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https://www.readbyqxmd.com/read/29662740/low-density-pedicle-screw-constructs-for-adolescent-idiopathic-scoliosis-evaluation-of-effectiveness-and-cost
#1
Oliver O Tannous, Kelly E Banagan, Eric J Belin, Ehsan Jazini, Tristan B Weir, Steven C Ludwig, Daniel E Gelb
Study Design: Retrospective cohort study. Objective: To determine whether a low-density (LD) screw construct can achieve curve correction similar to a high-density (HD) construct in adolescent scoliosis. Methods: Patients treated operatively for idiopathic scoliosis between 2007 and 2011 were identified through a database review. A consistent LD screw construct was used. Radiographic assessment included percent correction of major and fractional lumbar curves, T5-T12 kyphosis, and angle of lowest instrumented vertebra (LIV)...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29650388/evaluation-at-3-years-of-concurrent-bevacizumab-and-radiotherapy-for-breast-cancer-results-of-a-prospective-study
#2
A Dautruche, L Belin, P Cottu, P Bontemps, C Lemanski, B de la Lande, P Baumann, F Missohou, C Lévy, K Peignaux, A Reynaud-Bougnoux, F Denis, A Gobillion, V Pernin, Y Kirova
PURPOSE: To determine the 3 years late toxicity among patients with non-metastatic breast cancer who received concurrent bevacizumab and locoregional radiotherapy. MATERIAL AND METHODS: This is a single-arm, multicentre, prospective study, of the toxicity of adjuvant concomitant association of bevacizumab and radiotherapy in patients with breast cancer. Toxicity was assessed by the Common Terminology Criteria for Adverse Events version 3.0 during the radiotherapy and follow-up clinics at 12 and 36 months after its completion...
April 9, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29624771/assessing-cognitive-function-in-patients-treated-with-immune-checkpoint-inhibitors-a-feasibility-study
#3
Cuzzubbo Stefania, Belin Catherine, Chouahnia Kader, Baroudjian Barouyr, Duchemann Boris, Barlog Ciprian, Coarelli Giulia, Ursu Renata, Poirier Elodie, Lebbe Celeste, Antoine F Carpentier
No abstract text is available yet for this article.
April 6, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29609099/direct-speech-quotations-promote-low-relative-clause-attachment-in-silent-reading-of-english
#4
Bo Yao, Christoph Scheepers
The implicit prosody hypothesis (Fodor, 1998, 2002) proposes that silent reading coincides with a default, implicit form of prosody to facilitate sentence processing. Recent research demonstrated that a more vivid form of implicit prosody is mentally simulated during silent reading of direct speech quotations (e.g., Mary said, "This dress is beautiful"), with neural and behavioural consequences (e.g., Yao, Belin, & Scheepers, 2011; Yao & Scheepers, 2011). Here, we explored the relation between 'default' and 'simulated' implicit prosody in the context of relative-clause (RC) attachment in English...
March 31, 2018: Cognition
https://www.readbyqxmd.com/read/29581266/cracking-the-social-code-of-speech-prosody-using-reverse-correlation
#5
Emmanuel Ponsot, Juan José Burred, Pascal Belin, Jean-Julien Aucouturier
Human listeners excel at forming high-level social representations about each other, even from the briefest of utterances. In particular, pitch is widely recognized as the auditory dimension that conveys most of the information about a speaker's traits, emotional states, and attitudes. While past research has primarily looked at the influence of mean pitch, almost nothing is known about how intonation patterns, i.e., finely tuned pitch trajectories around the mean, may determine social judgments in speech. Here, we introduce an experimental paradigm that combines state-of-the-art voice transformation algorithms with psychophysical reverse correlation and show that two of the most important dimensions of social judgments, a speaker's perceived dominance and trustworthiness, are driven by robust and distinguishing pitch trajectories in short utterances like the word "Hello," which remained remarkably stable whether male or female listeners judged male or female speakers...
