter-study-results
#15
MULTICENTER STUDY
Joseph B Ciolino, Michael W Belin, Amit Todani, Khalid Al-Arfaj, Christopher J Rudnisky
OBJECTIVE: To report the retention rate of the Boston keratoprosthesis type 1 and to identify risk factors for keratoprosthesis loss. DESIGN: Cohort study. PARTICIPANTS: A total of 300 eyes of 300 patients who underwent implantation of the Boston keratoprosthesis type I device between January 2003 and July 2008 by 19 surgeons at 18 medical centers. METHODS: Forms reporting preoperative, intraoperative, and postoperative parameters were prospectively collected and subsequently analyzed at a central data collection site...
June 2013: Ophthalmology
https://www.readbyqxmd.com/read/22488114/effect-of-donor-and-recipient-factors-on-corneal-graft-rejection
#16
R Doyle Stulting, Alan Sugar, Roy Beck, Michael Belin, Mariya Dontchev, Robert S Feder, Robin L Gal, Edward J Holland, Craig Kollman, Mark J Mannis, Francis Price, Walter Stark, David D Verdier
PURPOSE: To assess the relationship between donor and recipient factors and corneal allograft rejection in eyes that underwent penetrating keratoplasty in the Cornea Donor Study. METHODS: Overall, 1090 subjects undergoing corneal transplantation for a moderate risk condition (principally Fuchs dystrophy or pseudophakic corneal edema) were followed for up to 5 years. Associations of baseline recipient and donor factors with the occurrence of a probable or definite rejection event were assessed in univariate and multivariate proportional hazards models...
October 2012: Cornea
https://www.readbyqxmd.com/read/22361316/risk-factors-for-the-development-of-retroprosthetic-membranes-with-boston-keratoprosthesis-type-1-multicenter-study-results
#17
MULTICENTER STUDY
Christopher J Rudnisky, Michael W Belin, Amit Todani, Khalid Al-Arfaj, Jared D Ament, Brian J Zerbe, Joseph B Ciolino
OBJECTIVE: The purpose of this study was to identify possible risk factors for retroprosthetic membrane (RPM) development in a large, multicenter cohort of patients receiving a Boston type 1 keratoprosthesis. DESIGN: Cohort study. PARTICIPANTS: The final analysis included 265 eyes of 265 patients who underwent implantation of a Boston keratoprosthesis type I device between January 2003 and July 2008 by 1 of 19 surgeons at 18 medical centers...
May 2012: Ophthalmology
https://www.readbyqxmd.com/read/21840680/international-values-of-corneal-elevation-in-normal-subjects-by-rotating-scheimpflug-camera
#18
RANDOMIZED CONTROLLED TRIAL
Matthew T Feng, Michael W Belin, Renato Ambrósio, Satinder P S Grewal, Wang Yan, Mohamed Shafik Shaheen, Charlotte A Jordon, Charles McGhee, Naoyuki Maeda, Tobias H Neuhann, H Burkhard Dick, Andreas Steinmueller
PURPOSE: To examine whether clinically significant differences exist in corneal elevation data from a sampling of countries worldwide. SETTING: International multicenter. DESIGN: Evaluation of diagnostic test or technology. METHODS: One randomly selected eye of normal adults from 8 countries spanning 6 continents was examined using the Pentacam Eye Scanner. Anterior and posterior elevations were measured at the apex and thinnest point...
October 2011: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/21800785/novel-pachymetric-parameters-based-on-corneal-tomography-for-diagnosing-keratoconus
#19
Renato Ambrósio, Ana Laura C Caiado, Frederico P Guerra, Ricardo Louzada, Abhijit Sinha Roy, Allan Luz, William J Dupps, Michael W Belin
PURPOSE: To describe pachymetric progression indices (PPI) of the Pentacam HR (Oculus Optikgeräte GmbH) and the concept of relational thickness, and to test their accuracy for differentiating keratoconic and normal corneas compared with single-point thickness values. METHODS: One hundred thirteen individual eyes randomly selected from 113 normal patients and 44 eyes of 44 patients with keratoconus were studied using the Pentacam HR by acquiring central corneal thickness (CCT), thinnest point (TP), position of the TP and PPI at minimal (PPI Min) and maximal (PPI Max) meridians, and the average (PPI Ave) of all meridians...
October 2011: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/21708379/what-s-in-a-name-keratoconus-pellucid-marginal-degeneration-and-related-thinning-disorders
#20
Michael W Belin, Ijeoma M Asota, Renato Ambrosio, Stephen S Khachikian
PURPOSE: To discuss the implications of the current nomenclature and use of current diagnostic modalities on the classification and treatment of pellucid marginal degeneration and keratoconus. DESIGN: Perspective analysis of the literature. METHODS: Analysis of published reports on the various treatment methods for pellucid marginal degeneration and keratoconus, and the technologies used in these studies to support the diagnosis and classification of these ectatic disorders...
August 2011: American Journal of Ophthalmology
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