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https://www.readbyqxmd.com/read/29456243/hopanoid-lipids-from-membranes-to-plant-bacteria-interactions
#1
REVIEW
Brittany J Belin, Nicolas Busset, Eric Giraud, Antonio Molinaro, Alba Silipo, Dianne K Newman
Lipid research represents a frontier for microbiology, as showcased by hopanoid lipids. Hopanoids, which resemble sterols and are found in the membranes of diverse bacteria, have left an extensive molecular fossil record. They were first discovered by petroleum geologists. Today, hopanoid-producing bacteria remain abundant in various ecosystems, such as the rhizosphere. Recently, great progress has been made in our understanding of hopanoid biosynthesis, facilitated in part by technical advances in lipid identification and quantification...
February 19, 2018: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29441714/time-dependent-regional-brain-distribution-of-methadone-and-naltrexone-in-the-treatment-of-opioid-addiction
#2
Belin G Teklezgi, Annapurna Pamreddy, Sooraj Baijnath, Hendrik G Kruger, Tricia Naicker, Nirmala D Gopal, Thavendran Govender
Opioid addiction is a serious public health concern with severe health and social implications; therefore, extensive therapeutic efforts are required to keep users drug free. The two main pharmacological interventions, in the treatment of addiction, involve management with methadone an mu (μ)-opioid agonist and treatment with naltrexone, μ-opioid, kappa (κ)-opioid and delta (δ)-opioid antagonist. MET and NAL are believed to help individuals to derive maximum benefit from treatment and undergo a full recovery...
February 14, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29429285/-analysis-on-the-role-of-sirius-combined-topography-and-tomography-system-in-screening-for-suspect-keratoconus
#3
Y Zhang, Y G Chen, H Y Yang, Y J Xia, R Zhao
Objective: To evaluate the role of Sirius combined topography and tomography system in screening for suspect keratoconus among the corneal refractive surgery candidates. Methods: Retrospective case series study. Eight hundred and sixteen consecutive ametropic patients (1 632 eyes) who underwent routine examinations before corneal refractive surgery at Peking University Third Hospital from January 2016 to September 2016 were reviewed. All the cases were analyzed with Sirius combined topography and tomography system...
January 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29396255/the-doubling-potential-of-t-lymphocytes-allows-clinical-grade-production-of-a-bank-of-genetically-modified-monoclonal-t-cell-populations
#4
Régine Vivien, Soraya Saïagh, Philippe Lemarre, Valérie Chabaud, Béline Jesson, Catherine Godon, Ulrich Jarry, Thierry Guillaume, Patrice Chevallier, Henri Vié, Béatrice Clémenceau
BACKGROUND AIMS: To produce an anti-leukemic effect after hematopoietic stem cell transplantation we have long considered the theoretical possibility of using banks of HLA-DP specific T-cell clones transduced with a suicide gene. For that application as for any others, a clonal strategy is constrained by the population doubling (PD) potential of T cells, which has been rarely explored or exploited. METHODS: We used clinical-grade conditions and two donors who were homozygous and identical for all HLA-alleles except HLA-DP...
January 21, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29384807/an-early-finding-of-keratoconus-increase-in-corneal-densitometry
#5
Mustafa Koc, Kemal Tekin, Merve Inanc Tekin, Mehmet Murat Uzel, Pinar Kosekahya, Kemal Ozulken, Pelin Yilmazbas
PURPOSE: To investigate the corneal densitometry in subclinical keratoconus with normal elevation and pachymetric parameters. METHODS: Patients with clinical keratoconus in one eye and subclinical keratoconus in the fellow eye were identified. The study group was selected from patients with subclinical keratoconus who showed normal results from topographic and Belin-Ambrósio Enhanced Ectasia Display III (BAD) analysis (Kmean <47.2 diopters, inferior-superior asymmetry <1...
January 30, 2018: Cornea
https://www.readbyqxmd.com/read/29377457/non-canonical-amino-acid-incorporation-into-2-5-diketopiperazines-by-cyclodipeptide-synthases
#6
Nicolas Canu, Pascal Belin, Robert Thai, Isabelle Correia, Olivier Lequin, Jérôme Seguin, Mireille Moutiez, Muriel Gondry
The manipulation of natural product biosynthetic pathways is a powerful means of expanding the chemical diversity of bioactive molecules. 2,5-diketopiperazines (2,5-DKPs) have been widely developed by medicinal chemists, but their biological production is yet to be exploited. We introduce here an in vivo method to incorporate non-canonical amino acids (ncAAs) into 2,5-DKPs using cyclodipeptide synthases (CDPSs), the enzymes responsible for scaffold assembly in many 2,5-DKP biosynthetic pathways. CDPSs use aminoacyl-tRNAs as substrates...