March 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29551382/electrochemical-behavior-of-titanium-exposed-to-a-biofilm-supplemented-with-different-sucrose-concentrations
#6
João Gabriel Silva Souza, Thamara Beline, Adaias Oliveira Matos, Bárbara Emanoele Costa Oliveira, Antônio Pedro Ricomini-Filho, Valentim Adelino Ricardo Barão
STATEMENT OF PROBLEM: Biofilms can reduce the corrosion resistance of titanium because of the bacterial metabolism of fermentable carbohydrates, including sucrose. However, studies evaluating whether biofilms exposed to higher sucrose concentrations can affect the electrochemical behavior of titanium are lacking. PURPOSE: The purpose of this in vitro study was to test the electrochemical behavior of titanium previously exposed to biofilm supplemented with different sucrose concentrations...
March 15, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29529989/s100b-polymorphisms-are-associated-with-age-of-onset-of-parkinson-s-disease
#7
Camilla Fardell, Anna Zettergren, Caroline Ran, Andrea Carmine Belin, Agneta Ekman, Olof Sydow, Lars Bäckman, Björn Holmberg, Nil Dizdar, Peter Söderkvist, Hans Nissbrandt
BACKGROUND: In this study we investigated the association between SNPs in the S100B gene and Parkinson's disease (PD) in two independent Swedish cohorts. The SNP rs9722 has previously been shown to be associated with higher S100B concentrations in serum and frontal cortex in humans. S100B is widely expressed in the central nervous system and has many functions such as regulating calcium homeostasis, inflammatory processes, cytoskeleton assembly/disassembly, protein phosphorylation and degradation, and cell proliferation and differentiation...
March 12, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29520592/decrease-of-cocaine-but-not-heroin-self-administration-and-relapse-by-the-tyrosine-kinase-inhibitor-masitinib-in-male-sprague-dawley-rats
#8
A Belin-Rauscent, J Lacoste, O Hermine, A Moussy, B J Everitt, David Belin
RATIONALE: Accumulating evidence shows that cocaine, and also heroin, influence several tyrosine kinases, expressed in neurons and in non-neuronal populations such as microglia, astrocytes and mast-cells. Drug-induced activation of mast cells both triggers inflammatory processes in the brain mediated by the glial cells they activate, and facilitates histamine release which may directly influence the dopamine system. Thus, by triggering the activation and degranulation of mast cells dependent on the tyrosine kinase c-kit and Fyn, the latter being also involved in NMDA-dependent synaptic plasticity, cocaine and heroin may indirectly influence the neural mechanisms that mediate their reinforcing properties...
March 8, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29514413/heroin-seeking-becomes-dependent-on-dorsal-striatal-dopaminergic-mechanisms-and-can-be-decreased-by-n-acetylcysteine
#9
Ritchy Hodebourg, Jennifer E Murray, Maxime Fouyssac, Mickaël Puaud, Barry J Everitt, David Belin
The alarming increase in heroin overdoses in the USA is a reminder of the need for efficacious and novel treatments for opiate addiction. This may reflect the relatively poor understanding of the neural basis of heroin, as compared to cocaine, seeking behavior. While cocaine reinforcement depends on the mesolimbic system, well established cocaine seeking is dependent on dorsolateral striatum (aDLS) dopamine-dependent mechanisms which are disrupted by N-acetylcysteine, through normalisation of corticostriatal glutamate homeostasis...
March 7, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29505829/structural-basis-for-partition-of-the-cyclodipeptide-synthases-into-two-subfamilies
#10
Gabrielle Bourgeois, Jérôme Seguin, Morgan Babin, Pascal Belin, Mireille Moutiez, Yves Mechulam, Muriel Gondry, Emmanuelle Schmitt
Cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNAs to catalyze the formation of two peptide bonds leading to cyclodipeptides that can be further used for the synthesis of diketopiperazines. It was shown that CDPSs fall into two subfamilies, NYH and XYP, characterized by the presence of specific sequence signatures. However, current understanding of CDPSs only comes from studies of enzymes from the NYH subfamily. The present study reveals the crystal structures of three CDPSs from the XYP subfamily. Comparison of the XYP and NYH enzymes shows that the two subfamilies mainly differ in the first half of their Rossmann fold...