January 29, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29352026/addictive-behaviour-in-experimental-animals-prospects-for-translation
#7
REVIEW
Barry J Everitt, Chiara Giuliano, David Belin
Since the introduction of intravenous drug self-administration methodology over 50 years ago, experimental investigation of addictive behaviour has delivered an enormous body of data on the neural, psychological and molecular mechanisms of drug reward and reinforcement and the neuroadaptations to chronic use. Whether or not these behavioural and molecular studies are viewed as modelling the underpinnings of addiction in humans, the discussion presented here highlights two areas-the impact of drug-associated conditioned stimuli-or drug cues-on drug seeking and relapse, and compulsive cocaine seeking...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29239677/effects-of-kinect-adventures-games-versus-conventional-physical-therapy-on-postural-control-in-elderly-people-a-randomized-controlled-trial
#8
Jéssica Maria Ribeiro Bacha, Gisele Cristine Vieira Gomes, Tatiana Beline de Freitas, Larissa Alamino Pereira Viveiro, Keyte Guedes da Silva, Géssika Costa Bueno, Eliana Maria Varise, Camila Torriani-Pasin, Angélica Castilho Alonso, Natalia Mariana Silva Luna, Júlia Maria D'Andrea Greve, José Eduardo Pompeu
OBJECTIVE: To compare the effectiveness of Kinect Adventures games versus conventional physiotherapy to improve postural control (PC), gait, cardiorespiratory fitness, and cognition of the elderly. In addition, we evaluated the safety, acceptability, and adherence to the interventions. MATERIALS AND METHODS: The study was a randomized clinical trial in which 46 elderly individuals were selected, mean age 69.3 (5.34) years. Participants were allocated to the Kinect Adventures Training Group (KATG) or the Conventional Physical Therapy Group (CPTG), 23 individuals in each group...
December 14, 2017: Games for Health
https://www.readbyqxmd.com/read/29227513/in-vivo-early-corneal-biomechanical-changes-after-corneal-cross-linking-in-patients-with-progressive-keratoconus
#9
Riccardo Vinciguerra, Vito Romano, Esmaeil M Arbabi, Matthias Brunner, Colin E Willoughby, Mark Batterbury, Stephen B Kaye
PURPOSE: To report early corneal biomechanical changes after corneal cross-linking (CXL) in patients with keratoconus. METHODS: Thirty-four eyes of 34 patients undergoing CXL for progressive keratoconus were included in this prospective clinical study. Dynamic corneal response (DCR) parameters obtained with the Corvis ST (OCULUS Optikgeräte GmbH; Wetzlar, Germany) were assessed at baseline (day of CXL) and after 1 month of follow-up; conversely, corneal tomography with the Pentacam (OCULUS Optikgeräte GmbH) was assessed at baseline and at 1, 3, and 6 months after CXL...