March 2, 2018: Journal of Structural Biology
https://www.readbyqxmd.com/read/29502620/repeatability-and-reliability-of-ectasia-display-and-topometric-indices-with-the-scheimpflug-system-in-normal-and-keratoconic-eyes
#11
Pinar Kosekahya, Mustafa Koc, Mehtap Caglayan, Hasan Kiziltoprak, Cemile Ucgul Atilgan, Pelin Yilmazbas
PURPOSE: To evaluate the repeatability and reliability of Belin-Ambrósio Enhanced Ectasia Display-III indices and topometric indices with a Scheimpflug system (Pentacam HR) in normal eyes and keratoconic eyes. SETTING: Ulucanlar Eye Research and Training Hospital, Ankara, Turkey. DESIGN: Prospective case series. METHODS: The same operator performed 3 consecutive successive measurements with the Scheimpflug device in the eyes of patients with keratoconus (keratoconus group) and healthy volunteers (normal group)...
January 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29483897/a-comprehensive-overview-of-the-cyclodipeptide-synthase-family-enriched-with-the-characterization-of-32-new-enzymes
#12
Muriel Gondry, Isabelle B Jacques, Robert Thai, Morgan Babin, Nicolas Canu, Jérôme Seguin, Pascal Belin, Jean-Luc Pernodet, Mireille Moutiez
Cyclodipeptide synthases (CDPSs) use as substrates two amino acids activated as aminoacyl-tRNAs to synthesize cyclodipeptides in secondary metabolites biosynthetic pathways. Since the first description of a CDPS in 2002, the number of putative CDPSs in databases has increased exponentially, reaching around 800 in June 2017. They are likely to be involved in numerous biosynthetic pathways but the diversity of their products is still under-explored. Here, we describe the activity of 32 new CDPSs, bringing the number of experimentally characterized CDPSs to about 100...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29478448/periodontal-status-of-current-methamphetamine-users
#13
Vladimir W Spolsky, Jason Clague, Debra A Murphy, Steven Vitero, Bruce A Dye, Thomas R Belin, Vivek Shetty
BACKGROUND: Methamphetamine (MA) use is associated with extensive dental caries. The purpose of this study was to determine the prevalence and severity of periodontal disease in a convenience sample of MA users. METHODS: In this cross-sectional survey, MA users were recruited with a combination of snowball sampling and street outreach techniques. Three dentists, trained and calibrated to the oral assessments used in the National Health and Nutrition Survey, measured and recorded the participants' attachment loss, probing depth, and gingival recession...
March 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29474345/opioid-related-genetic-polymorphisms-do-not-influence-postoperative-opioid-requirement-a-prospective-observational-study
#14
Frédéric Aubrun, Noël Zahr, Olivier Langeron, Nicolas Boccheciampe, Nathalie Cozic, Lisa Belin, Jean-Sebastien Hulot, Frederic Khiami, Bruno Riou
BACKGROUND: Among the various factors that may influence the pharmacological response to opioids, genetic polymorphisms [single nucleotide polymorphisms (SNP)] have generated some interest. OBJECTIVES: To examine the influence on morphine dose requirements and adverse events in the postoperative period of four SNP [opioid receptor mu1 (OPRM1), ATP-binding cassette subfamily B, member 1 (ABCB1) ex-21 and ex-26, catechol-o-methyltransferase (COMT)] in candidate genes involved in morphine pharmacodynamics and pharmacokinetics...
February 22, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29462131/pathological-complete-response-and-prognosis-after-neoadjuvant-chemotherapy-for-her2-positive-breast-cancers-before-and-after-trastuzumab-era-results-from-a-real-life-cohort
#15
Anne-Sophie Hamy, Lisa Belin, Hélène Bonsang-Kitzis, Caroline Paquet, Jean-Yves Pierga, Florence Lerebours, Paul Cottu, Roman Rouzier, Alexia Savignoni, Marick Lae, Fabien Reyal
This corrects the article DOI: 10.1038/bjc.2015.426.