December 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29225912/effects-of-virtual-rehabilitation-versus-conventional-physical-therapy-on-postural-control-gait-and-cognition-of-patients-with-parkinson-s-disease-study-protocol-for-a-randomized-controlled-feasibility-trial
#10
Keyte Guedes Silva, Tatiana Beline De Freitas, Flávia Doná, Fernando Freitas Ganança, Henrique Ballalai Ferraz, Camila Torriani-Pasin, José Eduardo Pompeu
Background: There is an association among postural instability, gait dysfunction, and cognitive impairment in subjects with Parkinson's disease (PD). Difficulty in dividing attention, response inhibition, and visuospatial attention deficiencies may contribute to the impairment of motor performance during daily activities. There are strong evidences that physical therapy can prevent physical and cognitive decline in individuals with PD. Recently, the European Physiotherapy Guideline (EPG) was developed based on randomized clinical trials about the effectiveness of the physical therapy to improve the functional deficiencies of individuals with PD...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29224092/sex-differences-in-leptin-control-of-cardiovascular-function-in-health-and-metabolic-diseases
#11
Eric J Belin de Chantemèle
Leptin, the adipocyte-derived hormone identified in 1994 for its major role in the control of satiety and body weight regulation, is an adipokine secreted in a sex-specific manner. Although it has clearly been established that females secrete three to four times more leptin than males and that this sexual dimorphism in leptin secretion is exacerbated with overweight and obesity, the origin and the physiological consequences of this sexual dimorphism remain ill-defined. The adipose tissue is the major site of leptin secretion; however, leptin receptors are ubiquitously expressed, conferring to leptin, and indirectly to the adipose tissue, a potential role in the control of numerous physiological functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29211860/changes-in-the-epigenome-and-transcriptome-of-the-poplar-shoot-apical-meristem-in-response-to-water-availability-affect-preferentially-hormone-pathways
#12
Clément Lafon-Placette, Anne-Laure Le Gac, Didier Chauveau, Vincent Segura, Alain Delaunay, Marie-Claude Lesage-Descauses, Irène Hummel, David Cohen, Béline Jesson, Didier Le Thiec, Marie-Béatrice Bogeat-Triboulot, Franck Brignolas, Stéphane Maury
The adaptive capacity of long-lived organisms such as trees to the predicted climate changes, including severe and successive drought episodes, will depend on the presence of genetic diversity and phenotypic plasticity. Here, the involvement of epigenetic mechanisms in phenotypic plasticity toward soil water availability was examined in Populus×euramericana. This work aimed at characterizing (i) the transcriptome plasticity, (ii) the genome-wide plasticity of DNA methylation, and (iii) the function of genes affected by a drought-rewatering cycle in the shoot apical meristem...
December 2, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29209171/influence-of-mechanical-stimuli-on-schwann-cell-biology
#13
REVIEW
Sophie Belin, Kristen L Zuloaga, Yannick Poitelon
Schwann cells are the glial cells of the peripheral nervous system (PNS). They insulate axons by forming a specialized extension of plasma membrane called the myelin sheath. The formation of myelin is essential for the rapid saltatory propagation of action potentials and to maintain the integrity of axons. Although both axonal and extracellular matrix (ECM) signals are necessary for myelination to occur, the cellular and molecular mechanisms regulating myelination continue to be elucidated. Schwann cells in peripheral nerves are physiologically exposed to mechanical stresses (i...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29202412/treatment-of-swine-wastewater-in-continuous-activated-sludge-systems-under-different-dissolved-oxygen-conditions-reactor-operation-and-evaluation-using-modelling
#14
Miyoko Waki, Tomoko Yasuda, Yasuyuki Fukumoto, Fabrice Béline, Albert Magrí
Swine wastewater was treated in two continuously aerated activated sludge (AS) systems at high (AS1: 1.7-2.6 mg/L) and low (AS2: 0.04-0.08 mg/L) dissolved oxygen (DO), and at three temperatures (10, 20, and 30 °C). Biochemical oxygen demand (BOD) removal was >94.8%. Meanwhile, total nitrogen (N) removal was significantly higher in AS2, at 64, 89, and 88%, than in AS1, at 12, 24, and 46%, for 10, 20, and 30 °C, respectively. The experimental data were considered in a simulation study using an AS model for BOD and N removal, which also included nitrite, free ammonia, free nitrous acid, and temperature...
November 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29187087/heart-transplantation-as-last-resort-treatment-for-relapsing-polychondritis-with-severe-cardiac-involvement
#15
Laurent Dormoy, Annette Belin, Fabien Labombarda
Relapsing polychondritis is a rare multisystem autoimmune disease characterized by recurrent inflammation and destruction of different cartilaginous and proteoglycan-rich structures like cardiovascular system. We reported a case of heart transplantation in a 20-year-old man having a relapsing polychondritis with severe multiple cardiovascular involvement. The immunosuppressive treatment used to prevent graft rejection allowed to turn out the inflammatory disease. Cardiac transplantation may be considered as last resort treatment option in relapsing polychondritis with intractable extensive heart lesions...