February 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29456243/hopanoid-lipids-from-membranes-to-plant-bacteria-interactions
#16
REVIEW
Brittany J Belin, Nicolas Busset, Eric Giraud, Antonio Molinaro, Alba Silipo, Dianne K Newman
Lipid research represents a frontier for microbiology, as showcased by hopanoid lipids. Hopanoids, which resemble sterols and are found in the membranes of diverse bacteria, have left an extensive molecular fossil record. They were first discovered by petroleum geologists. Today, hopanoid-producing bacteria remain abundant in various ecosystems, such as the rhizosphere. Recently, great progress has been made in our understanding of hopanoid biosynthesis, facilitated in part by technical advances in lipid identification and quantification...
February 19, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29441714/time-dependent-regional-brain-distribution-of-methadone-and-naltrexone-in-the-treatment-of-opioid-addiction
#17
Belin G Teklezgi, Annapurna Pamreddy, Sooraj Baijnath, Hendrik G Kruger, Tricia Naicker, Nirmala D Gopal, Thavendran Govender
Opioid addiction is a serious public health concern with severe health and social implications; therefore, extensive therapeutic efforts are required to keep users drug free. The two main pharmacological interventions, in the treatment of addiction, involve management with methadone an mu (μ)-opioid agonist and treatment with naltrexone, μ-opioid, kappa (κ)-opioid and delta (δ)-opioid antagonist. MET and NAL are believed to help individuals to derive maximum benefit from treatment and undergo a full recovery...
February 14, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29429285/-analysis-on-the-role-of-sirius-combined-topography-and-tomography-system-in-screening-for-suspect-keratoconus
#18
Y Zhang, Y G Chen, H Y Yang, Y J Xia, R Zhao
Objective: To evaluate the role of Sirius combined topography and tomography system in screening for suspect keratoconus among the corneal refractive surgery candidates. Methods: Retrospective case series study. Eight hundred and sixteen consecutive ametropic patients (1 632 eyes) who underwent routine examinations before corneal refractive surgery at Peking University Third Hospital from January 2016 to September 2016 were reviewed. All the cases were analyzed with Sirius combined topography and tomography system...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29396255/the-doubling-potential-of-t-lymphocytes-allows-clinical-grade-production-of-a-bank-of-genetically-modified-monoclonal-t-cell-populations
#19
Régine Vivien, Soraya Saïagh, Philippe Lemarre, Valérie Chabaud, Béline Jesson, Catherine Godon, Ulrich Jarry, Thierry Guillaume, Patrice Chevallier, Henri Vié, Béatrice Clémenceau
BACKGROUND AIMS: To produce an anti-leukemic effect after hematopoietic stem cell transplantation we have long considered the theoretical possibility of using banks of HLA-DP specific T-cell clones transduced with a suicide gene. For that application as for any others, a clonal strategy is constrained by the population doubling (PD) potential of T cells, which has been rarely explored or exploited. METHODS: We used clinical-grade conditions and two donors who were homozygous and identical for all HLA-alleles except HLA-DP...
January 21, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29384807/an-early-finding-of-keratoconus-increase-in-corneal-densitometry
#20
Mustafa Koc, Kemal Tekin, Merve Inanc Tekin, Mehmet Murat Uzel, Pinar Kosekahya, Kemal Ozulken, Pelin Yilmazbas
PURPOSE: To investigate the corneal densitometry in subclinical keratoconus with normal elevation and pachymetric parameters. METHODS: Patients with clinical keratoconus in one eye and subclinical keratoconus in the fellow eye were identified. The study group was selected from patients with subclinical keratoconus who showed normal results from topographic and Belin-Ambrósio Enhanced Ectasia Display III (BAD) analysis (Kmean <47.2 diopters, inferior-superior asymmetry <1...
January 30, 2018: Cornea
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