September 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29183178/health-providers-communication-skills-training-affects-hypertension-outcomes
#16
Seyedeh Belin Tavakoly Sany, Nooshin Peyman, Fatemeh Behzhad, Habibollah Esmaeily, Ali Taghipoor, Gordon Ferns
OBJECTIVE: Hypertension is a common cardiovascular risk factor within the Iranian population, and this may be improved through changes in lifestyle. We aimed at improving hypertension outcomes and health literacy skills among hypertensive patients through communication skills training targeting health providers. METHODS: A randomized controlled trial method was used to enroll 35 health providers and 240 hypertensive patients attending community-based healthcare practices in the Mashhad, Iran...
November 28, 2017: Medical Teacher
https://www.readbyqxmd.com/read/29172740/the-choroid-plexus-harbors-a-circadian-oscillator-modulated-by-estrogens
#17
Telma Quintela, Tânia Albuquerque, Gabriella Lundkvist, Andrea Carmine Belin, Daniela Talhada, Isabel Gonçalves, Eva Carro, Cecília R A Santos
The suprachiasmatic nucleus (SCN) of the hypothalamus is considered the master circadian oscillator in mammals. However, extra-SCN structures in the brain also display daily rhythms. Recently, we have demonstrated that the choroid plexus (CP) expresses core clock genes that are subjected to circadian regulation in a sex-dependent manner. By using CP explants cultured from female knock-in mice carrying the Period-luciferase transgene, we show that CP exhibits endogenous circadian rhythms of PERIOD2::LUCIFERASE expression...
November 27, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29158377/evidence-for-rrna-2-o-methylation-plasticity-control-of-intrinsic-translational-capabilities-of-human-ribosomes
#18
Jenny Erales, Virginie Marchand, Baptiste Panthu, Sandra Gillot, Stéphane Belin, Sandra E Ghayad, Maxime Garcia, Florian Laforêts, Virginie Marcel, Agnès Baudin-Baillieu, Pierre Bertin, Yohann Couté, Annie Adrait, Mélanie Meyer, Gabriel Therizols, Marat Yusupov, Olivier Namy, Théophile Ohlmann, Yuri Motorin, Frédéric Catez, Jean-Jacques Diaz
Ribosomal RNAs (rRNAs) are main effectors of messenger RNA (mRNA) decoding, peptide-bond formation, and ribosome dynamics during translation. Ribose 2'-O-methylation (2'-O-Me) is the most abundant rRNA chemical modification, and displays a complex pattern in rRNA. 2'-O-Me was shown to be essential for accurate and efficient protein synthesis in eukaryotic cells. However, whether rRNA 2'-O-Me is an adjustable feature of the human ribosome and a means of regulating ribosome function remains to be determined. Here we challenged rRNA 2'-O-Me globally by inhibiting the rRNA methyl-transferase fibrillarin in human cells...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29154223/mitochondrial-f1-atpase-extends-glycolysis-and-ph-decline-in-an-in-vitro-model
#19
Sulaiman K Matarneh, Mariane Beline, Saulo de Luz E Silva, Hao Shi, David E Gerrard
The experiment was conducted to identify the mitochondrial protein responsible for enhancing glycolytic flux. We hypothesized that mitochondrial F1-ATPase promotes ATP hydrolysis and thereby the flux through glycolysis. Porcine longissimus muscle mitochondria were incorporated into an in vitro system designed to recapitulate postmortem glycolysis with or without Na-azide to specifically inhibit the β-subunit of mitochondrial F1-ATPase that catalyzes ATP hydrolysis. Addition of mitochondria enhanced ATP hydrolysis, glycogen degradation, lactate accumulation, and pH decline in the in vitro system...
November 7, 2017: Meat Science
https://www.readbyqxmd.com/read/29135585/the-regulation-of-aldosterone-secretion-by-leptin-implications-in-obesity-related-cardiovascular-disease
#20
Jessica L Faulkner, Thiago Bruder-Nascimento, Eric J Belin de Chantemèle
PURPOSE OF REVIEW: Although it has been known for some time that increases in body mass enhance aldosterone secretion, particularly in women, the origin of this elevation in aldosterone production is not well defined. Adipocyte-derived factors have emerged as potential candidates to increase aldosterone production in obesity. RECENT FINDINGS: Emerging evidence suggests the presence of a mechanistic link in which the adipocyte-derived hormone leptin stimulates aldosterone production in obesity, thereby creating a positive feedback loop for obesity-associated cardiovascular disease...
November 10, 2017: Current Opinion in Nephrology and Hypertension
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